Progressive degeneration of human neural stem cells caused by pathogenic LRRK2

Lamin A-dependent nuclear defects in human aging

Scaffidi, P., & Misteli, T. (2006) · Science · doi:10.1126/science.1127168 · Cited by 1,125

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

Dechat, T., Pfleghaar, K., Sengupta, K., Shimi, T., Shumaker, D. K., Solimando, L., & Goldman, R. D. (2008) · Genes & Development · doi:10.1101/gad.1652708 · Cited by 940

Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome

Liu, G.-H., Barkho, B. Z., Ruiz, S., Diep, D., Qu, J., Yang, S.-L., Panopoulos, A. D., Suzuki, K., Kurian, L., Walsh, C., et al. (2011) · Nature · doi:10.1038/nature09879 · Cited by 575

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

Cookson, M. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2935 · Cited by 552

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2

Deng, X., Dzamko, N. L., Prescott, A. R., Davies, P., Liu, Q., Yang, Q., Lee, J., Patricelli, M. P., Nomanbhoy, T. K., Alessi, D. R., et al. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.538 · Cited by 434

Lamin B1 duplications cause autosomal dominant leukodystrophy

Padiath, Q. S., Saigoh, K., Schiffmann, R., Asahara, H., Yamada, T., Koeppen, A. H., Hogan, K. J., Ptáček, L. J., & Fu, Y. (2006) · Nature Genetics · doi:10.1038/ng1872 · Cited by 407

Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression

Gehrke, S., Imai, Y., Sokol, N. S., & Lu, B. (2010) · Nature · doi:10.1038/nature09191 · Cited by 398

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

Nichols, R. J., Dzamko, N. L., Morrice, N. A., Campbell, D. G., Deák, M., Ordureau, A., Macartney, T., Tong, Y., Shen, J., Prescott, A. R., et al. (2010) · Biochemical Journal · doi:10.1042/bj20100483 · Cited by 390

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localization

Dzamko, N. L., Deák, M., Hentati, F., Reith, A. D., Prescott, A. R., Alessi, D. R., & Nichols, R. J. (2010) · Biochemical Journal · doi:10.1042/bj20100784 · Cited by 377

Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors

Li, W., Sun, W., Zhang, Y., Wei, W., Ambasudhan, R., Xia, P., Talantova, M. V., Lin, T., Kim, J., Wang, X., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014041108 · Cited by 376

Regenerative strategies for kidney engineering

Montserrat, N., Garreta, E., & Belmonte, J. C. I. (2016) · FEBS Journal · doi:10.1111/febs.13704 · Cited by 45

Dysfunction of Synaptic Vesicle Endocytosis in Parkinson’s Disease

Zou, L., Tian, Y., & Zhang, Z. (2021) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2021.619160 · Cited by 44

When rejuvenation is a problem: challenges of modeling late-onset neurodegenerative disease

Vera, E., & Studer, L. (2015) · Development · doi:10.1242/dev.120667 · Cited by 45

Induced pluripotent stem cells for modeling neurological disorders

Russo, F. B. (2015) · World Journal of Transplantation · doi:10.5500/wjt.v5.i4.209 · Cited by 43

Calpain-Dependent Degradation of Nucleoporins Contributes to Motor Neuron Death in a Mouse Model of Chronic Excitotoxicity

Sugiyama, K., Aida, T., Nomura, M., Takayanagi, R., Zeilhofer, H. U., & Tanaka, K. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0730-17.2017 · Cited by 43

Stem Cells for Modeling and Therapy of Parkinson's Disease

Zhang, Q., Chen, W.-L., Tan, S., & Lin, T. (2016) · Human Gene Therapy · doi:10.1089/hum.2016.116 · Cited by 44

G2019S Variation in LRRK2: An Ideal Model for the Study of Parkinson’s Disease?

