Progressive degeneration of human neural stem cells caused by pathogenic LRRK2

Lamin A-dependent nuclear defects in human aging

Scaffidi, P., & Misteli, T. (2006) · Science · doi:10.1126/science.1127168 · Cited by 1,125

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

Dechat, T., Pfleghaar, K., Sengupta, K., Shimi, T., Shumaker, D. K., Solimando, L., & Goldman, R. D. (2008) · Genes & Development · doi:10.1101/gad.1652708 · Cited by 940

Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome

Liu, G.-H., Barkho, B. Z., Ruiz, S., Diep, D., Qu, J., Yang, S.-L., Panopoulos, A. D., Suzuki, K., Kurian, L., Walsh, C., et al. (2011) · Nature · doi:10.1038/nature09879 · Cited by 575

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

Cookson, M. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2935 · Cited by 552

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2

Deng, X., Dzamko, N. L., Prescott, A. R., Davies, P., Liu, Q., Yang, Q., Lee, J., Patricelli, M. P., Nomanbhoy, T. K., Alessi, D. R., et al. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.538 · Cited by 434

Lamin B1 duplications cause autosomal dominant leukodystrophy

Padiath, Q. S., Saigoh, K., Schiffmann, R., Asahara, H., Yamada, T., Koeppen, A. H., Hogan, K. J., Ptáček, L. J., & Fu, Y. (2006) · Nature Genetics · doi:10.1038/ng1872 · Cited by 407

Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression

Gehrke, S., Imai, Y., Sokol, N. S., & Lu, B. (2010) · Nature · doi:10.1038/nature09191 · Cited by 398

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

Nichols, R. J., Dzamko, N. L., Morrice, N. A., Campbell, D. G., Deák, M., Ordureau, A., Macartney, T., Tong, Y., Shen, J., Prescott, A. R., et al. (2010) · Biochemical Journal · doi:10.1042/bj20100483 · Cited by 390

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localization

Dzamko, N. L., Deák, M., Hentati, F., Reith, A. D., Prescott, A. R., Alessi, D. R., & Nichols, R. J. (2010) · Biochemical Journal · doi:10.1042/bj20100784 · Cited by 377

Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors

Li, W., Sun, W., Zhang, Y., Wei, W., Ambasudhan, R., Xia, P., Talantova, M. V., Lin, T., Kim, J., Wang, X., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014041108 · Cited by 376

Induced pluripotent stem cell technology: a decade of progress.

Shi, Y., Inoue, H., Wu, J. C., & Yamanaka, S. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.245 · Cited by 1,525

Autophagy and apoptosis dysfunction in neurodegenerative disorders

Ghavami, S., Shojaei, S., Yeganeh, B., Ande, S. R., Jangamreddy, J. R., Mehrpour, M., Christoffersson, J., Chaabane, W., Moghadam, A. R., Kashani, H. H., et al. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.10.004 · Cited by 1,039

Human iPSC-based modeling of late-onset disease via progerin-induced aging

Miller, J. D., Ganat, Y. M., Kishinevsky, S., Bowman, R. L., Liu, B., Tu, E. Y., Mandal, P. K., Vera, E., Shim, J.-W., Kriks, S., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.11.006 · Cited by 777

Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes

Raja, W. K., Mungenast, A. E., Lin, Y.-T., Ko, T., Abdurrob, F., Seo, J., & Tsai, L.-H. (2016) · PLOS ONE · doi:10.1371/journal.pone.0161969 · Cited by 569

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

Zhang, W., Li, J., Suzuki, K., Qu, J., Wang, P., Zhou, J., Liu, X., Ren, R., Xu, X., Ocampo, A., et al. (2015) · Science · doi:10.1126/science.aaa1356 · Cited by 551

Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression

Reinhardt, P., Schmid, B., Burbulla, L. F., Schöndorf, D. C., Wagner, L., Glatza, M., Höing, S., Hargus, G., Heck, S. A., Dhingra, A., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.01.008 · Cited by 512

Mitochondrial Regulation in Pluripotent Stem Cells

Xu, X., Duan, S., Yi, F., Ocampo, A., Liu, G., & Belmonte, J. C. I. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.06.005 · Cited by 375

Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development

Karagiannis, P., Takahashi, K., Saito, M. K., Yoshida, Y., Okita, K., Watanabe, A., Inoue, H., Yamashita, J. K., Todani, M., Nakagawa, M., et al. (2018) · Physiological Reviews · doi:10.1152/physrev.00039.2017 · Cited by 391

Ser 1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations

Sheng, Z., Zhang, S., Bustos, D. J., Kleinheinz, T., Pichon, C. E. L., Domínguez, S. L., Solanoy, H. O., Drummond, J., Zhang, X., Ding, X., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004485 · Cited by 358

Use of the CRISPR/Cas9 system as an intracellular defense against HIV-1 infection in human cells

Liao, H., Gu, Y., Diaz, A., Marlett, J. M., Takahashi, Y., Li, M., Suzuki, K., Xu, R., Hishida, T., Chang, C.-J., et al. (2015) · Nature Communications · doi:10.1038/ncomms7413 · Cited by 352

SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2

Pan, H., Guan, D., Liu, X., Li, J., Wang, L., Wu, J., Zhou, J., Zhang, W., Ren, R., Zhang, W., et al. (2016) · Cell Research · doi:10.1038/cr.2016.4 · Cited by 335

How to make a midbrain dopaminergic neuron

Arenas, E., Denham, M., & Villaescusa, C. (2015) · Development · doi:10.1242/dev.097394 · Cited by 321

Regulation of Stem Cell Aging by Metabolism and Epigenetics

Ren, R., Ocampo, A., Liu, G., & Belmonte, J. C. I. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.07.019 · Cited by 286

Investigating human disease using stem cell models

Sterneckert, J. L., Reinhardt, P., & Schöler, H. R. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3764 · Cited by 262

Deep learning-based predictive identification of neural stem cell differentiation

Zhu, Y., Huang, R., Wu, Z., Song, S., Cheng, L., & Zhu, R. (2021) · Nature Communications · doi:10.1038/s41467-021-22758-0 · Cited by 236

Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport

Gasset-Rosa, F., Chillón-Marinas, C., Goginashvili, A., Atwal, R. S., Artates, J. W., Tabet, R., Wheeler, V. C., Bang, A. G., Cleveland, D. W., & Lagier‐Tourenne, C. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.027 · Cited by 233

Synaptic dysfunction in neurodegenerative and neurodevelopmental diseases: an overview of induced pluripotent stem-cell-based disease models

Taoufik, E., Kouroupi, G., Zygogianni, O., & Matsas, R. (2018) · Open Biology · doi:10.1098/rsob.180138 · Cited by 213

Modeling Sporadic Alzheimer's Disease in Human Brain Organoids under Serum Exposure

Chen, X., Sun, G., Tian, E., Zhang, M., Davtyan, H., Beach, T. G., Reiman, E. M., Blurton‐Jones, M., Holtzman, D. M., & Shi, Y. (2021) · Advanced Science · doi:10.1002/advs.202101462 · Cited by 200

Opportunities and challenges of pluripotent stem cell neurodegenerative disease models

Sandoe, J., & Eggan, K. C. (2013) · Nature Neuroscience · doi:10.1038/nn.3425 · Cited by 198

SIRT6 deficiency results in developmental retardation in cynomolgus monkeys

Zhang, W., Wan, H., Feng, G., Qu, J. T., Wang, J., Jing, Y., Ren, R., Liu, Z., Zhang, L., Chen, Z., et al. (2018) · Nature · doi:10.1038/s41586-018-0437-z · Cited by 191

Metabolic rescue in pluripotent cells from patients with mtDNA disease

Ma, H., Folmes, C. D. L., Wu, J., Morey, R. E., Mora-Castilla, S., Ocampo, A., Ma, L., Poulton, J., Wang, X., Ahmed, R., et al. (2015) · Nature · doi:10.1038/nature14546 · Cited by 190

Programming and Reprogramming Cellular Age in the Era of Induced Pluripotency

Studer, L., Vera, E., & Cornacchia, D. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.05.004 · Cited by 192

Modeling Human Disease with Pluripotent Stem Cells: from Genome Association to Function

Merkle, F. T., & Eggan, K. C. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.05.016 · Cited by 190

Genetic predispositions of Parkinson’s disease revealed in patient-derived brain cells

