Cited by 355Motor Control and AdaptationMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

Skilled reaching relies on a V2a propriospinal internal copy circuit

Open access

Azim, Eiman, Jiang, Juan, Alstermark, Bror, Jessell, Thomas M.·2014·Nature

Open this paper in CoChat — free account

Abstract

The precision of skilled forelimb movement has long been presumed to rely on rapid feedback corrections triggered by internally directed copies of outgoing motor commands, but the functional relevance of inferred internal copy circuits has remained unclear. One class of spinal interneurons implicated in the control of mammalian forelimb movement, cervical propriospinal neurons (PNs), has the potential to convey an internal copy of premotor signals through dual innervation of forelimb-innervating motor neurons and precerebellar neurons of the lateral reticular nucleus. Here we examine whether the PN internal copy pathway functions in the control of goal-directed reaching. In mice, PNs include a genetically accessible subpopulation of cervical V2a interneurons, and their targeted ablation perturbs reaching while leaving intact other elements of forelimb movement. Moreover, optogenetic activation of the PN internal copy branch recruits a rapid cerebellar feedback loop that modulates forelimb motor neuron activity and severely disrupts reaching kinematics. Our findings implicate V2a PNs as the focus of an internal copy pathway assigned to the rapid updating of motor output during reaching behaviour.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nature13021

Cites

54 of 54 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The information capacity of the human motor system in controlling the amplitude of movement.
Fitts, P. M. (1954) · Journal of Experimental Psychology · doi:10.1037/h0055392 · Cited by 6,466
The information capacity of the human motor system in controlling the amplitude of movement.
Fitts, P. M. (1992) · Journal of Experimental Psychology General · doi:10.1037//0096-3445.121.3.262 · Cited by 6,296
Optimal feedback control as a theory of motor coordination
Todorov, E., & Jordan, M. I. (2002) · Nature Neuroscience · doi:10.1038/nn963 · Cited by 3,081
Internal models for motor control and trajectory planning.
Kawato, M. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)00028-8 · Cited by 2,685
Internal models in the cerebellum
Wolpert, D. M., Miall, R. C., & Kawato, M. (1998) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(98)01221-2 · Cited by 2,469
The cerebellum and neural control
Ito, M. (1984) · Cited by 2,314
The cerebellum and neural control
Tindall, S. C. (1985) · Surgical Neurology · doi:10.1016/0090-3019(85)90320-9 · Cited by 1,760
Descending Pathways in Motor Control
Lemon, R. N. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125547 · Cited by 1,599
THE FUNCTIONAL ORGANIZATION OF THE MOTOR SYSTEM IN THE MONKEY
Lawrence, D. G., & Kuypers, H. G. J. M. (1968) · Brain · doi:10.1093/brain/91.1.1 · Cited by 1,301
Spatial control of arm movements
Morasso, P. (2004) · Experimental Brain Research · doi:10.1007/bf00236911 · Cited by 1,215

Show all 54 references

Sorted by citations

Optogenetics: 10 years of microbial opsins in neuroscience
Deisseroth, K. A. (2015) · Nature Neuroscience · doi:10.1038/nn.4091 · Cited by 1,335
Decoding the organization of spinal circuits that control locomotion
Kiehn, O. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.9 · Cited by 742
Motor Cortex Is Required for Learning but Not for Executing a Motor Skill
Kawai, R., Markman, T. M., Poddar, R., Ko, R., Fantana, A. L., Dhawale, A. K., Kampff, A. R., & Ölveczky, B. P. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.024 · Cited by 583
Consensus Paper: Towards a Systems-Level View of Cerebellar Function: the Interplay Between Cerebellum, Basal Ganglia, and Cortex
Caligiore, D., Pezzulo, G., Baldassarre, G., Bostan, A. C., Strick, P. L., Doya, K., Helmich, R. C. G., Dirkx, M. F., Houk, J. C., Jörntell, H., et al. (2016) · The Cerebellum · doi:10.1007/s12311-016-0763-3 · Cited by 454
Massively Parallel Single Nucleus Transcriptional Profiling Defines Spinal Cord Neurons and Their Activity during Behavior
Sathyamurthy, A., Johnson, K. R., Matson, K. J. E., Dobrott, C. I., Li, L., Ryba, A. R., Bergman, T. B., Kelly, M. C., Kelley, M. W., & Levine, A. J. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.003 · Cited by 370
Anipose: A toolkit for robust markerless 3D pose estimation
Karashchuk, P., Rupp, K. L., Dickinson, E. S., Walling-Bell, S., Sanders, E., Azim, E., Brunton, B. W., & Tuthill, J. C. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109730 · Cited by 324
Self-citation
Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke
Wahl, A. S., Omlor, W., Rubio, J. C., Chen, J. L., Zheng, H., Schröter, A., Gullo, M., Weinmann, O., Kobayashi, K., Helmchen, F., et al. (2014) · Science · doi:10.1126/science.1253050 · Cited by 322
The neurons that restore walking after paralysis
Kathe, C., Skinnider, M. A., Hutson, T. H., Regazzi, N., Gautier, M., Demesmaeker, R., Komi, S., Ceto, S., James, N. D., Cho, N., et al. (2022) · Nature · doi:10.1038/s41586-022-05385-7 · Cited by 304
Internal models direct dragonfly interception steering
Mischiati, M., Lin, H., Herold, P., Imler, E., Olberg, R. M., & Leonardo, A. M. (2014) · Nature · doi:10.1038/nature14045 · Cited by 302
Presynaptic inhibition of spinal sensory feedback ensures smooth movement
Fink, A. J. P., Croce, K. R., Huang, Z. J., Abbott, L. F., Jessell, T. M., & Azim, E. (2014) · Nature · doi:10.1038/nature13276 · Cited by 260
Self-citation
Descending command neurons in the brainstem that halt locomotion
Bouvier, J., Caggiano, V., Leiras, R., Caldeira, V., Bellardita, C., Balueva, K., Fuchs, A., & Kiehn, O. (2015) · Cell · doi:10.1016/j.cell.2015.10.074 · Cited by 259
A harmonized atlas of mouse spinal cord cell types and their spatial organization
Russ, D. E., Cross, R. B. P., Li, L., Koch, S. C., Matson, K. J. E., Yadav, A., Alkaslasi, M. R., Lee, D. I., Le Pichon, C. E., Menon, V., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25125-1 · Cited by 255
Motor primitives — new data and future questions
Giszter, S. F. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2015.04.004 · Cited by 242
Internal models in biological control
McNamee, D., & Wolpert, D. M. (2019) · Annual Review of Control, Robotics, and Autonomous Systems · doi:10.1146/annurev-control-060117-105206 · Cited by 225
Early somatostatin interneuron connectivity mediates the maturation of deep layer cortical circuits
Tuncdemir, S. N., Wamsley, B., Stam, F. J., Osakada, F., Goulding, M., Callaway, E. M., Rudy, B., & Fishell, G. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.020 · Cited by 224
Flexible and stretchable nanowire-coated fibers for optoelectronic probing of spinal cord circuits
Lu, C., Park, S., Richner, T. J., Derry, A., Brown, I., Hou, C., Rao, S., Kang, J., Moritz, C. T., Fink, Y., et al. (2017) · Science Advances · doi:10.1126/sciadv.1600955 · Cited by 223
Corticospinal Circuits from the Sensory and Motor Cortices Differentially Regulate Skilled Movements through Distinct Spinal Interneurons
Ueno, M., Nakamura, Y., Li, J., Gu, Z., Niehaus, J. K., Maezawa, M., Crone, S. A., Goulding, M., Baccei, M. L., & Yoshida, Y. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.137 · Cited by 234
Deconstruction of Corticospinal Circuits for Goal-Directed Motor Skills
Wang, X., Liu, Y., Li, X., Zhang, Z., Yang, H., Zhang, Y., Williams, P. R., Alwahab, N. S. A., Kapur, K., Yu, B., et al. (2017) · Cell · doi:10.1016/j.cell.2017.08.014 · Cited by 225
Neural Stem Cell Grafts Form Extensive Synaptic Networks that Integrate with Host Circuits after Spinal Cord Injury
Ceto, S., Sekiguchi, K. J., Takashima, Y., Nimmerjahn, A., & Tuszynski, M. H. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.07.007 · Cited by 191
