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Robust neuronal dynamics in premotor cortex during motor planning
Open accessAbstract
Neural activity maintains representations that bridge past and future events, often over many seconds. Network models can produce persistent and ramping activity, but the positive feedback that is critical for these slow dynamics can cause sensitivity to perturbations. Here we use electrophysiology and optogenetic perturbations in the mouse premotor cortex to probe the robustness of persistent neural representations during motor planning. We show that preparatory activity is remarkably robust to large-scale unilateral silencing: detailed neural dynamics that drive specific future movements were quickly and selectively restored by the network. Selectivity did not recover after bilateral silencing of the premotor cortex. Perturbations to one hemisphere are thus corrected by information from the other hemisphere. Corpus callosum bisections demonstrated that premotor cortex hemispheres can maintain preparatory activity independently. Redundancy across selectively coupled modules, as we observed in the premotor cortex, is a hallmark of robust control systems. Network models incorporating these principles show robustness that is consistent with data.
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“Serial transformation of sensory inputs along bottom–up hierarchical pathways has been observed in rodents engaged in whisker-discrimination tasks (8, 9) with an increasingly stronger association with perceptual choice in S2 (10, 11) and premotor areas (12–14) rather than whisker-related wS1 (9).”
From Neural correlates of perceptual decision-making in the primary somatosensory cortex (2026) · cites this paper as [13]
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“Therefore, this global regulation is unlikely to originate directly from frontal cortical premotor areas (12–14) since frontal cortices have a high degree of symmetry for both ipsilateral and contralateral projections (59).”
From Neural correlates of perceptual decision-making in the primary somatosensory cortex (2026) · cites this paper as [13]
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“Hence, peak 4 is likely to reflect participation of the primary somatosensory cortex in motor preparatory activity, often observed in higher motor cortices (12–14).”
From Neural correlates of perceptual decision-making in the primary somatosensory cortex (2026) · cites this paper as [13]
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Self-citation
Metadata
- Authors
- Li, N., Daie, K., Svoboda, K., & Druckmann, S.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Svoboda, Karel
- Druckmann, Shaul
- Venue
- Nature
- Published
- 2016-04-13
- Volume
- 532
- Issue
- 7600
- Pages
- 459-464
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC5081260
- OpenAlex
- W2336155947
- Cited by
- 492
- References
- 53
- Citations by year
- 2026: 39 · 2025: 52 · 2024: 55 · 2023: 56 · 2022: 51 · 2021: 59 · 2020: 50 · 2019: 41 · 2018: 39 · 2017: 37 · 2016: 13
- FWCI
- 27.58
- Type
- journal article
- Language
- en
- Update notices
- erratum (2016-06-29)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- premotor cortex, motor planning, preparatory activity, network robustness, interhemispheric connectivity, network redundancy, working memory, optogenetic perturbation, mouse cortex, network models
- MeSH terms
- Animals, Brain Mapping, Corpus Callosum, Female, Light, Male, Memory, Short-Term, Models, Neurological, Motor Cortex, Movement, Neurons, Mice, Executive Function, Optogenetics
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