The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis
Open accessAbstract
Environmental nutrient levels impact cancer cell metabolism, resulting in context-dependent gene essentiality. Here, using loss-of-function screening based on RNA interference, we show that environmental oxygen levels are a major driver of differential essentiality between in vitro model systems and in vivo tumours. Above the 3-8% oxygen concentration typical of most tissues, we find that cancer cells depend on high levels of the iron-sulfur cluster biosynthetic enzyme NFS1. Mammary or subcutaneous tumours grow despite suppression of NFS1, whereas metastatic or primary lung tumours do not. Consistent with a role in surviving the high oxygen environment of incipient lung tumours, NFS1 lies in a region of genomic amplification present in lung adenocarcinoma and is most highly expressed in well-differentiated adenocarcinomas. NFS1 activity is particularly important for maintaining the iron-sulfur co-factors present in multiple cell-essential proteins upon exposure to oxygen compared to other forms of oxidative damage. Furthermore, insufficient iron-sulfur cluster maintenance robustly activates the iron-starvation response and, in combination with inhibition of glutathione biosynthesis, triggers ferroptosis, a non-apoptotic form of cell death. Suppression of NFS1 cooperates with inhibition of cysteine transport to trigger ferroptosis in vitro and slow tumour growth. Therefore, lung adenocarcinomas select for expression of a pathway that confers resistance to high oxygen tension and protects cells from undergoing ferroptosis in response to oxidative damage.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“which allows cells to proliferate in the absence of NFS1 (30, 34)”
From Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction (2022) · cites this paper as [30]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“cells require functional NFS1 to support ISC synthesis to maintain viability and proliferation (30, 34)”
From Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction (2022) · cites this paper as [30]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Furthermore, the importance of NFS1 and ISC stability in regulation of cancer cell sensitivity to ferroptosis has also been demonstrated (30, 31).”
From Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction (2022) · cites this paper as [30]
The cited source says what the claim attributes to it.
In the citing paper
“ISCs are stabilized under low oxygen conditions (3% O2)”
From Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction (2022) · cites this paper as [30]
The cited source says what the claim attributes to it.
In the citing paper
“ISCs are sensitive to degradation under atmospheric oxygen conditions (standard tissue culture is 21% O2)”
From Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction (2022) · cites this paper as [30]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Lee, M. Y., Hwang, J.-T., Lee, H., Jung, S., Kang, I., Chi, S.-G., Kim, S. S., & Ha, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306104200 · Cited by 234
RetractedFerroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
Barretina, J., Caponigro, G., Stransky, N., Venkatesan, K., Margolin, A. A., Kim, S., Wilson, C. J., Lehár, J., Kryukov, G. V., Sonkin, D., et al. (2012) · Nature · doi:10.1038/nature11003 · Cited by 7,950
Regulation of Ferroptotic Cancer Cell Death by GPX4
Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713
CellProfiler: image analysis software for identifying and quantifying cell phenotypes
