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Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
Open accessAbstract
Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed exome sequencing and copy number analysis to define genomic aberrations in a prospectively accrued clinical cohort (n = 142) of early (stage I and II) sporadic pancreatic ductal adenocarcinoma. Detailed analysis of 99 informative tumours identified substantial heterogeneity with 2,016 non-silent mutations and 1,628 copy-number variations. We define 16 significantly mutated genes, reaffirming known mutations (KRAS, TP53, CDKN2A, SMAD4, MLL3, TGFBR2, ARID1A and SF3B1), and uncover novel mutated genes including additional genes involved in chromatin modification (EPC1 and ARID2), DNA damage repair (ATM) and other mechanisms (ZIM2, MAP2K4, NALCN, SLC16A4 and MAGEA6). Integrative analysis with in vitro functional data and animal models provided supportive evidence for potential roles for these genetic aberrations in carcinogenesis. Pathway-based analysis of recurrently mutated genes recapitulated clustering in core signalling pathways in pancreatic ductal adenocarcinoma, and identified new mutated genes in each pathway. We also identified frequent and diverse somatic aberrations in genes described traditionally as embryonic regulators of axon guidance, particularly SLIT/ROBO signalling, which was also evident in murine Sleeping Beauty transposon-mediated somatic mutagenesis models of pancreatic cancer, providing further supportive evidence for the potential involvement of axon guidance genes in pancreatic carcinogenesis.
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“Among the identified genomic alterations (GAs) in PDAC, oncogenic KRAS mutations are the most common, occurring in close to 90% of patients, followed by TP53, CDKN2A, and SMAD47,8.”
From Impact of KRAS mutations and co-mutations on clinical outcomes in pancreatic ductal adenocarcinoma (2024) · cites this paper as [7]
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“Amongst these are four canonical mutations – KRAS (~85%), TP53 (60–70%), CDKN2A (>50%), and SMAD4 (~50%).”
From KRAS mutation in pancreatic cancer (2021) · cites this paper as [50]
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Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
Jemal, A., Siegel, R., Xu, J., & Ward, E. (2010) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20073 · Cited by 12,596
Trastuzumab-Induced Hepatotoxicity: A Case Report
Vucicevic, D., Carey, E. J., & Karlin, N. J. (2013) · Breast Care · doi:10.1159/000346844 · Cited by 4,432
Brocken, P., van der Heijden, E. H. F. M., Dekhuijzen, P. N. R., Peters-Bax, L., & de Geus‐Oei, L. (2013) · Respiration · doi:10.1159/000347096 · Cited by 4,011
Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969
Self-citationMermel, C. H., Schumacher, S. E., Hill, B., Meyerson, M. M., Beroukhim, R., & Getz, G. A. (2011) · Genome biology · doi:10.1186/gb-2011-12-4-r41 · Cited by 3,520
International network of cancer genome projects
The International Cancer Genome Consortium (2010) · Nature · doi:10.1038/nature08987 · Cited by 2,299
Self-citationNeoptolemos, J. P., Stocken, D. D., Bassi, C., Ghaneh, P., Cunningham, D., Goldstein, D., Padbury, R., Moore, M. J., Gallinger, S., Mariette, C., et al. (2010) · JAMA · doi:10.1001/jama.2010.1275 · Cited by 1,395
Self-citationThe patterns and dynamics of genomic instability in metastatic pancreatic cancer
Campbell, P. J., Yachida, S., Mudie, L. J., Stephens, P. J., Pleasance, E. D., Stebbings, L. A., Morsberger, L. A., Latimer, C., McLaren, S., Lin, M.-L., et al. (2010) · Nature · doi:10.1038/nature09460 · Cited by 1,317
Self-citationExome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
Varela, I., Tarpey, P. S., Raine, K. M., Huang, D., Ong, C. K., Stephens, P., Davies, H. R., Jones, D., Lin, M., Teague, J. W., et al. (2011) · Nature · doi:10.1038/nature09639 · Cited by 1,302
