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Ageing, neurodegeneration and brain rejuvenation
Open accessAbstract
Although systemic diseases take the biggest toll on human health and well-being, increasingly, a failing brain is the arbiter of a death preceded by a gradual loss of the essence of being. Ageing, which is fundamental to neurodegeneration and dementia, affects every organ in the body and seems to be encoded partly in a blood-based signature. Indeed, factors in the circulation have been shown to modulate ageing and to rejuvenate numerous organs, including the brain. The discovery of such factors, the identification of their origins and a deeper understanding of their functions is ushering in a new era in ageing and dementia research.
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“Aging leads to dramatic changes in cognitive and neuronal function, the decline of which contributes to the development of neurological disorders1.”
From MT1-MMP inhibition rejuvenates ageing brain and rescues cognitive deficits in obesity (2025) · cites this paper as [1]
Experimental — accuracy not yet measuredIn the citing paper
“The removal of circulating pro-ageing factors also holds the potential to revitalize the brain in animal studies.391”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [391]
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“Furthermore, the ability of interventions not only to slow the rate of aging but actually to rejuvenate cells and tissues seemingly by reversing aging processes expands the spectrum of healthspan-promoting treatments.79,80,81,82,83”
From Asynchronous, contagious and digital aging (2021) · cites this paper as [81]
In the citing paper
“Given that cell non-autonomous changes are also known to regulate aging-dependent changes 2,3 , we also detail ligand-receptor interactions among nearly all the cell types in the brain that are modified by aging.”
From Single-cell transcriptomic profiling of the aging mouse brain (2019) · cites this paper as [2]
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Metadata
- Authors
- Wyss-Coray, T.
- Venue
- Nature
- Published
- 2016-11
- Volume
- 539
- Issue
- 7628
- Pages
- 180-186
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC5172605
- OpenAlex
- W2549552700
- Cited by
- 1,147
- References
- 99
- Citations by year
- 2026: 88 · 2025: 127 · 2024: 133 · 2023: 156 · 2022: 162 · 2021: 143 · 2020: 122 · 2019: 91 · 2018: 79 · 2017: 44
- FWCI
- 10.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institute on Aging (P50AG047366, R01AG045034)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- brain aging, neurodegeneration, dementia, brain rejuvenation, circulating factors, blood-based biomarkers
- MeSH terms
- Aging, Animals, Brain, Cell Communication, Humans, Inflammation, Rejuvenation, Neurodegenerative Diseases, Proteome
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