Carpenter, A. E., Jones, T. R., Lamprecht, M. R., Clarke, C., Kang, I. H., Friman, O., Guertin, D. A., Chang, J. H., Lindquist, R. A., Moffat, J., et al. (2006) · Genome biology · doi:10.1186/gb-2006-7-10-r100 · Cited by 5,212
Self-citationThe tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180
The landscape of somatic copy-number alteration across human cancers
Beroukhim, R., Mermel, C. H., Porter, D., Wei, G., Raychaudhuri, S., Donovan, J., Barretina, J., Boehm, J. S., Dobson, J., Urashima, M., et al. (2010) · Nature · doi:10.1038/nature08822 · Cited by 4,017
CDD: NCBI's conserved domain database
Marchler‐Bauer, A., Derbyshire, M. K., Gonzales, N. R., Lu, S., Chitsaz, F., Geer, L. Y., Geer, R. C., He, J., Gwadz, M., Hurwitz, D. I., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1221 · Cited by 3,468
(1989) · PubMed · Cited by 3,343
Ferroptosis: Death by Lipid Peroxidation
Yang, W. S., & Stockwell, B. R. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.10.014 · Cited by 3,088
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–300 of 797
Molecular Mechanisms of Ferroptosis and Its Role in Pulmonary Disease
Tao, N., Li, K., & Liu, J. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/9547127 · Cited by 65
Sahoo, K., & Sharma, A. (2023) · APOPTOSIS · doi:10.1007/s10495-022-01806-0 · Cited by 68
Molecular Mechanisms of Ferroptosis and Its Roles in Hematologic Malignancies
Zhao, Y., Huang, Z., & Peng, H. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.743006 · Cited by 62
Targeting Cancer Cell Ferroptosis to Reverse Immune Checkpoint Inhibitor Therapy Resistance
Deng, J., Zhou, M. L., Liao, T., Kuang, W., Xia, H., Yin, Z., Tan, Q., Li, Y., Song, S., Zhou, E., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.818453 · Cited by 63
DNAJB6 Promotes Ferroptosis in Esophageal Squamous Cell Carcinoma
Jiang, B., Zhao, Y., Shi, M., Song, L., Wang, Q., Qin, Q., Song, X., Wu, S., Fang, Z. Y., & Liu, X. (2019) · Digestive Diseases and Sciences · doi:10.1007/s10620-019-05929-4 · Cited by 61
Dihydroisotanshinone I induced ferroptosis and apoptosis of lung cancer cells
Wu, C., Yang, Y., Lin, Y., Chang, G., Tsai, M., Hsu, C., Yeh, R., Shu, L., Cheng, Y., & Liu, H.-T. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111585 · Cited by 62
RETRACTED ARTICLE: MiR-19a suppresses ferroptosis of colorectal cancer cells by targeting IREB2
Fan, H., Ai, R., Mu, S., Niu, X., Guo, Z., & Liu, L. (2022) · Bioengineered · doi:10.1080/21655979.2022.2054194 · Cited by 62
RetractedOxidative Metabolism as a Cause of Lipid Peroxidation in the Execution of Ferroptosis
Fujii, J., & Imai, H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147544 · Cited by 65
Huang, J., Xie, H., Li, J., Huang, X., Cai, Y., Yang, R., Yang, D., Bao, W., Zhou, Y., Li, T., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103553 · Cited by 64
Ferroptosis in plants: triggers, proposed mechanisms, and the role of iron in modulating cell death
Distéfano, A. M., López, G. A., Setzes, N., Marchetti, F., Cainzos, M., Cascallares, M. M., Zabaleta, E. J., & Pagnussat, G. C. (2020) · Journal of Experimental Botany · doi:10.1093/jxb/eraa425 · Cited by 63
Shan, K., Feng, N., Zhu, D., Qu, H., Fu, G., Li, J., Cui, J., Chen, H., Wang, R., Qi, Y., et al. (2022) · European Journal of Nutrition · doi:10.1007/s00394-022-02940-w · Cited by 61
Ferroptosis and cuproptposis in kidney Diseases: dysfunction of cell metabolism
Chen, T., Liang, L., Wang, Y., Li, X., & Yang, C. (2023) · APOPTOSIS · doi:10.1007/s10495-023-01928-z · Cited by 62
Ferroptosis: a new hunter of hepatocellular carcinoma
Jiang, Y., Yu, Y., Pan, Z., Glandorff, C., & Sun, M. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01863-1 · Cited by 70
