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Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions
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“For example, certain peptides such as substance P can activate some mast cell populations to robustly release the granule-stored mediators; however, compared to the same cells activated via the FcεRI, such stimuli may less potently elicit release of lipid mediators or cytokines [14, 20, 21].”
From Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy (2020) · cites this paper as [21]
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“Activation of MRGPRX2 leads to mast cell degranulation 25,26 , and we used an established β -hexosaminidase release assay to measure the extent of degranulation upon the addition of the nanobodies to mast cells 27 .”
Metadata
- Authors
- McNeil, B. D., Pundir, P., Meeker, S., Han, L., Undem, B. J., Kulka, M., & Dong, X.
- Venue
- Nature
- Published
- 2014-12-17
- Volume
- 519
- Issue
- 7542
- Pages
- 237-241
- ISSN
- 0028-0836
- 1476-4687
- PMC
- PMC4359082
- Cited by
- 1,228
- References
- 0
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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