The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle
Open accessAbstract
Biologists have long been concerned about what constrains variation in cell size, but progress in this field has been slow and stymied by experimental limitations. Here we describe a new method, ergodic rate analysis (ERA), that uses single-cell measurements of fixed steady-state populations to accurately infer the rates of molecular events, including rates of cell growth. ERA exploits the fact that the number of cells in a particular state is related to the average transit time through that state. With this method, it is possible to calculate full time trajectories of any feature that can be labelled in fixed cells, for example levels of phosphoproteins or total cellular mass. Using ERA we find evidence for a size-discriminatory process at the G1/S transition that acts to decrease cell-to-cell size variation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Thus, the large variation induced by the cell cycle in some scRNA-seq experiments may conceal other important sources of biological variation101, especially cellular differentiation processes137,141,151,152.”
From Revealing the vectors of cellular identity with single-cell genomics (2016) · cites this paper as [141]
In the citing paper
“More recent studies have begun to determine regulatory circuit topology beyond pairwise interaction.”
From Revealing the vectors of cellular identity with single-cell genomics (2016) · cites this paper as [141]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression
Sakaue-Sawano, A., Kurokawa, H., Morimura, T., Hanyu, A., Hama, H., Osawa, H., Kashiwagi, S., Fukami, K., Miyata, T., Miyoshi, H., et al. (2008) · Cell · doi:10.1016/j.cell.2007.12.033 · Cited by 2,194
Analysis of transport phenomena
Deen, W. M. (1998) · Cited by 1,239
Mitchison, J. M. (1971) · Medical Entomology and Zoology · Cited by 715
Optical imaging of cell mass and growth dynamics
Popescu, G., Park, Y., Lue, N., Best-Popescu, C. A., DeFlores, L. P., Dasari, R. R., Feld, M. S., & Badizadegan, K. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00121.2008 · Cited by 521
Optical measurement of cycle-dependent cell growth
Mir, M., Wang, Z., Shen, Z. Z., Bednarz, M., Bashir, R., Golding, I., Prasanth, S. G., & Popescu, G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100506108 · Cited by 411
Cell Growth and Size Homeostasis in Proliferating Animal Cells
Tzur, A., Kafri, R., LeBleu, V. S., Lahav, G., & Kirschner, M. W. (2009) · Science · doi:10.1126/science.1174294 · Cited by 403
Self-citationKillander, D., & Zetterberg, A. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90285-5 · Cited by 254
Direct observation of mammalian cell growth and size regulation
Son, S., Tzur, A., Weng, Y., Jorgensen, P., Kim, J., Kirschner, M. W., & Manalis, S. R. (2012) · Nature Methods · doi:10.1038/nmeth.2133 · Cited by 220
Self-citationMitchison, J. M. (2003) · International review of cytology · doi:10.1016/s0074-7696(03)01004-0 · Cited by 168
Cell Shape Regulation and Cell Cycle in Embryonic Lens Cells
Hendrix, R. W., & Zwaan, J. (1974) · Nature · doi:10.1038/247145a0 · Cited by 47
Cited by
Sorted by citations
Regev, A., Teichmann, S. A., Lander, E. S., Amit, I., Benoist, C., Birney, E., Bodenmiller, B., Campbell, P., Carninci, P., Clatworthy, M., et al. (2017) · eLife · doi:10.7554/elife.27041 · Cited by 2,232
Regev, A., Teichmann, S. A., Lander, E. S., Amit, I., Benoist, C. O., Birney, E., Bodenmiller, B., & al, E. (2017) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-162597 · Cited by 1,457
DNA Replication Stress as a Hallmark of Cancer
Macheret, M., & Halazonetis, T. D. (2015) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012414-040424 · Cited by 860
Scaling single-cell genomics from phenomenology to mechanism
Tanay, A., & Regev, A. (2017) · Nature · doi:10.1038/nature21350 · Cited by 792
Kowalczyk, M. S., Tirosh, I., Heckl, D., Rao, T. N., Dixit, A., Haas, B. J., Schneider, R. K., Wagers, A. J., Ebert, B. L., & Regev, A. (2015) · Genome Research · doi:10.1101/gr.192237.115 · Cited by 778
Cell-Size Control and Homeostasis in Bacteria
Taheri-Araghi, S., Bradde, S., Sauls, J. T., Hill, N. S., Levin, P. A., Paulsson, J., Vergassola, M., & Jun, S. (2014) · Current Biology · doi:10.1016/j.cub.2014.12.009 · Cited by 715
Finding the Right (Bioorthogonal) Chemistry
Patterson, D. M., Nazarova, L. A., & Prescher, J. A. (2014) · ACS Chemical Biology · doi:10.1021/cb400828a · Cited by 679
Revealing the vectors of cellular identity with single-cell genomics
Wagner, A., Regev, A., & Yosef, N. (2016) · Nature Biotechnology · doi:10.1038/nbt.3711 · Cited by 632
Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence
Neurohr, G. E., Terry, R. L., Lengefeld, J., Bonney, M., Brittingham, G. P., Moretto, F., Miettinen, T. P., Vaites, L. P., Soares, L. M., Paulo, J. A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.01.018 · Cited by 518
“Labeling of total cellular protein with an amine reactive dye (Kafri et al., 2013) revealed similar results.”
ResultOn being the right (cell) size
Ginzberg, M. B., Kafri, R., & Kirschner, M. W. (2015) · Science · doi:10.1126/science.1245075 · Cited by 445
Self-citationLloyd, A. C. (2013) · Cell · doi:10.1016/j.cell.2013.08.053 · Cited by 393
Volpato, V., & Webber, C. (2020) · Disease Models & Mechanisms · doi:10.1242/dmm.042317 · Cited by 379
Fundamental limits on dynamic inference from single-cell snapshots
Weinreb, C., Wolock, S., Tusi, B. K., Socolovsky, M., & Klein, A. M. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1714723115 · Cited by 341
Label-free cell cycle analysis for high-throughput imaging flow cytometry
Blasi, T., Hennig, H., Summers, H. D., Theis, F. J., Cerveira, J., Patterson, J. O., Davies, D. C., Filby, A. J., Carpenter, A. E., & Rees, P. C. T. (2016) · Nature Communications · doi:10.1038/ncomms10256 · Cited by 299
Distinct cellular dynamics associated with response to CAR-T therapy for refractory B cell lymphoma
Haradhvala, N. J., Leick, M. B., Maurer, K., Gohil, S. H., Larson, R. C., Yao, N., Gallagher, K., Katsis, K., Frigault, M. J., Southard, J., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-01959-0 · Cited by 290
Live-cell mass profiling: an emerging approach in quantitative biophysics
Zangle, T. A., & Teitell, M. A. (2014) · Nature Methods · doi:10.1038/nmeth.3175 · Cited by 260
Cytoplasmic Volume Modulates Spindle Size During Embryogenesis
Good, M. C., Vahey, M. D., Skandarajah, A., Fletcher, D. A., & Heald, R. (2013) · Science · doi:10.1126/science.1243147 · Cited by 259
Skinner, S. O., Sepúlveda, L. A., Xu, H., & Golding, I. (2013) · Nature Protocols · doi:10.1038/nprot.2013.066 · Cited by 236
Challenges in measuring and understanding biological noise
Eling, N., Morgan, M. D., & Marioni, J. C. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0130-6 · Cited by 247
Size control in mammalian cells involves modulation of both growth rate and cell cycle duration
Cadart, C., Monnier, S., Grilli, J., Sáez, P. J., Srivastava, N., Attia, R., Terriac, E., Baum, B., Lagomarsino, M. C., & Piel, M. (2018) · Nature Communications · doi:10.1038/s41467-018-05393-0 · Cited by 235
Mitotic Wnt Signaling Promotes Protein Stabilization and Regulates Cell Size
Acebrón, S. P., Karaulanov, E., Berger, B. S., Huang, Y., & Niehrs, C. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.04.014 · Cited by 228
Systems biology primer: the basic methods and approaches
Tavassoly, I., Goldfarb, J., & Iyengar, R. (2018) · Essays in Biochemistry · doi:10.1042/ebc20180003 · Cited by 228
Exploring the Function of Cell Shape and Size during Mitosis
Cadart, C., Zlotek-Zlotkiewicz, E., Berre, M. L., Piel, M., & Matthews, H. K. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.04.009 · Cited by 191
Size Does Matter: Why Polyploid Tumor Cells are Critical Drug Targets in the War on Cancer
Coward, J. I. G., & Harding, A. S. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00123 · Cited by 197
Cell cycle proliferation decisions: the impact of single cell analyses
Matson, J. P., & Cook, J. G. (2016) · FEBS Journal · doi:10.1111/febs.13898 · Cited by 183
Concerted control of Escherichia coli cell division
Osella, M., Nugent, E., & Lagomarsino, M. C. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313715111 · Cited by 181
Cell-Size ControlPreprint
Amodeo, A. A., & Skotheim, J. M. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019083 · Cited by 172
Reconstructing cell cycle pseudo time-series via single-cell transcriptome data
Liu, Z., Lou, H., Xie, K., Wang, H. E., Chen, N., Aparicio, O. M., Zhang, M. Q., Jiang, R., & Chen, T. (2017) · Nature Communications · doi:10.1038/s41467-017-00039-z · Cited by 160
Single-cell analysis of transcription kinetics across the cell cycle
Skinner, S. O., Xu, H., Nagarkar-Jaiswal, S., Freire, P. R., Zwaka, T. P., & Golding, I. (2016) · eLife · doi:10.7554/elife.12175 · Cited by 151
Nanotechnology: emerging tools for biology and medicine
Wong, I. Y., Bhatia, S. N., & Toner, M. (2013) · Genes & Development · doi:10.1101/gad.226837.113 · Cited by 132
Jones, A. R., Forero, M. G., Withers, S. P., Smith, R. S., Traas, J. A., Dewitte, W., & Murray, J. A. H. (2017) · Nature Communications · doi:10.1038/ncomms15060 · Cited by 145
The physics of cell-size regulation across timescales
Cadart, C., Venkova, L. S., Recho, P., Lagomarsino, M. C., & Piel, M. (2019) · Nature Physics · doi:10.1038/s41567-019-0629-y · Cited by 146
Soltani, M., Vargas-García, C. A., Antunes, D., & Singh, A. (2016) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004972 · Cited by 125
Ginzberg, M. B., Chang, N. W., D'Souza, H., Patel, N., Kafri, R., & Kirschner, M. W. (2018) · eLife · doi:10.7554/elife.26957 · Cited by 127
Self-citationInferring population dynamics from single-cell RNA-sequencing time series data
Fischer, D. S., Fiedler, A., Kernfeld, E. M., Genga, R. M. J., Bastidas-Ponce, A., Bakhti, M., Lickert, H., Hasenauer, J., Maehr, R., & Theis, F. J. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0088-0 · Cited by 119
Evolution of cellular morpho-phenotypes in cancer metastasis.
