Cited by 603Circadian rhythm and melatoninSirtuins and Resveratrol in MedicineSleep and Work-Related Fatigue

Crosstalk between components of circadian and metabolic cycles in mammals

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Asher, Gad, Schibler, Ueli·2011·Cell Metabolism

Abstract

In mammals, most metabolic processes are influenced by biological clocks and feeding rhythms. The mechanisms that couple metabolism to circadian oscillators are just emerging. NAD-dependent enzymes (e.g., Sirtuins and poly[ADP-ribose] polymerases), redox- and/or temperature-dependent transcription factors (e.g., CLOCK, NPAS2, and HSF1), nutrient-sensing transcriptional regulatory proteins (e.g., CREB-CBP-CRCT2, FOXO-p300, nuclear receptors, PGC-1, and SP1 family members) and protein kinases (e.g., AMPK), are plausible candidates for conveying a cell's metabolic state to the core clock circuitry. The intertwining between these acute regulators and circadian clock components is so tight that the discrimination between metabolic and circadian oscillations may be somewhat arbitrary.

Integrity signals

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Crossref · 10.1016/j.cmet.2011.01.006

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107 of 107 references verified0 citation errors · 0 not checkable

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  • Time-keeping signals are passed on from the suprachiasmatic nucleus to oscillators in peripheral tissues also containing core clock genes.

    “Time-keeping signals are passed on from the suprachiasmatic nucleus to oscillators in peripheral tissues also containing core clock genes.”
  • Circadian rhythms are endogenously generated in the suprachiasmatic nucleus of the hypothalamus by feedback loops of transcripts of a group of "core clock" genes, including the CLOCK gene.

    “Circadian rhythms are endogenously generated in the suprachiasmatic nucleus of the hypothalamus by feedback loops of transcripts of a group of “core clock” genes, including the CLOCK gene.40,41”
  • In vivo NAD levels are subjected to daily variations, thereby giving rhythmic input to the genetic clock.

    “Interestingly, in vivo NAD levels are subjected to daily variations, thereby giving rhythmic input to the genetic clock [44–46]”

    From Circadian control of glucose metabolism (2014) · cites this paper as [46]

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Authors
Asher, G., & Schibler, U.
Affiliations
University of Geneva (CH)
Corresponding author
  • Asher, Gad
  • Schibler, Ueli
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2011-02
Volume
13
Issue
2
Pages
125-137
ISSN
1550-4131 (ISSN-L)
OpenAlex
W2053210485
Cited by
601
References
107
Citations by year
2026: 21 · 2025: 18 · 2024: 27 · 2023: 28 · 2022: 38 · 2021: 33 · 2020: 29 · 2019: 35 · 2018: 30 · 2017: 34 · 2016: 47 · 2015: 63 · 2014: 54 · 2013: 54 · 2012: 65
FWCI
6.63
Type
journal article
Language
en
Open access
Locations
  • Cell Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
circadian clock, metabolic rhythms, feeding rhythm, sirtuins, poly(ADP-ribose) polymerase, clock proteins, NPAS2, HSF1, nuclear receptors, PGC-1, AMPK, transcriptional regulation, metabolic status
MeSH terms
Animals, Body Temperature, Circadian Rhythm, Glucose, Poly(ADP-ribose) Polymerases, Receptors, Cytoplasmic and Nuclear, Mice, Kruppel-Like Transcription Factors, Sirtuin 1, Circadian Clocks

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