Ren, C., Ding, Y., Wei, S., Guan, L., Zhang, C., Ji, Y., Wang, F., Yin, S., & Yin, P. (2019) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2019.00306 · Cited by 42

Mitochondrial dysfunction and oxidative stress in induced pluripotent stem cell models of Parkinson's disease

Bose, A., & Beal, M. F. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14264 · Cited by 43

SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation

Kaufmann, T., Kukolj, E., Brachner, A., Beltzung, E., Bruno, M., Kostrhon, S., Opravil, S., Hudecz, O., Mechtler, K., Warren, G., et al. (2016) · Journal of Cell Science · doi:10.1242/jcs.192633 · Cited by 43

Simplified Brain Organoids for Rapid and Robust Modeling of Brain Disease

Ha, J., Kang, J. S., Lee, M., Baek, A., Kim, S., Chung, S., Lee, M., & Kim, J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.594090 · Cited by 40

Application of human induced pluripotent stem cells for modeling and treating neurodegenerative diseases

Payne, N. L., Sylvain, A., O’Brien, C., Herszfeld, D., Sun, G., & Bernard, C. C. A. (2014) · New Biotechnology · doi:10.1016/j.nbt.2014.05.001 · Cited by 41

Mechanisms of Mutant LRRK2 Neurodegeneration

Cookson, M. R. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-49969-7_12 · Cited by 41

LRRK2 functions as a scaffolding kinase of ASK1-mediated neuronal cell death

Yoon, J., Mo, J., Kim, M., Ann, E., Ahn, J., Jo, E.-H., Lee, H.-J., Lee, Y. C., Seol, W., Yarmoluk, S. M., et al. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2017.09.001 · Cited by 38

Parkinson’s disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging

Chen, X., Xie, C., Tian, W., Sun, L., Zheng, W., Hawes, S., Chang, L., Kung, J. E., Ding, J., Chen, S., et al. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00360-0 · Cited by 38

Olfactory stem cells reveal MOCOS as a new player in autism spectrum disorders

Feron, F. P., Gepner, B., Lacassagne, E., Stephan, D., Mesnage, B., Blanchard, M.-P., Boulanger, N., Tardif, C., Devèze, A., Rousseau, S., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.106 · Cited by 39

Developmental SALL2 transcription factor: a new player in cancer

Hermosilla, V. E., Hepp, M. I., Escobar, D., Farkas, C., Riffo, E. N., Castro, A. F., & Pincheira, R. (2017) · Carcinogenesis · doi:10.1093/carcin/bgx036 · Cited by 38

A Single “All-in-One” Helper-Dependent Adenovirus to Deliver Donor DNA and CRISPR/Cas9 for Efficient Homology-Directed Repair

Palmer, D. J., Turner, D. L., & Ng, P. (2020) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2020.01.014 · Cited by 37

Modelling Parkinson’s Disease: iPSCs towards Better Understanding of Human Pathology

Avazzadeh, S., Baena-Montes, J. M., Keighron, C. N., Sánchez, Y. F., & Quinlan, L. R. (2021) · Brain Sciences · doi:10.3390/brainsci11030373 · Cited by 38

Progress and prospects in stem cell therapy

Xu, X., Yi, F., Pan, H., Duan, S., Ding, Z., Yuan, G., Qu, J. T., Zhang, H., & Liu, G. (2013) · Acta Pharmacologica Sinica · doi:10.1038/aps.2013.77 · Cited by 36

iPS cells in the study of PD molecular pathogenesis

Cobb, M. M., Ravisankar, A., Skibinski, G., & Finkbeiner, S. M. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2749-y · Cited by 35

Mitochondria and Other Organelles in Neural Development and Their Potential as Therapeutic Targets in Neurodegenerative Diseases

Zhang, S., Zhao, J., Quan, Z., Li, H., & Qing, H. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.853911 · Cited by 35

Pre-differentiation GenX exposure induced neurotoxicity in human dopaminergic-like neurons

Wu, S., Xie, J., Zhao, H., Sánchez, O. F., Zhao, X., Freeman, J. L., & Yuan, C. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.138900 · Cited by 36

Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs

Fu, L., Xu, X., Ren, R., Wu, J., Zhang, W., Yang, J., Ren, X., Wang, S., Zhao, Y., Sun, L., et al. (2016) · Protein & Cell · doi:10.1007/s13238-016-0244-y · Cited by 35

Modeling Parkinson’s Disease Using Induced Pluripotent Stem Cells

Hu, X., Mao, C., Fan, L., Luo, H., Hu, Z., Zhang, S., Yang, Z., Zheng, H., Sun, H., Fan, Y., et al. (2020) · Stem Cells International · doi:10.1155/2020/1061470 · Cited by 36

