Cited by 1,598Gut microbiota and healthT-cell and B-cell ImmunologyImmune Response and Inflammation

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Reciprocal interactions of the intestinal microbiota and immune system

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Maynard, Craig L., Elson, Charles O., Hatton, Robin D., Weaver, Casey T.·2012·Nature

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Abstract

The emergence of the adaptive immune system in vertebrates set the stage for evolution of an advanced symbiotic relationship with the intestinal microbiota. The defining features of specificity and memory that characterize adaptive immunity have afforded vertebrates the mechanisms for efficiently tailoring immune responses to diverse types of microbes, whether to promote mutualism or host defence. These same attributes can put the host at risk of immune-mediated diseases that are increasingly linked to the intestinal microbiota. Understanding how the adaptive immune system copes with the remarkable number and diversity of microbes that colonize the digestive tract, and how the system integrates with more primitive innate immune mechanisms to maintain immune homeostasis, holds considerable promise for new approaches to modulate immune networks to treat and prevent disease.

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Authors: Maynard, C. L., Elson, C. O., Hatton, R. D., & Weaver, C. T.
Affiliations: University of Alabama at Birmingham (US)
Corresponding author: Weaver, Casey T.
ORCID: Maynard, Craig L.
Elson, Charles O.
Hatton, Robin D.
Weaver, Casey T.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2012-09
Volume: 489
Issue: 7415
Pages: 231-241
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature11551
PMC: PMC4492337
OpenAlex: W2083102356
Cited by: 1,598
References: 101
Citations by year: 2026: 50 · 2025: 81 · 2024: 122 · 2023: 136 · 2022: 126 · 2021: 143 · 2020: 148 · 2019: 122 · 2018: 120 · 2017: 100 · 2016: 118 · 2015: 120 · 2014: 110 · 2013: 96 · 2012: 4
FWCI: 9.63
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Crohn's and Colitis Foundation
National Institute of Allergy and Infectious Diseases (R01AI057956, T32AI007051)
National Institute of Diabetes and Digestive and Kidney Diseases (R24DK064400, P01DK071176, R01DK093015)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: gut microbiota, adaptive immunity, innate immunity, host-microbe symbiosis, immune homeostasis, immune-mediated diseases, immunological memory, gut microbiota modulation, host defense
MeSH terms: Blood Group Antigens, Cesarean Section, Epithelium, Female, Homeostasis, Humans, Infant, Infant, Newborn, Intestines, Pregnancy, T-Lymphocytes, Vagina, Metagenome

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