Wu, P.-H., Phillip, J. M., Khatau, S. B., Chen, W.-C., Stirman, J., Rosseel, S., Tschudi, K., Van Patten, J., Wong, M., Gupta, S., et al. (2015) · Scientific Reports · doi:10.1038/srep18437 · Cited by 117
Oh, S., Lee, C., Yang, W., Li, A., Mukherjee, A., Basan, M., Ran, C., Yin, W. H., Tabin, C. J., Fu, D., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2117938119 · Cited by 116
Self-citationFast and accurate single-cell RNA-seq analysis by clustering of transcript-compatibility counts
Ntranos, V., Kamath, G. M., Zhang, J. M., Pachter, L. S., & Tse, D. N. C. (2016) · Genome biology · doi:10.1186/s13059-016-0970-8 · Cited by 110
Generalized and scalable trajectory inference in single-cell omics data with VIA
Stassen, S. V., Yip, G. G. K., Wong, K. K. Y., Ho, J. W. K., & Tsia, K. K. (2021) · Nature Communications · doi:10.1038/s41467-021-25773-3 · Cited by 109
Biophysical and biomolecular determination of cellular age in humans
Phillip, J. M., Wu, P.-H., Gilkes, D. M., Williams, W. A., McGovern, S., Daya, J., Chen, J., Aifuwa, I., Lee, J. S. H., Fan, R., et al. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0093 · Cited by 106
Trajectories of cell-cycle progression from fixed cell populations
Gut, G., Tadmor, M. D., Pe’er, D., Pelkmans, L., & Liberali, P. (2015) · Nature Methods · doi:10.1038/nmeth.3545 · Cited by 100
Rapid DNA replication origin licensing protects stem cell pluripotency
Matson, J. P., Dumitru, R., Coryell, P., Baxley, R. M., Chen, W., Twaroski, K., Webber, B. R., Tolar, J., Bielinsky, A., Purvis, J. E., et al. (2017) · eLife · doi:10.7554/elife.30473 · Cited by 97
Single-cell and multivariate approaches in genetic perturbation screens
Liberali, P., Snijder, B., & Pelkmans, L. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3768 · Cited by 94
Wang, W., Douglas, D. L., Zhang, J., Kumari, S., Enuameh, M. S., Dai, Y., Wallace, C. T., Watkins, S. C., Shu, W., & Xing, J. (2020) · Science Advances · doi:10.1126/sciadv.aba9319 · Cited by 91
The importance of water and hydraulic pressure in cell dynamics
Li, Y., Konstantopoulos, K., Zhao, R., Mori, Y., & Sun, S. X. (2020) · Journal of Cell Science · doi:10.1242/jcs.240341 · Cited by 98
Cell size control – a mechanism for maintaining fitness and function
Miettinen, T. P., Caldez, M. J., Kaldis, P., & Björklund, M. (2017) · BioEssays · doi:10.1002/bies.201700058 · Cited by 93
Geometry of the Gene Expression Space of Individual Cells
Korem, Y., Szekely, P., Hart, Y., Sheftel, H., Hausser, J., Mayo, A., Rothenberg, M. E., Kalisky, T., & Alon, U. (2015) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1004224 · Cited by 85
Differential Scaling of Gene Expression with Cell Size May Explain Size Control in Budding Yeast
Chen, Y., Zhao, G., Zahumenský, J., Honey, S. A., & Futcher, B. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.03.012 · Cited by 82
Inherited DNA lesions determine G1 duration in the next cell cycle
Lezaja, A., & Altmeyer, M. (2017) · Cell Cycle · doi:10.1080/15384101.2017.1383578 · Cited by 84
Adlung, L., Kar, S., Wagner, M., She, B., Chakraborty, S., Bao, J., Lattermann, S., Boerries, M., Busch, H. S., Wuchter, P., et al. (2017) · Molecular Systems Biology · doi:10.15252/msb.20167258 · Cited by 81
On the Molecular Mechanisms Regulating Animal Cell Size Homeostasis
Zatulovskiy, E. A., & Skotheim, J. M. (2020) · Trends in Genetics · doi:10.1016/j.tig.2020.01.011 · Cited by 80
A G1 Sizer Coordinates Growth and Division in the Mouse Epidermis
Xie, S., & Skotheim, J. M. (2020) · Current Biology · doi:10.1016/j.cub.2019.12.062 · Cited by 85
Sizing up to Divide: Mitotic Cell-Size Control in Fission Yeast
Wood, E., & Nurse, P. (2015) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100814-125601 · Cited by 78
Time series modeling of live-cell shape dynamics for image-based phenotypic profiling
Gordonov, S., Hwang, M. K., Wells, A. H., Gertler, F. B., Lauffenburger, D. A., & Bathe, M. (2015) · Integrative Biology · doi:10.1039/c5ib00283d · Cited by 78