Tran, J., Anastacio, H. T. D., & Bardy, C. (2020) · npj Parkinson s Disease · doi:10.1038/s41531-020-0110-8 · Cited by 190

Targeted Gene Correction Minimally Impacts Whole-Genome Mutational Load in Human-Disease-Specific Induced Pluripotent Stem Cell Clones

Suzuki, K., Yu, C., Qu, J., Li, M., Yao, X., Yuan, T., Goebl, A., Tang, S., Ren, R., Aizawa, E., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.06.016 · Cited by 169

PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype

Duan, S., Yuan, G., Liu, X., Ren, R., Li, J., Zhang, W., Wu, J., Xu, X., Fu, L., Li, Y., et al. (2015) · Nature Communications · doi:10.1038/ncomms10068 · Cited by 172

SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer

Bi, S., Liu, Z., Wu, Z., Wang, Z., Liu, X., Wang, S., Ren, J., Yao, Y., Zhang, W., Song, M., et al. (2020) · Protein & Cell · doi:10.1007/s13238-020-00728-4 · Cited by 162

Manifestation of Huntington’s disease pathology in human induced pluripotent stem cell-derived neurons

Nekrasov, E. D., Vigont, V. A., Klyushnikov, S. A., Lebedeva, O. S., Vassina, E. M., Bogomazova, A. N., Chestkov, I. V., Semashko, T. A., Владимировна, К. Е., Suldina, L. A., et al. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0092-5 · Cited by 160

Oxidative and nitrative alpha‐synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies

Schildknecht, S., Gerding, H. R., Karreman, C., Drescher, M., Lashuel, H. A., Outeiro, T. F., Di Monte, D. A., & Leist, M. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12226 · Cited by 148

3D Cultures of Parkinson's Disease‐Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing

Bolognin, S., Fossépré, M., Qing, X., Jarazo, J., Ščančar, J., Moreno, E. L., Nickels, S., Wasner, K., Ouzren-Zarhloul, N., Walter, J., et al. (2018) · Advanced Science · doi:10.1002/advs.201800927 · Cited by 151

Genome editing of human pluripotent stem cells to generate human cellular disease models

Musunuru, K. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.012054 · Cited by 148

Mutant LRRK2 Toxicity in Neurons Depends on LRRK2 Levels and Synuclein But Not Kinase Activity or Inclusion Bodies

Skibinski, G., Nakamura, K., Cookson, M., & Finkbeiner, S. M. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2712-13.2014 · Cited by 143

Maintenance of Nucleolar Homeostasis by CBX4 Alleviates Senescence and Osteoarthritis

Ren, X., Hu, B., Song, M., Ding, Z., Dang, Y., Liu, Z., Zhang, W., Ji, Q., Ren, R., Ding, J., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.088 · Cited by 139

Large-scale generation of human iPSC-derived neural stem cells/early neural progenitor cells and their neuronal differentiation

D’Aiuto, L., Zhi, Y., Kumar Das, D., Wilcox, M. R., Johnson, J. W., McClain, L., MacDonald, M. L., Di Maio, R., Schurdak, M. E., Piazza, P., et al. (2014) · Organogenesis · doi:10.1080/15476278.2015.1011921 · Cited by 131

Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cells

Mungenast, A. E., Siegert, S., & Tsai, L. (2015) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2015.11.010 · Cited by 136

A Cut above the Rest: Targeted Genome Editing Technologies in Human Pluripotent Stem Cells

Li, M., Suzuki, K., Kim, N. Y., Liu, G., & Belmonte, J. C. I. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.r113.488247 · Cited by 123

Cancer-testis antigens: Unique cancer stem cell biomarkers and targets for cancer therapy

Гордеева, О. Ф. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.08.006 · Cited by 122

FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration

Yan, P., Li, Q., Wang, L., Lü, P., Suzuki, K., Liu, Z., Lei, J., Li, W., He, X., Wang, S., et al. (2019) · Cell stem cell · doi:10.1016/j.stem.2018.12.002 · Cited by 123

Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs

Liu, G.-H., Suzuki, K., Li, M., Qu, J. T., Montserrat, N., Tarantino, C., Gu, Y., Yi, F., Xu, X., Zhang, W., et al. (2014) · Nature Communications · doi:10.1038/ncomms5330 · Cited by 125

CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs

Wang, L., Yi, F., Fu, L., Yang, J., Wang, S., Wang, Z., Suzuki, K., Sun, L., Xu, X., Yu, Y., et al. (2017) · Protein & Cell · doi:10.1007/s13238-017-0397-3 · Cited by 124

Single-nucleus transcriptomic landscape of primate hippocampal aging

Zhang, H., Li, J., Ren, J., Sun, S., Ma, S., Zhang, W., Yu, Y., Cai, Y., Yan, K., Li, W., et al. (2021) · Protein & Cell · doi:10.1007/s13238-021-00852-9 · Cited by 122

Generation of homogeneous midbrain organoids with in vivo-like cellular composition facilitates neurotoxin-based Parkinson's disease modeling

Kwak, T. H., Kang, J. H., Hali, S., Kim, J., Kim, K.-P., Park, C., Lee, J., Ryu, H. K., Na, J. E., Jo, J., et al. (2020) · Stem Cells · doi:10.1002/stem.3163 · Cited by 114

Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1

Weygant, N., Qu, D., Berry, W. L., May, R. J., Chandrakesan, P., Owen, D. B., Sureban, S. M., Ali, N., Janknecht, R., & Houchen, C. W. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-103 · Cited by 115

Emerging Therapeutic Strategies for Parkinson’s Disease and Future Prospects: A 2021 Update

Gouda, N. A., Elkamhawy, A., & Cho, J. (2022) · Biomedicines · doi:10.3390/biomedicines10020371 · Cited by 112

Modeling human neurological disorders with induced pluripotent stem cells

Imaizumi, Y., & Okano, H. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12625 · Cited by 111

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation

Madero‐Pérez, J., Fdez, E., Fernández, B., Ordóñez, A. J. L., Ramírez, M. B., Gómez‐Suaga, P., Waschbüsch, D., Lobbestael, E., Baekelandt, V., Nairn, A. C., et al. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0235-y · Cited by 107

Neural stem cells in Parkinson’s disease: a role for neurogenesis defects in onset and progression

Grand, J. N. L., González-Cano, L., Pavlou, M. A. S., & Schwamborn, J. C. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1774-1 · Cited by 105

Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality

Walter, J., Bolognin, S., Antony, P. M. A., Nickels, S., Poovathingal, S. K., Salamanca, L., Magni, S., Perfeito, R., Hoel, F., Qing, X., et al. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.03.004 · Cited by 102

Molecular Features Underlying Neurodegeneration Identified through In Vitro Modeling of Genetically Diverse Parkinson’s Disease Patients

Lin, L., Göke, J., Cukuroglu, E., Dranias, M. R., VanDongen, A. M. J., & Stanton, L. W. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.022 · Cited by 95

Modeling neurological diseases using iPSC-derived neural cells: iPSC modeling of neurological diseases

Li, L., Chao, J., & Shi, Y. (2018) · Cell and Tissue Research · doi:10.1007/s00441-017-2713-x · Cited by 89

Non-coding RNA in neural function, disease, and aging

Szafranski, K. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00087 · Cited by 86

Higher Vulnerability and Stress Sensitivity of Neuronal Precursor Cells Carrying an Alpha-Synuclein Gene Triplication

Flierl, A., Oliveira, L. M. A., Falomir‐Lockhart, L. J., Mak, S. K., Hesley, J., Soldner, F., Arndt‐Jovin, D. J., Jaenisch, R., Langston, J. W., Jovin, T. M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112413 · Cited by 87

Spatial genome organization and cognition

Rajarajan, P., Espeso‐Gil, S., Brennand, K., & Akbarian, S. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.124 · Cited by 83

Genome-wide R-loop Landscapes during Cell Differentiation and Reprogramming

Yan, P., Liu, Z., Song, M., Wu, Z., Xu, W. M., Li, K., Ji, Q., Wang, S., Liu, X., Yan, K., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107870 · Cited by 81

Vitamin C alleviates aging defects in a stem cell model for Werner syndrome

Li, Y., Zhang, W., Chang, L., Han, Y., Sun, L., Gong, X., Tang, H., Liu, Z., Deng, H., Ye, Y., et al. (2016) · Protein & Cell · doi:10.1007/s13238-016-0278-1 · Cited by 79

Rescue of premature aging defects in Cockayne syndrome stem cells by CRISPR/Cas9-mediated gene correction