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Zill, O. A., Greene, C., Sebisanovic, D., Siew, L. M., Leng, J., Vu, M., Hendifar, A. E., Wang, Z., Atreya, C. E., Kelley, R. K., et al. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0274 · Cited by 282
Self-citationCancer-specific defects in DNA repair pathways as targets for personalized therapeutic approaches
Dietlein, F., Thelen, L., & Reinhardt, H. C. (2014) · Trends in Genetics · doi:10.1016/j.tig.2014.06.003 · Cited by 290
Nerve–Cancer Cell Cross-talk: A Novel Promoter of Tumor Progression
Jobling, P., Pundavela, J., Oliveira, S. M. R., Roselli, S., Walker, M. M., & Hondermarck, H. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3180 · Cited by 272
Liao, M., Yao, D., Wu, L., Luo, C., Wang, Z., Zhang, J., & Liu, B. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.12.003 · Cited by 299
Pishvaian, M. J., Bender, R. J., Halverson, D., Rahib, L., Hendifar, A. E., Mikhail, S., Chung, V., Picozzi, V. J., Sohal, D., Blais, E. M., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-0531 · Cited by 245
Vennin, C., Chin, V. T., Warren, S. C., Lucas, M. C., Herrmann, D., Magenau, A., Mélénec, P., Walters, S. N., del Monte‐Nieto, G., Conway, J. R. W., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aai8504 · Cited by 266
Self-citationTumor Neurobiology and the War of Nerves in Cancer
Faulkner, S., Jobling, P., March, B., Jiang, C. C., & Hondermarck, H. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-1398 · Cited by 275
Castillo, J., Bernard, V., Lucas, F. A. S., Allenson, K., Capello, M., Kim, D. U., Gascoyne, P. R. C., Mulu, F. C., Stephens, B. M., Huang, J. H., et al. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx542 · Cited by 267
Self-citationPant, S., Wainberg, Z. A., Weekes, C. D., Furqan, M., Kasi, P. M., Devoe, C. E., Leal, A. D., Chung, V., Basturk, O., VanWyk, H., et al. (2024) · Nature Medicine · doi:10.1038/s41591-023-02760-3 · Cited by 267
Chiou, S., Winters, I. P., Wang, J., Naranjo, S., Dudgeon, C., Tamburini, F. B., Brady Jennifer, J., Yang, D., Grüner, B. M., Chuang, C.-H., et al. (2015) · Genes & Development · doi:10.1101/gad.264861.115 · Cited by 267
Lennon, A. M., Wolfgang, C. L., Canto, M. I., Klein, A. P., Herman, J. M., Goggins, M., Fishman, E. K., Kamel, I. R., Weiss, M. J., Diaz, L. A., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0734 · Cited by 268
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Zhu, H., Wei, M., Xu, J., Hua, J., Chen, L., Meng, Q., Zhang, Y., Liu, J., Zhang, B., Yu, X., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01167-9 · Cited by 263
WIPI proteins: essential PtdIns3 P effectors at the nascent autophagosome
Proikas‐Cezanne, T., Takács, Z., Dönnes, P., & Kohlbacher, O. (2015) · Journal of Cell Science · doi:10.1242/jcs.146258 · Cited by 267
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Scourzic, L., Mouly, E., & Bernard, O. (2015) · Genome Medicine · doi:10.1186/s13073-015-0134-6 · Cited by 263
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Hosein, A. N., Dougan, S. K., Aguirre, A. J., & Maitra, A. (2022) · Nature Cancer · doi:10.1038/s43018-022-00349-2 · Cited by 255
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Frankiw, L., Baltimore, D., & Li, G. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0195-7 · Cited by 253
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Alfert, A., Moreno, N., & Kerl, K. (2019) · Epigenetics & Chromatin · doi:10.1186/s13072-019-0264-y · Cited by 255
Pellagatti, A., Armstrong, R. N., Steeples, V., Sharma, E., Repapi, E., Singh, S., Sanchi, A., Radujkovic, A., Horn, P., Dolatshad, H., et al. (2018) · Blood · doi:10.1182/blood-2018-04-843771 · Cited by 248
Ordered and deterministic cancer genome evolution after p53 loss
