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A phosphoinositide conversion mechanism for exit from endosomes

Ketel, Katharina, Krauss, Michael, Nicot, Anne-Sophie, Puchkov, Dmytro, Wieffer, Marnix, Müller, Rainer, Subramanian, Devaraj, Schultz, Carsten, Laporte, Jocelyn, Haucke, Volker·2016·Nature
DOI 10.1038/nature16516
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  • Other PI(4,5)P2 phosphatases and kinases impact trafficking and degradation of the epidermal growth factor receptor and the transferrin receptor.

    “Notably, other PI(4,5)P2 phosphatases (e.g. Lowe oculocerebrorenal syndrome protein (OCRL), also known as INPP5F) and kinases have been reported to impact trafficking and degradation of the epidermal growth factor receptor and the transferrin receptor, which are recycled and degraded in a manner similar to LDLR11–13.”

    From Phosphatidylinositol-(4,5)-Bisphosphate Regulates Plasma Cholesterol Through LDL (Low-Density Lipoprotein) Receptor Lysosomal Degradation (2020) · cites this paper as [12]

    Section 1.4 reports that the kinase PI4K2α affects EGFR endosomal trafficking and TfR recycling, and section 1.2.2 describes a role for the PI(4,5)P2 phosphatase OCRL in endocytic membrane traffic. The copy does not establish that OCRL affects EGFR or TfR trafficking or degradation specifically. Its enzyme table also lists INPP5F as Sac2, not OCRL, while PI4K2α synthesizes PI(4)P rather than PI(4,5)P2. (LLM, conf=0.86)

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Research works printed but not linked: 32

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Metadata

Authors
Ketel, K., Krauss, M., Nicot, A.-S., Puchkov, D., Wieffer, M., Müller, R., Subramanian, D., Schultz, C., Laporte, J., & Haucke, V.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2016-01
Volume
529
Issue
7586
Pages
408-412
ISSN
  • 0028-0836
  • 1476-4687
DOI
10.1038/nature16516
Cited by
189
References
0
Language
en
Licence
www.springer.com/tdm (tdm)

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