Liu, Y., Chen, S.-C., Wan, X., Wang, R., Luo, H., Chang, C., Dai, P., Gan, Y., Guo, Y., Hou, Y., et al. (2024) · 癌症：英文版 · doi:10.1002/cac2.12608 · Cited by 61
Li, Y., Li, Y., Yu, Y., Ren, X., Yang, C., Jin, W., Li, K., Zhou, Y., Wu, C., Shen, Y., et al. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.06.006 · Cited by 60
Polyamine pathway activity promotes cysteine essentiality in cancer cells
Zhang, T., Bauer, C., Newman, A. C., Uribe, A. H., Athineos, D., Blyth, K., & Maddocks, O. D. K. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0253-2 · Cited by 56
Tian, Q., Zhou, Y., Zhu, L., Gao, H., & Yang, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.684259 · Cited by 58
p53 tumor suppressor and iron homeostasis
Zhang, J., & Chen, X. (2018) · FEBS Journal · doi:10.1111/febs.14638 · Cited by 59
Understanding the mechanistic regulation of ferroptosis in cancer: the gene matters
Gao, M., Fan, K., Chen, Y., Zhang, G., Chen, J., & Zhang, Y. (2022) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2022.06.002 · Cited by 57
Targeting lipid metabolism for ferroptotic cancer therapy
Luo, M., Yan, J., Hu, X., Li, H., Li, H., Liu, Q., Chen, Y., & Zou, Z. (2022) · APOPTOSIS · doi:10.1007/s10495-022-01795-0 · Cited by 62
Ferroptosis in cancer: revealing the multifaceted functions of mitochondria
Ding, X., Cui, L., Mi, Y., Hu, J., Cai, Z., Tang, Q., Yang, L., Yang, Z., Wang, Q., Li, H., et al. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05812-8 · Cited by 64
Sviderskiy, V. O., Blumenberg, L., Gorodetsky, E., Karakousi, T. R., Hirsh, N., Alvarez, S. W., Terzi, E. M., Kaparos, E., Whiten, G. C., Ssebyala, S., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.10.016 · Cited by 56
Self-citationFerroptosis: A New Promising Target for Lung Cancer Therapy
Xiong, R., He, R., Liu, B., Jiang, W., Wang, B., Li, N., & Geng, Q. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/8457521 · Cited by 57
Dihydroartemisinin Induces Ferroptosis in HCC by Promoting the Formation of PEBP1/15‐LO
Su, Y., Zhao, D., Jin, C., Li, Z., Sun, S., Xia, S., Zhang, Y., Zhang, Z., Zhang, F., Xu, X., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/3456725 · Cited by 56
Asperti, M., Bellini, S., Grillo, E., Gryzik, M., Cantamessa, L., Ronca, R., Maccarinelli, F., Salvi, A., Petro, G. D., Arosio, P., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.04.024 · Cited by 56
Mechanisms and pharmacological applications of ferroptosis: a narrative review
Zhang, J., Du, J., Kong, N., Zhang, G., Liu, M., & Liu, C. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-1595 · Cited by 58
Metabolic Regulation of Ferroptosis in Cancer
Kim, M. J., Yun, G. J., & Kim, S. E. (2021) · Biology · doi:10.3390/biology10020083 · Cited by 54
Wang, W., Fu, F., Huang, Z., Wang, W., Chen, M., Xiao, Y., Fu, J., Feng, X., Huang, Y., Wu, C., et al. (2022) · ACS Nano · doi:10.1021/acsnano.2c02634 · Cited by 54
Piccolo, M., Ferraro, M. G., Iazzetti, F., Santamaria, R., & Irace, C. (2024) · Cancers · doi:10.3390/cancers16061220 · Cited by 59
RNA m6A modification in ferroptosis: implications for advancing tumor immunotherapy
Shi, J.-X., Zhang, Z., Yin, H.-Z., Piao, X.-J., Liu, C., Liu, Q.-J., Zhang, J.-C., Zhou, W.-X., Liu, F., Yang, F., et al. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02132-6 · Cited by 56
Ward, N. P., Kang, Y. P., Falzone, A., Boyle, T. A., & DeNicola, G. M. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20191689 · Cited by 55
Liu, Y., Duan, C., Dai, R., & Zeng, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.739392 · Cited by 58
Ferroptosis as a Major Factor and Therapeutic Target for Neuroinflammation in Parkinson’s Disease