Adenoviral Vectors Meet Gene Editing: A Rising Partnership for the Genomic Engineering of Human Stem Cells and Their Progeny

Tasca, F., Wang, Q., & Gonçalves, M. A. F. V. (2020) · Cells · doi:10.3390/cells9040953 · Cited by 34

Deficiency of STING Signaling in Embryonic Cerebral Cortex Leads to Neurogenic Abnormalities and Autistic‐Like Behaviors

Zhang, D., Liu, C., Li, H., & Jiao, J. (2020) · Advanced Science · doi:10.1002/advs.202002117 · Cited by 35

Modeling physiological and pathological human neurogenesis in the dish

Broccoli, V., Giannelli, S. G., & Mazzara, P. G. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00183 · Cited by 35

Gain-of-function mutations in the ALS8 causative gene VAPB have detrimental effects on neurons and muscles

Sanhueza, M., Zechini, L., Gillespie, T., & Pennetta, G. (2013) · Biology Open · doi:10.1242/bio.20137070 · Cited by 34

The therapeutic potential of cell identity reprogramming for the treatment of aging-related neurodegenerative disorders

Smith, D. K., He, M., Zhang, C., & Zheng, J. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.01.006 · Cited by 34

LRRK2: an éminence grise of Wnt-mediated neurogenesis?

Berwick, D. C., & Harvey, K. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00082 · Cited by 33

Stress-induced precocious aging in PD-patient iPSC-derived NSCs may underlie the pathophysiology of Parkinson’s disease

Zhu, L., Sun, C., Ren, J., Wang, G., Ma, R., Sun, L., Yang, D., Gao, S., Ning, K., Wang, Z., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1313-y · Cited by 31

p53-mediated ferroptosis is required for 1-methyl-4-phenylpyridinium-induced senescence of PC12 cells

Li, S., Wang, M., Wang, Y., Guo, Y., Tao, X., Wang, X., Cao, Y., Tian, S., & Li, Q. (2021) · Toxicology in Vitro · doi:10.1016/j.tiv.2021.105146 · Cited by 31

Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons

Fonseca‐Ornelas, L., Stricker, J. M. S., Soriano-Cruz, S., Weykopf, B., Dettmer, U., Muratore, C., Scherzer, C. R., & Selkoe, D. J. (2022) · npj Parkinson s Disease · doi:10.1038/s41531-022-00380-1 · Cited by 31

Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes

Gu, Y., Liu, G., Plongthongkum, N., Benner, C. W., Yi, F., Qu, J. T., Suzuki, K., Yang, J., Zhang, W., Li, M., et al. (2013) · Protein & Cell · doi:10.1007/s13238-013-0016-x · Cited by 31

Role of ALKBH1 in the Core Transcriptional Network of Embryonic Stem Cells

Ougland, R., Jonson, I., Moen, M. N., Nesse, G., Asker, G., Klungland, A., & Larsen, E. (2016) · Cellular Physiology and Biochemistry · doi:10.1159/000438619 · Cited by 31

Using induced pluripotent stem cells for modeling Parkinson’s disease

Ke, M., Chong, C., & Su, H. (2019) · World Journal of Stem Cells · doi:10.4252/wjsc.v11.i9.634 · Cited by 31

Physiological and pathological roles of LRRK2 in the nuclear envelope integrity

Shani, V., Safory, H., Szargel, R., Wang, N., Cohen, T., Elghani, F. A., Hamza, H., Savyon, M., Radzishevsky, I. S., Shaulov, L., et al. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz245 · Cited by 31

Cell‐Based Therapy for Canavan Disease Using Human iPSC‐Derived NPCs and OPCs

Feng, L., Chao, J., Tian, E., Li, L., Ye, P., Zhang, M., Chen, X., Cui, Q., Sun, G., Zhou, T., et al. (2020) · Advanced Science · doi:10.1002/advs.202002155 · Cited by 30

Modeling axonal defects in hereditary spastic paraplegia with human pluripotent stem cells

Denton, K. R., Xu, C., Shah, H., & Li, X. J. (2016) · Frontiers in Biology · doi:10.1007/s11515-016-1416-0 · Cited by 30

Current Opinion on the Role of Neurogenesis in the Therapeutic Strategies for Alzheimer Disease, Parkinson Disease, and Ischemic Stroke; Considering Neuronal Voiding Function

