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Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
Open accessAbstract
Nuclear-architecture defects have been shown to correlate with the manifestation of a number of human diseases as well as ageing. It is therefore plausible that diseases whose manifestations correlate with ageing might be connected to the appearance of nuclear aberrations over time. We decided to evaluate nuclear organization in the context of ageing-associated disorders by focusing on a leucine-rich repeat kinase 2 (LRRK2) dominant mutation (G2019S; glycine-to-serine substitution at amino acid 2019), which is associated with familial and sporadic Parkinson's disease as well as impairment of adult neurogenesis in mice. Here we report on the generation of induced pluripotent stem cells (iPSCs) derived from Parkinson's disease patients and the implications of LRRK2(G2019S) mutation in human neural-stem-cell (NSC) populations. Mutant NSCs showed increased susceptibility to proteasomal stress as well as passage-dependent deficiencies in nuclear-envelope organization, clonal expansion and neuronal differentiation. Disease phenotypes were rescued by targeted correction of the LRRK2(G2019S) mutation with its wild-type counterpart in Parkinson's disease iPSCs and were recapitulated after targeted knock-in of the LRRK2(G2019S) mutation in human embryonic stem cells. Analysis of human brain tissue showed nuclear-envelope impairment in clinically diagnosed Parkinson's disease patients. Together, our results identify the nucleus as a previously unknown cellular organelle in Parkinson's disease pathology and may help to open new avenues for Parkinson's disease diagnoses as well as for the potential development of therapeutics targeting this fundamental cell structure.
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Metadata
- Authors
- Liu, G.-H., Qu, J., Suzuki, K., Nivet, E., Li, M., Montserrat, N., Yi, F., Xu, X., Ruiz, S., Zhang, W., Wagner, U., Kim, A., Ren, B., Li, Y., Goebl, A., Kim, J., Soligalla, R. D., Dubova, I., Thompson, J., III, J. Y., Esteban, C. R., Sancho-Martinez, I., & Belmonte, J. C. I.
- Affiliations
- Salk Institute for Biological Studies (US)
- Chinese Academy of Sciences (CN)
- University of California San Diego (US)
- Scripps Research Institute (US)
- Corresponding author
- Liu, Guang-Hui
- ORCID
- Venue
- Nature
- Published
- 2012-10-17
- Volume
- 491
- Issue
- 7425
- Pages
- 603-607
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3504651
- OpenAlex
- W2088778610
- Cited by
- 339
- References
- 31
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 19 · 2023: 14 · 2022: 24 · 2021: 15 · 2020: 38 · 2019: 28 · 2018: 21 · 2017: 27 · 2016: 36 · 2015: 28 · 2014: 28 · 2013: 34 · 2012: 6
- FWCI
- 19.99
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL AMU (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- National Institute of General Medical Sciences (P41GM103533)
- National Institute of Environmental Health Sciences (U01ES017166, ES017166)
- National Center for Research Resources (P41RR011823)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- Parkinson's disease, LRRK2, G2019S mutation, neural stem cells, nuclear envelope, nuclear organization, induced pluripotent stem cells, clonal expansion, neuronal differentiation, human brain tissue
- MeSH terms
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Cell Differentiation, Cell Division, Cell Line, Clone Cells, Humans, Mutation, Nuclear Envelope, Parkinson Disease, Stress, Physiological, Apoptosis, Protein Serine-Threonine Kinases, Proteasome Endopeptidase Complex, Mutant Proteins, Embryonic Stem Cells, Gene Knock-In Techniques, Induced Pluripotent Stem Cells, Neural Stem Cells
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