Ko, C., Gao, S.-L., Lin, T., Chu, P., & Lin, H. (2021) · Biomedicines · doi:10.3390/biomedicines9111679 · Cited by 54
Du, S., Zeng, F., Sun, H., Liu, Y., Han, P., Zhang, B., Xue, W., Deng, G., Yin, M., & Cui, B. (2022) · Bioengineered · doi:10.1080/21655979.2021.2017627 · Cited by 52
Sun, R., Liu, M., Xu, K., Pu, Y., Huang, J., Liu, J., Zhang, J., Yin, L., & Pu, Y. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.110004 · Cited by 52
Ferroptosis-mediated immune responses in cancer
Qi, D., & Peng, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1188365 · Cited by 53
Corosolic acid sensitizes ferroptosis by upregulating HERPUD1 in liver cancer cells
Peng, Y., Li, N., Tang, F., Qian, C., Jia, T., Liu, J., & Xu, Y. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01169-0 · Cited by 49
Homma, T., Kobayashi, S., & Fujii, J. (2020) · Free Radical Research · doi:10.1080/10715762.2020.1780229 · Cited by 51
Ru, Q., Li, Y., Zhang, F., Chen, L., Wu, Y., Min, J., & Wang, F. (2025) · Bone Research · doi:10.1038/s41413-024-00398-6 · Cited by 62
Ferroptosis: CD8+T cells’ blade to destroy tumor cells or poison for self-destruction
Liang, Y., Zhao, Y., Li, X., Li, X., & Zhao, Y. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02415-x · Cited by 56
Cheng, Z., Chen, Y., & Huang, H. (2023) · Vaccines · doi:10.3390/vaccines11020205 · Cited by 49
The potential of breath analysis to improve outcome for patients with lung cancer
Antoniou, S., Gaude, E., Ruparel, M., van der Schee, M. P., Janes, S. M., & Rintoul, R. C. (2019) · Journal of Breath Research · doi:10.1088/1752-7163/ab0bee · Cited by 49
Iron metabolism, ferroptosis, and lncRNA in cancer: knowns and unknowns
Qu, L., He, X., Tang, Q., Xiao, F., Liu, J., & Lin, A. (2022) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2200194 · Cited by 48
The solute carrier transporters (SLCs) family in nutrient metabolism and ferroptosis
Sun, L., He, H.-Y., Li, W., Jin, W., & Wei, Y. (2024) · Biomarker Research · doi:10.1186/s40364-024-00645-2 · Cited by 49
Yu, H., Han, Z., Xu, Z., An, C., Xu, L., & Hua, X. (2019) · Oncology Letters · doi:10.3892/ol.2019.10191 · Cited by 48
A Ferroptosis-Related Gene Signature Predicts Overall Survival in Patients with Lung Adenocarcinoma
Gao, X., Tang, M., Tian, S., Li, J., & Liu, W. (2021) · Future Oncology · doi:10.2217/fon-2020-1113 · Cited by 47
Iron–Sulfur Cluster Biogenesis as a Critical Target in Cancer
Petronek, M. S., Spitz, D. R., & Allen, B. G. (2021) · Antioxidants · doi:10.3390/antiox10091458 · Cited by 46
A New Ferroptosis-Related lncRNA Signature Predicts the Prognosis of Bladder Cancer Patients
Chen, M., Nie, Z., Li, Y., Gao, Y., Wen, X., Cao, H., & Zhang, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.699804 · Cited by 47
Zhang, N., Huang, J., Xu, M., & Wang, Y. (2022) · Journal of Cancer · doi:10.7150/jca.65017 · Cited by 47
Role of ferroptosis and ferroptosis-related long non'coding RNA in breast cancer
Xiang, S., Yan, W., Ren, X., Feng, J., & Zu, X. (2024) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00560-2 · Cited by 51
IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis
Jiang, D., Guo, Y., Wang, T., Wang, L., Yan, Y., Xia, L., Bam, R., Yang, Z., Lee, H., Iwawaki, T., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48330-0 · Cited by 52
Exploiting metabolic cell death for cancer therapy
Mao, C., Jiang, D., Koong, A. C., & Gan, B. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00879-8 · Cited by 70
Ferroptosis in gastrointestinal cancer: from mechanisms to implications
Zhang, R., Kang, R., & Tang, D. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216147 · Cited by 46