Making sense out of spinal cord somatosensory development
Lai, H. C., Seal, R. P., & Johnson, J. E. (2016) · Development · doi:10.1242/dev.139592 · Cited by 188
Graded arrays of spinal and supraspinal V2a interneuron subtypes underlie forelimb and hindlimb motor control
Hayashi, M., Hinckley, C. A., Driscoll, S. P., Moore, N. J., Levine, A. J., Hilde, K. L., Sharma, K., & Pfaff, S. L. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.023 · Cited by 188
An Interglomerular Circuit Gates Glomerular Output and Implements Gain Control in the Mouse Olfactory Bulb
Banerjee, A., Marbach, F., Anselmi, F., Koh, M., Davis, M. B., da Silva, P. G., Delevich, K. M., Oyibo, H. K., Gupta, P., Li, B., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.019 · Cited by 183
Restoration of skilled locomotion by sprouting corticospinal axons induced by co-deletion of PTEN and SOCS3
Jin, D., Liu, Y., Sun, F., Wang, X., Liu, X., & He, Z. (2015) · Nature Communications · doi:10.1038/ncomms9074 · Cited by 182
Neurocognitive Mechanisms
Piccinini, G. (2020) · doi:10.1093/oso/9780198866282.001.0001 · Cited by 181
Brainstem neurons that command mammalian locomotor asymmetries
Cregg, J. M., Leiras, R., Montalant, A., Wanken, P., Wickersham, I. R., & Kiehn, O. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0633-7 · Cited by 154
Beyond the brain: Optogenetic control in the spinal cord and peripheral nervous system
Montgomery, K. L., Iyer, S. M., Christensen, A. J., Deisseroth, K., & Delp, S. L. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad7577 · Cited by 147
Cerebellar Control of Reach Kinematics for Endpoint Precision
Becker, M. I., & Person, A. L. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.007 · Cited by 147
Feedback control during voluntary motor actions
Scott, S. H., Cluff, T., Lowrey, C. R., & Takei, T. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2015.03.006 · Cited by 162
Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure
Amin, N. D., Bai, G., Klug, J. R., Bonanomi, D., Pankratz, M. T., Gifford, W. D., Hinckley, C. A., Sternfeld, M. J., Driscoll, S. P., Dominguez, B., et al. (2015) · Science · doi:10.1126/science.aad2509 · Cited by 154
Spinal Control of Locomotion: Individual Neurons, Their Circuits and Functions
Côté, M., Murray, L. M., & Knikou, M. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00784 · Cited by 146
Circuit Changes in Motor Cortex During Motor Skill Learning
Papale, A. E., & Hooks, B. M. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.09.010 · Cited by 158
Recovery of walking after paralysis by regenerating characterized neurons to their natural target region
Squair, J. W., Milano, M., de Coucy, A., Gautier, M., Skinnider, M. A., James, N. D., Cho, N., Lasne, A., Kathe, C., Hutson, T. H., et al. (2023) · Science · doi:10.1126/science.adi6412 · Cited by 149
Optogenetic Editing Reveals the Hierarchical Organization of Learned Action Sequences
Geddes, C. E., Li, H., & Jin, X. (2018) · Cell · doi:10.1016/j.cell.2018.06.012 · Cited by 148
Perspectives on classical controversies about the motor cortex
Omrani, M., Kaufman, M. T., Hatsopoulos, N. G., & Cheney, P. D. (2017) · Journal of Neurophysiology · doi:10.1152/jn.00795.2016 · Cited by 139
Can injured adult CNS axons regenerate by recapitulating development?
Hilton, B. J., & Bradke, F. (2017) · Development · doi:10.1242/dev.148312 · Cited by 139
Conserved genetic signatures parcellate cardinal spinal neuron classes into local and projection subsets
Osseward, P. J., Amin, N. D., Moore, J. D., Temple, B. A., Barriga, B. K., Bachmann, L. C., Beltran, F., Gullo, M., Clark, R. C., Driscoll, S. P., et al. (2021) · Science · doi:10.1126/science.abe0690 · Cited by 115
Quantification of gait parameters in freely walking rodents
Mendes, C. S., Bartos, I., Márka, Z., Akay, T., Szabolcs Marka, C., & Mann, R. S. (2015) · BMC Biology · doi:10.1186/s12915-015-0154-0 · Cited by 114
Role of Synchronous Activation of Cerebellar Purkinje Cell Ensembles in Multi-joint Movement Control
Hoogland, T. M., Gruijl, J. R. D., Witter, L., Canto, C. B., & Zeeuw, C. I. D. (2015) · Current Biology · doi:10.1016/j.cub.2015.03.009 · Cited by 112
DeepBehavior: A Deep Learning Toolbox for Automated Analysis of Animal and Human Behavior Imaging Data
Arac, A., Zhao, P., Dobkin, B. H., Carmichael, S. T., & Golshani, P. (2019) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2019.00020 · Cited by 112
Motor-Circuit Communication Matrix from Spinal Cord to Brainstem Neurons Revealed by Developmental Origin
Pivetta, C., Esposito, M. S., Sigrist, M., & Arber, S. (2014) · Cell · doi:10.1016/j.cell.2013.12.014 · Cited by 112
A functional map for diverse forelimb actions within brainstem circuitry
Ruder, L., Schina, R., Kanodia, H., Garcia, S. V., Pivetta, C., & Arber, S. (2021) · Nature · doi:10.1038/s41586-020-03080-z · Cited by 114
RORβ Spinal Interneurons Gate Sensory Transmission during Locomotion to Secure a Fluid Walking Gait
Koch, S. C., Del Barrio, M. G., Dalet, A., Gatto, G., Günther, T., Zhang, J., Seidler, B., Saur, D., Schüle, R., & Goulding, M. (2017) · Neuron · doi:10.1016/j.neuron.2017.11.011 · Cited by 102
Predictive Sensing: The Role of Motor Signals in Sensory Processing
Brooks, J. X., & Cullen, K. E. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.06.003 · Cited by 110
The Impact of Acute Stress Physiology on Skilled Motor Performance: Implications for Policing
Andérson, G. S., Nota, P. M. D., Metz, G. A. S., & Andersen, J. P. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.02501 · Cited by 106
Regenerating Corticospinal Axons Innervate Phenotypically Appropriate Neurons within Neural Stem Cell Grafts
Kumamaru, H., Lu, P., Rosenzweig, E. S., Kadoya, K., & Tuszynski, M. H. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.099 · Cited by 93
Cortico-fugal output from visual cortex promotes plasticity of innate motor behaviour
Liu, B., Huberman, A. D., & Scanziani, M. (2016) · Nature · doi:10.1038/nature19818 · Cited by 97
Human Spinal Motor Control
Nielsen, J. B. (2016) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070815-013913 · Cited by 98
Contribution of propriospinal neurons to recovery of hand dexterity after corticospinal tract lesions in monkeys
Tohyama, T., Kinoshita, M., Kobayashi, K., Isa, K., Watanabe, D., Kobayashi, K., Liu, M., & Isa, T. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1610787114 · Cited by 91
Transplantation of Neural Progenitors and V2a Interneurons after Spinal Cord Injury
Zholudeva, L. V., Iyer, N. R., Qiang, L., Spruance, V. M., Randelman, M. L., White, N., Bezdudnaya, T., Fischer, I., Sakiyama‐Elbert, S. E., & Lane, M. A. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2017.5439 · Cited by 88
Control of orienting movements and locomotion by projection-defined subsets of brainstem V2a neurons
Usseglio, G., Gatier, E., Heuzé, A., Hérent, C., & Bouvier, J. (2020) · Current Biology · doi:10.1016/j.cub.2020.09.014 · Cited by 87
Cell type and circuit modules in the spinal cord
Osseward, P. J., & Pfaff, S. L. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.03.003 · Cited by 93
Axial elongation of caudalized human organoids mimics aspects of neural tube development
Libby, A. R. G., Joy, D. A., Elder, N. H., Bulger, E. A., Krakora, M. Z., Gaylord, E. A., Mendoza-Camacho, F. N., Butts, J. C., & McDevitt, T. C. (2021) · Development · doi:10.1242/dev.198275 · Cited by 86
The Neuroplastic and Therapeutic Potential of Spinal Interneurons in the Injured Spinal Cord
Zholudeva, L. V., Qiang, L., Marchenko, V., Dougherty, K. J., Sakiyama‐Elbert, S. E., & Lane, M. A. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.06.004 · Cited by 86
Recent advances in our understanding of the primate corticospinal system
Lemon, R. (2019) · F1000Research · doi:10.12688/f1000research.17445.1 · Cited by 86
Motor cortical output for skilled forelimb movement is selectively distributed across projection neuron classes
Park, J., Phillips, J. W., Guo, J., Martin, K. A., Hantman, A. W., & Dudman, J. T. (2022) · Science Advances · doi:10.1126/sciadv.abj5167 · Cited by 85
Optogenetically stimulating intact rat corticospinal tract post-stroke restores motor control through regionalized functional circuit formation
Wahl, A.-S., Büchler, U., Brändli, A., Brattoli, B., Musall, S., Kasper, H., Ineichen, B. V., Helmchen, F., Ommer, B., & Schwab, M. E. (2017) · Nature Communications · doi:10.1038/s41467-017-01090-6 · Cited by 79
Assembly and function of spinal circuits for motor control
Catela, C., Shin, M. M., & Dasen, J. S. (2015) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100814-125155 · Cited by 77
Electrical neuromodulation of the cervical spinal cord facilitates forelimb skilled function recovery in spinal cord injured rats
Alam, M., García‐Alías, G., Jin, B., Keyes, J., Zhong, H., Roy, R. R., Gerasimenko, Y., Lu, D. C.-T., & Edgerton, V. R. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.02.006 · Cited by 76
A Single Bolus of Docosahexaenoic Acid Promotes Neuroplastic Changes in the Innervation of Spinal Cord Interneurons and Motor Neurons and Improves Functional Recovery after Spinal Cord Injury
Liu, Z., Yip, P. K., Adams, L., Davies, M., Lee, J., Michael, G. J., Priestley, J. V., & Michael-Titus, A. T. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0605-15.2015 · Cited by 75
Inhibition of HDAC increases BDNF expression and promotes neuronal rewiring and functional recovery after brain injury
Sada, N., Fujita, Y., Mizuta, N., Ueno, M., Furukawa, T., & Yamashita, T. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02897-w · Cited by 77
Neuromodulation and Strategic Action Choice in Drosophila Aggression
Asahina, K. (2017) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-072116-031240 · Cited by 76
Descending motor circuitry required for NT-3 mediated locomotor recovery after spinal cord injury in mice
Han, Q., Ordaz, J. D., Liu, N., Richardson, Z., Wu, W., Xia, Y., Qu, W., Wang, Y., Dai, H., Zhang, Y. P., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13854-3 · Cited by 73
Differentiation of V2a interneurons from human pluripotent stem cells
Butts, J. C., McCreedy, D. A., Martinez-Vargas, J. A., Mendoza-Camacho, F. N., Hookway, T. A., Gifford, C. A., Taneja, P., Noble‐Haeusslein, L. J., & McDevitt, T. C. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1608254114 · Cited by 73
Hierarchical control of locomotion by distinct types of spinal V2a interneurons in zebrafish
Menelaou, E., & McLean, D. L. (2019) · Nature Communications · doi:10.1038/s41467-019-12240-3 · Cited by 73
Accessory respiratory muscles enhance ventilation in ALS model mice and are activated by excitatory V2a neurons
Romer, S. H., Seedle, K., Turner, S. M., Li, J., Baccei, M. L., & Crone, S. A. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.05.033 · Cited by 71
Brainstem Circuits Controlling Action Diversification
Ruder, L., & Arber, S. (2019) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070918-050201 · Cited by 69
Motor cortex and spinal cord neuromodulation promote corticospinal tract axonal outgrowth and motor recovery after cervical contusion spinal cord injury
Zareen, N., Shinozaki, M., Ryan, D., Alexander, H., Amer, A., Truong, D. Q., Khadka, N., Sarkar, A. D., Naeem, S., Bikson, M., et al. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.08.004 · Cited by 72
Precision of Discrete and Rhythmic Forelimb Movements Requires a Distinct Neuronal Subpopulation in the Interposed Anterior Nucleus
Low, A. Y. T., Thanawalla, A., Yip, A. K. K., Kim, J., Wong, K. L. L., Tantra, M., Augustine, G. J., & Chen, A. I. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.017 · Cited by 71
Efference copy in kinesthetic perception: a copy of what is it?
Latash, M. L. (2021) · Journal of Neurophysiology · doi:10.1152/jn.00545.2020 · Cited by 74
Corticospinal populations broadcast complex motor signals to coordinated spinal and striatal circuits
Nelson, A., Abdelmesih, B., & Costa, R. M. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00939-w · Cited by 68
Transient deactivation of dorsal premotor cortex or parietal area 5 impairs feedback control of the limb in macaques
Takei, T., Lomber, S. G., Cook, D. J., & Scott, S. H. (2021) · Current Biology · doi:10.1016/j.cub.2021.01.049 · Cited by 64
Treatment With the Neutralizing Antibody Against Repulsive Guidance Molecule-a Promotes Recovery From Impaired Manual Dexterity in a Primate Model of Spinal Cord Injury
Nakagawa, H., Ninomiya, T., Yamashita, T., & Takada, M. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx338 · Cited by 64
Precisely timed dopamine signals establish distinct kinematic representations of skilled movements
Bova, A. S., Gaidica, M., Hurst, A., Iwai, Y., Hunter, J., & Leventhal, D. (2020) · eLife · doi:10.7554/elife.61591 · Cited by 63
Myoclonic Twitching and Sleep-Dependent Plasticity in the Developing Sensorimotor System
Tiriac, A., Sokoloff, G., & BLUMBERG, M. S. (2015) · Current Sleep Medicine Reports · doi:10.1007/s40675-015-0009-9 · Cited by 61
Targeting Sensory and Motor Integration for Recovery of Movement After CNS Injury
Asan, A. S., McIntosh, J. R., & Carmel, J. B. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.791824 · Cited by 71
Internal models for interpreting neural population activity during sensorimotor control
Golub, M. D., Yu, B. M., & Chase, S. M. (2015) · eLife · doi:10.7554/elife.10015 · Cited by 61
Comprehensive Monosynaptic Rabies Virus Mapping of Host Connectivity with Neural Progenitor Grafts after Spinal Cord Injury
Adler, A. F., Lee-Kubli, C. A., Kumamaru, H., Kadoya, K., & Tuszynski, M. H. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.04.004 · Cited by 58
Neural Representations Observed
Thomson, E. E., & Piccinini, G. (2018) · Minds and Machines · doi:10.1007/s11023-018-9459-4 · Cited by 62
Spinal V2b neurons reveal a role for ipsilateral inhibition in speed control
Callahan, R. A., Roberts, R., Sengupta, M., Kimura, Y., Higashijima, S.-I., & Bagnall, M. W. (2019) · eLife · doi:10.7554/elife.47837 · Cited by 57
Anatomical and Molecular Properties of Long Descending Propriospinal Neurons in Mice
Flynn, J. R., Conn, V. L., Boyle, K. A., Hughes, D. I., Watanabe, M., Velasquez, T., Goulding, M., Callister, R. J., & Graham, B. A. (2017) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2017.00005 · Cited by 57
The indirect pathway of the basal ganglia promotes transient punishment but not motor suppression
Isett, B. R., Nguyen, K. P., Schwenk, J. C., Yurek, J. R., Snyder, C. N., Vounatsos, M. V., Adegbesan, K., Ziausyte, U., & Gittis, A. H. (2023) · Neuron · doi:10.1016/j.neuron.2023.04.017 · Cited by 56
Spinal microcircuits comprising dI3 interneurons are necessary for motor functional recovery following spinal cord transection
Bui, T. V., Stifani, N., Akay, T., & Brownstone, R. M. (2016) · eLife · doi:10.7554/elife.21715 · Cited by 56
Gating of reafference in the external cuneate nucleus during self-generated movements in wake but not sleep
Tiriac, A., & BLUMBERG, M. S. (2016) · eLife · doi:10.7554/elife.18749 · Cited by 56
Evolution of Patterning Systems and Circuit Elements for Locomotion
Jung, H., & Dasen, J. S. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.01.008 · Cited by 51
An Optogenetic Demonstration of Motor Modularity in the Mammalian Spinal Cord
Caggiano, V., Cheung, V. C. K., & Bizzi, E. (2016) · Scientific Reports · doi:10.1038/srep35185 · Cited by 50
Basal ganglia-spinal cord pathway that commands locomotor gait asymmetries in mice
Cregg, J. M., Sidhu, S. K., Leiras, R., & Kiehn, O. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01569-8 · Cited by 48
Somatosensory Substrates of Flight Control in Bats
Marshall, K. L., Chadha, M., deSouza, L. A., Sterbing-D’Angelo, S. J., Moss, C. F., & Lumpkin, E. A. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.001 · Cited by 48
The Monitoring and Control of Task Sequences in Human and Non-Human Primates
Desrochers, T. M., Burk, D. C., Badre, D., & Sheinberg, D. L. (2016) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00185 · Cited by 48
Proprioception and the predictive sensing of active self-motion
Cullen, K. E., & Zobeiri, O. A. (2021) · Current Opinion in Physiology · doi:10.1016/j.cophys.2020.12.001 · Cited by 48
Cerebrospinal fluid-contacting neuron tracing reveals structural and functional connectivity for locomotion in the mouse spinal cord
Nakamura, Y., Kurabe, M., Matsumoto, M., Sato, T., Miyashita, S., Hoshina, K., Kamiya, Y., Tainaka, K., Matsuzawa, H., Ohno, N., et al. (2023) · eLife · doi:10.7554/elife.83108 · Cited by 49
The Brain Is Needed to Cure Spinal Cord Injury
Isa, T. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.08.002 · Cited by 47
Role of muscle spindle feedback in regulating muscle activity strength during walking at different speed in mice
Mayer, W. P., Murray, A., Brenner‐Morton, S., Jessell, T. M., Tourtellotte, W. G., & Akay, T. (2018) · Journal of Neurophysiology · doi:10.1152/jn.00250.2018 · Cited by 47
Self-citation
Dissecting the Tectal Output Channels for Orienting and Defense Responses
Isa, K., Sooksawate, T., Kobayashi, K., Kobayashi, K., Redgrave, P., & Isa, T. (2020) · eNeuro · doi:10.1523/eneuro.0271-20.2020 · Cited by 49
An automated rat single pellet reaching system with high-speed video capture
Ellens, D. J., Gaidica, M., Toader, A. C., Peng, S., Shue, S., John, T., Bova, A. S., & Leventhal, D. (2016) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2016.07.009 · Cited by 45
Generation of V2a Interneurons from Mouse Embryonic Stem Cells
Brown, C. R., Butts, J. C., McCreedy, D. A., & Sakiyama‐Elbert, S. E. (2014) · Stem Cells and Development · doi:10.1089/scd.2013.0628 · Cited by 42
Spinal nociceptive circuit analysis with recombinant adeno‐associated viruses: the impact of serotypes and promoters
Haenraets, K., Foster, E., Johannssen, H. C., Kandra, V., Frezel, N., Steffen, T., Jaramillo, V., Paterna, J., Zeilhofer, H. U., & Wildner, H. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14124 · Cited by 42
Plasticity of motor network and function in the absence of corticospinal projection
Han, Q., Cao, C., Ding, Y., So, K., Wu, W., Qu, Y., & Zhou, L. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.03.008 · Cited by 44
Dexterous Hand Movements and Their Recovery After Central Nervous System Injury
Isa, T. (2019) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070918-050436 · Cited by 43
Rhesus macaque versus rat divergence in the corticospinal projectome
Sinopoulou, E., Rosenzweig, E. S., Conner, J. M., Gibbs, D., Weinholtz, C. A., Weber, J. L., Brock, J. H., Nout‐Lomas, Y. S., Royz, E., Takashima, Y., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.07.002 · Cited by 41
Active mechanosensory feedback during locomotion in the zebrafish spinal cord
Knafo, S., & Wyart, C. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.04.010 · Cited by 40

Authors: Azim, E., Jiang, J., Alstermark, B., & Jessell, T. M.
Affiliations: Howard Hughes Medical Institute (US)
Umeå University (SE)
Corresponding author: Azim, Eiman
Alstermark, Bror
Jessell, Thomas M.
ORCID: Azim, Eiman
Jiang, Juan
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2014-02-02
Volume: 508
Issue: 7496
Pages: 357-363
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature13021
PMC: PMC4230338
OpenAlex: W2125043585
Cited by: 355
References: 54
Citations by year: 2026: 12 · 2025: 31 · 2024: 21 · 2023: 29 · 2022: 26 · 2021: 27 · 2020: 50 · 2019: 28 · 2018: 27 · 2017: 33 · 2016: 30 · 2015: 29 · 2014: 12
FWCI: 19.33
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Howard Hughes Medical Institute
National Institute of Neurological Disorders and Stroke (R01NS080932, NS033245, R37NS033245, R01NS033245)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: skilled reaching, V2a interneurons, lateral reticular nucleus, brainstem reticular formation, motor neuron activity, spinal interneurons, motor control circuit, mice, optogenetic stimulation, neuronal ablation
MeSH terms: Animals, Cerebellum, Female, Forelimb, Interneurons, Male, Mice, Inbred C57BL, Models, Neurological, Motor Neurons, Motor Skills, Movement, Neural Pathways, Psychomotor Performance, Spinal Cord, Feedback, Physiological, Mice, Optogenetics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Skilled reaching relies on a V2a propriospinal internal copy circuit

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks