Orthotopic patient-derived xenografts of paediatric solid tumours

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Organoid Cultures Derived from Patients with Advanced Prostate Cancer

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Bioassay Analysis using R

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High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response

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Progressive development of melanoma-induced cachexia differentially impacts organ systems in mice

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Hallmark discoveries in the biology of Wilms tumour

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Single-cell imaging of human cancer xenografts using adult immunodeficient zebrafish

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Neuroblastoma in the Era of Precision Medicine: A Clinical Review

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Challenges and Opportunities for Childhood Cancer Drug Development

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Mouse models of high-risk neuroblastoma

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A secondary role for hypoxia and HIF1 in the regulation of (IFNγ-induced) PD-L1 expression in melanoma

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MYOD-SKP2 axis boosts tumorigenesis in fusion negative rhabdomyosarcoma by preventing differentiation through p57Kip2 targeting

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The Single-Cell Pediatric Cancer Atlas: Data portal and open-source tools for single-cell transcriptomics of pediatric tumors

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LIN28B alters ribosomal dynamics to promote metastasis in MYCN-driven malignancy

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Regulation of EWSR1-FLI1 Function by Post-Transcriptional and Post-Translational Modifications

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Generation of patient‐derived tumor xenografts from percutaneous tumor biopsies in children with bone sarcomas

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Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity

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Synthetic Matrix Scaffolds Engineer the In Vivo Tumor Immune Microenvironment for Immunotherapy Screening

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DRAP: a toolbox for drug response analysis and visualization tailored for preclinical drug testing on patient-derived xenograft models

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(S)-10-Hydroxycamptothecin Inhibits Esophageal Squamous Cell Carcinoma Growth In Vitro and In Vivo Via Decreasing Topoisomerase I Enzyme Activity

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High Specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG Positive Ewing Sarcoma

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Pharmacogenomics and Pharmacogenetics in Osteosarcoma: Translational Studies and Clinical Impact

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Deep-learning and MR images to target hypoxic habitats with evofosfamide in preclinical models of sarcoma

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Next-generation humanized patient-derived xenograft mouse model for pre-clinical antibody studies in neuroblastoma

Nguyen, R., Patel, A. G., Griffiths, L. M., Dapper, J. D., Stewart, E. A., Houston, J., Johnson, M. D., Akers, W. J., Furman, W. L., & Dyer, M. A. (2020) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-020-02713-6 · Cited by 22

iTReX: Interactive exploration of mono- and combination therapy dose response profiling data

ElHarouni, D., Berker, Y., Peterziel, H., Gopisetty, A., Turunen, L., Kreth, S., Stainczyk, S. A., Oehme, I., Pietiäinen, V. M., Jäger, N., et al. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105996 · Cited by 22

High-content drug screening in zebrafish xenografts reveals high efficacy of dual MCL-1/BCL-XL inhibition against Ewing sarcoma

Grissenberger, S., Sturtzel, C., Wenninger-Weinzierl, A., Radic-Sarikas, B., Scheuringer, E., Bierbaumer, L., Etienne, V., Némati, F., Pascoal, S., Tötzl, M., et al. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.216028 · Cited by 24

Recent advances in understanding osteosarcoma and emerging therapies

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The Promise of Patient-Derived Preclinical Models to Accelerate the Implementation of Personalised Medicine for Children with Neuroblastoma

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Patient-Derived Organoids as a Promising Tool for Multimodal Management of Sarcomas

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Preclinical evaluation of the combination of AZD1775 and irinotecan against selected pediatric solid tumors: A Pediatric Preclinical Testing Consortium report

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Lurbinectedin Inhibits the EWS–WT1 Transcription Factor in Desmoplastic Small Round Cell Tumor

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Lessons learned from 20 years of preclinical testing in pediatric cancers

Smith, M. A., Houghton, P. J., Lock, R. B., Maris, J. M., Gorlick, R. G., Kurmasheva, R. T., Li, X., Teicher, B. A., Chuang, J. H., Cruz, F. S. D., et al. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108742 · Cited by 19

The Combination of Trametinib and Ganitumab is Effective in RAS-Mutated PAX-Fusion Negative Rhabdomyosarcoma Models

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Novel cancer gene variants and gene fusions of triple-negative breast cancers (TNBCs) reveal their molecular diversity conserved in the patient-derived xenograft (PDX) model