Wang, Z., Zhou, P., Li, Y., Zhang, D., Chu, F., Feng, Y., Pan, B., & Gao, F. (2023) · Small · doi:10.1002/smll.202308397 · Cited by 46
Mao, C., Lei, G., Horbath, A. D., Wang, M., Lu, Z., Yan, Y., Liu, X., Kondiparthi, L., Chen, X., Cheng, J., et al. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.04.009 · Cited by 50
Pulling back the mitochondria’s iron curtain
David, S. B. Z., Shkuri, L., & Ast, T. (2025) · npj Metabolic Health and Disease · doi:10.1038/s44324-024-00045-y · Cited by 59
PCSK9: A emerging participant in heart failure
Xu, Q., Zhao, Y.-M., He, N.-Q., Gao, R., Xu, W., Zhuo, X.-J., Ren, Z., Wu, C., & Liu, L. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114106 · Cited by 47
Liu, F., Yang, Z., Li, J., Wu, T., Li, X., Zhao, L., Wang, W., Yu, W., Zhang, G., & Xu, Y. (2024) · Molecular Medicine · doi:10.1186/s10020-024-01020-5 · Cited by 51
Rashidipour, N., Karami‐Mohajeri, S., Mandegary, A., Mohammadinejad, R., Wong, A., Mohit, M., Salehi, J., Ashrafizadeh, M., Najafi, A., & Abiri, A. (2020) · Toxicology · doi:10.1016/j.tox.2020.152407 · Cited by 47
The mechanisms and therapeutic targets of ferroptosis in cancer
Ye, L., Jin, F., Kumar, S. K., & Dai, Y. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.2011206 · Cited by 44
Impact of ferroptosis on preeclampsia: A review
Shan, Y., Guan, C., Wang, J., Qi, W., Chen, A., & Liu, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115466 · Cited by 47
Understanding the unique mechanism of ferroptosis: a promising therapeutic target
Kong, Y., Li, J., Lin, R., Lu, S., Rong, L., Yao, X. X., & Fang, Y. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1329147 · Cited by 49
Kumar, B., Adebayo, A. K., Prasad, M. S., Capitano, M. L., Wang, R., Bhat‐Nakshatri, P., Anjanappa, M., Simpson, E. R., Chen, D., Liu, Y., et al. (2022) · Science Advances · doi:10.1126/sciadv.abh3375 · Cited by 45
Translating ferroptosis into oncology: challenges, opportunities and future directions
Kang, R., Liu, J., Wang, J., Kroemer, G., & Tang, D. (2026) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-026-01128-z · Cited by 55
Novera, W., Lee, Z., Nin, D. S., Dai, M. Z.-Y., Idres, S. B., Wu, H., Damen, M. J. A., Tan, T. Z., Sim, A. Y. L., Long, Y. C., et al. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7850 · Cited by 44
Ferroptosis, novel therapeutics in asthma
Lv, X., Dong, M., Tang, W., Qin, J., Wang, W., Li, M., Teng, F., Yi, L., Dong, J., & Wei, Y. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113516 · Cited by 43
Nrf2 Is a Potential Modulator for Orchestrating Iron Homeostasis and Redox Balance in Cancer Cells
Zhang, L., Zhang, J., Jin, Y., Yao, G., Zhao, H., Qiao, P., & Wu, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.728172 · Cited by 45
Heme oxygenase-1 determines the cell fate of ferroptotic death of alveolar macrophages in COPD
Li, Y., Yang, Y., Guo, T., Weng, C., Yang, Y., Wang, Z., Zhang, L., & Li, W. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1162087 · Cited by 45
The Regulation of Ferroptosis by Noncoding RNAs
Zheng, X., & Zhang, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713336 · Cited by 45
Tumor iron homeostasis and immune regulation
Zhang, Y., Han, Y., Li, W.-N., Xu, R., & Ju, H. (2024) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.12.003 · Cited by 43
Thompson, L. R., Oliveira, T. G., Hermann, E. R., Chowanadisai, W., Clarke, S. L., & Montgomery, M. R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186751 · Cited by 44
Jiang, P., Yang, F., Zou, C., Bao, T., Wu, M., Yang, D., & Bu, S. (2021) · Aging · doi:10.18632/aging.202801 · Cited by 43
Can Polyphenols Inhibit Ferroptosis?
