Inflamed brain: Targeting immune changes and inflammation for treatment of depression

Sakamoto, Shinji; Zhu, Xiaolei; Hasegawa, Yuto; Karma, Sadik; Obayashi, Mizuho; Alway, Emily; Kamiya, Atsushi

doi:10.1111/pcn.13286

Cited by 51Tryptophan and brain disordersTreatment of Major DepressionStress Responses and Cortisol

Inflamed brain: Targeting immune changes and inflammation for treatment of depression

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Sakamoto, Shinji, Zhu, Xiaolei, Hasegawa, Yuto, Karma, Sadik, Obayashi, Mizuho, Alway, Emily, Kamiya, Atsushi·2021·Psychiatry and Clinical Neurosciences

DOI 10.1111/pcn.13286PMC PMC8683253

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Abstract

Although there are a number of clinically effective treatments for depression, many patients exhibit treatment resistance. Recent clinical and preclinical studies reveal that peripheral and brain immune changes and inflammation are involved in the pathophysiology of depression. This ‘Inflamed Brain’ research provides critical clues for understanding of disease pathophysiology and many candidate molecules that are potentially useful for identifying novel drug targets for the treatment of depression. In this review, we will present clinical evidence on the role of inflammation in the pathophysiology of depression. We will also summarize current clinical trials which test drugs targeting inflammation for the treatment of patients with depression. Furthermore, we will briefly provide preclinical evidence demonstrating altered immune system function and inflammation in stress‐induced animal models and will discuss the future potential of inflammation‐related drug targets. Collectively, inflammatory signatures identified in clinical and preclinical studies may allow us to stratify depressive patients based on biotypes, contributing to the development of novel mechanism‐based interventions that target specific patient populations.

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Recent evidence suggests the involvement of the immune system in several psychiatric conditions; one of the most studied in this respect is depression.
“Recent evidence suggests the involvement of the immune system in several psychiatric conditions [203–205]; one of the most studied in this respect is depression [206–208].”
From Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review (2022) · cites this paper as [207]

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Authors: Sakamoto, S., Zhu, X., Hasegawa, Y., Karma, S., Obayashi, M., Alway, E., & Kamiya, A.
Affiliations: Johns Hopkins University (US)
Corresponding author: Kamiya, Atsushi
ORCID: Sakamoto, Shinji
Zhu, Xiaolei
Karma, Sadik
Alway, Emily
Kamiya, Atsushi
Venue: Psychiatry and Clinical Neurosciences
Publisher: Wiley
Published: 2021-07-28
Volume: 75
Issue: 10
Pages: 304-311
ISSN: 1323-1316 (ISSN-L)
1440-1819
DOI: 10.1111/pcn.13286
PMC: PMC8683253
OpenAlex: W3180130693
Cited by: 51
References: 113
Citations by year: 2026: 4 · 2025: 14 · 2024: 11 · 2023: 10 · 2022: 12
FWCI: 0.78
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Psychiatry and Clinical Neurosciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Japanese Society of Clinical Neuropsychopharmacology
Kanae Foundation for the Promotion of Medical Science
National Institutes of Health (AG065168, AT010984, DA041208, MH094268)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: depression, neuroinflammation, treatment-resistant depression, immunological markers, patient stratification, depression pathophysiology
MeSH terms: Animals, Brain, Depression, Humans, Inflammation, Stress, Psychological

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