Cited by 1,147Dementia and Cognitive Impairment ResearchGenetics, Aging, and Longevity in Model OrganismsNeuroinflammation and Neurodegeneration Mechanisms

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Ageing, neurodegeneration and brain rejuvenation

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Wyss-Coray, Tony·2016·Nature

DOI 10.1038/nature20411PMC PMC5172605

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Abstract

Although systemic diseases take the biggest toll on human health and well-being, increasingly, a failing brain is the arbiter of a death preceded by a gradual loss of the essence of being. Ageing, which is fundamental to neurodegeneration and dementia, affects every organ in the body and seems to be encoded partly in a blood-based signature. Indeed, factors in the circulation have been shown to modulate ageing and to rejuvenate numerous organs, including the brain. The discovery of such factors, the identification of their origins and a deeper understanding of their functions is ushering in a new era in ageing and dementia research.

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Authors: Wyss-Coray, T.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2016-11
Volume: 539
Issue: 7628
Pages: 180-186
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature20411
PMC: PMC5172605
OpenAlex: W2549552700
Cited by: 1,147
References: 99
Citations by year: 2026: 88 · 2025: 127 · 2024: 133 · 2023: 156 · 2022: 162 · 2021: 143 · 2020: 122 · 2019: 91 · 2018: 79 · 2017: 44
FWCI: 10.25
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institute on Aging (P50AG047366, R01AG045034)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: brain aging, neurodegeneration, dementia, brain rejuvenation, circulating factors, blood-based biomarkers
MeSH terms: Aging, Animals, Brain, Cell Communication, Humans, Inflammation, Rejuvenation, Neurodegenerative Diseases, Proteome

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