Baslan, T., Morris, J. P., Zhao, Z., Reyes, J., Ho, Y.-J., Tsanov, K. M., Bermeo, J., Tian, S., Zhang, S., Askan, G., et al. (2022) · Nature · doi:10.1038/s41586-022-05082-5 · Cited by 221
Self-citationChantrill, L. A., Nagrial, A. M., Watson, C., Johns, A. L., Martyn-Smith, M., Simpson, S. H., Mead, S., Jones, M. D., Samra, J. S., Gill, A. J., et al. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-0426 · Cited by 239
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Schönhuber, N., Seidler, B., Schuck, K., Veltkamp, C., Schachtler, C., Zukowska, M., Eser, S., Feyerabend, T. B., Paul, M. C., Eser, P., et al. (2014) · Nature Medicine · doi:10.1038/nm.3646 · Cited by 245
Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy
Koikawa, K., Kibe, S., Suizu, F., Sekino, N., Kim, N., Manz, T. D., Pinch, B. J., Akshinthala, D., Verma, A., Gaglia, G., et al. (2021) · Cell · doi:10.1016/j.cell.2021.07.020 · Cited by 243
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Maurer, C., Holmstrom, S. R., He, J., Laise, P., Su, T., Ahmed, A., Hibshoosh, H., Chabot, J. A., Oberstein, P. E., Sepulveda, A. R., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-317706 · Cited by 216
Biology and evolution of poorly differentiated neuroendocrine tumors
Rickman, D. S., Beltran, H., Demichelis, F., & Rubin, M. A. (2017) · Nature Medicine · doi:10.1038/nm.4341 · Cited by 230
Connor, A. A., Denroche, R. E., Jang, G. H., Lemire, M., Zhang, A. X. W., Chan‐Seng‐Yue, M., Wilson, G. W., Grant, R. C., Merico, D., Lungu, I. M., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2018.12.010 · Cited by 227
Self-citationNones, K., Waddell, N., Song, S., Patch, A., Miller, D. K., Johns, A. L., Wu, J., Kassahn, K. S., Wood, D., Bailey, P. J., et al. (2014) · International Journal of Cancer · doi:10.1002/ijc.28765 · Cited by 229
Self-citationThe Protein Interaction Landscape of the Human CMGC Kinase Group
Varjosalo, M. T., Keskitalo, S., van Drogen, A., Nurkkala, H., Vichalkovski, A., Aebersold, R. H., & Gstaiger, M. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.03.027 · Cited by 235
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CAMCAP Study Group, Wedge, D. C., Gundem, G., Mitchell, T., Woodcock, D. J., Martincorena, I., Ghori, M., Zamora, J., Butler, A. P., Whitaker, H. C., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0086-z · Cited by 227
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Yao, W., Rose, J. L., Wang, W., Seth, S., Jiang, H., Taguchi, A., Liu, J., Yan, L., Kapoor, A., Hou, P., et al. (2019) · Nature · doi:10.1038/s41586-019-1062-1 · Cited by 214
Self-citationFrancescone, R., Costa, D. B. V., Franco‐Barraza, J., Wagner, J., Muir, A., Lau, A. N., Gabitova, L., Pazina, T., Gupta, S., Luong, T., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-0775 · Cited by 227
Liang, Q., Teoh, N., Xu, L., Pok, S., Li, X., Chu, E. S., Chiu, J., Dong, L., Arfianti, A., Haigh, W. G., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06931-6 · Cited by 229
Fujimoto, A., Furuta, M., Shiraishi, Y., Gotoh, K., Kawakami, Y., Arihiro, K., Nakamura, T., Ueno, M., Ariizumi, S.-I., Hà, N. H., et al. (2015) · Nature Communications · doi:10.1038/ncomms7120 · Cited by 223
Wang, X., Haswell, J. R., & Roberts, C. W. M. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-0280 · Cited by 224
Noll, E. M., Eisen, C., Stenzinger, A., Espinet, E., Muckenhuber, A., Klein, C., Vogel, V., Klaus, B., Nadler, W. M., Roesli, C., et al. (2016) · Nature Medicine · doi:10.1038/nm.4038 · Cited by 228
Advanced-stage pancreatic cancer: therapy options
Werner, J., Combs, S. E., Springfeld, C., Hartwig, W., Hackert, T., & Büchler, M. W. (2013) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2013.66 · Cited by 220
Gruber, R., Panayiotou, R., Nye, E. L., Spencer‐Dene, B., Stamp, G., & Behrens, A. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.05.006 · Cited by 214
