The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Zika virus infection damages the testes in mice
Open accessAbstract
Infection of pregnant women with Zika virus (ZIKV) can cause congenital malformations including microcephaly, which has focused global attention on this emerging pathogen. In addition to transmission by mosquitoes, ZIKV can be detected in the seminal fluid of affected males for extended periods of time and transmitted sexually. Here, using a mouse-adapted African ZIKV strain (Dakar 41519), we evaluated the consequences of infection in the male reproductive tract of mice. We observed persistence of ZIKV, but not the closely related dengue virus (DENV), in the testis and epididymis of male mice, and this was associated with tissue injury that caused diminished testosterone and inhibin B levels and oligospermia. ZIKV preferentially infected spermatogonia, primary spermatocytes and Sertoli cells in the testis, resulting in cell death and destruction of the seminiferous tubules. Less damage was caused by a contemporary Asian ZIKV strain (H/PF/2013), in part because this virus replicates less efficiently in mice. The extent to which these observations in mice translate to humans remains unclear, but longitudinal studies of sperm function and viability in ZIKV-infected humans seem warranted.
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Cites
Zika Virus Infection in Pregnant Women in Rio de Janeiro
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A Mouse Model of Zika Virus Pathogenesis
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Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise
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Self-citationZika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling
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Evidence of Sexual Transmission of Zika Virus
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Cited by
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Self-citationThe emergence of Zika virus and its new clinical syndromes
Pierson, T. C., & Diamond, M. S. (2018) · Nature · doi:10.1038/s41586-018-0446-y · Cited by 391
Self-citationAnimal Models of Zika Virus Infection, Pathogenesis, and Immunity
Morrison, T. E., & Diamond, M. S. (2017) · Journal of Virology · doi:10.1128/jvi.00009-17 · Cited by 275
Self-citationVaccine Mediated Protection Against Zika Virus-Induced Congenital Disease
Richner, J. M., Jagger, B. W., Shan, C., Fontes, C. R., Dowd, K. A., Cao, B., Himansu, S., Caine, E. A., Nunes, B. T. D., Medeiros, D. B. A., et al. (2017) · Cell · doi:10.1016/j.cell.2017.06.040 · Cited by 267
Self-citationZika Virus Structure, Maturation, and Receptors
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Metadata
- Authors
- Govero, J., Esakky, P., Scheaffer, S. M., Fernandez, E., Drury, A., Platt, D. J., Gorman, M. J., Richner, J. M., Caine, E. A., Salazar, V., Moley, K. H., & Diamond, M. S.
- Venue
- Nature
- Published
- 2016-10-31
- Volume
- 540
- Issue
- 7633
- Pages
- 438-442
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2540278950
- Cited by
- 498
- References
- 29
- FWCI
- 85.55
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Govero, J., Esakky, P., Scheaffer, S. M., Fernandez, E., Drury, A., Platt, D. J., Gorman, M. J., Richner, J. M., Caine, E. A., Salazar, V., Moley, K. H., & Diamond, M. S. (2016). Zika virus infection damages the testes in mice. Nature. https://doi.org/10.1038/nature20556
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