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PATIENT-DERIVED XENOGRAFTS AS A PRECLINICAL MODEL FOR BONE SARCOMAS

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PLK2 modulation of enriched TAp73 affects osteogenic differentiation and prognosis in human osteosarcoma

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Patient-derived xenografts of central nervous system metastasis reveal expansion of aggressive minor clones

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Charting a path for prioritization of novel agents for clinical trials in osteosarcoma: A report from the Children's Oncology Group New Agents for Osteosarcoma Task Force

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Antigen cross-presentation in young tumor-bearing hosts promotes CD8 + T cell terminal differentiation

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Integrative Multi-OMICs Identifies Therapeutic Response Biomarkers and Confirms Fidelity of Clinically Annotated, Serially Passaged Patient-Derived Xenografts Established from Primary and Metastatic Pediatric and AYA Solid Tumors

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Patient-derived models: Advanced tools for precision medicine in neuroblastoma

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Establishment of a high-fidelity patient-derived xenograft model for cervical cancer enables the evaluation of patient’s response to conventional and novel therapies

Liu, L., Wu, M., Huang, A., Gao, C., Yang, Y., Liu, H., Jiang, H., Yu, L., Huang, Y., & Wang, H. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04444-5 · Cited by 17

DNAJB1-PRKACA fusion neoantigens elicit rare endogenous T cell responses that potentiate cell therapy for fibrolamellar carcinoma

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K-Ras and p53 mouse model with molecular characteristics of human rhabdomyosarcoma and translational applications

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Caffeine Supplementation and FOXM1 Inhibition Enhance the Antitumor Effect of Statins in Neuroblastoma

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Establishment and characterization of in vivo orthotopic bioluminescent xenograft models from human osteosarcoma cell lines in Swiss nude and NSG mice

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Establishment of patient‐derived xenograft model in ovarian cancer and its influence factors analysis

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Preclinical In Vivo Modeling of Pediatric Sarcoma—Promises and Limitations

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Ewing Sarcoma PDX Models

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Target actionability review to evaluate CDK4/6 as a therapeutic target in paediatric solid and brain tumours

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Genomic profiling of subcutaneous patient-derived xenografts reveals immune constraints on tumor evolution in childhood solid cancer

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PAX fusion proteins deregulate gene networks controlling mitochondrial translation in pediatric rhabdomyosarcoma

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Synovial Sarcoma Preclinical Modeling: Integrating Transgenic Mouse Models and Patient-Derived Models for Translational Research

Landuzzi, L., Ruzzi, F., Lollini, P., & Scotlandi, K. (2023) · Cancers · doi:10.3390/cancers15030588 · Cited by 15

Temporal chromatin accessibility changes define transcriptional states essential for osteosarcoma metastasis

Pontius, W., Hong, E. S., Faber, Z. J., Gray, J., Peacock, C. D., Bayles, I., Lovrenert, K., Chin, D. H., Gryder, B. E., Bartels, C. F., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42656-x · Cited by 14

Advancements and application prospects of three-dimensional models for primary liver cancer: a comprehensive review

Zhu, L., Cheng, C., Liu, S., Yang, L., Han, P., Cui, T., & Zhang, Y. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1343177 · Cited by 15

HDAC3 genetic and pharmacologic inhibition radiosensitizes fusion positive rhabdomyosarcoma by promoting DNA double-strand breaks

Cassandri, M., Porrazzo, A., Pomella, S., Noce, B., Zwergel, C., Aiello, F. A., Vulcano, F., Milazzo, L., Camero, S., Pajalunga, D., et al. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02115-y · Cited by 14

Primary Bone Tumors and Breast Cancer-Induced Bone Metastases: In Vivo Animal Models and New Alternative Approaches

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Enrichment of Wee1/CDC2 and NF-κB Signaling Pathway Constituents Mutually Contributes to CDDP Resistance in Human Osteosarcoma

Hu, Z., Li, L., Lan, W., Xiao, W. L., Wen, X., Wu, P., Zhang, X., Xi, X., Li, Y., Wu, L., et al. (2021) · Cancer Research and Treatment · doi:10.4143/crt.2021.320 · Cited by 14

Rhabdomyosarcoma: How Advanced Molecular Methods Are Shaping the Diagnostic and Therapeutic Paradigm