Jiao, W., Atwal, G., Polak, P. P., Karlić, R., Cuppen, E. P. J. G., Al‐Shahrour, F., Atwal, G., Bailey, P. J., Biankin, A. V., Boutros, P. C., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13825-8 · Cited by 223
Self-citationPancreatic Cancer Metabolism: Breaking It Down to Build It Back Up
Perera, R. M., & Bardeesy, N. M. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0671 · Cited by 218
Immunohistochemistry for Diagnosis of Metastatic Carcinomas of Unknown Primary Site
Sèlves, J., Long-Mira, É., Mathieu, M., Rochaix, P., & Ilié, M. (2018) · Cancers · doi:10.3390/cancers10040108 · Cited by 224
Ge, Y. C., & Porse, B. T. (2013) · BioEssays · doi:10.1002/bies.201300156 · Cited by 219
Pancreatic cancer: optimizing treatment options, new, and emerging targeted therapies
Chiorean, E. G., & Coveler, A. L. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s60328 · Cited by 217
Jurcak, N. R., Rucki, A. A., Muth, S. T., Thompson, E. D., Sharma, R. B., Ding, D., Zhu, Q., Eshleman, J. R., Anders, R. A., Jaffee, E. M., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.05.065 · Cited by 216
Self-citationDeBoever, C., Ghia, E. M., Shepard, P. J., Rassenti, L. Z., Barrett, C. L., Jepsen, K., Jamieson, C. H. M., Carson, D. A., Kipps, T. J., & Frazer, K. A. (2015) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004105 · Cited by 220
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Self-citationThe pancreatic cancer genome revisited
Hayashi, A., Hong, J., & Iacobuzio-Donahue, C. A. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00463-z · Cited by 211
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Garg, M., Nagata, Y., Kanojia, D., Mayakonda, A., Yoshida, K., Keloth, S. H., Zang, Z. J., Okuno, Y., Shiraishi, Y., Chiba, K., et al. (2015) · Blood · doi:10.1182/blood-2015-05-646240 · Cited by 212
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Mendiratta, G., Ke, E., Aziz, M., Liarakos, D., Tong, M. M., & Stites, E. C. (2021) · Nature Communications · doi:10.1038/s41467-021-26213-y · Cited by 225
Lee, J. W., Komar, C. A., Bengsch, F., Graham, K. L., & Beatty, G. L. (2016) · Current Protocols in Pharmacology · doi:10.1002/cpph.2 · Cited by 212
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Humphris, J. L., Patch, A., Nones, K., Bailey, P. J., Johns, A. L., McKay, S., Chang, D. K.-F., Miller, D. K., Pajic, M., Kassahn, K. S., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.09.060 · Cited by 209
Self-citationCremona, C. A., & Behrens, A. (2013) · Oncogene · doi:10.1038/onc.2013.275 · Cited by 219
Hayashi, A., Fan, J., Chen, R., Ho, Y.-J., Makohon-Moore, A. P., Lecomte, N., Zhong, Y., Hong, J., Huang, J., Sakamoto, H., et al. (2020) · Nature Cancer · doi:10.1038/s43018-019-0010-1 · Cited by 205
Self-citationBelow, C. R., Kelly, J., Brown, A., Humphries, J. D., Hutton, C., Xu, J., Lee, B. Y., Cintas, C., Zhang, X., Hernandez-Gordillo, V., et al. (2022) · Nature Materials · doi:10.1038/s41563-021-01085-1 · Cited by 194
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Mello, S. S., Sinow, C., Raj, N., Mazur, P. K., Bieging-Rolett, K. T., Brož, D. K., Conklin, J. F., Vogel, H. S., Wood, L. D., Sage, J., et al. (2017) · Genes & Development · doi:10.1101/gad.284661.116 · Cited by 209
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Vennin, C., Murphy, K. J., Morton, J. P., Cox, T. R., Pajic, M., & Timpson, P. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.11.280 · Cited by 207
Self-citationMurphy, S. J., Hart, S. N., Lima, J. F., Kipp, B. R., Klebig, M. L., Winters, J. L., Szabo, C., Zhang, L., Eckloff, B. W., Petersen, G. M., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.07.049 · Cited by 199
Self-citationRen, S., Wei, G., Liu, D., Wang, L., Hou, Y., Zhu, S., Peng, L., Zhang, Q., Cheng, Y., Su, H. L., et al. (2017) · European Urology · doi:10.1016/j.eururo.2017.08.027 · Cited by 198