Han, M., Lee, E.-H., & Koh, S. (2016) · International Neurourology Journal · doi:10.5213/inj.1632776.388 · Cited by 29

Multiplication of theSNCAlocus exacerbates neuronal nuclear aging

Tagliafierro, L., Zamora, M. E., & Chiba‐Falek, O. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy355 · Cited by 30

Induced pluripotent stem cell‐based modeling of mutant LRRK 2‐associated Parkinson's disease

Weykopf, B., Haupt, S., Jungverdorben, J., Flitsch, L. J., Hebisch, M., Liu, G., Suzuki, K., Belmonte, J. C. I., Peitz, M., Blaess, S., et al. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14345 · Cited by 30

Production of CRISPR/Cas9-Mediated Self-Cleaving Helper-Dependent Adenoviruses

Palmer, D. J., Turner, D. L., & Ng, P. (2019) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2019.04.003 · Cited by 30

Patient-Derived Induced Pluripotent Stem Cell-Based Models in Parkinson’s Disease for Drug Identification

Kouroupi, G., Antoniou, N., Prodromidou, K., Taoufik, E., & Matsas, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197113 · Cited by 30

Generation of iPSCs carrying a common LRRK2 risk allele for in vitro modeling of idiopathic Parkinson's disease

Marrone, L., Bus, C., Schöndorf, D. C., Fitzgerald, J. C., Kübler, M., Schmid, B., Reinhardt, P., Reinhardt, L., Deleidi, M., Levin, T., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0192497 · Cited by 30

A Novel Suppressive Effect of Alcohol Dehydrogenase 5 in Neuronal Differentiation

Wu, K., Ren, R., Su, W., Wen, B., Zhang, Y., Yi, F., Qiao, X., Yuan, T., Wang, J., Liu, L., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.c114.561860 · Cited by 28

Genetic causes of PD: A pathway to disease modification

Toffoli, M., Vieira, S. R. L., & Schapira, A. H. V. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108022 · Cited by 28

CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells

Wang, P., Liu, Z., Zhang, X., Li, J., Sun, L., Ju, Z., Li, J., Chan, P., Liu, G., Zhang, W., et al. (2018) · Protein & Cell · doi:10.1007/s13238-018-0560-5 · Cited by 28

Correction to: Parkinson’s disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging

Chen, X., Xie, C., Tian, W., Sun, L., Zheng, W., Hawes, S., Chang, L., Kung, J., Ding, J., Chen, S., et al. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00371-x · Cited by 28

Enhancing Cutaneous Wound Healing Based on Human Induced Neural Stem Cell-derived Exosomes

Li, J., Gao, H. Z., Xiong, Y., Wang, L., Zhang, H., He, F., Zhao, J., Liu, S., Gao, L., Guo, Y., et al. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s377502 · Cited by 27

Single-cell multimodal transcriptomics to study neuronal diversity in human stem cell-derived brain tissue and organoid models

van den Hurk, M., & Bardy, C. (2019) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2019.108350 · Cited by 28

Proteasome activator PA200 maintains stability of histone marks during transcription and aging

Jiang, T.-X., Ma, S., Han, X., Luo, Z.-Y., Zhu, Q., Chiba, T., Xie, W., Chen, S., Lin, K., & Qiu, X. (2020) · Theranostics · doi:10.7150/thno.48744 · Cited by 29

Positioning nuclei within the cytoplasm of striated muscle fiber

Volk, T. (2012) · Nucleus · doi:10.4161/nucl.23086 · Cited by 27

Understanding Parkinson’s Disease through the Use of Cell Reprogramming

Playne, R., & Connor, B. J. (2017) · Stem Cell Reviews and Reports · doi:10.1007/s12015-017-9717-5 · Cited by 28

Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson’s disease

Kuzumaki, N., Suda, Y., Iwasawa, C., Narita, M., Sone, T., Watanabe, M., Maekawa, A., Matsumoto, T., Akamatsu, W., Igarashi, K., et al. (2019) · Brain · doi:10.1093/brain/awz084 · Cited by 26

From “Directed Differentiation” to “Neuronal Induction”: Modeling Neuropsychiatric Disease

Ho, S., Topol, A., & Brennand, K. (2015) · Biomarker Insights · doi:10.4137/bmi.s20066 · Cited by 28

