Cited by 698Tryptophan and brain disordersNeuroinflammation and Neurodegeneration MechanismsNeuroendocrine regulation and behavior

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Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour

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Filiano, Anthony J., Xu, Yang, Tustison, Nicholas J., Marsh, Rachel L., Baker, Wendy, Smirnov, Igor, Overall, Christopher C., Gadani, Sachin P., Turner, Stephen D., Weng, Zhiping, Peerzade, Sayeda Najamussahar, Chen, Hao, Lee, Kevin S., Scott, Michael M., Beenhakker, Mark P., Litvak, Vladimir, Kipnis, Jonathan·2016·Nature

DOI 10.1038/nature18626PMC PMC4961620

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Abstract

Immune dysfunction is commonly associated with several neurological and mental disorders. Although the mechanisms by which peripheral immunity may influence neuronal function are largely unknown, recent findings implicate meningeal immunity influencing behaviour, such as spatial learning and memory. Here we show that meningeal immunity is also critical for social behaviour; mice deficient in adaptive immunity exhibit social deficits and hyper-connectivity of fronto-cortical brain regions. Associations between rodent transcriptomes from brain and cellular transcriptomes in response to T-cell-derived cytokines suggest a strong interaction between social behaviour and interferon-γ (IFN-γ)-driven responses. Concordantly, we demonstrate that inhibitory neurons respond to IFN-γ and increase GABAergic (γ-aminobutyric-acid) currents in projection neurons, suggesting that IFN-γ is a molecular link between meningeal immunity and neural circuits recruited for social behaviour. Meta-analysis of the transcriptomes of a range of organisms reveals that rodents, fish, and flies elevate IFN-γ/JAK-STAT-dependent gene signatures in a social context, suggesting that the IFN-γ signalling pathway could mediate a co-evolutionary link between social/aggregation behaviour and an efficient anti-pathogen response. This study implicates adaptive immune dysfunction, in particular IFN-γ, in disorders characterized by social dysfunction and suggests a co-evolutionary link between social behaviour and an anti-pathogen immune response driven by IFN-γ signalling.

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Authors: Filiano, A. J., Xu, Y., Tustison, N. J., Marsh, R. L., Baker, W., Smirnov, I., Overall, C. C., Gadani, S. P., Turner, S. D., Weng, Z., Peerzade, S. N., Chen, H., Lee, K. S., Scott, M. M., Beenhakker, M. P., Litvak, V., & Kipnis, J.
Affiliations: University of Virginia (US)
University of Massachusetts Chan Medical School (US)
Corresponding author: Filiano, Anthony J.
Litvak, Vladimir
Kipnis, Jonathan
ORCID: Filiano, Anthony J.
Xu, Yang
Tustison, Nicholas J.
Smirnov, Igor
Gadani, Sachin P.
Turner, Stephen D.
Weng, Zhiping
Peerzade, Sayeda Najamussahar
Beenhakker, Mark P.
Kipnis, Jonathan
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2016-07
Volume: 535
Issue: 7612
Pages: 425-429
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature18626
PMC: PMC4961620
OpenAlex: W2469685265
Cited by: 697
References: 66
Citations by year: 2026: 62 · 2025: 76 · 2024: 91 · 2023: 78 · 2022: 74 · 2021: 69 · 2020: 70 · 2019: 60 · 2018: 56 · 2017: 41 · 2016: 17
FWCI: 3.47
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institutes of Health
National Institute on Aging (AG034113, R01AG034113, R37AG034113)
National Institute of Allergy and Infectious Diseases (T32AI007496)
National Institute of Neurological Disorders and Stroke (R01NS081026, NS081026)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords: interferon-gamma, social behavior, meningeal immunity, GABAergic neurotransmission, prefrontal cortex, neural circuits, JAK/STAT signaling, T cell cytokines, neuroimmune interactions, social dysfunction
MeSH terms: Animals, Drosophila melanogaster, Female, Interferon-gamma, Male, Meninges, Mice, Inbred C57BL, Neural Pathways, Social Behavior, T-Lymphocytes, Zebrafish, Signal Transduction, Prefrontal Cortex, Mice, Rats, GABAergic Neurons, Transcriptome

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Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour

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