Cited by 797Ferroptosis and cancer prognosisCancer, Hypoxia, and MetabolismIron Metabolism and Disorders

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

Open access

Alvarez, Samantha W., Sviderskiy, Vladislav O., Terzi, Erdem M., Papagiannakopoulos, Thales, Moreira, Andre L., Adams, Sylvia, Sabatini, David M., Birsoy, Kıvanç, Possemato, Richard·2017·Nature

DOI 10.1038/nature24637PMC PMC5808442

Open this paper in CoChat — free account Open PDF

Abstract

Environmental nutrient levels impact cancer cell metabolism, resulting in context-dependent gene essentiality. Here, using loss-of-function screening based on RNA interference, we show that environmental oxygen levels are a major driver of differential essentiality between in vitro model systems and in vivo tumours. Above the 3-8% oxygen concentration typical of most tissues, we find that cancer cells depend on high levels of the iron-sulfur cluster biosynthetic enzyme NFS1. Mammary or subcutaneous tumours grow despite suppression of NFS1, whereas metastatic or primary lung tumours do not. Consistent with a role in surviving the high oxygen environment of incipient lung tumours, NFS1 lies in a region of genomic amplification present in lung adenocarcinoma and is most highly expressed in well-differentiated adenocarcinomas. NFS1 activity is particularly important for maintaining the iron-sulfur co-factors present in multiple cell-essential proteins upon exposure to oxygen compared to other forms of oxidative damage. Furthermore, insufficient iron-sulfur cluster maintenance robustly activates the iron-starvation response and, in combination with inhibition of glutathione biosynthesis, triggers ferroptosis, a non-apoptotic form of cell death. Suppression of NFS1 cooperates with inhibition of cysteine transport to trigger ferroptosis in vitro and slow tumour growth. Therefore, lung adenocarcinomas select for expression of a pathway that confers resistance to high oxygen tension and protects cells from undergoing ferroptosis in response to oxidative damage.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nature24637

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

AMP-activated Protein Kinase Activity Is Critical for Hypoxia-inducible Factor-1 Transcriptional Activity and Its Target Gene Expression under Hypoxic Conditions in DU145 Cells
Lee, M. Y., Hwang, J.-T., Lee, H., Jung, S., Kang, I., Chi, S.-G., Kim, S. S., & Ha, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306104200 · Cited by 234
Retracted
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
Barretina, J., Caponigro, G., Stransky, N., Venkatesan, K., Margolin, A. A., Kim, S., Wilson, C. J., Lehár, J., Kryukov, G. V., Sonkin, D., et al. (2012) · Nature · doi:10.1038/nature11003 · Cited by 7,950
Regulation of Ferroptotic Cancer Cell Death by GPX4
Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713
CellProfiler: image analysis software for identifying and quantifying cell phenotypes
Carpenter, A. E., Jones, T. R., Lamprecht, M. R., Clarke, C., Kang, I. H., Friman, O., Guertin, D. A., Chang, J. H., Lindquist, R. A., Moffat, J., et al. (2006) · Genome biology · doi:10.1186/gb-2006-7-10-r100 · Cited by 5,212
Self-citation
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180
The landscape of somatic copy-number alteration across human cancers
Beroukhim, R., Mermel, C. H., Porter, D., Wei, G., Raychaudhuri, S., Donovan, J., Barretina, J., Boehm, J. S., Dobson, J., Urashima, M., et al. (2010) · Nature · doi:10.1038/nature08822 · Cited by 4,017
CDD: NCBI's conserved domain database
Marchler‐Bauer, A., Derbyshire, M. K., Gonzales, N. R., Lu, S., Chitsaz, F., Geer, L. Y., Geer, R. C., He, J., Gwadz, M., Hurwitz, D. I., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1221 · Cited by 3,468