Toward pluripotency by reprogramming: mechanisms and application

Wang, T., Warren, S. T., & Jin, P. (2013) · Protein & Cell · doi:10.1007/s13238-013-3074-1 · Cited by 26

Hippocampal proliferation is increased in presymptomatic Parkinson’s disease and due to microglia

Doorn, K. J., Drukarch, B., van Dam, A.-M., & Lucassen, P. J. (2014) · Neural Plasticity · doi:10.1155/2014/959154 · Cited by 24

Advances in Reprogramming-Based Study of Neurologic Disorders

Nityanandam, A., & Baldwin, K. K. (2015) · Stem Cells and Development · doi:10.1089/scd.2015.0044 · Cited by 25

Modeling Neuropsychiatric and Neurodegenerative Diseases With Induced Pluripotent Stem Cells

LaMarca, E. A., Powell, S. K., Akbarian, S., & Brennand, K. (2018) · Frontiers in Pediatrics · doi:10.3389/fped.2018.00082 · Cited by 29

Does Developmental Variability in the Number of Midbrain Dopamine Neurons Affect Individual Risk for Sporadic Parkinson’s Disease?

von Linstow, C. U., DeLano-Taylor, M., Kordower, J. H., & Brundin, P. (2020) · Journal of Parkinson s Disease · doi:10.3233/jpd-191877 · Cited by 25

Neuroprotective Effects of Cryptotanshinone in a Direct Reprogramming Model of Parkinson’s Disease

Lee, J., Sim, H., Yoo, H. M., Lee, M., Baek, A., Jeon, Y., Seo, K.-S., Son, M., Yoon, J. S., & Kim, J. (2020) · Molecules · doi:10.3390/molecules25163602 · Cited by 24

Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement

Fdez, E., Madero‐Pérez, J., Ordóñez, A. J. L., Naaldijk, Y., Fasiczka, R., Aiastui, A., Ruiz‐Martínez, J., de Munaín, A. L., Cowley, S. A., Wade‐Martins, R., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104476 · Cited by 24

Structural and functional damage to neuronal nuclei caused by extracellular tau oligomers

Sun, X., Eastman, G., Shi, Y., Saibaba, S., Oliveira, A. K., Lukens, J. R., Norambuena, A., Thompson, J. A., Purdy, M. D., Dryden, K. A., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13535 · Cited by 24

Mitochondrial and Autophagic Regulation of Adult Neurogenesis in the Healthy and Diseased Brain

Büeler, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073342 · Cited by 26

Nuclear pore and nucleocytoplasmic transport impairment in oxidative stress-induced neurodegeneration: relevance to molecular mechanisms in Pathogenesis of Parkinson’s and other related neurodegenerative diseases

Riaz, Z., Richardson, G. S., Jin, H., Zenitsky, G. D., Anantharam, V., Kanthasamy, A., & Kanthasamy, A. G. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00774-0 · Cited by 26

The Progress of Induced Pluripotent Stem Cells as Models of Parkinson’s Disease

Kang, J.-F., Tang, B., & Guo, J. (2016) · Stem Cells International · doi:10.1155/2016/4126214 · Cited by 24

WD40-Repeat Proteins in Ciliopathies and Congenital Disorders of Endocrine System

Kim, Y.-J., & Kim, S. (2020) · Endocrinology and Metabolism · doi:10.3803/enm.2020.302 · Cited by 23

Eliminate mitochondrial diseases by gene editing in germ-line cells and embryos

Wang, S., Yi, F., & Qu, J. T. (2015) · Protein & Cell · doi:10.1007/s13238-015-0177-x · Cited by 23

Genome engineering tools for building cellular models of disease

Lin, J. J., & Musunuru, K. (2016) · FEBS Journal · doi:10.1111/febs.13763 · Cited by 23

iPhemap: an atlas of phenotype to genotype relationships of human iPSC models of neurological diseases

Hollingsworth, E. W., Vaughn, J., Orack, J. C., Skinner, C., Khouri, J., Lizarraga, S. B., Hester, M. E., Watanabe, F., Kosik, K. S., & Imitola, J. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201708191 · Cited by 23

The multifaceted role of LRRK2 in Parkinson's disease: From human iPSC to organoids

Oun, A., Sabogal-Guáqueta, A. M., Galuh, S., Alexander, A., Kortholt, A., & Dolga, A. M. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105837 · Cited by 23