Akopyan, K., Cascales, H. S., Hukasova, E., Saurin, A. T., Müllers, E., Jaiswal, H., Hollman, D. A. A., Kops, G. J. P. L., Medema, R. H., & Lindqvist, A. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.01.031 · Cited by 74
Probing Mammalian Cell Size Homeostasis by Channel-Assisted Cell Reshaping
Varsano, G., Wang, Y., & Wu, M. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.06.057 · Cited by 74
The Human Cell AtlasPreprint
Regev, A., Teichmann, S. A., Lander, E. S., Amit, I., Benoist, C. O., Birney, E., Bodenmiller, B., Campbell, P. J., Carninci, P., Clatworthy, M. R., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/121202 · Cited by 86
Complex Cartography: Regulation of E2F Transcription Factors by Cyclin F and Ubiquitin
Emanuele, M. J., Enrico, T. P., Mouery, R. D., Wasserman, D., Nachum, S., & Tzur, A. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.05.002 · Cited by 72
Active Control of Cell Size Generates Spatial Detail during Plant Organogenesis
Serrano-Mislata, A., Schiessl, K., & Sablowski, R. W. M. (2015) · Current Biology · doi:10.1016/j.cub.2015.10.008 · Cited by 69
Intrinsic and extrinsic noise of gene expression in lineage trees
Thomas, P. (2019) · Scientific Reports · doi:10.1038/s41598-018-35927-x · Cited by 71
Liu, S., Ginzberg, M. B., Patel, N., Hild, M., Leung, B., Li, Z., Chen, Y., Chang, N. W., Wang, Y., Tan, C., et al. (2018) · eLife · doi:10.7554/elife.26947 · Cited by 72
Self-citationLiedekerke, P. V., Neitsch, J., Johann, T., Alessandri, K., Nassoy, P., & Drasdo, D. (2019) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1006273 · Cited by 66
Ly, T., Whigham, A., Clarke, R. G., Murillo, A. B., Estes, B., Madhessian, D., Lundberg, E. K., Wadsworth, P., & Lamond, A. I. (2017) · eLife · doi:10.7554/elife.27574 · Cited by 66
Genome Biology and the Evolution of Cell-Size DiversityPreprint
Mueller, R. L. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019125 · Cited by 69
Temporal and spatial topography of cell proliferation in cancer
Gaglia, G., Kabraji, S. K., Rammos, D., Dai, Y., Verma, A., Wang, S., Mills, C. E., Chung, M., Bergholz, J. S., Coy, S., et al. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00860-9 · Cited by 62
Making sense of snapshot data: ergodic principle for clonal cell populations
Thomas, P. (2017) · Journal of The Royal Society Interface · doi:10.1098/rsif.2017.0467 · Cited by 60
Spatial discordances between mRNAs and proteins in the intestinal epithelium
Harnik, Y., Buchauer, L., Ben‐Moshe, S., Averbukh, I., Levin, Y., Savidor, A., Eilam, R., Moor, A. E., & Itzkovitz, S. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00504-6 · Cited by 56
Cell size homeostasis is tightly controlled throughout the cell cycle
Liu, X., Yan, J., & Kirschner, M. W. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002453 · Cited by 59
Self-citationFastProject: a tool for low-dimensional analysis of single-cell RNA-Seq data
DeTomaso, D., & Yosef, N. (2016) · BMC Bioinformatics · doi:10.1186/s12859-016-1176-5 · Cited by 58
Lgr5+ intestinal stem cells reside in an unlicensed G1 phase
Carroll, T. D., Newton, I. P., Chen, Y., Blow, J. J., & Näthke, I. S. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201708023 · Cited by 58
YAP and TAZ regulate cell volume
Perez-Gonzalez, N. A., Rochman, N. D., Yao, K., Tao, J., Le, M.-T. T., Flanary, S. M., Sablich, L., Toler, B., Crentsil, E. U., Takaesu, F., et al. (2019) · The Journal of Cell Biology · doi:10.1083/jcb.201902067 · Cited by 58
Berry, S. M., Müller, M., Rai, A., & Pelkmans, L. (2022) · Cell Systems · doi:10.1016/j.cels.2022.04.005 · Cited by 54
Uncovering Hidden Layers of Cell Cycle Regulation through Integrative Multi-omic Analysis
Aviner, R., Shenoy, A., Elroy‐Stein, O., & Geiger, T. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005554 · Cited by 54
Coordination of plant cell growth and division: collective control or mutual agreement?
