The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Galanin neurons in the medial preoptic area govern parental behaviour
Open accessAbstract
Mice display robust, stereotyped behaviours towards pups: virgin males typically attack pups, whereas virgin females and sexually experienced males and females display parental care. Here we show that virgin males genetically impaired in vomeronasal sensing do not attack pups and are parental. Furthermore, we uncover a subset of galanin-expressing neurons in the medial preoptic area (MPOA) that are specifically activated during male and female parenting, and a different subpopulation that is activated during mating. Genetic ablation of MPOA galanin neurons results in marked impairment of parental responses in males and females and affects male mating. Optogenetic activation of these neurons in virgin males suppresses inter-male and pup-directed aggression and induces pup grooming. Thus, MPOA galanin neurons emerge as an essential regulatory node of male and female parenting behaviour and other social responses. These results provide an entry point to a circuit-level dissection of parental behaviour and its modulation by social experience.
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Self-citationMedial preoptic area and maternal behavior in the female rat.
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Self-citationMapping of Brain Activity by Automated Volume Analysis of Immediate Early Genes
Renier, N., Adams, E. L., Kirst, C., Wu, Z., Azevedo, R., Kohl, J., Autry, A. E., Kadiri, L., Umadevi Venkataraju, K., Zhou, Y., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.007 · Cited by 918
Self-citationOxytocin enables maternal behaviour by balancing cortical inhibition
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CRH Engagement of the Locus Coeruleus Noradrenergic System Mediates Stress-Induced Anxiety
McCall, J. G., Al-Hasani, R., Siuda, E. R., Hong, D. Y., Norris, A. J., Ford, C. P., & Bruchas, M. R. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.002 · Cited by 666
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Metadata
- Authors
- Wu, Z., Autry, A. E., Bergan, J. F., Watabe-Uchida, M., & Dulac, C. G.
- Venue
- Nature
- Published
- 2014-05
- Volume
- 509
- Issue
- 7500
- Pages
- 325-330
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2087453951
- Cited by
- 594
- References
- 11
- FWCI
- 48.16
- Type
- journal article
- Language
- en
- Open access
- green
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