Giannikopoulos, P., & Parham, D. M. (2021) · Pediatric and Developmental Pathology · doi:10.1177/10935266211013621 · Cited by 14

Combining APR-246 and HDAC-Inhibitors: A Novel Targeted Treatment Option for Neuroblastoma

Müller, M., Rösch, L., Najafi, S., Gatzweiler, C., Ridinger, J., Gerloff, X. F., Jones, D., Baßler, J., Kreth, S., Stainczyk, S. A., et al. (2021) · Cancers · doi:10.3390/cancers13174476 · Cited by 14

High-throughput screening for drug discovery targeting the cancer cell-microenvironment interactions in hematological cancers

Giri, A. K., & Ianevski, A. (2021) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2022.1991306 · Cited by 15

Differences in treatment outcome between translational platforms in developing therapies for gastrointestinal cancers

Wawrzak-Pienkowska, K., Pienkowski, T., Tankiewicz‐Kwedlo, A., Ciborowski, M., Kurek, K., & Pawlak, D. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177309 · Cited by 14

Tumorigenic and Antiproliferative Properties of the TALE-Transcription Factors MEIS2D and MEIS2A in Neuroblastoma

Groß, A., Schulz, C., Kolb, J., Köster, J., Wehner, S., Czaplinski, S., Khilan, A., Rohrer, H., Harter, P. N., Klingebiel, T. E., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-1860 · Cited by 13

Future Match Making: When Pediatric Oncology Meets Organoid Technology

Barbet, V., & Broutier, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.674219 · Cited by 19

Cancer research with a human touch

May, M. (2018) · Nature · doi:10.1038/d41586-018-04161-w · Cited by 13

Xenografting Human Musculoskeletal Sarcomas in Mice, Chick Embryo, and Zebrafish: How to Boost Translational Research

Giusti, V., Miserocchi, G., Sbanchi, G., Pannella, M., Hattinger, C. M., Cesari, M., Fantoni, L., Guerrieri, A. N., Bellotti, C., Vita, A. D., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12081921 · Cited by 12

Establishment and Preclinical Therapy of Patient-derived Hepatocellular Carcinoma Xenograft Model

Wu, Y., Wang, J., Zheng, X., Chen, Y., Huang, M., Huang, Q., Xiao, W., Wei, H., Tian, Z., Sun, R., et al. (2020) · Immunology Letters · doi:10.1016/j.imlet.2020.04.009 · Cited by 12

Chemoradiation impairs myofiber hypertrophic growth in a pediatric tumor model

Paris, N. D., Kallenbach, J. G., Bachman, J. F., Blanc, R. S., Johnston, C. J., Hernady, E., Williams, J. P., & Chakkalakal, J. V. (2020) · Scientific Reports · doi:10.1038/s41598-020-75913-w · Cited by 12

MethylationToActivity: a deep-learning framework that reveals promoter activity landscapes from DNA methylomes in individual tumors

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Patient-derived xenograft: a developing tool for screening biomarkers and potential therapeutic targets for human esophageal cancers

Lan, T., Xia, X., Dunmall, L. C., Miao, J., & Wang, Y. (2021) · Aging · doi:10.18632/aging.202934 · Cited by 12

Developmental Heterogeneity of RhabdomyosarcomaPreprint

Stevens, B. T., & Hatley, M. E. (2024) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041583 · Cited by 12

Tumor Growth Analysis of Ewing Sarcoma Cell Lines Using Subcutaneous Xenografts in Mice

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Probing the interaction between metastatic breast cancer cells and osteoblasts in a thread-based breast–bone co-culture device

Wu, S. M., Chen, F., Yang, X. Y., Wu, T. F., Sun, W., & Yu, L. D. (2023) · Lab on a Chip · doi:10.1039/d3lc00106g · Cited by 11

Early stability and late random tumor progression of a HER2-positive primary breast cancer patient-derived xenograft

Landuzzi, L., Palladini, A., Ceccarelli, C., Asioli, S., Nicoletti, G., Giusti, V., Ruzzi, F., Ianzano, M. L., Scalambra, L., Laranga, R., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-81085-y · Cited by 11

Longitudinal characterization of primary osteosarcoma and derived subcutaneous and orthotopic relapsed patient-derived xenograft models

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Somatic gene delivery faithfully recapitulates a molecular spectrum of high-risk sarcomas

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