Sablowski, R. W. M. (2016) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2016.09.004 · Cited by 55
Shaping Organs: Shared Structural Principles Across Kingdoms
Hamant, O., & Saunders, T. E. (2020) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-012820-103850 · Cited by 51
Liu, X., Oh, S., Peshkin, L., & Kirschner, M. W. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2002152117 · Cited by 55
Self-citationDistinct levels in Pom1 gradients limit Cdr2 activity and localization to time and position division
Bhatia, P., Hachet, O., Hersch, M., Rincón, S. A., Berthelot‐Grosjean, M., Dalessi, S., Basterra, L., Bergmann, S., Paoletti, A., & Martin, S. G. (2013) · Cell Cycle · doi:10.4161/cc.27411 · Cited by 52
Conditions for Cell Size Homeostasis: A Stochastic Hybrid System Approach
Vargas-García, C. A., Soltani, M., & Singh, A. (2016) · IEEE Life Sciences Letters · doi:10.1109/lls.2016.2646383 · Cited by 52
Scaling of biosynthesis and metabolism with cell size
Cadart, C., & Heald, R. (2022) · Molecular Biology of the Cell · doi:10.1091/mbc.e21-12-0627 · Cited by 50
Variation in traction forces during cell cycle progression
Vianay, B., Senger, F., Álamos, S., Anjur-Dietrich, M. I., Bearce, E. A., Cheeseman, B. L., Lee, L. K., & Théry, M. (2018) · Biology of the Cell · doi:10.1111/boc.201800006 · Cited by 50
The uniformity and stability of cellular mass density in mammalian cell culture
Liu, X., Oh, S., & Kirschner, M. W. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1017499 · Cited by 49
Self-citationHu, C.-T., Guo, L.-L., Feng, N., Zhang, L., Zhou, N., Ma, L.-L., Shen, L., Tong, G.-H., Yan, Q.-W., Zhu, S.-J., et al. (2015) · OncoTarget · doi:10.18632/oncotarget.4198 · Cited by 51
YAP regulates cell size and growth dynamics via non-cell autonomous mediators
Mugahid, D., Kalocsay, M., Liu, X., Gruver, J. S., Peshkin, L., & Kirschner, M. W. (2020) · eLife · doi:10.7554/elife.53404 · Cited by 52
Self-citationCell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK
Tan, C., Ginzberg, M. B., Webster, R., Iyengar, S., Liu, S., Papadopoli, D. J., Concannon, J. B., Wang, Y., Auld, D. S., Jenkins, J. L., et al. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.04.030 · Cited by 51
Self-citationThomas, P., & Shahrezaei, V. (2021) · Journal of The Royal Society Interface · doi:10.1098/rsif.2021.0274 · Cited by 44
Dario, M. D., & Sablowski, R. W. M. (2019) · Annual Review of Genetics · doi:10.1146/annurev-genet-112618-043602 · Cited by 44
Volume growth in animal cells is cell cycle dependent and shows additive fluctuations
Cadart, C., Venkova, L. S., Piel, M., & Lagomarsino, M. C. (2022) · eLife · doi:10.7554/elife.70816 · Cited by 38
The palette of techniques for cell cycle analysis
Eastman, A. E., & Guo, S. (2020) · FEBS Letters · doi:10.1002/1873-3468.13842 · Cited by 45
Graml, V. M., Studera, X. E., Lawson, J., Chessel, A., Geymonat, M., Bortfeld‐Miller, M., Walter, T., Wagstaff, L., Piddini, E., & Salas, R. E. C. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.09.005 · Cited by 41
Hyperdiploid tumor cells increase phenotypic heterogeneity within Glioblastoma tumors