Untitled work
(1989) · PubMed · Cited by 3,343
Ferroptosis: Death by Lipid Peroxidation
Yang, W. S., & Stockwell, B. R. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.10.014 · Cited by 3,088

Show all 34 references

Sorted by citations

Items 601–700 of 797

SMARCA4 regulates spatially restricted metabolic plasticity in 3D multicellular tissuePreprint
Čermáková, K., Smith, E. A., Chan, Y. S., Cabrera, M. L., Chambers, C., Jarvis, M., Simon, L. M., Xu, Y., Jain, A. K., Putluri, N., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.21.436346 · Cited by 4
Genetic Regulation of Alternative Polyadenylation Provides Novel Insights into Molecular Mechanisms Underlying Non‐small Cell Lung Cancer
Jin, M., Huang, Y., Li, B., Wang, Y., Li, Y., Chen, Z., Tang, Z., Liu, C., Zhang, L., Yuan, X., et al. (2025) · Advanced Science · doi:10.1002/advs.202502008 · Cited by 3
Antioxidant capacity of the iron–sulfur cluster assembly protein IscU2 is mediated by aspartate metabolism to promote tumor survival
Yang, X., Liang, N., Liu, D., Yan, J., Yang, X., Lv, J., Xiao, S., Wei, X., Chen, X., Yang, Z., et al. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110234 · Cited by 4
BOLA3 as a key protein for the treatment of diabetic skeletal muscle atrophy
Yang, L., Chen, M., Song, Y., Sun, Q., Zhang, S., Wang, P., Liu, X., Huang, Q., & Zhang, Y. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115383 · Cited by 3
Ferroptosis and head and neck cancer: Mechanisms and therapeutic perspectives (Review)
Kang, C., Li, X., & Wei, X. (2025) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2025.5625 · Cited by 3
Rewiring amino acids in cancer
Zhang, Y., Lyu, J., & Fang, H. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189465 · Cited by 4
Ferroptosis and Alzheimer’s disease: unraveling the molecular mechanisms and therapeutic opportunities
Yuan, F., Han, Z., Yang, S., Chen, J., Li, R., Zhang, Z., Song, J., Wang, D., & Ban, Y. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1758041 · Cited by 5
Ferroptosis in lung cancer: Emerging mechanisms, therapeutic targeting, and immune modulation
Li, Y., Liu, Y., Zhao, Y., Runa, A., Piao, H., An, S., Quan, C., Lin, Z., & Han, A. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112403 · Cited by 4
Empagliflozin attenuates dexamethasone-induced non-alcoholic steatohepatitis by regulation of ferroptosis, inflammation and autophagy
Alharbi, N. S., Abdelmageed, M. E., Nader, M. A., & Serrya, M. S. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1741926 · Cited by 3
Metal‐dependent regulated cell death: Molecular architecture and translational frontiers
Hu, H., Chen, Z., Li, Y., Peng, J., Cao, J., Zhou, H., Wang, M., Du, Y., Wu, H., Zhao, H., et al. (2026) · iMeta · doi:10.1002/imt2.70141 · Cited by 6
The role of ferroptosis in the side effects of dexamethasone
Zhao, H., & Shang, H. (2022) · All Life · doi:10.1080/26895293.2022.2156623 · Cited by 3
Modern representations about signaling pathways and protective mechanisms of ferroptosis. A biological role of diffusion of death signals of ferroptotic cells
Иванович, В. В., Sorocoletova, E. F., & Shabanov, P. D. (2023) · Reviews on Clinical Pharmacology and Drug Therapy · doi:10.17816/rcf567780 · Cited by 3
A signature of four ferroptosis-related genes in laryngeal squamous cell carcinoma
Zhao, R., Chen, Q., Qiao, P., Lu, Y., & Chen, X. (2024) · Translational Cancer Research · doi:10.21037/tcr-23-2046 · Cited by 3
Frataxin: from the sequence to the biological role
Pignataro, M. F., Noguera, M. E., Herrera, M. G., Román, E. A., & Santos, J. (2025) · Biophysical Reviews · doi:10.1007/s12551-025-01311-z · Cited by 3