One Step Into the Future: New iPSC Tools to Advance Research in Parkinson’s Disease and Neurological Disorders

Mohamed, N., Larroquette, F., Beitel, L. K., Fon, E. A., & Durcan, T. M. (2019) · Journal of Parkinson s Disease · doi:10.3233/jpd-181515 · Cited by 23

Astrocytes contribute to toll-like receptor 2-mediated neurodegeneration and alpha-synuclein pathology in a human midbrain Parkinson’s model

Weiss, F. C., Hughes, L. P., Fu, Y., Bardy, C., Halliday, G. M., & Dzamko, N. L. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00448-3 · Cited by 25

Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing

Yuan, B., Zhou, X., Suzuki, K., Ramos‐Mandujano, G., Wang, M., Tehseen, M., Cortés-Medina, L. V., Moresco, J. J., Dunn, S. E., Hernández‐Benítez, R., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31220-8 · Cited by 21

CRISPR–Cas technologies in neurodegenerative disorders: mechanistic insights, therapeutic potential, and translational challenges

Yashooa, R. K., Nabi, A. Q., Smail, S. W., Azeez, S. S., Nooh, W. A., Mustafa, S. A., Al-Farha, A. A.-B., Capitanio, N., & Shekha, M. S. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2025.1737468 · Cited by 21

Nuclear pore dysfunction and disease: a complex opportunity

Fare, C. M., & Rothstein, J. D. (2024) · Nucleus · doi:10.1080/19491034.2024.2314297 · Cited by 21

Fas-Activated Mitochondrial Apoptosis Culls Stalled Embryonic Stem Cells to Promote Differentiation

Wang, E. S., Reyes, N., Melton, C. A., Huskey, N. E., Momčilović, O., Goga, A., Blelloch, R. H., & Oakes, S. A. (2015) · Current Biology · doi:10.1016/j.cub.2015.10.020 · Cited by 20

Impaired serine metabolism complements LRRK2-G2019S pathogenicity in PD patients

Nickels, S., Walter, J., Bolognin, S., Gérard, D., Jaeger, C., Qing, X., Tisserand, J., Jarazo, J., Hemmer, K., Harms, A. C., et al. (2019) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2019.09.018 · Cited by 20

LRRK2 kinase inhibitors reduce alpha-synuclein in human neuronal cell lines with the G2019S mutation

Zhao, Y., Keshiya, S., Perera, G., Schramko, L., Halliday, G. M., & Dzamko, N. L. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105049 · Cited by 20

Two- and Three-Dimensional In Vitro Models of Parkinson’s and Alzheimer’s Diseases: State-of-the-Art and Applications

Solana‐Manrique, C., Sánchez‐Pérez, A. M., Paricio, N., & Muñoz‐Descalzo, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020620 · Cited by 21

Modeling LRRK2 Pathobiology in Parkinson’s Disease: From Yeast to Rodents

Daniel, G., & Moore, D. J. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_311 · Cited by 19

Pluripotent Stem Cells for Modelling and Cell Therapy of Parkinson’s Disease

Lebedeva, O. S., & Lagarkova, M. A. (2018) · Biochemistry (Moscow) · doi:10.1134/s0006297918090067 · Cited by 19

Concealing cellular defects in pluripotent stem cells

Zhang, W., Qu, J. T., Suzuki, K., Liu, G., & Belmonte, J. C. I. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.07.001 · Cited by 19

Sequential Application of Discrete Topographical Patterns Enhances Derivation of Functional Mesencephalic Dopaminergic Neurons from Human Induced Pluripotent Stem Cells

Tan, K. K. B., Lim, W. W. M., Chai, C., Kukumberg, M., Lim, K. L., Goh, E. L. K., & Yim, E. K. F. (2018) · Scientific Reports · doi:10.1038/s41598-018-27653-1 · Cited by 19

Dissecting the non-neuronal cell contribution to Parkinson’s disease pathogenesis using induced pluripotent stem cells

Pons-Espinal, M., Blasco-Agell, L., & Consiglio, A. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03700-x · Cited by 18

Unraveling Parkinson's disease: The mystery of mitochondria and the role of aging

Liu, T., Li, J., Wu, H., Qiao, J., & Wei, J. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101719 · Cited by 18