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Kanji, Z. S., & Gallinger, S. (2013) · Canadian Medical Association Journal · doi:10.1503/cmaj.121368 · Cited by 196
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Griffith, M., Miller, C. A., Griffith, O. L., Krysiak, K., Skidmore, Z. L., Ramu, A., Walker, J., Dang, H. X., Trani, L., Larson, D. E., et al. (2015) · Cell Systems · doi:10.1016/j.cels.2015.08.015 · Cited by 195
von Figura, G., Fukuda, A., Roy, N., Liku, M. E., Morris IV, J. P., Kim, G. E., Russ, H. A., Firpo, M. A., Mulvihill, S. J., Dawson, D. W., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb2916 · Cited by 190
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Takai, E., Totoki, Y., Nakamura, H. K., Morizane, C., Nara, S., Hama, N., Suzuki, M., Furukawa, E., Kato, M., Hayashi, H., et al. (2015) · Scientific Reports · doi:10.1038/srep18425 · Cited by 196
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Paschalis, A., Sharp, A., Welti, J. C., Neeb, A., Raj, G. V., Luo, J., Plymate, S. R., & Bono, J. S. D. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0085-0 · Cited by 190
Wong, S. S., Kim, K., Ting, J. C., Yu, K., Fu, J., Liu, S., Cristescu, R., Nebozhyn, M., Gong, L., Yue, Y. G., et al. (2014) · Nature Communications · doi:10.1038/ncomms6477 · Cited by 190
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Muzumdar, M. D., Chen, P.-Y., Dorans, K. J., Chung, K. M., Bhutkar, A., Hong, E., Noll, E. M., Sprick, M. R., Trumpp, A., & Jacks, T. (2017) · Nature Communications · doi:10.1038/s41467-017-00942-5 · Cited by 177
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Takeda, T., Banno, K., Okawa, R., Yanokura, M., Iijima, M., Irie, H., Nakamura, K., Iida, M., Adachi, M., Umene, K., et al. (2015) · Oncology Reports · doi:10.3892/or.2015.4421 · Cited by 194
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Mann, K. M., Ying, H., Juan, J. M., Jenkins, N. A., & Copeland, N. G. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.09.003 · Cited by 192
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Yachida, S., Wood, L. D., Suzuki, M., Takai, E., Totoki, Y., Kato, M., Luchini, C., Arai, Y., Nakamura, H. K., Hama, N., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2015.12.012 · Cited by 183
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Yachida, S., & Iacobuzio–Donahue, C. A. (2013) · Oncogene · doi:10.1038/onc.2013.29 · Cited by 185
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Zeitouni, D., Pylayeva‐Gupta, Y., Der, C. J., & Bryant, K. L. (2016) · Cancers · doi:10.3390/cancers8040045 · Cited by 191
Kabacaoğlu, D., Ciecielski, K. J., Ruess, D. A., & Algül, H. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01878 · Cited by 181
Guler, G. D., Ning, Y., Ku, C., Phillips, T. C., McCarthy, E., Ellison, C. K., Bergamaschi, A., Collin, F., Lloyd, P., Scott, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18965-w · Cited by 177
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Seki, M., Nishimura, R., Yoshida, K., Shimamura, T., Shiraishi, Y., Sato, Y., Kato, M., Chiba, K., Tanaka, H., Hoshino, N., et al. (2015) · Nature Communications · doi:10.1038/ncomms8557 · Cited by 182
SF3B1 mutations constitute a novel therapeutic target in breast cancer
Maguire, S. L., Leonidou, A., Wai, P. T., Marchiò, C., Ng, C. K. Y., Sapino, A., Vincent‐Salomon, A., Reis-Filho, J. S., Weigelt, B., & Natrajan, R. (2014) · The Journal of Pathology · doi:10.1002/path.4483 · Cited by 178
Hintzsche, J. D., Gorden, N. T., Amato, C. M., Kim, J., Wuensch, K. E., Robinson, S. E., Applegate, A. J., Couts, K. L., Medina, T. M., Wells, K. R., et al. (2017) · Melanoma Research · doi:10.1097/cmr.0000000000000345 · Cited by 179
Harnessing metabolic dependencies in pancreatic cancers
Encarnación-Rosado, J., & Kimmelman, A. C. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00431-7 · Cited by 190
Pancreatic cancer: advances in treatment.