Ferroptosis in immune chaos: Unraveling its impact on disease and therapeutic potential
Direksunthorn, T., Ahmed, A. T., Pluetrattanabha, N., Uthirapathy, S., Ballal, S., Singh, A., Al‐Hetty, H. R. A. K., Devi, A., Sharma, G. C., & Yumashev, A. V. (2025) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-025-01078-7 · Cited by 4
Overexpression of the ferroptosis-related gene, NFS1, corresponds to gastric cancer growth and tumor immune infiltration
Mao, Z., Shi, Z., Cui, M., Ma, X., Wang, Y., Zhang, X., Jing, R., & Wang, J. (2025) · Open Life Sciences · doi:10.1515/biol-2025-1135 · Cited by 4
Development and validation of a novel mRNA signature for predicting early relapse in non-small cell lung cancer
Lin, J., Weng, J., Lin, S., Lin, C., Huang, J., Zhang, C., Zhang, S., Dong, C., Ji, H., & Ke, X. (2021) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyab075 · Cited by 3
STUB1 promotes the degradation of HSPB1 and induces ferroptosis in lung cancer cells
Tieliwaerdi, A., Aini, A., Amuti, M., Aierken, Y., Nijiati, M., & Luo, B. (2024) · Environmental Toxicology · doi:10.1002/tox.24296 · Cited by 3
Ferroptosis in Liver Disease
Galmiche, A. (2019) · Springer eBooks · doi:10.1007/978-3-030-26780-3_13 · Cited by 3
Ferroptose et cancer
Birsen, R., Grignano, É., Chapuis, N., & Bouscary, D. (2021) · médecine/sciences · doi:10.1051/medsci/2021108 · Cited by 6
Lysyl oxidase promotes neuronal ferroptosis exacerbating seizure-induced hippocampal damagePreprint
Mao, X., Jin, M., Li, Q., Jia, J.-N., Sun, Q., Zhou, H.-H., Liu, Z., & Jin, W. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/839852 · Cited by 3
GOT1 Inhibition Primes Pancreatic Cancer for Ferroptosis through the Autophagic Release of Labile IronPreprint
Kremer, D. M., Nelson, B. S., Lin, L., Yarosz, E. L., Halbrook, C. J., Kerk, S. A., Sajjakulnukit, P., Myers, A. L., Thurston, G., Hou, S. W., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.28.970228 · Cited by 3
The effectiveness of sanggenon c in alleviating SLC7A11-induced ferroptosis in lung cancer was evaluated using in vivo, in vitro, and computational approaches
Liu, Y., Tang, A., Liu, M., Luo, Z., Cao, F., & Yang, C. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113819 · Cited by 2
Tailored mechano-responsive micelles mimic the iron starvation response and impair pH homeostasis for triggered cancer therapy
Leng, H., Li, Y., Wang, H., Du, P., Zhao, N., Wang, Z., Li, X., Li, H., & Zhao, Y. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114279 · Cited by 3
Integrating TWAS, chemical-genomic networks, and experimental models: melatonin as a ferroptosis inhibitor in osteoarthritis therapy
Feng, R., Aihaiti, Y., Yu, H., Xu, K., Lu, C., & Xu, P. (2025) · Clinical Rheumatology · doi:10.1007/s10067-025-07669-5 · Cited by 2
SLC transporters as metalloptotic gatekeepers in tumorigenesis: From molecular mechanisms to clinical potential
Pan, B., Li, T., Deng, N., Zhang, X., Peng, Y., Li, Y., Jing, J., & Sun, L. L. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.108061 · Cited by 3
Platycodon D promotes immunogenic cell death in lung cancer cells by targeting NFS1 to induce PANoptosis
Wu, M., Wang, J., Wu, Y., Chen, G., Jiang, W., Zhang, Z., Chen, Z., Wang, L., Zhang, C., Shen, Z., et al. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158249 · Cited by 3
Nanomedicine-enabled ferroptosis intervention:from antitumor effects to immune remodeling in lung diseases
Zhang, Y., Huang, W., Zhu, K., Si, Q., Wang, T., & Qin, Y. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124301 · Cited by 2
The functional role of ferroptosis in the development and progression of common cancers
