Autophagy in the Cellular Energetic Balance
Open accessAbstract
Autophagy mediates the degradation of cellular components in lysosomes, assuring removal of altered or dysfunctional proteins and organelles. Autophagy is not only activated in response to cellular damage; in fact, one of its strongest and better-characterized stimuli is starvation. Activation of autophagy when nutrients are scarce allows cells to reutilize their own constituents for energy. Besides protein breakdown, autophagy also contributes to the mobilization of diverse cellular energy stores. This recently discovered interplay between autophagy and lipid and carbohydrate metabolism reveals the existence of a dynamic feedback between autophagy and cellular energy balance.
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The BLESS trial has shown modification in the microbiota of non-cystic fibrosis bronchiectasis patients receiving erythromycin for 48 months.
“The BLESS trial (115) has shown modification in the microbiota of non-cystic fibrosis bronchectasis patients receiving erythromycin for 48 months.”
From ESPEN guideline on clinical nutrition in the intensive care unit. (2019) · cites this paper as [115]
The cited paper’s sections on autophagy and lipid metabolism and on metabolic dysfunction discuss cellular energy balance, not the BLESS trial. Searches for BLESS, bronchiectasis, erythromycin, and airway microbiota found no passage addressing the claimed treatment or duration. (LLM, conf=0.78)
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Cites
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“Studies in cultured cells have shown that the proteasome system contributes most of the amino acids to this pool in the first hours of starvation (Vabulas and Hartl, 2005), whereas macroautophagy starts right after and reaches a peak at about 6–8 hr into the starvation period (Deter et al., 1967).”
InfluentialControl of autophagy initiation by phosphoinositide 3‐phosphatase jumpy
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- Authors
- Singh, R., & Cuervo, A. M.
- Affiliations
- Albert Einstein College of Medicine (US)
- Corresponding author
- Singh, Rajat
- ORCID
- Singh, Rajat
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 13
- Issue
- 5
- Pages
- 495-504
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC3099265
- OpenAlex
- W2004325124
- Cited by
- 788
- References
- 11
- Citations by year
- 2026: 21 · 2025: 40 · 2024: 39 · 2023: 37 · 2022: 58 · 2021: 62 · 2020: 78 · 2019: 62 · 2018: 60 · 2017: 48 · 2016: 61 · 2015: 63 · 2014: 44 · 2013: 59 · 2012: 43
- FWCI
- 5.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 844 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (AG021904, AG031782, DK041918, DK087776, NS038370)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- autophagy, starvation, lysosomal degradation, protein turnover, organelle turnover, lipid metabolism, carbohydrate metabolism, energy stores, nutrient scarcity
- MeSH terms
- Animals, Autophagy, Cell Membrane, Energy Metabolism, Humans
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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