Cited by 596Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia ResearchMesenchymal stem cell research

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Clonal analysis of lineage fate in native haematopoiesis

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Rodriguez-Fraticelli, Alejo E., Wolock, Samuel L., Weinreb, Caleb S., Panero, Riccardo, Patel, Sachin H., Jankovic, Maja, Sun, Jianlong, Calogero, Raffaele A., Klein, Allon M., Camargo, Fernando D.·2018·Nature

DOI 10.1038/nature25168PMC PMC5884107

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Abstract

Haematopoiesis, the process of mature blood and immune cell production, is functionally organized as a hierarchy, with self-renewing haematopoietic stem cells and multipotent progenitor cells sitting at the very top. Multiple models have been proposed as to what the earliest lineage choices are in these primitive haematopoietic compartments, the cellular intermediates, and the resulting lineage trees that emerge from them. Given that the bulk of studies addressing lineage outcomes have been performed in the context of haematopoietic transplantation, current models of lineage branching are more likely to represent roadmaps of lineage potential than native fate. Here we use transposon tagging to clonally trace the fates of progenitors and stem cells in unperturbed haematopoiesis. Our results describe a distinct clonal roadmap in which the megakaryocyte lineage arises largely independently of other haematopoietic fates. Our data, combined with single-cell RNA sequencing, identify a functional hierarchy of unilineage- and oligolineage-producing clones within the multipotent progenitor population. Finally, our results demonstrate that traditionally defined long-term haematopoietic stem cells are a significant source of megakaryocyte-restricted progenitors, suggesting that the megakaryocyte lineage is the predominant native fate of long-term haematopoietic stem cells. Our study provides evidence for a substantially revised roadmap for unperturbed haematopoiesis, and highlights unique properties of multipotent progenitors and haematopoietic stem cells in situ.

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Authors: Rodriguez-Fraticelli, A. E., Wolock, S. L., Weinreb, C. S., Panero, R., Patel, S. H., Jankovic, M., Sun, J., Calogero, R. A., Klein, A. M., & Camargo, F. D.
Affiliations: Boston Children's Hospital (US)
Harvard University (US)
University of Turin (IT)
Corresponding author: Camargo, Fernando D.
ORCID: Rodriguez-Fraticelli, Alejo E.
Wolock, Samuel L.
Weinreb, Caleb S.
Panero, Riccardo
Patel, Sachin H.
Jankovic, Maja
Sun, Jianlong
Calogero, Raffaele A.
Klein, Allon M.
Camargo, Fernando D.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2018-01
Volume: 553
Issue: 7687
Pages: 212-216
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature25168
PMC: PMC5884107
OpenAlex: W2781886817
Cited by: 596
References: 39
Citations by year: 2026: 41 · 2025: 70 · 2024: 76 · 2023: 56 · 2022: 75 · 2021: 76 · 2020: 91 · 2019: 68 · 2018: 43
FWCI: 49.81
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Howard Hughes Medical Institute
Leukemia and Lymphoma Society
Life Sciences Research Foundation
National Institutes of Health (P01HL13147)
National Heart, Lung, and Blood Institute (R01HL128850, P01HL131477)
National Institute of General Medical Sciences (T32GM080177)
National Institute of Diabetes and Digestive and Kidney Diseases (U54DK110805, P30DK034854)
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Keywords: hematopoiesis, hematopoietic stem cells, multipotent progenitors, clonal tracing, transposon tagging, megakaryocyte lineage, single-cell transcriptomics, megakaryopoiesis
MeSH terms: Animals, Clone Cells, Female, Hematopoiesis, Hematopoietic Stem Cells, Male, Megakaryocytes, Sequence Analysis, RNA, Cell Lineage, Multipotent Stem Cells, Mice, Single-Cell Analysis, Transcriptome

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Clonal analysis of lineage fate in native haematopoiesis

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