The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium
Open accessAbstract
Commitment to and completion of sexual development are essential for malaria parasites (protists of the genus Plasmodium) to be transmitted through mosquitoes. The molecular mechanism(s) responsible for commitment have been hitherto unknown. Here we show that PbAP2-G, a conserved member of the apicomplexan AP2 (ApiAP2) family of DNA-binding proteins, is essential for the commitment of asexually replicating forms to sexual development in Plasmodium berghei, a malaria parasite of rodents. PbAP2-G was identified from mutations in its encoding gene, PBANKA_143750, which account for the loss of sexual development frequently observed in parasites transmitted artificially by blood passage. Systematic gene deletion of conserved ApiAP2 genes in Plasmodium confirmed the role of PbAP2-G and revealed a second ApiAP2 member (PBANKA_103430, here termed PbAP2-G2) that significantly modulates but does not abolish gametocytogenesis, indicating that a cascade of ApiAP2 proteins are involved in commitment to the production and maturation of gametocytes. The data suggest a mechanism of commitment to gametocytogenesis in Plasmodium consistent with a positive feedback loop involving PbAP2-G that could be exploited to prevent the transmission of this pernicious parasite.
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“Lines generated in this way were designated m(7,8,9)mxClx, indicating the mouse and clone number identifiers from the negative selection process.”
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Biology of Malaria Transmission
Meibalan, E., & Marti, M. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025452 · Cited by 251
Lee, H. J., Georgiadou, A., Walther, M., Nwakanma, D., Stewart, L. B., Levin, M., Otto, T. D., Conway, D. J., Coin, L. J., & Cunnington, A. J. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aar3619 · Cited by 141
Self-citationHanhsen, B., Farrukh, A., Pradel, G., & Ngwa, C. J. (2022) · Cells · doi:10.3390/cells11101666 · Cited by 27
Sayers, C., Pandey, V., Balakrishnan, A., Michie, K., Svedberg, D., Hunziker, M., Pardo, M., Choudhary, J., Berntsson, R., & Billker, O. (2024) · Cell Systems · doi:10.1016/j.cels.2024.10.008 · Cited by 22
Self-citationSIP2 is the master transcription factor of Plasmodium merozoite formation
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Metadata
- Authors
- Sinha, A., Hughes, K. R., Modrzynska, K. K., Otto, T. D., Pfander, C., Dickens, N. J., Religa, A. A., Bushell, E., Graham, A. L., Cameron, R., Kafsack, B. F. C., Williams, A. E., Llinás, M., Berriman, M., Billker, O., & Waters, A. P.
- Venue
- Nature
- Published
- 2014-02-23
- Volume
- 507
- Issue
- 7491
- Pages
- 253-257
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2094381221
- Cited by
- 438
- References
- 4
- FWCI
- 37.38
- Type
- journal article
- Language
- en
- Open access
- green
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- Sinha, A., Hughes, K. R., Modrzynska, K. K., Otto, T. D., Pfander, C., Dickens, N. J., Religa, A. A., Bushell, E., Graham, A. L., Cameron, R., Kafsack, B. F. C., Williams, A. E., Llinás, M., Berriman, M., Billker, O., & Waters, A. P. (2014). A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium. Nature. https://doi.org/10.1038/nature12970
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