Mohammed, S., Buren, G. V., & Fisher, W. E. (2014) · PubMed Central · doi:10.3748/wjg.v20.i28.9354 · Cited by 175
Self-citationThe sodium leak channel, NALCN, in health and disease
Cochet-Bissuel, M., Lory, P., & Monteil, A. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00132 · Cited by 172
Emerging roles of the CXCL12/CXCR4 axis in pancreatic cancer progression and therapy
Sleightholm, R. L., Neilsen, B. K., Li, J., Steele, M. M., Singh, R. K., Hollingsworth, M. A., & Oupický, D. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.05.012 · Cited by 171
Hadano, N., Murakami, Y., Uemura, K., Hashimoto, Y., Kondo, N., Nakagawa, N., Sueda, T., & Hiyama, E. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.175 · Cited by 173
Hou, S., Tiriac, H., Sridharan, B. P., Scampavia, L. D., Madoux, F., Seldin, J., Souza, G. R., Watson, D., Tuveson, D. A., & Spicer, T. (2018) · SLAS DISCOVERY · doi:10.1177/2472555218766842 · Cited by 175
Self-citationMo, D., Jiang, P., Yang, Y., Mao, X., Xuyan, T., Tang, X., Wei, D., Li, B., Wang, X., Tang, L. P., et al. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.05.007 · Cited by 168
Maresch, R., Mueller, S., Veltkamp, C., Öllinger, R., Friedrich, M., Heid, I., Steiger, K., Weber, J., Engleitner, T., Barenboim, M., et al. (2016) · Nature Communications · doi:10.1038/ncomms10770 · Cited by 171
Marchetti, C., Zyner, K. G., Ohnmacht, S. A., Robson, M. P., Haider, S. M., Morton, J. P., Marsico, G., Vo, T. D., Laughlin, S., Ahmed, A. A., et al. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b01781 · Cited by 168
Wang, L., & Shilatifard, A. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.01.001 · Cited by 165
Dysregulation and therapeutic targeting of RNA splicing in cancer
Stanley, R. F., & Abdel-Wahab, O. I. (2022) · Nature Cancer · doi:10.1038/s43018-022-00384-z · Cited by 172
Yu, J., Sadakari, Y., Shindo, K., Suenaga, M., Brant, A., Almario, J. A. N., Borges, M., Barkley, T., Fesharakizadeh, S., Ford, M., et al. (2017) · Gut · doi:10.1136/gutjnl-2015-311166 · Cited by 164
Self-citationTargeting DNA Damage Response and Replication Stress in Pancreatic Cancer
Dreyer, S. B., Upstill‐Goddard, R., Paulus-Hock, V., Paris, C., Lampraki, E.-M., Dray, E. V., Serrels, B., Caligiuri, G., Rebus, S., Plenker, D., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.09.043 · Cited by 165
Self-citationThe cancer COMPASS: navigating the functions of MLL complexes in cancer
Ford, D. J., & Dingwall, A. K. (2015) · Cancer Genetics · doi:10.1016/j.cancergen.2015.01.005 · Cited by 169
Pancreatic Cancer Genomes: Implications for Clinical Management and Therapeutic Development
Dreyer, S. B., Chang, D. K.-F., Bailey, P. J., & Biankin, A. V. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-2411 · Cited by 168
Self-citationModulating splicing with small molecular inhibitors of the spliceosome
Effenberger, K. A., Urabe, V. K., & Jurica, M. S. (2016) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1381 · Cited by 161
Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review
Kenner, B., Chari, S. T., Kelsen, D., Klimstra, D. S., Pandol, S. J., Rosenthal, M., Rustgi, A. K., Taylor, J. A., Yala, A., Abul-Husn, N., et al. (2021) · Pancreas · doi:10.1097/mpa.0000000000001762 · Cited by 158
Self-citationTargeting galectin-1 inhibits pancreatic cancer progression by modulating tumor–stroma crosstalk
