Cited by 322Genetics and Neurodevelopmental DisordersAnimal Genetics and ReproductionVirus-based gene therapy research

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Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2

Liu, Zhen, Li, Xiao, Zhang, Jun-Tao, Cai, Yi-Jun, Cheng, Tian-Lin, Cheng, Cheng, Wang, Yan, Zhang, Chen-Chen, Nie, Yan-Hong, Chen, Zhi-Fang, Bian, Wen-Jie, Zhang, Ling, Xiao, Jianqiu, Lu, Bin, Zhang, Yue-Fang, Zhang, Xiao-Di, Sang, Xiao, Wu, Jia-Jia, Xu, Xiu, Xiong, Zhi-Qi, Zhang, Feng, Yu, Xiang, Gong, Neng, Zhou, Wen-Hao, Sun, Qiang, Qiu, Zilong·2016·Nature

DOI 10.1038/nature16533

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Abstract

Methyl-CpG binding protein 2 (MeCP2) has crucial roles in transcriptional regulation and microRNA processing. Mutations in the MECP2 gene are found in 90% of patients with Rett syndrome, a severe developmental disorder with autistic phenotypes. Duplications of MECP2-containing genomic segments cause the MECP2 duplication syndrome, which shares core symptoms with autism spectrum disorders. Although Mecp2-null mice recapitulate most developmental and behavioural defects seen in patients with Rett syndrome, it has been difficult to identify autism-like behaviours in the mouse model of MeCP2 overexpression. Here we report that lentivirus-based transgenic cynomolgus monkeys (Macaca fascicularis) expressing human MeCP2 in the brain exhibit autism-like behaviours and show germline transmission of the transgene. Expression of the MECP2 transgene was confirmed by western blotting and immunostaining of brain tissues of transgenic monkeys. Genomic integration sites of the transgenes were characterized by a deep-sequencing-based method. As compared to wild-type monkeys, MECP2 transgenic monkeys exhibited a higher frequency of repetitive circular locomotion and increased stress responses, as measured by the threat-related anxiety and defensive test. The transgenic monkeys showed less interaction with wild-type monkeys within the same group, and also a reduced interaction time when paired with other transgenic monkeys in social interaction tests. The cognitive functions of the transgenic monkeys were largely normal in the Wisconsin general test apparatus, although some showed signs of stereotypic cognitive behaviours. Notably, we succeeded in generating five F1 offspring of MECP2 transgenic monkeys by intracytoplasmic sperm injection with sperm from one F0 transgenic monkey, showing germline transmission and Mendelian segregation of several MECP2 transgenes in the F1 progeny. Moreover, F1 transgenic monkeys also showed reduced social interactions when tested in pairs, as compared to wild-type monkeys of similar age. Together, these results indicate the feasibility and reliability of using genetically engineered non-human primates to study brain disorders.

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Differential expression analysis for sequence count data
Anders, S., & Huber, W. (2010) · Genome Biology · doi:10.1186/gb-2010-11-10-r106 · Cited by 15,581
Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
Amir, R. E., Van den Veyver, I. B., Wan, M., Tran, C. Q., Francke, U., & Zoghbi, H. Y. (1999) · Nature Genetics · doi:10.1038/13810 · Cited by 4,990
MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription
Chahrour, M., Jung, S. Y., Shaw, C., Zhou, X., Wong, S. T. C., Qin, J., & Zoghbi, H. Y. (2008) · Science · doi:10.1126/science.1153252 · Cited by 1,823
MeCP2 Is a Transcriptional Repressor with Abundant Binding Sites in Genomic Chromatin
Nan, X., Campoy, F. J., & Bird, A. P. (1997) · Cell · doi:10.1016/s0092-8674(00)81887-5 · Cited by 1,288
MapSplice: Accurate mapping of RNA-seq reads for splice junction discovery
Wang, K., Singh, D., Zeng, Z., Coleman, S. J., Huang, Y., Savich, G. L., He, X., Mieczkowski, P., Grimm, S. A., Perou, C. M., et al. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq622 · Cited by 1,193
Generation of transgenic non-human primates with germline transmission
Sasaki, E., Suemizu, H., Shimada, A., Hanazawa, K., Oiwa, R., Kamioka, M., Tomioka, I., Sotomaru, Y., Hirakawa, R., Eto, T., et al. (2009) · Nature · doi:10.1038/nature08090 · Cited by 712
Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs
Meehan, R. R., Lewis, J., McKay, S. J., Kleiner, E., & Bird, A. P. (1989) · Cell · doi:10.1016/0092-8674(89)90430-3 · Cited by 677
Mild overexpression of MeCP2 causes a progressive neurological disorder in mice
Collins, A. L., Levenson, J. M., Vilaythong, A. P., Richman, R., Armstrong, D. L., Noebels, J. L., David Sweatt, J., & Zoghbi, H. Y. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh282 · Cited by 626
Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2
Young, J. I., Hong, E. P., Castle, J. C., Crespo-Barreto, J., Bowman, A. B., Rose, M. F., Kang, D., Richman, R., Johnson, J. M., Berget, S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507856102 · Cited by 484
Early determinants of behaviour: evidence from primate studies
Suomi, S. J. (1997) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a011598 · Cited by 483

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Authors: Liu, Z., Li, X., Zhang, J.-T., Cai, Y.-J., Cheng, T.-L., Cheng, C., Wang, Y., Zhang, C.-C., Nie, Y.-H., Chen, Z.-F., Bian, W.-J., Zhang, L., Xiao, J., Lu, B., Zhang, Y.-F., Zhang, X.-D., Sang, X., Wu, J.-J., Xu, X., Xiong, Z.-Q., Zhang, F., Yu, X., Gong, N., Zhou, W.-H., Sun, Q., & Qiu, Z.
Affiliations: Chinese Academy of Sciences (CN)
Fudan University (CN)
Corresponding author: Sun, Qiang
Qiu, Zilong
ORCID: Liu, Zhen
Cheng, Tian-Lin
Cheng, Cheng
Wang, Yan
Bian, Wen-Jie
Zhang, Ling
Xiao, Jianqiu
Sang, Xiao
Xu, Xiu
Xiong, Zhi-Qi
Zhang, Feng
Yu, Xiang
Gong, Neng
Sun, Qiang
Qiu, Zilong
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2016-01-25
Volume: 530
Issue: 7588
Pages: 98-102
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature16533
OpenAlex: W2261151942
Cited by: 322
References: 45
Citations by year: 2026: 12 · 2025: 26 · 2024: 26 · 2023: 22 · 2022: 32 · 2021: 44 · 2020: 30 · 2019: 32 · 2018: 27 · 2017: 39 · 2016: 30
FWCI: 34.43
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Animal Genetics and Reproduction
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Keywords: MECP2 duplication syndrome, Rett syndrome, autism-like behavior, social interaction deficits, anxiety, germline transmission, stress response, neurodevelopmental disorders, nonhuman primate model, stereotypy, cognitive function
MeSH terms: Animals, Anxiety, Autistic Disorder, Brain, Cognition, Disease Models, Animal, Female, Humans, Locomotion, Macaca fascicularis, Male, Phenotype, Social Behavior, Germ-Line Mutation, Transgenes, Sperm Injections, Intracytoplasmic, Animals, Genetically Modified, Heredity, Methyl-CpG-Binding Protein 2

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Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2

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