Crosstalk between components of circadian and metabolic cycles in mammals
Open accessAbstract
In mammals, most metabolic processes are influenced by biological clocks and feeding rhythms. The mechanisms that couple metabolism to circadian oscillators are just emerging. NAD-dependent enzymes (e.g., Sirtuins and poly[ADP-ribose] polymerases), redox- and/or temperature-dependent transcription factors (e.g., CLOCK, NPAS2, and HSF1), nutrient-sensing transcriptional regulatory proteins (e.g., CREB-CBP-CRCT2, FOXO-p300, nuclear receptors, PGC-1, and SP1 family members) and protein kinases (e.g., AMPK), are plausible candidates for conveying a cell's metabolic state to the core clock circuitry. The intertwining between these acute regulators and circadian clock components is so tight that the discrimination between metabolic and circadian oscillations may be somewhat arbitrary.
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Time-keeping signals are passed on from the suprachiasmatic nucleus to oscillators in peripheral tissues also containing core clock genes.
“Time-keeping signals are passed on from the suprachiasmatic nucleus to oscillators in peripheral tissues also containing core clock genes.”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [41]
Circadian rhythms are endogenously generated in the suprachiasmatic nucleus of the hypothalamus by feedback loops of transcripts of a group of "core clock" genes, including the CLOCK gene.
“Circadian rhythms are endogenously generated in the suprachiasmatic nucleus of the hypothalamus by feedback loops of transcripts of a group of “core clock” genes, including the CLOCK gene.40,41”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [41]
In vivo NAD levels are subjected to daily variations, thereby giving rhythmic input to the genetic clock.
“Interestingly, in vivo NAD levels are subjected to daily variations, thereby giving rhythmic input to the genetic clock [44–46]”
From Circadian control of glucose metabolism (2014) · cites this paper as [46]
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- Authors
- Asher, G., & Schibler, U.
- Affiliations
- University of Geneva (CH)
- Corresponding author
- Asher, Gad
- Schibler, Ueli
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2011-02
- Volume
- 13
- Issue
- 2
- Pages
- 125-137
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2053210485
- Cited by
- 601
- References
- 107
- Citations by year
- 2026: 21 · 2025: 18 · 2024: 27 · 2023: 28 · 2022: 38 · 2021: 33 · 2020: 29 · 2019: 35 · 2018: 30 · 2017: 34 · 2016: 47 · 2015: 63 · 2014: 54 · 2013: 54 · 2012: 65
- FWCI
- 6.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- circadian clock, metabolic rhythms, feeding rhythm, sirtuins, poly(ADP-ribose) polymerase, clock proteins, NPAS2, HSF1, nuclear receptors, PGC-1, AMPK, transcriptional regulation, metabolic status
- MeSH terms
- Animals, Body Temperature, Circadian Rhythm, Glucose, Poly(ADP-ribose) Polymerases, Receptors, Cytoplasmic and Nuclear, Mice, Kruppel-Like Transcription Factors, Sirtuin 1, Circadian Clocks
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