Dual Roles of Microglia in the Basal Ganglia in Parkinson’s Disease

Choudhury, M. E., Kigami, Y., & Tanaka, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083907 · Cited by 18

Opportunities and Challenges for Molecular Chaperone Modulation to Treat Protein-Conformational Brain Diseases

van der Putten, H., & Lotz, G. P. (2013) · Neurotherapeutics · doi:10.1007/s13311-013-0186-5 · Cited by 18

Advances in Gene Therapy Techniques to Treat LRRK2 Gene Mutation

Chung, S., & Lee, S. (2022) · Biomolecules · doi:10.3390/biom12121814 · Cited by 17

Pluripotent stem cells to model Hutchinson-Gilford progeria syndrome (HGPS): Current trends and future perspectives for drug discovery

Cicero, A. L., & Nissan, X. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.10.002 · Cited by 17

The translational potential of human induced pluripotent stem cells for clinical neurology

Devine, H. E., & Patani, R. (2016) · Cell Biology and Toxicology · doi:10.1007/s10565-016-9372-7 · Cited by 18

Direct Reprogramming to Human Induced Neuronal Progenitors from Fibroblasts of Familial and Sporadic Parkinson's Disease Patients

Lee, M., Sim, H., Ahn, H. M., Ha, J., Baek, A., Jeon, Y.-J., Son, M., & Kim, J. (2019) · International Journal of Stem Cells · doi:10.15283/ijsc19075 · Cited by 17

Black phosphorus nanosheets suppress oxidative damage of stem cells for improved neurological recovery

He, F., Liu, Z., Xu, J., Xiong, Y., Zhang, X., Qi, J., Lin, X., Chu, C., Shen, L., Liu, G., et al. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.138737 · Cited by 17

Stemming the Hype: What Can We Learn from iPSC Models of Parkinson's Disease and How Can We Learn It?

Jacobs, B. M. (2014) · Journal of Parkinson s Disease · doi:10.3233/jpd-130268 · Cited by 18

Solving the puzzle of Parkinson’s disease using induced pluripotent stem cells

Zhao, P., Luo, Z., Tian, W., Yang, J., Ibañez, D. P., Huang, Z., Tortorella, M. D., Esteban, M. A., & Fan, W. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370214538588 · Cited by 16

Integrated Genomic Medicine

Schork, N. J., & Nazor, K. L. (2017) · Advances in genetics · doi:10.1016/bs.adgen.2017.06.001 · Cited by 16

Synaptopathy Mechanisms in ALS Caused by C9orf72 Repeat Expansion

Nishimura, A. L., & Arias, N. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.660693 · Cited by 17

Patient-Specific iPSCs-Based Models of Neurodegenerative Diseases: Focus on Aberrant Calcium Signaling

Grekhnev, D. A., Kaznacheyeva, E. V., & Vigont, V. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020624 · Cited by 16

Induced pluripotent stem cells (iPSCs) as game‐changing tools in the treatment of neurodegenerative disease: Mirage or reality?

Yousefi, N., Abdollahii, S., Kouhbanani, M. A. J., & Hassanzadeh, A. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29800 · Cited by 17

The Parkinson's Disease-Associated LRRK2 Mutation R1441G Inhibits Neuronal Differentiation of Neural Stem Cells

Bahnassawy, L., Nicklas, S., Palm, T., Menzl, I., Birzele, F., Gillardon, F., & Schwamborn, J. C. (2013) · Stem Cells and Development · doi:10.1089/scd.2013.0163 · Cited by 46

Ageing of neural stem cells in a Parkinson's disease Model

Menzl, I. (2013) · University of Vienna · doi:10.25365/thesis.27046

Neural stem cell degeneration in PD linked to nuclear defects

Malpass, K. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.230

Modelling and analysis of LRRK2 mutations in iPSC-derived dopaminergic neurons and astrocytes

Booth, H. (2017) · Oxford University Research Archive (ORA) (University of Oxford) · doi:10.5287/ora-nyqekmbqk · Cited by 1

LRRK2 Attenuates Antioxidant Response in Familial Parkinson’s Disease Derived Neural Stem Cells

Kim, J., Daadi, E. W., Daadi, E. S., Oh, T. T., Deleidi, M., & Daadi, M. M. (2023) · Cells · doi:10.3390/cells12212550 · Cited by 12