Cited by 492Neural dynamics and brain functionMotor Control and AdaptationMemory and Neural Mechanisms

The DOI matches its Crossref record; 50 of the 53 references it cites were found in a registry or an index.

Robust neuronal dynamics in premotor cortex during motor planning

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Abstract

Neural activity maintains representations that bridge past and future events, often over many seconds. Network models can produce persistent and ramping activity, but the positive feedback that is critical for these slow dynamics can cause sensitivity to perturbations. Here we use electrophysiology and optogenetic perturbations in the mouse premotor cortex to probe the robustness of persistent neural representations during motor planning. We show that preparatory activity is remarkably robust to large-scale unilateral silencing: detailed neural dynamics that drive specific future movements were quickly and selectively restored by the network. Selectivity did not recover after bilateral silencing of the premotor cortex. Perturbations to one hemisphere are thus corrected by information from the other hemisphere. Corpus callosum bisections demonstrated that premotor cortex hemispheres can maintain preparatory activity independently. Redundancy across selectively coupled modules, as we observed in the premotor cortex, is a hallmark of robust control systems. Network models incorporating these principles show robustness that is consistent with data.

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Metadata

Authors
Li, N., Daie, K., Svoboda, K., & Druckmann, S.
Affiliations
Howard Hughes Medical Institute (US)
Corresponding author
  • Svoboda, Karel
  • Druckmann, Shaul
Venue
Nature
Published
2016-04-13
Volume
532
Issue
7600
Pages
459-464
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W2336155947
Cited by
492
References
53
Citations by year
2026: 39 · 2025: 52 · 2024: 55 · 2023: 56 · 2022: 51 · 2021: 59 · 2020: 50 · 2019: 41 · 2018: 39 · 2017: 37 · 2016: 13
FWCI
27.58
Type
journal article
Language
en
Update notices
erratum (2016-06-29)
Open access
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Funders
Howard Hughes Medical Institute
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
premotor cortex, motor planning, preparatory activity, network robustness, interhemispheric connectivity, network redundancy, working memory, optogenetic perturbation, mouse cortex, network models
MeSH terms
Animals, Brain Mapping, Corpus Callosum, Female, Light, Male, Memory, Short-Term, Models, Neurological, Motor Cortex, Movement, Neurons, Mice, Executive Function, Optogenetics

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