Orozco, C. A., Martínez‐Bosch, N., Guerrero, P. E., Vinaixa, J., Dalotto‐Moreno, T., Iglesias, M., Moreno, M., Djurec, M., Poirier, F., Gabius, H., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1722434115 · Cited by 158
Wu, H., Hwang‐Verslues, W. W., Lee, W.-H., Huang, C.-K., Wei, P., Chen, C.-L., Shew, J., Lee, E. Y.-H. P., Jeng, Y., Tien, Y., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20141702 · Cited by 160
Heßmann, E., Schneider, G., Ellenrieder, V., & Siveke, J. T. (2015) · Oncogene · doi:10.1038/onc.2015.216 · Cited by 178
Metadata
- Authors
- Initiative, A. P. C. G., Biankin, A. V., Waddell, N., Kassahn, K. S., Gingras, M.-C., Muthuswamy, L. B., Johns, A. L., Miller, D. K., Wilson, P. J., Patch, A.-M., Wu, J., Chang, D. K., Cowley, M. J., Gardiner, B. B., Song, S., Harliwong, I., Idrisoglu, S., Nourse, C., Nourbakhsh, E., Manning, S., Wani, S., Gongora, M., Pajic, M., Scarlett, C. J., Gill, A. J., Pinho, A. V., Rooman, I., Anderson, M., Holmes, O., Leonard, C., Taylor, D., Wood, S., Xu, Q., Nones, K., Lynn Fink, J., Christ, A., Bruxner, T., Cloonan, N., Kolle, G., Newell, F., Pinese, M., Scott Mead, R., Humphris, J. L., Kaplan, W., Jones, M. D., Colvin, E. K., Nagrial, A. M., Humphrey, E. S., Chou, A., Chin, V. T., Chantrill, L. A., Mawson, A., Samra, J. S., Kench, J. G., Lovell, J. A., Daly, R. J., Merrett, N. D., Toon, C., Epari, K., Nguyen, N. Q., Barbour, A., Zeps, N., Kakkar, N., Zhao, F., Qing Wu, Y., Wang, M., Muzny, D. M., Fisher, W. E., Charles Brunicardi, F., Hodges, S. E., Reid, J. G., Drummond, J., Chang, K., Han, Y., Lewis, L. R., Dinh, H., Buhay, C. J., Beck, T., Timms, L., Sam, M., Begley, K., Brown, A., Pai, D., Panchal, A., Buchner, N., De Borja, R., Denroche, R. E., Yung, C. K., Serra, S., Onetto, N., Mukhopadhyay, D., Tsao, M.-S., Shaw, P. A., Petersen, G. M., Gallinger, S., Hruban, R. H., Maitra, A., Iacobuzio-Donahue, C. A., Schulick, R. D., Wolfgang, C. L., Morgan, R. A., Lawlor, R. T., Capelli, P., Corbo, V., Scardoni, M., Tortora, G., Tempero, M. A., Mann, K. M., Jenkins, N. A., Perez-Mancera, P. A., Adams, D. J., Largaespada, D. A., Wessels, L. F. A., Rust, A. G., Stein, L. D., Tuveson, D. A., Copeland, N. G., Musgrove, E. A., Scarpa, A., Eshleman, J. R., Hudson, T. J., Sutherland, R. L., Wheeler, D. A., Pearson, J. V., McPherson, J. D., Gibbs, R. A., & Grimmond, S. M.
- Affiliations
- Garvan Institute of Medical Research (AU)
- The University of Queensland (AU)
- Ontario Institute for Cancer Research (CA)
- The University of Sydney (AU)
- Royal Adelaide Hospital (AU)
- St John of God Subiaco Hospital (AU)
- Baylor College of Medicine (US)
- University of California, Los Angeles (US)
- University Health Network (CA)
- Johns Hopkins University (US)
- University of Verona (IT)
- Houston Methodist (US)
- University of Minnesota (US)
- Wellcome Sanger Institute (GB)
- Corresponding author
- Grimmond, Sean M.
- ORCID
- Biankin, Andrew V.
- Waddell, Nicola
- Kassahn, Karin S.
- Gingras, Marie-Claude
- Muthuswamy, Lakshmi B.
- Johns, Amber L.
- Wilson, Peter J.
- Patch, Ann-Marie
- Wu, Jianmin
- Chang, David K.
- Cowley, Mark J.
- Gardiner, Brooke B.
- Song, Sarah
- Harliwong, Ivon
- Nourbakhsh, Ehsan
- Manning, Suzanne
- Wani, Shivangi
- Pajic, Marina
- Scarlett, Christopher J.
- Gill, Anthony J.
- Pinho, Andreia V.
- Rooman, Ilse
- Anderson, Matthew
- Holmes, Oliver
- Leonard, Conrad
- Wood, Scott
- Christ, Angelika
- Cloonan, Nicole
- Newell, Felicity
- Pinese, Mark
- Kaplan, Warren
- Jones, Marc D.
- Colvin, Emily K.
- Nagrial, Adnan M.
- Chou, Angela
- Chin, Venessa T.
- Chantrill, Lorraine A.
- Mawson, Amanda
- Samra, Jaswinder S.
- Kench, James G.
- Daly, Roger J.
- Merrett, Neil D.
- Toon, Christopher
- Nguyen, Nam Q.
- Barbour, Andrew
- Zeps, Nikolajs
- Zhao, Fengmei
- Muzny, Donna M.
- Drummond, Jennifer
- Chang, Kyle
- Han, Yi
- Dinh, Huyen
- Beck, Timothy
- Begley, Kimberly
- Brown, Andrew
- Denroche, Robert E.
- Yung, Christina K.
- Serra, Stefano
- Mukhopadhyay, Debabrata
- Tsao, Ming-Sound
- Petersen, Gloria M.
- Hruban, Ralph H.
- Maitra, Anirban
- Schulick, Richard D.
- Wolfgang, Christopher L.
- Lawlor, Rita T.
- Corbo, Vincenzo
- Tortora, Giampaolo
- Tempero, Margaret A.
- Mann, Karen M.
- Jenkins, Nancy A.
- Adams, David J.
- Wessels, Lodewyk F. A.
- Rust, Alistair G.
- Stein, Lincoln D.
- Tuveson, David A.
- Scarpa, Aldo
- Eshleman, James R.
- Hudson, Thomas J.
- Wheeler, David A.
- Pearson, John V.
- McPherson, John D.
- Gibbs, Richard A.
- Grimmond, Sean M.
- Venue
- Nature
- Published
- 2012-10-24
- Volume
- 491
- Issue
- 7424
- Pages
- 399-405
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3530898
- OpenAlex
- W2161884651
- Cited by
- 2,058
- References
- 41
- Citations by year
- 2026: 62 · 2025: 98 · 2024: 90 · 2023: 128 · 2022: 173 · 2021: 190 · 2020: 168 · 2019: 163 · 2018: 159 · 2017: 187 · 2016: 191 · 2015: 176 · 2014: 157 · 2013: 113 · 2012: 1
- FWCI
- 70.75
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- eSpace (Curtin University) (submittedVersion)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- NOVA (University of Newcastle Australia) (submittedVersion)
- Funders
- American Association for Cancer Research
- Cancer Prevention and Research Institute of Texas (RP101353-P7, RP101353)
- Johns Hopkins University (P50CA062924)
- Royal College of Pathologists of Australasia
- Wellcome Trust
- Australian Government
- Cancer Research UK (13031)
- Australian Cancer Research Foundation
- Cancer Institute NSW
- Gastroenterological Society of Australia
- Royal Australasian College of Physicians
- Agency for Science, Technology and Research
- Petre Foundation
- Queensland Government
- R.T. Hall Trust
- Associazione Italiana per la Ricerca sul Cancro (12182, 5 x mille)
- Università degli Studi di Verona
- Ministero dello Sviluppo Economico
- National Institutes of Health (CA102701)
- Medical Research Council
- National Health and Medical Research Council (535914, 631701, 535903, 427601)
- Cancer Council NSW (SRP06-01)
- National Human Genome Research Institute (HG003273, U54HG003273)
- National Cancer Institute (CA102701, R01CA-97075, P01CA134292, P50CA101955, P50CA102701, R01CA113636, R01CA097075, P50CA062924)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- pancreatic ductal adenocarcinoma, axon guidance genes, somatic mutations, copy number variation, chromatin modification, DNA repair, ATM, carcinogenesis, pathway analysis, patient survival, Sleeping Beauty transposon mutagenesis, early-stage pancreatic cancer
- MeSH terms
- Animals, Axons, Humans, Mutation, Pancreatic Neoplasms, Proteins, Signal Transduction, Gene Expression Regulation, Neoplastic, Genome, Gene Dosage, Carcinoma, Pancreatic Ductal, Mice, Kaplan-Meier Estimate
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