Lesjak, M. M., Simin, N. Đ., & Srai, S. K. (2022) · Antioxidants · doi:10.3390/antiox11010150 · Cited by 44
Ward, N. P., Yoon, S. J., Flynn, T., Sherwood, A., Olley, M. A., Madej, J., & DeNicola, G. M. (2024) · Nature Communications · doi:10.1038/s41467-024-48695-2 · Cited by 44
Sulfur sequestration promotes multicellularity during nutrient limitation
Kelly, B. L., Carrizo, G., Edwards-Hicks, J., Sanin, D. E., Stanczak, M. A., Priesnitz, C., Flachsmann, L. J., Curtis, J. D., Mittler, G., Musa, Y., et al. (2021) · Nature · doi:10.1038/s41586-021-03270-3 · Cited by 40
CPEB1 enhances erastin‐induced ferroptosis in gastric cancer cells by suppressing twist1 expression
Wang, J., Wang, T., Zhang, Y., Liu, J., Song, J., Han, Y., Wang, L., Yang, S., Zhu, L., Geng, R., et al. (2021) · IUBMB Life · doi:10.1002/iub.2525 · Cited by 41
Ferroptosis Regulation by Nutrient Signalling
Qi, Y., Zhang, X., Wu, Z., Tian, M., Chen, F., Guan, W., & Zhang, S. (2021) · Nutrition Research Reviews · doi:10.1017/s0954422421000226 · Cited by 42
The Hemagglutinin of Influenza A Virus Induces Ferroptosis to Facilitate Viral Replication
Ouyang, A., Chen, T., Feng, Y., Zou, J., Tu, S., Jiang, M., Sun, H., & Zhou, H. (2024) · Advanced Science · doi:10.1002/advs.202404365 · Cited by 39
The Evolving Role of Ferroptosis in Breast Cancer: Translational Implications Present and Future
Lin, H., Ho, H.-W., Chang, Y., Wei, C.-J., & Chu, P. (2021) · Cancers · doi:10.3390/cancers13184576 · Cited by 41
Lin, C., Tseng, H.-F., Hsieh, P., Chiu, V. J.-Y., Lin, T., Lan, C., Tzeng, I., Chao, H.-N., Hsu, C.-C., & Kuo, C. (2021) · Biomedicines · doi:10.3390/biomedicines9091283 · Cited by 40
Correia, M. J., Pimpão, A. B., Fernandes, D., Morelló, J., Sequeira, C. O., Calado, J., Antunes, A. M. M., Almeida, M., Branco, P. Q., Monteiro, E. C., et al. (2022) · Molecules · doi:10.3390/molecules27041416 · Cited by 40
Liproxstatin-1 Attenuates Morphine Tolerance through Inhibiting Spinal Ferroptosis-like Cell Death
Chen, X., Zhang, B., Liu, T., Feng, M., Zhang, Y., Zhang, C., Yao, W., & Wan, L. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00539 · Cited by 38
Song, S., Wen, F., Gu, S., Gu, P., Huang, W., Ruan, S., Chen, X., Zhou, J., Ye, L., Liu, J., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.820059 · Cited by 39
Roles of Ferroptosis in Cardiovascular Diseases
Guo, Y., Zhang, W., Zhou, X., Zhao, S., Wang, J., Guo, Y., Liao, Y., Lu, H., Liu, J., Cai, Y., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.911564 · Cited by 40
mTORC1 beyond anabolic metabolism: Regulation of cell death
Zhu, J., Wang, H., & Jiang, X. (2022) · The Journal of Cell Biology · doi:10.1083/jcb.202208103 · Cited by 42
The role of ferroptosis in fish inflammation
Gao, F., Shi, X., Pei, C., Zhao, X., Zhu, L., Zhang, J., Li, L., Li, C., & Kong, X. (2022) · Reviews in Aquaculture · doi:10.1111/raq.12719 · Cited by 38
Regulation of FSP1 myristoylation by NADPH: A novel mechanism for ferroptosis inhibition
Liu, N., Wu, W.-L., Wan, X., Wang, J., Huang, J., Jiang, Y., Sheng, Y.-C., Wu, J., Liang, Z., Qin, Z., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103176 · Cited by 38
Molecular Mechanisms of Ferroptosis and Updates of Ferroptosis Studies in Cancers and Leukemia
Akiyama, H., Carter, B. Z., Andreeff, M., & Ishizawa, J. (2023) · Cells · doi:10.3390/cells12081128 · Cited by 38
Ma, T., Zhou, Y., Wang, C., Wang, L., Chen, J., Yang, H., Zhang, C.-Y., Zhou, Y., & Guan, C. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/1098970 · Cited by 62
Ferroptosis: Biology and Role in Gastrointestinal Disease
Escuder‐Rodríguez, J.-J., Liang, D., Jiang, X., & Sinicrope, F. A. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.01.051 · Cited by 41
Ferroptosis in Cancer and Inflammatory Diseases: Mechanisms and Therapeutic Implications
Shen, G., Liu, J., Wang, Y., Deng, Z., & Deng, F. (2025) · MedComm · doi:10.1002/mco2.70349 · Cited by 47
