Cited by 355Motor Control and AdaptationMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

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Skilled reaching relies on a V2a propriospinal internal copy circuit

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Azim, Eiman, Jiang, Juan, Alstermark, Bror, Jessell, Thomas M.·2014·Nature

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Abstract

The precision of skilled forelimb movement has long been presumed to rely on rapid feedback corrections triggered by internally directed copies of outgoing motor commands, but the functional relevance of inferred internal copy circuits has remained unclear. One class of spinal interneurons implicated in the control of mammalian forelimb movement, cervical propriospinal neurons (PNs), has the potential to convey an internal copy of premotor signals through dual innervation of forelimb-innervating motor neurons and precerebellar neurons of the lateral reticular nucleus. Here we examine whether the PN internal copy pathway functions in the control of goal-directed reaching. In mice, PNs include a genetically accessible subpopulation of cervical V2a interneurons, and their targeted ablation perturbs reaching while leaving intact other elements of forelimb movement. Moreover, optogenetic activation of the PN internal copy branch recruits a rapid cerebellar feedback loop that modulates forelimb motor neuron activity and severely disrupts reaching kinematics. Our findings implicate V2a PNs as the focus of an internal copy pathway assigned to the rapid updating of motor output during reaching behaviour.

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Authors: Azim, E., Jiang, J., Alstermark, B., & Jessell, T. M.
Affiliations: Howard Hughes Medical Institute (US)
Umeå University (SE)
Corresponding author: Azim, Eiman
Alstermark, Bror
Jessell, Thomas M.
ORCID: Azim, Eiman
Jiang, Juan
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2014-02-02
Volume: 508
Issue: 7496
Pages: 357-363
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature13021
PMC: PMC4230338
OpenAlex: W2125043585
Cited by: 355
References: 54
Citations by year: 2026: 12 · 2025: 31 · 2024: 21 · 2023: 29 · 2022: 26 · 2021: 27 · 2020: 50 · 2019: 28 · 2018: 27 · 2017: 33 · 2016: 30 · 2015: 29 · 2014: 12
FWCI: 19.33
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Howard Hughes Medical Institute
National Institute of Neurological Disorders and Stroke (R01NS080932, NS033245, R37NS033245, R01NS033245)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: skilled reaching, V2a interneurons, lateral reticular nucleus, brainstem reticular formation, motor neuron activity, spinal interneurons, motor control circuit, mice, optogenetic stimulation, neuronal ablation
MeSH terms: Animals, Cerebellum, Female, Forelimb, Interneurons, Male, Mice, Inbred C57BL, Models, Neurological, Motor Neurons, Motor Skills, Movement, Neural Pathways, Psychomotor Performance, Spinal Cord, Feedback, Physiological, Mice, Optogenetics

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Skilled reaching relies on a V2a propriospinal internal copy circuit

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