The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
The nuclear receptor Rev-erbα controls circadian thermogenic plasticity
Open accessAbstract
Circadian oscillation of body temperature is a basic, evolutionarily conserved feature of mammalian biology. In addition, homeostatic pathways allow organisms to protect their core temperatures in response to cold exposure. However, the mechanism responsible for coordinating daily body temperature rhythm and adaptability to environmental challenges is unknown. Here we show that the nuclear receptor Rev-erbα (also known as Nr1d1), a powerful transcriptional repressor, links circadian and thermogenic networks through the regulation of brown adipose tissue (BAT) function. Mice exposed to cold fare considerably better at 05:00 (Zeitgeber time 22) when Rev-erbα is barely expressed than at 17:00 (Zeitgeber time 10) when Rev-erbα is abundant. Deletion of Rev-erbα markedly improves cold tolerance at 17:00, indicating that overcoming Rev-erbα-dependent repression is a fundamental feature of the thermogenic response to cold. Physiological induction of uncoupling protein 1 (Ucp1) by cold temperatures is preceded by rapid downregulation of Rev-erbα in BAT. Rev-erbα represses Ucp1 in a brown-adipose-cell-autonomous manner and BAT Ucp1 levels are high in Rev-erbα-null mice, even at thermoneutrality. Genetic loss of Rev-erbα also abolishes normal rhythms of body temperature and BAT activity. Thus, Rev-erbα acts as a thermogenic focal point required for establishing and maintaining body temperature rhythm in a manner that is adaptable to environmental demands.
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Cites
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Self-citationNonshivering thermogenesis and its adequate measurement in metabolic studies
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Clocks, metabolism, and the epigenome
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Circadian physiology of metabolism
Panda, S. (2016) · Science · doi:10.1126/science.aah4967 · Cited by 1,092
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Potter, G. D. M., Skene, D. J., Arendt, J., Cade, J. E., Grant, P. J., & Hardie, L. J. (2016) · Endocrine Reviews · doi:10.1210/er.2016-1083 · Cited by 709
He, B., Nohara, K., Park, N., Park, Y.-S., Guillory, B., Zhao, Z., Garcia, J. M., Koike, N., Lee, C. C., Takahashi, J. S., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.03.007 · Cited by 507
Discrete functions of nuclear receptor Rev-erbα couple metabolism to the clock
Zhang, Y., Fang, B., Emmett, M. J., Damle, M., Sun, Z., Feng, D., Armour, S. M., Remsberg, J. R., Jager, J., Soccio, R. E., et al. (2015) · Science · doi:10.1126/science.aab3021 · Cited by 318
Self-citation
Metadata
- Authors
- Gerhart-Hines, Z., Feng, D., Emmett, M. J., Everett, L. J., Loro, E., Briggs, E. R., Bugge, A., Hou, C., Ferrara, C., Seale, P., Pryma, D. A., Khurana, T. S., & Lazar, M. A.
- Venue
- Nature
- Published
- 2013-10-27
- Volume
- 503
- Issue
- 7476
- Pages
- 410-413
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1591773525
- Cited by
- 261
- References
- 11
- FWCI
- 14.69
- Type
- journal article
- Language
- en
- Open access
- green
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