The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
The role of senescent cells in ageing
Open accessAbstract
Cellular senescence has historically been viewed as an irreversible cell-cycle arrest mechanism that acts to protect against cancer, but recent discoveries have extended its known role to complex biological processes such as development, tissue repair, ageing and age-related disorders. New insights indicate that, unlike a static endpoint, senescence represents a series of progressive and phenotypically diverse cellular states acquired after the initial growth arrest. A deeper understanding of the molecular mechanisms underlying the multi-step progression of senescence and the development and function of acute versus chronic senescent cells may lead to new therapeutic strategies for age-related pathologies and extend healthy lifespan.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Cellular senescence is an evolutionarily conserved state of stable replicative arrest induced by pro-ageing stressors also implicated in IPF pathogenesis, including telomere attrition, oxidative stress, DNA damage and proteome instability.”
From Cellular senescence mediates fibrotic pulmonary disease (2017) · cites this paper as [8]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Through secretion of the senescence-associated secretory phenotype (SASP), a broad repertoire of cytokines, chemokines, matrix remodelling proteases and growth factors, senescent cells paracrinely promote proliferation and tissue deterioration8.”
From Cellular senescence mediates fibrotic pulmonary disease (2017) · cites this paper as [8]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“These data establish that inhibition of STING, both in cells and in human tissue, can block the inflammatory response of senescent cells—major contributors to inflammation during ageing8.”
From cGAS–STING drives ageing-related inflammation and neurodegeneration (2023) · cites this paper as [8]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Both proliferating and post-mitotic cells (e.g., fully differentiated cells) can be induced to senescence,3,4”
From Single-cell senescence identification reveals senescence heterogeneity, trajectory, and modulators (2024) · cites this paper as [4]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Senescent cells (SnCs) accumulate in many vertebrate tissues with age and contribute to age-related pathologies1–3, presumably through their secretion of factors contributing to the senescence-associated secretory phenotype (SASP)4–6.”
From Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment (2017) · cites this paper as [2]
The cited source says what the claim attributes to it.
In the citing paper
“Senescence is triggered by stressors such as telomere shortening, DNA damage, oxidative stress, and oncogenic signals5,6,7,8”
From Cellular senescence in human liver under normal aging and cancer (2026) · cites this paper as [8]
The cited source says what the claim attributes to it.
In the citing paper
“Senescent cells, which have been implicated in the etiology of aging35”
From SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age (2014) · cites this paper as [35]
The cited source says what the claim attributes to it.
In the citing paper
“Senescent cells accumulate inside the body during aging4,8”
From Single-cell senescence identification reveals senescence heterogeneity, trajectory, and modulators (2024) · cites this paper as [4]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“However, most studies analyze senescent phenotypes 7–10 days after applying the senescence inducers [36, 37].”
From Unmasking Transcriptional Heterogeneity in Senescent Cells (2017) · cites this paper as [37]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“When AP was administered during wound closure, healing was delayed with similar kinetics as 4- or 18-month-old ATTAC mice without prior AP treatment, indicating that acute senescence mechanisms are preserved with aging and not influenced by constitutive clearance of senescent cells 3 .”
From Naturally occurring p16Ink4a-positive cells shorten healthy lifespan (2016) · cites this paper as [3]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“We and others have previously described a role of the cGAS–STING pathway in the regulation of cellular senescence—a hallmark of ageing5–8.”
From cGAS–STING drives ageing-related inflammation and neurodegeneration (2023) · cites this paper as [8]
Experimental — accuracy not yet measuredIn the citing paper
“Senescence is considered to be a highly dynamic, multi-step process, during which the properties of senescent cells continuously evolve and diversify in a context dependent manner.”
From Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype (2021) · cites this paper as Van Deursen, 2014
In the citing paper
“Mounting evidence, however, indicates that senescent cells accumulate during organismal aging due to their increased generation coupled to inefficient clearance [935, 941, 960, 961].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [935]
In the citing paper
“cellular senescence, driven by telomere dysfunction, has been shown to be a causal driver of ageing and age-related pathology (van Deursen, 2014).”
From Telomeres and cell senescence—size matters not (2017) · cites this paper as van Deursen, 2014
In the citing paper
“Among these aging hallmarks, cellular senescence plays a crucial role in brain aging, neurodegeneration, and dementia 36 through the SASP, which represents a major source of inflammation. 37”
From Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer's disease: Evidence from clinical and preclinical studies (2024) · cites this paper as [37]
In the citing paper
“It may also be a key effector mechanism of many types of anticancer therapies, such as chemotherapy, radiotherapy, and endocrine therapies, both directly and via bioactive molecules released by senescent cells that may stimulate an immune response.”
From Senescence and Cancer: A Review of Clinical Implications of Senescence and Senotherapies (2020) · cites this paper as [52]
In the citing paper
“Many types of chemotherapy cause DNA damage (DNA strand breaks or cross linking), which can, if severe, cause cell death via the DNA damage response, or they may trigger a non-lethal DDR, leading to acute or chronic senescence, depending on the extent and duration of the stimulus [52].”
From Senescence and Cancer: A Review of Clinical Implications of Senescence and Senotherapies (2020) · cites this paper as [52]
In the citing paper
“As senescent cells accumulate during aging, causing chronic inflammation (van Deursen, 2014)”
From Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-β Pathway (2017) · cites this paper as van Deursen, 2014
In the citing paper
“While the limit to the extent of proliferation of cells that have damaged DNA is considered to be a natural defense against malignancy, the accumulation of senescent cells is associated with the ageing of tissues [17, 18].”
From Senescence of T Lymphocytes: Implications for Enhancing Human Immunity (2016) · cites this paper as [18]
In the citing paper
“In addition, the secretion of chemoattractants including IL-8 and MIP-1 recruit immune cells to ageing tissue [18]”
From Senescence of T Lymphocytes: Implications for Enhancing Human Immunity (2016) · cites this paper as [18]
In the citing paper
“Senescent cells accumulate with age throughout the body and, although playing a protective role by preventing the appearance of cancer cells, they eventually promote tissue deterioration, producing a low-grade but chronic inflammatory context and acquiring a phenotype that prevents their clearance from the tissue in which they reside [14, 114].”
From Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology (2023) · cites this paper as [114]
In the citing paper
“Mounting evidence from human samples and preclinical animal models shows that the excessive presence of senescent cells is a contributing cause of ageing, which is featured by a functional decline in multiple physiological systems [39,40].”
From Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases (2020) · cites this paper as [39]
In the citing paper
“Accumulation of senescent cells in tissues contributes to age-related diseases [[3], [4], [5], [6], [7]].”
From Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy (2019) · cites this paper as [4]
In the citing paper
“Our results demonstrate that PPARα ligands selectively eliminate senescent chondrocytes via cell death through apoptosis [4].”
From Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy (2019) · cites this paper as [4]
In the citing paper
“It is widely accepted that cellular senescence plays a crucial role in aging and age-related diseases (36).”
From Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice (2021) · cites this paper as [36]
In the citing paper
“One major hallmark of aging is the chronic accumulation of cellular senescence, a permanent state of cell-cycle arrest in response to various damaging stimuli.3,4”
From Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice (2020) · cites this paper as [4]
In the citing paper
“Senescent cells accumulated in different tissues of aged mice,4,40,41 which was consistent with our observation that SA-β-gal-positive cells increased in aged livers, kidneys and lungs (Supplementary information, Fig. S5a–c).”
From Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice (2020) · cites this paper as [4]
In the citing paper
“Senescent cells accumulate with age [23, 157, 175], neurodegenerative disease and cognitive decline [15], neuropsychiatric disorders [33], and have recently been discovered to accumulate after TBI [3, 123, 131, 132, 151].”
From Early onset senescence and cognitive impairment in a murine model of repeated mTBI (2021) · cites this paper as [157]
In the citing paper
“Senescent MEFs remain viable (Fig. S1B) and can be metabolically active in culture for many months [2].”
From Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis (2018) · cites this paper as [2]
In the citing paper
“Activation of the senescence programme leads to cellular and molecular changes such as proliferation arrest, chromatin remodelling, elevated expression of cell cycle inhibitors (such as p16INK4A or p21CIP1), activation of a DNA damage response, enlargement of the lysosomal compartment, and activation of a senescence-associated secretory phenotype (SASP).5,6”
From Paracrine roles of cellular senescence in promoting tumourigenesis (2018) · cites this paper as [6]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670
Aging, Cellular Senescence, and Cancer
Campisi, J. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183653 · Cited by 2,954
Oxidative stress shortens telomeres
von Zglinicki, T. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)02110-2 · Cited by 2,524
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Xue, W., Zender, L., Miething, C., Dickins, R. A., Hernando, E., Krizhanovsky, V., Cordon-Cardo, C., & Lowe, S. W. (2007) · Nature · doi:10.1038/nature05529 · Cited by 2,473
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287
Flagged first, then by citations
Cited by
Sorted by citations
Items 901–1,000 of 1,016
Nutrition and cellular senescence in obesity-related disorders
Rubio‐Tomás, T., Rueda‐Robles, A., Plaza‐Díaz, J., & Álvarez‐Mercado, A. I. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108861 · Cited by 40
Targeting cellular senescence in cancer by plant secondary metabolites: A systematic review
Fakhri, S., Moradi, S. Z., Ash-Rafzadeh, A., & Bishayee, A. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105961 · Cited by 37
Sirtuin-1 attenuates cadmium-induced renal cell senescence through p53 deacetylation
Chou, X., Li, X., Min, Z., Ding, F., Ma, K., Shen, Y. L., Sun, D., & Wu, Q. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.114098 · Cited by 37
Khatri, R., Krishnan, S., Roy, S., Chattopadhyay, S., Kumar, V., & Mukhopadhyay, A. (2016) · Stem Cells and Development · doi:10.1089/scd.2015.0391 · Cited by 37
Fu, B.-Q., Yang, J., Chen, J., Lin, L.-R., Chen, K., Zhang, W., Zhang, J., & He, Y. (2018) · Frontiers of Medicine · doi:10.1007/s11684-017-0586-8 · Cited by 37
Barnes, P. J. (2019) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-3681-2_3 · Cited by 37
Aging and the Biological Response to Liver Injury
Marzioni, M., Pinto, C., Ninfole, E., Gaggiano, L., Benedetti, A., & Maroni, L. (2020) · Seminars in Liver Disease · doi:10.1055/s-0039-3402033 · Cited by 36
Molecular Mechanisms of Cellular Senescence in Neurodegenerative Diseases
Lee, H.-J., Yoon, Y.-S., & Lee, S.-J. (2023) · Journal of Molecular Biology · doi:10.1016/j.jmb.2023.168114 · Cited by 36
Reamon-Buettner, S. M., Hackbarth, A., Leonhardt, A., Braun, A. C., & Ziemann, C. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111412 · Cited by 36
Acar, M. B., Ayaz‐Güner, Ş., Bernardo, G. D., Güner, H., Murat, A., Peluso, G., Özcan, S., & Galderisi, U. (2020) · Aging · doi:10.18632/aging.202423 · Cited by 36
Contribution of viral and bacterial infections to senescence and immunosenescence
Reyes, A., Ortiz, G., Duarte, L. F., Fernández, C., Hernández‐Armengol, R., Palacios, P. A., Prado, Y., Andrade, C. A., Rodríguez‐Guilarte, L., Kalergis, A. M., et al. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1229098 · Cited by 38
Kong, M., Zhou, J., Kang, A., Kuai, Y., Xu, H., Li, M., Miao, X., Guo, Y., Fan, Z., Xu, Y., et al. (2024) · Gut · doi:10.1136/gutjnl-2023-329671 · Cited by 37
de Luzy, I. R., Lee, M. K., Mobley, W. C., & Studer, L. (2024) · Nature Aging · doi:10.1038/s43587-024-00586-3 · Cited by 37
Shen, K., Zhou, H., Zuo, Q., Gu, Y., Cheng, J., Yan, K., Zhang, H., Song, H., Liang, W.-W., Zhou, J., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-55335-2 · Cited by 42
Pace, M., Giorgi, C., Lombardozzi, G., Cimini, A., Castelli, V., & d’Angelo, M. (2025) · Biomolecules · doi:10.3390/biom15081115 · Cited by 37
Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion
Leontieva, O. V., & Blagosklonny, M. V. (2014) · Oncotarget · doi:10.18632/oncotarget.3011 · Cited by 37
Taira, W., Hiyama, A., Nohara, C., Sakauchi, K., & Otaki, J. M. (2015) · Journal of Radiation Research · doi:10.1093/jrr/rrv068 · Cited by 36
Cellular Senescence, Immunosenescence and HIV
Fülöp, T., Herbein, G., Cossarizza, A., Witkowski, J. M., Frost, E. H., Dupuis, G., Pawelec, G., & Larbi, A. (2016) · Interdisciplinary topics in gerontology and geriatrics · doi:10.1159/000448542 · Cited by 38
Senotherapy: growing old and staying young?
Schmitt, R. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1972-4 · Cited by 36
Serebryannyy, L., & Misteli, T. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201706061 · Cited by 37
IGFBP-3 plays an important role in senescence as an aging marker
Hong, S., & Kim, M. (2018) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2018.03.014 · Cited by 40
Healthy aging: A bibliometric analysis of the literature
Gu, Y., Bai, J., Chen, X., Wu, W., Liu, X., & Tan, X. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.11.014 · Cited by 40
Sun, L., Chiang, J. Y., Choi, J. Y., Xiong, Z., Mao, X., Collins, F. S., Hodes, R. J., & Cao, K. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1907199116 · Cited by 36
Houri, K., Mori, T., Onodera, Y., Tsujimoto, T., Takehara, T., Nakao, S., Teramura, T., & Fukuda, K. (2020) · Scientific Reports · doi:10.1038/s41598-020-60346-2 · Cited by 37
From Development to Aging: The Path to Cellular Senescence
Sacco, A., Belloni, L., & Latella, L. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8071 · Cited by 38
Ferreira-González, S., Man, T. Y., Esser, H., Aird, R. E., Kilpatrick, A. M., Rodrigo‐Torres, D., Younger, N. T., Campana, L., Gadd, V. L., Dwyer, B. J., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abj4375 · Cited by 36
Matsumoto, R., Fukuoka, H., Iguchi, G., Odake, Y., Yoshida, K., Bando, H., Suda, K., Nishizawa, H., Takahashi, M., Yamada, S., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140189 · Cited by 38
p53 regulates autophagic activity in senescent rat mesenchymal stromal cells
Zheng, Y., Lei, Y., Hu, C., & Hu, C. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.01.004 · Cited by 36
Senopathies-Diseases Associated with Cellular Senescence
Lushchak, O., Schosserer, M., & Grillari, J. (2023) · Biomolecules · doi:10.3390/biom13060966 · Cited by 35
Implications of inflammatory states on dysfunctional immune responses in aging and obesity
Thomas, A. L., Alarcon, P. C., Divanovic, S., Chougnet, C. A., Hildeman, D. A., & Moreno-Fernandez, M. E. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.732414 · Cited by 35
Sim, B. C., Kang, Y. E., You, S. K., Lee, S. E., Nga, H. T., Lee, H. Y., Nguyen, T. L., Moon, J. S., Tian, J., Jang, H. J., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06146-8 · Cited by 35
Lumbar intervertebral disc degeneration in low back pain
Chiu, A. P., Catherine, C. H. I. A., Arendt‐Nielsen, L., & Curatolo, M. (2024) · Minerva Anestesiologica · doi:10.23736/s0375-9393.24.17843-1 · Cited by 35
Exploration of the mechanism and therapy of ovarian aging by targeting cellular senescence
Tang, W., Wang, K., Feng, Y., Tsui, K., Singh, K. K., Stout, M. B., Wang, S., & Wu, M. (2025) · Life Medicine · doi:10.1093/lifemedi/lnaf004 · Cited by 37
Targeting the hallmarks of aging: mechanisms and therapeutic opportunities
Sanada, F., Hayashi, S., & Morishita, R. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1631578 · Cited by 40
Pang, L., Li, P., Zhang, R., Xu, Y., Song, L., & Zhou, Q. (2017) · Bioscience Reports · doi:10.1042/bsr20170718 · Cited by 35
RetractedASF1a inhibition induces p53-dependent growth arrest and senescence of cancer cells
Wu, Y., Li, X., Yu, J., Björkholm, M., & Xu, D. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1357-z · Cited by 37
Biomarkers in the path from cellular senescence to frailty
Zampino, M., Ferrucci, L., & Semba, R. D. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110750 · Cited by 35
Cellular senescence and hepatitis B‐related hepatocellular carcinoma: An intriguing link
Karakousis, N. D., Papatheodoridi, A. M., Chatzigeorgiou, A., & Papatheodoridis, G. (2020) · Liver International · doi:10.1111/liv.14659 · Cited by 35
mTOR as a senescence manipulation target: A forked road
Saoudaoui, S., Bernard, M., Cardin, G. B., Malaquin, N., Christopoulos, A., & Rodier, F. (2021) · Advances in cancer research · doi:10.1016/bs.acr.2021.02.002 · Cited by 36
Solovyeva, E. M., Ibebunjo, C., Utzinger, S., Eash, J. K., Dunbar, A., Naumann, U., Zhang, Y., Serluca, F. C., Demirci, S., Oberhauser, B., et al. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111510 · Cited by 35
Teissier, T., Temkin, V., Pollak, R. D., & Cox, L. S. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.812157 · Cited by 35
Hurvitz, N., Elkhateeb, N., Sigawi, T., Rinsky‐Halivni, L., & Ilan, Y. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.1044038 · Cited by 38
Oguma, Y., Alessio, N., Aprile, D., Dezawa, M., Peluso, G., Bernardo, G. D., & Galderisi, U. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01280-4 · Cited by 35
The Molecular Intersection Between Senescence and Major Depression in the Elderly
Diniz, B. S. (2018) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2018.07.005 · Cited by 36
Context‐dependent roles of cellular senescence in normal, aged, and disease states
Moiseeva, V., Cisneros, A., Cobos, A. C., Tarrega, A. B., Oñate, C. S., Perdiguero, E., Serrano, A. L., & Muñoz‐Cánoves, P. (2023) · The FEBS Journal · doi:10.1111/febs.16573 · Cited by 34
Targeting Autophagy for Developing New Therapeutic Strategy in Intervertebral Disc Degeneration
Bahar, M. E., Hwang, J. S., Ahmed, M., Lai, T. H., Pham, T. M., Elashkar, O., Akter, K.-M., Kim, D., Yang, J., & Kim, D. R. (2022) · Antioxidants · doi:10.3390/antiox11081571 · Cited by 34
Neural cell state shifts and fate loss in ageing and age-related diseases
Traxler, L., Lucciola, R., Herdy, J. R., Jones, J. R., Mertens, J., & Gage, F. H. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00815-0 · Cited by 37
MicroRNAs and lncRNAs in senescence: A re‐view
Bischof, O., & Martínez‐Zamudio, R. I. (2015) · IUBMB Life · doi:10.1002/iub.1373 · Cited by 35
Mercurio, L., Lulli, D., Mascia, F., Dellambra, E., Scarponi, C., Morelli, M., Valente, C., Carbone, M. L., Pallotta, S., Girolomoni, G., et al. (2020) · Aging · doi:10.18632/aging.103045 · Cited by 34
Effects of cellular senescence on metabolic pathways in non-immune and immune cells
Frasca, D., Saada, Y. B., Garcia, D., & Friguet, B. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111428 · Cited by 35
Early growth response 2 (EGR2) is a novel regulator of the senescence programme
Tyler, E. J., del Arroyo, A. G., Wallis, R., Hughes, B., Garbe, J. C., Stampfer, M. R., Koh, J., Lowe, R., Philpott, M. P., & Bishop, C. L. (2021) · Aging Cell · doi:10.1111/acel.13318 · Cited by 34
Xia, Y., Li, J., Wang, L., Luo, X., Xie, Y., & Liu, Y. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202115764 · Cited by 34
Romani, M., Berger, M. M., & D’Amelio, P. (2022) · Nutrients · doi:10.3390/nu14030483 · Cited by 34
Axolotl: A resourceful vertebrate model for regeneration and beyond
Bölük, A., Yavuz, M., & Demircan, T. (2022) · Developmental Dynamics · doi:10.1002/dvdy.520 · Cited by 36
Challenges and perspectives of tendon-derived cell therapy for tendinopathy: from bench to bedside
Chen, Z., Chen, P., Zheng, M., Gao, J., Liu, D., Wang, P. A., Zheng, Q., Leys, T., Tai, A. C. P., & Zheng, M. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03113-6 · Cited by 34
Unsupervised learning of aging principles from longitudinal data
Avchaciov, K., Antoch, M. P., Andrianova, E. L., Tarkhov, A. E., Menshikov, L. I., Burmistrova, O., Gudkov, A. V., & Fedichev, P. O. (2022) · Nature Communications · doi:10.1038/s41467-022-34051-9 · Cited by 25
Senescent cancer cell-derived nanovesicle as a personalized therapeutic cancer vaccine
Hong, J., Jung, M., Kim, C., Kang, M., Go, S., Sohn, H. S., Moon, S., Kwon, S., Song, S. Y., & Kim, B. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-00951-z · Cited by 34
Aging, metabolism and stem cells: Spotlight on muscle stem cells
García-Prat, L., & Muñoz-Cánoves, P. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.08.021 · Cited by 34
Dókus, L. E., Lajkó, E., Ranđelović, I., Mező, D., Schlosser, G., Kőhidai, L., Tóvári, J., & Mező, G. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12060576 · Cited by 34
Molecular hallmarks of ageing in amyotrophic lateral sclerosis
Jagaraj, C. J., Shadfar, S., Kashani, S. A., Saravanabavan, S., Farzana, F., & Atkin, J. D. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05164-9 · Cited by 39
Ding, X., Ma, X., Meng, P., Yue, J., Li, L., & Xu, L. (2024) · Clinical Interventions in Aging · doi:10.2147/cia.s447514 · Cited by 33
Pramotton, F. M., Spitz, S., & Kamm, R. D. (2024) · Advanced Science · doi:10.1002/advs.202403892 · Cited by 33
Senolytic intervention improves cognition, metabolism, and adiposity in female APPNL−F/NL−F mice
Fang, Y., Peck, M. R., Quinn, K., Chapman, J. E., Medina, D., McFadden, S., Bartke, A., Hascup, E. R., & Hascup, K. N. (2024) · GeroScience · doi:10.1007/s11357-024-01308-8 · Cited by 33
Senolytic treatment for low back pain
Mannarino, M., Cherif, H., Darband, S. G., Martinez, O. W., Sheng, K., Cousineau, E., Lee, S., Millecamps, M., Gao, C., Gilbert, A., et al. (2025) · Science Advances · doi:10.1126/sciadv.adr1719 · Cited by 33
Mechanical rejuvenation of senescent stem cells and aged bone via chromatin remodeling
Liu, X., Ye, Y., Li, Z., Liao, L., & Wei, Q. (2026) · Nature Communications · doi:10.1038/s41467-026-68387-3 · Cited by 36
UHRF1 is required for basal stem cell proliferation in response to airway injury
Xiang, H., Yuan, L., Gao, X., Alexander, P. B., Lopez, O. M., Lau, C. E., Ding, Y., Chong, M., Sun, T., Chen, R., et al. (2017) · Cell Discovery · doi:10.1038/celldisc.2017.19 · Cited by 33
Noncoding RNAs in Vascular Aging
Cao, Q., Wu, J., Wang, X., & Song, C. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/7914957 · Cited by 33
Generation of rhBMP-2-induced juvenile ossicles in aged mice
Dai, K., Shen, T., Yu, Y., Deng, S., Mao, L., Wang, J., & Liu, C. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120284 · Cited by 33
Shachar, S. S., Deal, A. M., Reeder-Hayes, K. E., Nyrop, K. A., Mitin, N., Anders, C. K., Carey, L., Dees, E. C., Jolly, T. A., Kimmick, G. G., et al. (2020) · JNCI Cancer Spectrum · doi:10.1093/jncics/pkaa082 · Cited by 33
Wang, H., Karuppan, M. K. M., Devadoss, D., Nair, M., Chand, H. S., & Lakshmana, M. K. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.06.003 · Cited by 35
Dietary sugar intake and risk of Alzheimer's disease in older women
Liu, L., Volpe, S. L., Ross, J. A., Grimm, J. A., Bockstaele, E. J. V., & Eisen, H. J. (2021) · Nutritional Neuroscience · doi:10.1080/1028415x.2021.1959099 · Cited by 36
Age‐related cellular and microstructural changes in the rotator cuff enthesis
Long, Z., Nakagawa, K., Wang, Z., Amadio, P. C., Zhao, C., & Gingery, A. (2021) · Journal of Orthopaedic Research® · doi:10.1002/jor.25211 · Cited by 34
Tissue engineering strategies to bioengineer the ageing skin phenotype in vitro
Costello, L., DiColandrea, T., Tasseff, R. A., Isfort, R. J., Bascom, C., von Zglinicki, T., & Przyborski, S. A. (2022) · Aging Cell · doi:10.1111/acel.13550 · Cited by 33
Therapeutic Antiaging Strategies
Mishra, S. K., Balendra, V., Esposto, J., Obaid, A. A., Maccioni, R. B., Jha, N. K., Perry, G. L., Moustafa, M., Al-Shehri, M., Singh, M. P., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10102515 · Cited by 34
Genetic enhancement: an avenue to combat aging-related diseases
Cai, Y., Ji, Z., Wang, S., Zhang, W., Qu, J. T., Belmonte, J. C. I., & Liu, G. (2022) · Life Medicine · doi:10.1093/lifemedi/lnac054 · Cited by 33
Mesenchymal stromal cell senescence in haematological malignancies
Plakhova, N., Panagopoulos, V., Vandyke, K., Zannettino, A. C. W., & Mrozik, K. M. (2023) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10069-9 · Cited by 33
Extracellular Vesicles as “Very Important Particles” (VIPs) in Aging
Mas‐Bargues, C., & Alique, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044250 · Cited by 34
G-quadruplexes and associated proteins in aging and Alzheimer’s disease
Kumar, M. J. V., Morales, R., & Tsvetkov, A. S. (2023) · Frontiers in Aging · doi:10.3389/fragi.2023.1164057 · Cited by 34
Unfolding the story of chromatin organization in senescent cells
Swanson, E. C., Rapkin, L. M., Bazett‐Jones, D. P., & Lawrence, J. B. (2015) · Nucleus · doi:10.1080/19491034.2015.1057670 · Cited by 34
Herman, A. B., Anerillas, C., Harris, S. C., Munk, R., Martindale, J. L., Yang, X., Mazan-Mamczarz, K., Zhang, Y., Heckenbach, I. J., Scheibye-Knudsen, M., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab538 · Cited by 31
Brooks, L. R. K., & Mias, G. I. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00392 · Cited by 32
Ueno, D., Ikeda, K., Yamazaki, E., Katayama, A., Urata, R., & Matoba, S. (2023) · Scientific Reports · doi:10.1038/s41598-023-35447-3 · Cited by 32
Shamagian, L. G., Rogers, R. G., Luther, K. M., Angert, D., Echavez, A. K., Liu, W., Middleton, R., Antes, T. J., Valle, J., Fourier, M., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-39370-5 · Cited by 34
Liang, H., Luo, R., Li, G., Zhang, W., Zhu, D., Wu, D., Zhou, X., Tong, B., Wang, B., Feng, X., et al. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01210-4 · Cited by 32
Senescence and SASP Are Potential Therapeutic Targets for Ischemic Stroke
Ouvrier, B., Ismael, S., & Bix, G. J. (2024) · Pharmaceuticals · doi:10.3390/ph17030312 · Cited by 32
A nutrigeroscience approach: Dietary macronutrients and cellular senescence
Calubag, M. F., Robbins, P. D., & Lamming, D. W. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.07.025 · Cited by 33
An aging bone marrow exacerbates lung fibrosis by fueling profibrotic macrophage persistence
Farhat, A., Radhouani, M., Deckert, F., Zahalka, S., Pimenov, L., Fokina, A., Hakobyan, A., Oberndorfer, F., Brösamlen, J., Hladik, A., et al. (2025) · Science Immunology · doi:10.1126/sciimmunol.adk5041 · Cited by 35
Dissecting cellular senescence and SASP in Drosophila
Ito, T., & Igaki, T. (2016) · Inflammation and Regeneration · doi:10.1186/s41232-016-0031-4 · Cited by 34
Molecular basis of senescence transmitting in the population of human endometrial stromal cells
Griukova, A., Deryabin, P. I., Shatrova, A. N., Burova, E., Severino, V., Farina, A., Nikolsky, N. N., & Borodkina, A. V. (2019) · Aging · doi:10.18632/aging.102441 · Cited by 32
Markiewicz, E., & Idowu, O. C. (2019) · Open Biology · doi:10.1098/rsob.190208 · Cited by 32
Cellular Aging Characteristics and Their Association with Age-Related Disorders
Rudzińska, M., Parodi, A., Balakireva, A. V., Chepikova, O. E., Venanzi, F. M., & Zamyatnin, A. A. (2020) · Antioxidants · doi:10.3390/antiox9020094 · Cited by 32
Rapid senescence‐like response after acute injury
Chu, X., Wen, J., & Raju, R. P. (2020) · Aging Cell · doi:10.1111/acel.13201 · Cited by 33
Insight into the Role of Angiopoietins in Ageing-Associated Diseases
Hayashi, S.-I., Rakugi, H., & Morishita, R. (2020) · Cells · doi:10.3390/cells9122636 · Cited by 33
Distinct types of stem cell divisions determine organ regeneration and aging in hair follicles
Matsumura, H., Liu, N., Nanba, D., Ichinose, S., Takada, A., Kurata, S., Morinaga, H., Mohri, Y., Arcangelis, A. D., Ohno, S., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00033-7 · Cited by 32
Gillispie, G. J., Sah, E., Krishnamurthy, S., Ahmidouch, M. Y., Zhang, B., & Orr, M. E. (2021) · Life · doi:10.3390/life11020153 · Cited by 31
Senescence and associated blood–brain barrier alterations in vitro
Salvador, E., Burek, M., Löhr, M., Nagai, M., Hagemann, C., & Förster, C. Y. (2021) · Histochemistry and Cell Biology · doi:10.1007/s00418-021-01992-z · Cited by 32
Lee, S. H., Lee, J. Y., Lim, K.-H., Lee, Y., & Koh, J. (2021) · Calcified Tissue International · doi:10.1007/s00223-021-00912-6 · Cited by 34
Ionizing irradiation-induced Fgr in senescent cells mediates fibrosis
Mukherjee, A., Epperly, M. W., Shields, D. S., Hou, W., Fisher, R., Hamade, D. F., Wang, H., Huq, M. S., Bao, R., Tabib, T., et al. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00741-4 · Cited by 33
Piperine: An Anticancer and Senostatic Drug
Lim, J. S., Lee, D. Y., Lim, J. H., Oh, W. K., Park, J. T., Park, S. C., & Cho, K. A. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2704137 · Cited by 33
Matacchione, G., Valli, D., Silvestrini, A., Giuliani, A., Sabbatinelli, J., Giordani, C., Coppari, S., Rippo, M. R., Albertini, M. C., & Olivieri, F. (2022) · Antioxidants · doi:10.3390/antiox11061037 · Cited by 32
Metadata
- Authors
- van Deursen, J. M.
- Venue
- Nature
- Published
- 2014-05-21
- Volume
- 509
- Issue
- 7501
- Pages
- 439-446
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4214092
- OpenAlex
- W2130458932
- Cited by
- 2,623
- References
- 99
- Citations by year
- 2026: 160 · 2025: 217 · 2024: 251 · 2023: 295 · 2022: 285 · 2021: 364 · 2020: 272 · 2019: 203 · 2018: 195 · 2017: 132 · 2016: 140 · 2015: 83 · 2014: 24
- FWCI
- 14.84
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- Foundation for the National Institutes of Health
- Glenn Foundation for Medical Research
- National Institute on Aging (AG41122-01P2, P01AG041122)
- National Cancer Institute (R01CA166347, R01CA096985, R01CA96985)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- cellular senescence, aging, senolytics, age-related diseases, tissue repair, cancer prevention, growth arrest, healthspan, senolytic therapy
- MeSH terms
- Aging, Animals, Disease, Humans, Longevity, Mitosis, Models, Biological, Cellular Senescence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