Wang, S., Min, Z., Ji, Q., Geng, L., Su, Y., Liu, Z., Hu, H., Wang, L., Zhang, W., Suzuiki, K., et al. (2019) · Protein & Cell · doi:10.1007/s13238-019-0623-2 · Cited by 78

Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration

Tsika, E., Kannan, M., Foo, C. S.-Y., Dikeman, D. A., Glauser, L., Gellhaar, S., Galter, D., Knott, G. W., Dawson, T. M., Dawson, V. L., et al. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.08.027 · Cited by 83

Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation

Jing, Y., Jiang, X., Ji, Q., Wu, Z., Wang, W., Liu, Z., Guillén-García, P., Esteban, C. R., Reddy, P., Horvath, S., et al. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.09.007 · Cited by 77

Opportunities and challenges for the use of induced pluripotent stem cells in modelling neurodegenerative disease

Wu, Y., Chiu, F., Yeh, C.-S., & Kuo, H. (2019) · Open Biology · doi:10.1098/rsob.180177 · Cited by 78

Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression

Žagare, A., Barmpa, K., Smajić, S., Smits, L. M., Grzyb, K., Grünewald, A., Skupin, A., Nickels, S., & Schwamborn, J. C. (2022) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2021.12.009 · Cited by 75

Visualization of aging-associated chromatin alterations with an engineered TALE system

Ren, R., Deng, L., Xue, Y., Suzuki, K., Zhang, W., Yu, Y., Wu, J., Sun, L., Gong, X., Luan, H., et al. (2017) · Cell Research · doi:10.1038/cr.2017.18 · Cited by 75

Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2

Schmidt, S. H., Weng, J., Aoto, P. C., Boassa, D., Mathea, S., Silletti, S., Torres-Paris, C., Hu, J., Wallbott, M., Komives, E. A., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2100844118 · Cited by 72

The mechanistic role of alpha-synuclein in the nucleus: impaired nuclear function caused by familial Parkinson’s disease SNCA mutations

Chen, V., Moncalvo, M., Tringali, D., Tagliafierro, L., Sriskanda, A., Ilich, E., Dong, W., Kantor, B., & Chiba‐Falek, O. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa183 · Cited by 72

Human Pluripotent Stem Cells in Neurodegenerative Diseases: Potentials, Advances and Limitations

Kolagar, T. A., Farzaneh, M., Nikkar, N., & Khoshnam, S. E. (2019) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x14666190823142911 · Cited by 71

Induced pluripotent stem cells: a tool for modeling Parkinson’s disease

Bose, A., Petsko, G. A., & Studer, L. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.05.001 · Cited by 74

I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway

Ohta, E., Nihira, T., Uchino, A., Imaizumi, Y., Okada, Y., Akamatsu, W., Takahashi, K., Hayakawa, H., Nagai, M., Ohyama, M., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv212 · Cited by 69

Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells

Ling, C., Liu, Z., Song, M., Zhang, W., Wang, S., Liu, X., Ma, S., Sun, S., Fu, L., Chu, Q., et al. (2019) · Protein & Cell · doi:10.1007/s13238-019-0608-1 · Cited by 68

Myopathy in Marinesco–Sjögren syndrome links endoplasmic reticulum chaperone dysfunction to nuclear envelope pathology

Roos, A., Buchkremer, S., Kollipara, L., Labisch, T., Gatz, C., Zitzelsberger, M., Brauers, E., Nolte, K. W., Schröder, J. M., Kirschner, J., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1224-4 · Cited by 65

Disease modeling and drug screening for neurological diseases using human induced pluripotent stem cells

Xu, X., & Zhong, Z. (2013) · Acta Pharmacologica Sinica · doi:10.1038/aps.2013.63 · Cited by 67

Phosphoproteomic evaluation of pharmacological inhibition of leucine‐ rich repeat kinase 2 reveals significant off‐target effects of LRRK ‐2‐ IN ‐1

Luerman, G. C., Nguyen, C., Samaroo, H., Loos, P., Xi, H. S., Hurtado‐Lorenzo, A., Needle, E., Noell, G. S., Galatsis, P., Dunlop, J., et al. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12483 · Cited by 63

iPS cell derived neuronal cells for drug discovery

Heilker, R., Traub, S., Reinhardt, P., Schöler, H. R., & Sterneckert, J. L. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.07.003 · Cited by 62

Using iPS Cells toward the Understanding of Parkinson’s Disease

Torrent, R., Rigotti, F., Dell’Era, P., Memo, M., Raya, Á., & Consiglio, A. (2015) · Journal of Clinical Medicine · doi:10.3390/jcm4040548 · Cited by 65

Multisystem Lewy body disease and the other parkinsonian disorders

Langston, J. W., Schüle, B., Rees, L., Nichols, R. J., & Barlow, C. (2015) · Nature Genetics · doi:10.1038/ng.3454 · Cited by 61

Remodeling neurodegeneration: somatic cell reprogramming-based models of adult neurological disorders

Qiang, L., Fujita, R., & Abeliovich, A. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.002 · Cited by 59

Human pluripotent stem cells as tools for neurodegenerative and neurodevelopmental disease modeling and drug discovery

Corti, S. P., Faravelli, I., Cardano, M., & Conti, L. (2015) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2015.1037737 · Cited by 65

Is Parkinson's Disease a Neurodevelopmental Disorder and Will Brain Organoids Help Us to Understand It?

Schwamborn, J. C. (2018) · Stem Cells and Development · doi:10.1089/scd.2017.0289 · Cited by 62

PINK1 expression increases during brain development and stem cell differentiation, and affects the development of GFAP-positive astrocytes

Choi, I., Choi, D., Yang, H., Woo, J. H., Chang, M., Kim, J. Y., Sun, W., Park, S.-M., Jou, I., Lee, S., et al. (2016) · Molecular Brain · doi:10.1186/s13041-016-0186-6 · Cited by 58

Suppressing Aneuploidy-Associated Phenotypes Improves the Fitness of Trisomy 21 Cells

Hwang, S., Williams, J. F., Kneissig, M., Lioudyno, M., Rivera, I., Helguera, P. R., Busciglio, J. A., Štorchová, Z., King, M. C., & Torres, E. M. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.059 · Cited by 58

Stem Cells on the Brain: Modeling Neurodevelopmental and Neurodegenerative Diseases Using Human Induced Pluripotent Stem Cells

Srikanth, P., & Young‐Pearse, T. L. (2014) · Journal of Neurogenetics · doi:10.3109/01677063.2014.881358 · Cited by 61

Back and forth in time: Directing age in iPSC-derived lineages

Cornacchia, D., & Studer, L. (2017) · Brain Research · doi:10.1016/j.brainres.2015.11.013 · Cited by 56

Dissecting Alzheimer's disease pathogenesis in human 2D and 3D models

Cenini, G., Hebisch, M., Iefremova, V., Flitsch, L. J., Breitkreuz, Y., Tanzi, R. E., Kim, D. Y., Peitz, M., & Brüstle, O. (2020) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2020.103568 · Cited by 60

Mechanisms and consequences of aneuploidy and chromosome instability in the aging brain

Andriani, G. A., Vijg, J., & Montagna, C. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.03.007 · Cited by 56

LRRK2 inhibitors and their potential in the treatment of Parkinson’s disease: current perspectives

Atashrazm, F., & Dzamko, N. L. (2016) · Clinical Pharmacology Advances and Applications · doi:10.2147/cpaa.s102191 · Cited by 57

Recent Developments in LRRK2-Targeted Therapy for Parkinson’s Disease

Zhao, Y., & Dzamko, N. L. (2019) · Drugs · doi:10.1007/s40265-019-01139-4 · Cited by 54

Untitled work

(2023) · doi:10.1016/j.celrep.2023.112593 · Cited by 53

Induced pluripotent stem cell (iPSC)-derived dopaminergic models of Parkinson's disease

Beevers, J. E., Caffrey, T. M., & Wade‐Martins, R. (2013) · Biochemical Society Transactions · doi:10.1042/bst20130194 · Cited by 53

Clinical Therapy Using iPSCs: Hopes and Challenges

Lu, X., & Zhao, T. (2013) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2013.09.002 · Cited by 52

Probing disorders of the nervous system using reprogramming approaches

Ichida, J. K., & Kiskinis, E. (2015) · The EMBO Journal · doi:10.15252/embj.201591267 · Cited by 51

Targeting LRRK2 in Parkinson’s disease: an update on recent developments

Chan, S. L., & Tan, E. (2017) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2017.1323881 · Cited by 51

A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway

Salašová, A., Yokota, C., Potěšil, D., Zdráhal, Z., Bryja, V., & Arenas, E. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0193-9 · Cited by 52

Human stem cell models of neurodegeneration: a novel approach to study mechanisms of disease development

Hargus, G., Ehrlich, M., Hallmann, A.-L., & Kuhlmann, T. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1222-6 · Cited by 54

Basic and translational aging research in China: present and future

Major Program Expert Group, He, X., Song, M., Qu, J. T., Guo, Y., Cao, H., Sun, R., Liu, G., & Shen, Y. (2019) · Protein & Cell · doi:10.1007/s13238-019-0617-0 · Cited by 50

Measurement of LRRK2 and Ser910/935 Phosphorylated LRRK2 in Peripheral Blood Mononuclear Cells from Idiopathic Parkinson's Disease Patients

Dzamko, N. L., Chua, G., Ranola, M., Rowe, D. B., & Halliday, G. M. (2013) · Journal of Parkinson s Disease · doi:10.3233/jpd-130174 · Cited by 51

iPSCs: On the Road to Reprogramming Aging

Soria‐Valles, C., & López-Otı́n, C. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.05.010 · Cited by 49

The StemCellFactory: A Modular System Integration for Automated Generation and Expansion of Human Induced Pluripotent Stem Cells

Elanzew, A., Nießing, B., Langendoerfer, D., Rippel, O., Piotrowski, T., Schenk, F., Kulik, M., Peitz, M., Breitkreuz, Y., Jung, S., et al. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.580352 · Cited by 47

Concise Review: Generation of Neurons From Somatic Cells of Healthy Individuals and Neurological Patients Through Induced Pluripotency or Direct Conversion

Velasco, I., Salazar, P., Giorgetti, A., Ramos–Mejía, V., Castaño, J., Romero–Moya, D., & Menéndez, P. R. (2014) · Stem Cells · doi:10.1002/stem.1782 · Cited by 49

Using Patient-Derived Induced Pluripotent Stem Cells to Identify Parkinson’s Disease-Relevant Phenotypes

Sison, S. L., Vermilyea, S., Emborg, M. E., & Ebert, A. D. (2018) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-018-0893-8 · Cited by 49

Neuron type‐specific increase in lamin B1 contributes to nuclear dysfunction in Huntington’s disease

Alcalá‐Vida, R., García-Forn, M., Castany‐Pladevall, C., Creus‐Muncunill, J., Ito, Y., Blanco, E., Golbano, A., Crespí‐Vázquez, K., Parry, A., Slater, G., et al. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.202012105 · Cited by 48

The Parkinson’s-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1

Walter, J., Bolognin, S., Poovathingal, S. K., Magni, S., Gérard, D., Antony, P. M. A., Nickels, S., Salamanca, L., Berger, E., Smits, L. M., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109864 · Cited by 47

Transcriptional comparison of human induced and primary midbrain dopaminergic neurons

Xia, N., Zhang, P., Fang, F., Wang, Z., Rothstein, M., Angulo, B., Chiang, R., Taylor, J., & Pera, R. A. R. (2016) · Scientific Reports · doi:10.1038/srep20270 · Cited by 46

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Bahnassawy, L., Nicklas, S., Palm, T., Menzl, I., Birzele, F., Gillardon, F., & Schwamborn, J. C. (2013) · Stem Cells and Development · doi:10.1089/scd.2013.0163 · Cited by 46

Ageing of neural stem cells in a Parkinson's disease Model

Menzl, I. (2013) · University of Vienna · doi:10.25365/thesis.27046

Neural stem cell degeneration in PD linked to nuclear defects

Malpass, K. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.230

Modelling and analysis of LRRK2 mutations in iPSC-derived dopaminergic neurons and astrocytes

Booth, H. (2017) · Oxford University Research Archive (ORA) (University of Oxford) · doi:10.5287/ora-nyqekmbqk · Cited by 1

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Kim, J., Daadi, E. W., Daadi, E. S., Oh, T. T., Deleidi, M., & Daadi, M. M. (2023) · Cells · doi:10.3390/cells12212550 · Cited by 12