The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
The evolutionary history of lethal metastatic prostate cancer
Open accessAbstract
Cancers emerge from an ongoing Darwinian evolutionary process, often leading to multiple competing subclones within a single primary tumour. This evolutionary process culminates in the formation of metastases, which is the cause of 90% of cancer-related deaths. However, despite its clinical importance, little is known about the principles governing the dissemination of cancer cells to distant organs. Although the hypothesis that each metastasis originates from a single tumour cell is generally supported, recent studies using mouse models of cancer demonstrated the existence of polyclonal seeding from and interclonal cooperation between multiple subclones. Here we sought definitive evidence for the existence of polyclonal seeding in human malignancy and to establish the clonal relationship among different metastases in the context of androgen-deprived metastatic prostate cancer. Using whole-genome sequencing, we characterized multiple metastases arising from prostate tumours in ten patients. Integrated analyses of subclonal architecture revealed the patterns of metastatic spread in unprecedented detail. Metastasis-to-metastasis spread was found to be common, either through de novo monoclonal seeding of daughter metastases or, in five cases, through the transfer of multiple tumour clones between metastatic sites. Lesions affecting tumour suppressor genes usually occur as single events, whereas mutations in genes involved in androgen receptor signalling commonly involve multiple, convergent events in different metastases. Our results elucidate in detail the complex patterns of metastatic spread and further our understanding of the development of resistance to androgen-deprivation therapy in prostate cancer.
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Cites
Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing
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Distant metastasis occurs late during the genetic evolution of pancreatic cancer
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Self-citationThe Life History of 21 Breast Cancers
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Self-citationHeterogeneity of genomic evolution and mutational profiles in multiple myeloma
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Cited by
Tumour heterogeneity and resistance to cancer therapies
Dagogo-Jack, I., & Shaw, A. T. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.166 · Cited by 3,846
Integrative Clinical Genomics of Advanced Prostate Cancer
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“Although certain primary prostate cancer alterations or signatures have prognostic clinical significance (Hieronymus et al., 2014; Lalonde et al., 2014), the therapeutic impact of primary prostate cancer genomic events has not yet been realized.”
Clonal heterogeneity and tumor evolution: past, present, and the future
McGranahan, N., & Swanton, C. (2017) · Cell · doi:10.1016/j.cell.2017.01.018 · Cited by 2,840
Molecular principles of metastasis: a hallmark of cancer revisited
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Metastatic colonization by circulating tumour cells
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Metadata
- Authors
- ICGC Prostate UK Group, Gundem, G., Van Loo, P., Kremeyer, B., Alexandrov, L. B., Tubio, J. M. C., Papaemmanuil, E., Brewer, D. S., Kallio, H. M. L., Högnäs, G., Annala, M., Kivinummi, K., Goody, V., Latimer, C., O'Meara, S., Dawson, K. J., Isaacs, W., Emmert-Buck, M. R., Nykter, M., Foster, C., Kote-Jarai, Z., Easton, D., Whitaker, H. C., Neal, D. E., Cooper, C. S., Eeles, R. A., Visakorpi, T., Campbell, P. J., McDermott, U., Wedge, D. C., & Bova, G. S.
- Venue
- Nature
- Published
- 2015-04
- Volume
- 520
- Issue
- 7547
- Pages
- 353-357
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2050146329
- Cited by
- 1,388
- References
- 11
- FWCI
- 49.07
- Type
- journal article
- Language
- en
- Open access
- green
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- ICGC Prostate UK Group, Gundem, G., Van Loo, P., Kremeyer, B., Alexandrov, L. B., Tubio, J. M. C., Papaemmanuil, E., Brewer, D. S., Kallio, H. M. L., Högnäs, G., Annala, M., Kivinummi, K., Goody, V., Latimer, C., O'Meara, S., Dawson, K. J., Isaacs, W., Emmert-Buck, M. R., Nykter, M., . . . Bova, G. S. (2015). The evolutionary history of lethal metastatic prostate cancer. Nature. https://doi.org/10.1038/nature14347
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
