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Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour
Open accessAbstract
Immune dysfunction is commonly associated with several neurological and mental disorders. Although the mechanisms by which peripheral immunity may influence neuronal function are largely unknown, recent findings implicate meningeal immunity influencing behaviour, such as spatial learning and memory. Here we show that meningeal immunity is also critical for social behaviour; mice deficient in adaptive immunity exhibit social deficits and hyper-connectivity of fronto-cortical brain regions. Associations between rodent transcriptomes from brain and cellular transcriptomes in response to T-cell-derived cytokines suggest a strong interaction between social behaviour and interferon-γ (IFN-γ)-driven responses. Concordantly, we demonstrate that inhibitory neurons respond to IFN-γ and increase GABAergic (γ-aminobutyric-acid) currents in projection neurons, suggesting that IFN-γ is a molecular link between meningeal immunity and neural circuits recruited for social behaviour. Meta-analysis of the transcriptomes of a range of organisms reveals that rodents, fish, and flies elevate IFN-γ/JAK-STAT-dependent gene signatures in a social context, suggesting that the IFN-γ signalling pathway could mediate a co-evolutionary link between social/aggregation behaviour and an efficient anti-pathogen response. This study implicates adaptive immune dysfunction, in particular IFN-γ, in disorders characterized by social dysfunction and suggests a co-evolutionary link between social behaviour and an anti-pathogen immune response driven by IFN-γ signalling.
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“Given the ability of the immune environment to affect behavior (Filiano et al, 2016)”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Filiano et al, 2016
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“Further, severe combined immunodeficiency mice have impaired social preference [195].”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [195]
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Functional immune cell–astrocyte interactions
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Pathway-level information extractor (PLIER) for gene expression data
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Metadata
- Authors
- Filiano, A. J., Xu, Y., Tustison, N. J., Marsh, R. L., Baker, W., Smirnov, I., Overall, C. C., Gadani, S. P., Turner, S. D., Weng, Z., Peerzade, S. N., Chen, H., Lee, K. S., Scott, M. M., Beenhakker, M. P., Litvak, V., & Kipnis, J.
- Affiliations
- University of Virginia (US)
- University of Massachusetts Chan Medical School (US)
- Corresponding author
- Filiano, Anthony J.
- Litvak, Vladimir
- Kipnis, Jonathan
- ORCID
- Venue
- Nature
- Published
- 2016-07
- Volume
- 535
- Issue
- 7612
- Pages
- 425-429
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4961620
- OpenAlex
- W2469685265
- Cited by
- 697
- References
- 66
- Citations by year
- 2026: 62 · 2025: 76 · 2024: 91 · 2023: 78 · 2022: 74 · 2021: 69 · 2020: 70 · 2019: 60 · 2018: 56 · 2017: 41 · 2016: 17
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (AG034113, R01AG034113, R37AG034113)
- National Institute of Allergy and Infectious Diseases (T32AI007496)
- National Institute of Neurological Disorders and Stroke (R01NS081026, NS081026)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- interferon-gamma, social behavior, meningeal immunity, GABAergic neurotransmission, prefrontal cortex, neural circuits, JAK/STAT signaling, T cell cytokines, neuroimmune interactions, social dysfunction
- MeSH terms
- Animals, Drosophila melanogaster, Female, Interferon-gamma, Male, Meninges, Mice, Inbred C57BL, Neural Pathways, Social Behavior, T-Lymphocytes, Zebrafish, Signal Transduction, Prefrontal Cortex, Mice, Rats, GABAergic Neurons, Transcriptome
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