Tetramethyl bisphenol a inhibits leydig cell function in late puberty by inducing ferroptosis
Hu, D., Tian, L., Li, X., Chen, Y., Xu, Z., Ge, R., & Wang, Y. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113515 · Cited by 37
Culbertson, B., Garcia, K., Markett, D., Asgharian, H., Chen, L., Fish, L., Navickas, A., Yu, J. X., Woo, B., Nanda, A. S., et al. (2023) · Nature Cancer · doi:10.1038/s43018-023-00554-7 · Cited by 38
Ferroptosis Inducers as Promising Radiosensitizer Agents in Cancer Radiotherapy
Jalali-Zefrei, F., Shormij, M., Dastranj, L., Alvandi, M., Shaghaghi, Z., Farzipour, S., & Polgardani, N. Z. (2023) · Current Radiopharmaceuticals · doi:10.2174/0118744710262369231110065230 · Cited by 39
Regulation of iron metabolism in ferroptosis: From mechanism research to clinical translation
Zhang, X., Yang, X., Wang, Q., Bai, X., Meng, D., Wu, J., Sun, K., Zhang, L., Qiang, R., Liu, W., et al. (2025) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2025.101304 · Cited by 36
Lv, Z., Wang, J., Wang, X., Mo, M., Tang, G., Xu, H., Wang, J., Li, Y., & Liu, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.666025 · Cited by 35
Feng, D., Shi, X., Xiong, Q., Zhang, F., Li, D., Wei, W., & Yang, L. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.803766 · Cited by 37
The Relationship Between Ferroptosis and Diseases
Lv, J., Hou, B., Song, J., Xu, Y., & Xie, S. (2022) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s382643 · Cited by 36
Li, M., Wang, K., Zhang, Y., Fan, M., Li, A., Zhou, J., Yang, T., Shi, P., Li, D., Zhang, G., et al. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.693959 · Cited by 36
Ferroptosis in Lung Cancer: From Molecular Mechanisms to Prognostic and Therapeutic Opportunities
Tabnak, P., HajiEsmailPoor, Z., & Soraneh, S. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.792827 · Cited by 35
Metadata
- Authors
- Alvarez, S. W., Sviderskiy, V. O., Terzi, E. M., Papagiannakopoulos, T., Moreira, A. L., Adams, S., Sabatini, D. M., Birsoy, K., & Possemato, R.
- Affiliations
- NYU Langone’s Laura and Isaac Perlmutter Cancer Center (US)
- Broad Institute (US)
- Corresponding author
- Sabatini, David M.
- Birsoy, Kıvanç
- Possemato, Richard
- ORCID
- Venue
- Nature
- Published
- 2017-11-22
- Volume
- 551
- Issue
- 7682
- Pages
- 639-643
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC5808442
- OpenAlex
- W2770709665
- Cited by
- 787
- References
- 34
- Citations by year
- 2026: 63 · 2025: 90 · 2024: 116 · 2023: 105 · 2022: 138 · 2021: 148 · 2020: 57 · 2019: 46 · 2018: 20 · 2017: 2
- FWCI
- 28.28
- Type
- journal article
- Language
- en
- Update notices
- correction (2022-09-14)
- Open access
- bronze
- doi.org
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- PMC
- Funders
- Leukemia and Lymphoma Society
- Broad Institute
- Agios Pharmaceuticals
- Scheme for Promotion of Academic and Research Collaboration
- National Institutes of Health (1s10od018338-01, 1s10od010584-01a1, 1s10od016304-01, CA129105, CA168940)
- National Cancer Institute (K99CA168940, R01CA103866, K22CA193660, R01CA129105, R00CA168940, P30CA016087)
- National Institute of General Medical Sciences (T32GM007308, T32GM115313)
- National Institute of Allergy and Infectious Diseases (T32AI007389, R37AI047389)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- NFS1, iron-sulfur cluster assembly, ferroptosis, lung adenocarcinoma, tumor hypoxia, high oxygen tension, oxidative damage, iron starvation response, glutathione synthesis, cysteine transport, gene amplification, tumour metastasis, cancer metabolism
- MeSH terms
- Animals, Carcinoma, Non-Small-Cell Lung, Cysteine, Glutathione, Humans, Iron-Sulfur Proteins, Lung Neoplasms, Neoplasm Metastasis, Oxygen, Carbon-Sulfur Lyases, Cell Death, Oxidative Stress, RNA Interference, Cell Line, Tumor, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