Donovan, P., Cato, K., Legaie, R., Jayalath, R., Olsson, G., Hall, B. I., Olson, S., Boros, S., Reynolds, B. A., & Harding, A. S. (2014) · Molecular BioSystems · doi:10.1039/c3mb70484j · Cited by 40
Zuleta, I. A., Aranda-Díaz, A., Li, H., & El‐Samad, H. (2014) · Nature Methods · doi:10.1038/nmeth.2879 · Cited by 37
Marr, C., Zhou, J., & Huang, S. (2016) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2016.04.015 · Cited by 38
Apparent simplicity and emergent robustness in the control of the Escherichia coli cell cycle
Govers, S. K., Campos, M., Tyagi, B., Laloux, G., & Jacobs, C. (2023) · Cell Systems · doi:10.1016/j.cels.2023.12.001 · Cited by 39
New Insights into Mechanisms and Functions of Nuclear Size Regulation
Vukovic, L. D., Jevtić, P., Edens, L. J., & Levy, D. L. (2016) · International review of cytology · doi:10.1016/bs.ircmb.2015.11.001 · Cited by 37
A Data-Driven, Mathematical Model of Mammalian Cell Cycle Regulation
Weis, M. C., Avva, J., Jacobberger, J. W., & Sreenath, S. N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097130 · Cited by 35
Theodosakis, N., Held, M. A., Marzuka-Alcalá, A., Meeth, K. M., Micevic, G., Long, G. V., Scolyer, R. A., Stern, D. F., & Bosenberg, M. (2015) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0080 · Cited by 36
Systematic spatial mapping of proteins at exocytic and endocytic structures
Larson, B. T., Sochacki, K. A., Kindem, J. M., & Taraska, J. W. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-02-0771 · Cited by 32
Eukaryotic cell size regulation and its implications for cellular function and dysfunction
Chadha, Y., Khurana, A., & Schmoller, K. M. (2024) · Physiological Reviews · doi:10.1152/physrev.00046.2023 · Cited by 31
Constitutive expression of a fluorescent protein reports the size of live human cells
Berenson, D. F., Zatulovskiy, E. A., Xie, S., & Skotheim, J. M. (2019) · Molecular Biology of the Cell · doi:10.1091/mbc.e19-03-0171 · Cited by 43
Huang, S., Li, F., Zhou, J., & Qian, H. (2017) · Journal of The Royal Society Interface · doi:10.1098/rsif.2017.0097 · Cited by 31
Metadata
- Authors
- Kafri, R., Levy, J., Ginzberg, M. B., Oh, S., Lahav, G., & Kirschner, M. W.
- Affiliations
- Harvard University (US)
- University of Ottawa (CA)
- Corresponding author
- Kirschner, Marc W.
- Venue
- Nature
- Published
- 2013-02
- Volume
- 494
- Issue
- 7438
- Pages
- 480-483
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3730528
- OpenAlex
- W2087252982
- Cited by
- 232
- References
- 11
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 13 · 2023: 10 · 2022: 21 · 2021: 12 · 2020: 23 · 2019: 18 · 2018: 18 · 2017: 31 · 2016: 15 · 2015: 24 · 2014: 20 · 2013: 7
- FWCI
- 9.80
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM083303, R01GM026875, GM 26875)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Physical Sciences › Mathematics › Modeling and Simulation › Mathematical Biology Tumor Growth
- Keywords
- cell size control, cell growth rate, cell cycle, G1/S transition, single-cell measurement, transit time
- MeSH terms
- Cell Count, Cell Cycle, Cell Line, Cycloheximide, Dimethyl Sulfoxide, HeLa Cells, Humans, Leupeptins, Phosphoproteins, G1 Phase, S Phase, Sirolimus, Feedback, Physiological, Cell Size, Cell Proliferation, Single-Cell Analysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