Turska-Skrodzka, W., Ostrowska, A., Kretowski, A. J., & Niemira, M. (2026) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2026.105050 · Cited by 2
The Dual Role of Ferroptosis in Cancer: Molecular Mechanisms, Microenvironment Crosstalk, and Precision Therapeutics
Zhu, Y., Chen, M., Chen, J., Wang, J., Zhou, R., Cui, Y., & Li, G. (2026) · Cancers · doi:10.3390/cancers18111832 · Cited by 2
Mitochondria setting the stage for ferroptosis
Ahola, S. (2026) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2026.06.006 · Cited by 2
Iron Chelation Therapy in COVID-19 Infection: A Review Article
Kmoniček, I. K., Tomić, A., & Kocur, J. (2022) · Southeastern European medical journal · doi:10.26332/seemedj.v6i2.246 · Cited by 2
Emerging Role of Ferroptosis in Breast Cancer: Characteristics, Therapy, and Translational Implications for the Present and Future
Ray, S. K., & Mukherjee, S. (2023) · Current Molecular Medicine · doi:10.2174/1566524023666230913105735 · Cited by 2
Clinicopathologic Significance of Quaking Expression in Hepatocellular Carcinoma
Kim, S. E., Park, C. K., PARK, J. W., Lee, J. W., Choe, J., & Cho, Y. A. (2024) · In Vivo · doi:10.21873/invivo.13665 · Cited by 2
Prognostic significance of a 3-gene ferroptosis-related signature in lung cancer via LASSO analysis and cellular functions of UBE2Z
Xie, B., Chen, Q., Dai, Z., Jiang, C., Sun, J., Guan, A., & Chen, X. (2024) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2024.108192 · Cited by 2
Characterization of a ferroptosis-related gene signature predicting survival and immunotherapeutic response in lung adenocarcinoma
Zhang, C., Su, Y., Wang, H., Dang, D., Huang, X., Shi, S., Shi, Y. X., Zhang, P., & Yang, M. W. (2024) · Aging · doi:10.18632/aging.206110 · Cited by 2
Bioinformatics revealed biomarkers for diagnosis in kidney stones
He, Z., Song, C., Wang, Z., Dong, C., Jiang, Q., Yu, X. Y., & Shan, G. L. (2025) · Frontiers in Genetics · doi:10.3389/fgene.2025.1542840 · Cited by 2
Ferroptosis in Cancer Disease
Hassannia, B., & Berghe, T. V. (2019) · Springer eBooks · doi:10.1007/978-3-030-26780-3_17 · Cited by 2
Development and validation of a combined ferroptosis- and pyroptosis-related gene signatures for the prediction of clinical outcomes in lung adenocarcinoma.
Gu, X., Wei, S., Chen, B., Zhang, W., & Zheng, S. (2022) · PubMed Central · Cited by 2
Construction of cuproptosis signature based on bioinformatics and experimental validation in clear cell renal cell carcinoma
Tian, X., Zhu, S., Liu, W., Wu, X., Wei, G., Zhang, J., Anwaier, A., Chen, C., Ye, S., Che, X., et al. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-05259-z · Cited by 2
Research progress on the mechanism and signalling pathway of ferroptosis and its potential role in dermatosis research
Li, M., Gong, J., Liu, Q., & Wu, W. (2024) · Experimental Dermatology · doi:10.1111/exd.15114 · Cited by 2
Molecular Identification of Immunity- and Ferroptosis-related Gene Signature in Non-small Cell Lung CancerPreprint
Liu, T., Zhang, J., Hu, X., Xie, T., & Zhang, J. (2021) · Research Square · doi:10.21203/rs.3.rs-390478/v1 · Cited by 2
FAM207A acts as a novel and potential biomarker in lung adenocarcinoma and shapes the immunesuppressive tumor microenvironment
Wang, L., Lin, F., Yuan, J., Wu, X., Zhong, Y., Li, S., & Lv, Y. (2025) · Clinical and Experimental Medicine · doi:10.1007/s10238-025-01657-4 · Cited by 1
Inhibiting NFS1 by Targeting Liposomes for Combating Cisplatin‐Resistant Colorectal Cancer
Shao, X., Hou, J., Zhang, S., Deng, S., Yang, N., Sun, X., Feng, X., Yin, L., Zhang, T., He, Z., et al. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202519005 · Cited by 1
SLC16A3 drives lung adenocarcinoma progression and gefitinib resistance through coordinated regulation of ferroptosis and lactate metabolism
Cai, W., Liu, Y., Zhao, K., Zhu, Z., Jin, J., Wen, J., & Xue, Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1699540 · Cited by 1
Ferroptosis in biliary tract cancer: Molecular mechanisms and therapeutic applications (Review)
Zou, R.-Q., Dai, Y.-S., Yang, S., Hu, H., Li, F., & Liu, F. (2025) · International Journal of Oncology · doi:10.3892/ijo.2025.5819 · Cited by 2
Early-life BPS exposure induces reproductive toxicity in offspring mice via ferroptosis
Su, Y., Guo, X., Xu, N., Pan, M., Lin, K., Zeng, H., & He, Q. (2026) · Reproductive Toxicology · doi:10.1016/j.reprotox.2026.109175 · Cited by 1
Norepinephrine triggers ovarian granulosa cell ferroptosis via α1 receptor-mediated FDXR suppression
Hong, H., Sun, J., Weng, L., Hou, L., Xiao, C., Wang, Q., & Lai, D. (2026) · Journal of Ovarian Research · doi:10.1186/s13048-026-02118-6 · Cited by 1
Dual regulation of NFS1 by TRIM67-mediated degradation and CEBPA-driven transcription modulates colorectal cancer progression
Wang, B., Huang, X., Xing, Y., Jiao, W., Jiang, J., Liu, G., Li, G., Li, Q., Yang, C., & 史良会 (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112561 · Cited by 1
Ferritinophagy Rewires Carnitine‐Dependent Lipid Metabolism to Inhibit PRRSV and IAV Replication
Guan, K., Yuan, C., Meng, Z., Wang, Y., Zhai, X., Huang, C., Zhou, X., & Zhang, G. (2026) · Advanced Science · doi:10.1002/advs.75721 · Cited by 1
The iron-sulfur cluster assembly factor FDX2 is required for tumor initiation but not for growth of established tumors in transplantation models
Hashimoto, E., Ohuchi, M., Nomura, M., Miyahara, S., Hayashi, K., Saito, M., Yamashita, Y., Shimada, M., Yamada, H., & Tanuma, N. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.113200 · Cited by 1
Rewiring tumor metabolism for lethality: Nanomedicine-mediated induction of metabolic cell death
Liu, H., He, S., Huang, Y., Liu, J., Chen, Y., Wei, H., & Yu, C. (2026) · Precision medicine and engineering. · doi:10.1016/j.preme.2026.100072 · Cited by 1
Targeting NFS1-mediated ferroptosis mitigates alveolar injury in experimental idiopathic pulmonary fibrosis
Li, J., Cao, Y., Wang, Y., & Shi, H. (2026) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2026.117912 · Cited by 1
Ferroptosis in depression: mechanisms, association, and therapeutic strategies
Zhang, C., Chen, S. Y., Yan, C., Jiang, Y., Wang, Y., Yu, Z., Xie, T., Tian, M., Yao, G., Yan, Y., et al. (2026) · Journal of Neural Transmission · doi:10.1007/s00702-026-03248-3 · Cited by 1
Adapting to the environment
Seton-Rogers, S. E. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.123 · Cited by 1
GPx2
Kipp, A. P. (2018) · CRC Press eBooks · doi:10.1201/9781351261760-8 · Cited by 1
Ferroptosis in Cancer Therapy
Zhang, X., Guo, S., Yang, Y., Xue, X., & Wang, J. (2019) · Springer eBooks · doi:10.1007/978-3-030-26780-3_18 · Cited by 1
Clinical Significance and Immune Landscape of Recurrence-Associated Ferroptosis Signature in Early-Stage Lung Adenocarcinoma
Yi, L., Huang, P. C., Gu, Y., Wu, G., Zou, X., Guo, L., Wen, C., Zhu, J., & Zhao, D. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.794293 · Cited by 1
Construction and Validation of a CNV-Driven Ferroptosis-Related Gene Signature for Predicting the Prognosis of Lung Adenocarcinoma
Wang, Y., Zhao, Y., Li, Y. H., Luo, Z., & Chen, H. (2022) · Journal of Sensors · doi:10.1155/2022/6883739 · Cited by 1
Retracted
Molecular mechanisms associated with ferroptosis during various pulmonary disorders and the possible therapeutic regimens for lung cancer.
Ghareeb, D. A., & El-Salakawy, M. S. (2023) · Alexandria Journal of Science and Technology · doi:10.21608/ajst.2023.215256.1011 · Cited by 1
Ferroptosis induction by engineered liposomes for enhanced tumor therapy
Ghasempour, A., Tokallou, M. A., Allaf, M. R. N., Moradi, M., Dehghan, H., Sedighi, M., Shahbazi, M., & Arab, F. L. (2025) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.16.97 · Cited by 1
Effect of COVID-19 on Hemoglobin: Theories and recommended Drugs
Hassan, Z. A., Ahmed, M. L. C. B., Sanad, H. H., & Ali, A. (2021) · Journal of Advanced Pharmacy Research · doi:10.21608/aprh.2021.79803.1134 · Cited by 1
Ferroptosis
Liao, D. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-814208-0.00005-1 · Cited by 1
The differential usage of molecular machinery in brain cancer patients with iron-enriched glioma environments
Lucke-Wold, B. P., Joseph, D. M., Song, J. J., Sai, B., Root, K. T., Karan, P., & Kamil, T. (2022) · Journal of Surgery and Surgical Research · doi:10.17352/2455-2968.000150 · Cited by 1
Integrated analysis of ferroptosis-related gene signature for overall survival prediction in Asian patients with hepatocellular carcinoma
Wang, Z., Zhang, L., Xu, J., & Song, W. (2022) · Clinical & Translational Oncology · doi:10.1007/s12094-022-02977-7 · Cited by 1
Iron chelation by curcumin suppress both curcumin-induced autoghagy and cell death together with iron overload neoplastic transformationPreprint
Rainey, N., Moustapha, A., Šariċ, A., Nicolas, G., Sureau, F., & Petit, P. (2019) · bioRxiv · doi:10.1101/722942 · Cited by 9
[The perception of anxiety and stress in day surgery: a comparison among patients, family members and nurses].
Palese, A., Burlon, A., Rizzato, M., Dritti, P., Matuella, D., & Conte, L. (2004) · PubMed · Cited by 1
Identification of a nine ferroptosis-related lncRNA prognostic signature for lung adenocarcinomaPreprint
Tong, X., Zhang, Y., Yang, G., & Yi, G. (2021) · Research Square · doi:10.21203/rs.3.rs-210507/v1 · Cited by 1
Identification the ferroptosis-related gene signature in Gastric cancer based on weighted gene co-expression network analysis (WGCNA)Preprint
Wang, F., Chen, C., Chen, W., Li, Z.-L., & Cheng, H. (2021) · Research Square · doi:10.21203/rs.3.rs-486587/v1 · Cited by 1
The HIPAA privacy rule: answers to frequently asked questions.
Gosfield, A. G. (2002) · PubMed · Cited by 1
Identification of a nine ferroptosis-related lncRNA prognostic signature for lung adenocarcinomaPreprint
Tong, X., Zhang, Y., Yang, G., & Yi, G. (2021) · Research Square · doi:10.21203/rs.3.rs-210507/v2 · Cited by 1
A Novel Ferroptosis-Related Genes Model for Prognosis Prediction of Lung AdenocarcinomaPreprint
Li, F., Ge, D., & Sun, S. (2021) · Research Square · doi:10.21203/rs.3.rs-354347/v1 · Cited by 1
Overexpression of ferroptosis-related gene NFS1 correlates with gastric cancer progression and tumor immune infiltrationPreprint
Mao, Z., Shi, Z., Cui, M., Ma, X., Wang, Y., Jing, R., & Wang, J. (2023) · Research Square · doi:10.21203/rs.3.rs-3265046/v1 · Cited by 1
A machine learning and drug repurposing approach to target ferroptosis in colorectal cancer stratified by sex and KRASPreprint
Yan, H. Y., Shen, X., Yao, Y., Khan, S. A., Ma, S., & Johnson, C. H. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.24.600340 · Cited by 1
Probing Cancer Targets and Therapeutic Mechanisms using Small Molecules
Zhang, Y. (2018) · doi:10.7916/d8wm2xc5
Papers of note in Nature 551 (7682)
VanHook, A. M. (2017) · Science Signaling · doi:10.1126/scisignal.aar6316
GSH hoards all the cysteine—what a slimy thing to do
Ward, N. P., & DeNicola, G. M. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00365-z
Peer Review #2 of "Construction and validation of a 15-gene ferroptosis signature in lung adenocarcinoma (v0.3)"
(2021) · PeerJ · doi:10.7287/peerj.11687v0.3/reviews/2
Peer Review #2 of "Construction and validation of a 15-gene ferroptosis signature in lung adenocarcinoma (v0.2)"
(2021) · PeerJ · doi:10.7287/peerj.11687v0.2/reviews/2
Peer Review #2 of "Construction and validation of a 15-gene ferroptosis signature in lung adenocarcinoma (v0.1)"
(2021) · PeerJ · doi:10.7287/peerj.11687v0.1/reviews/2
The Essential Roles of Exosome and CircRNA_101093 to Desensitize Lung Adenocarcinoma to FerroptosisPreprint
Zhang, X., Xu, Y., Ma, L., Yu, K., Niu, Y., Xu, X., Shi, Y. Y., Guo, S., Xue, X., Wang, Y., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-829314/v1
A Ferroptosis-Related Long Non-Coding RNA Signature Predicts Prognosis and Immune Microenvironment for Lung Squamous Cell CarcinomaPreprint
Liu, Z., Xie, Z., Zhi, C., Lin, X., Ma, W., Tan, X., Li, P., Ouyang, S., Yu, J., Chen, X., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-963713/v1
Astragaloside IV Regulates the Ferroptosis Signaling Pathway via the Nrf2/SLC7A11/GPX4 Axis to Inhibit PM2.5-Mediated Acute Lung Injury in MicePreprint
Wang, X., Wang, Y., Huang, D., Shi, S., Pei, C., Wu, Y., Shen, Z., Wang, F., & Wang, Z. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3994578
Peer Review #1 of "Construction and validation of a 15-gene ferroptosis signature in lung adenocarcinoma (v0.2)"
(2021) · PeerJ · doi:10.7287/peerj.11687v0.2/reviews/1
Peer Review #1 of "Construction and validation of a 15-gene ferroptosis signature in lung adenocarcinoma (v0.1)"
(2021) · PeerJ · doi:10.7287/peerj.11687v0.1/reviews/1
Peer Review #3 of "Construction and validation of a 15-gene ferroptosis signature in lung adenocarcinoma (v0.1)"
(2021) · PeerJ · doi:10.7287/peerj.11687v0.1/reviews/3
Quercetin relieves ferroptosis and M1 polarization in neutrophilic asthmatic mouse modelPreprint
Wang, Y., Wan, R., Peng, W., Li, Y., Zhao, X., Bai, W., Chen, Q., & Hu, C. (2022) · Research Square · doi:10.21203/rs.3.rs-1270741/v1
Peer Review #3 of "Construction and validation of a 15-gene ferroptosis signature in lung adenocarcinoma (v0.2)"
(2021) · PeerJ · doi:10.7287/peerj.11687v0.2/reviews/3
A ferroptosis-related signature for predicting prognosis and immunotherapy response in cervical squamous carcinomaPreprint
Yang, Y., Fu, X., & Yang, Y. (2022) · Research Square · doi:10.21203/rs.3.rs-1478458/v1
Peer Review #3 of "Establishment of a ferroptosis-related gene signature for prognosis in lung adenocarcinoma patients (v0.1)"
(2021) · PeerJ · doi:10.7287/peerj.11931v0.1/reviews/3
Faculty Opinions recommendation of Systematic Identification of Regulators of Oxidative Stress Reveals Non-canonical Roles for Peroxisomal Import and the Pentose Phosphate Pathway.
Mecsas, J. C. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737324804.793574246
Peer Review #1 of "Establishment of a ferroptosis-related gene signature for prognosis in lung adenocarcinoma patients (v0.1)"
(2021) · PeerJ · doi:10.7287/peerj.11931v0.1/reviews/1
Peer Review #2 of "Establishment of a ferroptosis-related gene signature for prognosis in lung adenocarcinoma patients (v0.2)"
(2021) · PeerJ · doi:10.7287/peerj.11931v0.2/reviews/2
Peer Review #2 of "Establishment of a ferroptosis-related gene signature for prognosis in lung adenocarcinoma patients (v0.1)"
(2021) · PeerJ · doi:10.7287/peerj.11931v0.1/reviews/2
Faculty Opinions recommendation of CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy.
Koralov, S. B., & Ivanova, E. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735645515.793561811
Faculty Opinions recommendation of Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity.
Chandel, N. S. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735113622.793559425
A ferroptosis-related signature for predicting prognosis and immunotherapy response in cervical squamous carcinomaPreprint
Yang, Y., Fu, X., & Yang, Y. (2022) · Research Square · doi:10.21203/rs.3.rs-1478458/v2
Ana Hatları ile Ferroptozis
Gezer, A., & SARI, E. K. (2022) · Turkish Veterinary Journal · doi:10.51755/turkvetj.1078397
Cancer suppression by ferroptosis and its role in digestive system tumors
Li, J., Xia, X., Wu, L., Zhu, Z. G., Shi, Y.-N., Zhang, X., Xia, Y.-S., & Lu, G. (2022) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v30.i16.718
Ferroptosis-related ACSL3 and ACTC1 predict metastasis free survival for prostate cancer patients unfergoing radical radiotherapyPreprint
Shi, X., Feng, D., Zhu, W., Han, P., Yang, L., Wei, Q., & Wei, W. (2022) · Research Square · doi:10.21203/rs.3.rs-2245420/v1

Authors: Alvarez, S. W., Sviderskiy, V. O., Terzi, E. M., Papagiannakopoulos, T., Moreira, A. L., Adams, S., Sabatini, D. M., Birsoy, K., & Possemato, R.
Affiliations: NYU Langone’s Laura and Isaac Perlmutter Cancer Center (US)
Broad Institute (US)
Corresponding author: Sabatini, David M.
Birsoy, Kıvanç
Possemato, Richard
ORCID: Sviderskiy, Vladislav O.
Terzi, Erdem M.
Papagiannakopoulos, Thales
Moreira, Andre L.
Adams, Sylvia
Sabatini, David M.
Birsoy, Kıvanç
Possemato, Richard
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2017-11-22
Volume: 551
Issue: 7682
Pages: 639-643
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature24637
PMC: PMC5808442
OpenAlex: W2770709665
Cited by: 787
References: 34
Citations by year: 2026: 63 · 2025: 90 · 2024: 116 · 2023: 105 · 2022: 138 · 2021: 148 · 2020: 57 · 2019: 46 · 2018: 20 · 2017: 2
FWCI: 28.28
Type: journal article
Language: en
Update notices: correction (2022-09-14)
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
PMC
Funders: Leukemia and Lymphoma Society
Broad Institute
Agios Pharmaceuticals
Scheme for Promotion of Academic and Research Collaboration
National Institutes of Health (1s10od018338-01, 1s10od010584-01a1, 1s10od016304-01, CA129105, CA168940)
National Cancer Institute (K99CA168940, R01CA103866, K22CA193660, R01CA129105, R00CA168940, P30CA016087)
National Institute of General Medical Sciences (T32GM007308, T32GM115313)
National Institute of Allergy and Infectious Diseases (T32AI007389, R37AI047389)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords: NFS1, iron-sulfur cluster assembly, ferroptosis, lung adenocarcinoma, tumor hypoxia, high oxygen tension, oxidative damage, iron starvation response, glutathione synthesis, cysteine transport, gene amplification, tumour metastasis, cancer metabolism
MeSH terms: Animals, Carcinoma, Non-Small-Cell Lung, Cysteine, Glutathione, Humans, Iron-Sulfur Proteins, Lung Neoplasms, Neoplasm Metastasis, Oxygen, Carbon-Sulfur Lyases, Cell Death, Oxidative Stress, RNA Interference, Cell Line, Tumor, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks