Clonal analysis of lineage fate in native haematopoiesis

Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells

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Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

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Identification of Flt3+ Lympho-Myeloid Stem Cells Lacking Erythro-Megakaryocytic Potential

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Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics

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Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells

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The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype

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Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors

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Human haematopoietic stem cell lineage commitment is a continuous process

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Clonal dynamics of native haematopoiesis

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Osteoblast Lineage Support of Hematopoiesis in Health and Disease

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Phenotypic Analysis of the Mouse Hematopoietic Hierarchy Using Spectral Cytometry: From Stem Cell Subsets to Early Progenitor Compartments

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Current understanding of human megakaryocytic-erythroid progenitors and their fate determinants

Kwon, N., Thompson, E. N., Mayday, M. Y., Scanlon, V. M., Lu, Y.-C., & Krause, D. S. (2020) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000625 · Cited by 25

Cellular origins and lineage relationships of the intestinal epithelium

Capdevila, C., Trifas, M., Miller, J. D., Anderson, T., Sims, P. A., & Yan, K. S. (2021) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00188.2021 · Cited by 28

The biology of hematopoietic stem cells and its clinical implications

Skulimowska, I., Sośniak, J., Gońka, M., Szade, A., Józkowicz, A., & Szade, K. (2021) · FEBS Journal · doi:10.1111/febs.16192 · Cited by 27

Creating Lineage Trajectory Maps Via Integration of Single‐Cell RNA‐Sequencing and Lineage Tracing

Fletcher, R. B., Das, D., & Ngai, J. (2018) · BioEssays · doi:10.1002/bies.201800056 · Cited by 25

Understanding and Modulating Immunity With Cell Reprogramming

Pires, C. F., Rosa, F. A., Kurochkin, I., & Pereira, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02809 · Cited by 25

Notch Signaling in the Bone Marrow Lymphopoietic Niche

Sottoriva, K., & Pajcini, K. V. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.723055 · Cited by 25

Combining single-cell tracking and omics improves blood stem cell fate regulator identification

Wehling, A., Loeffler, D., Zhang, Y., Kull, T., Donato, C., Szczerba, B. M., Ortega, G. C., Lee, M., Moor, A. E., Göttgens, B., et al. (2022) · Blood · doi:10.1182/blood.2022016880 · Cited by 27

Regeneration following blood loss and acute inflammation proceeds without contribution of primitive HSCs

Munz, C. M., Dressel, N., Chen, M., Grinenko, T., Roers, A., & Gerbaulet, A. (2023) · Blood · doi:10.1182/blood.2022018996 · Cited by 28

Hematopoietic Stem Cells Self-Renew Symmetrically or Gradually Proceed to DifferentiationPreprint

Barile, M., Busch, K., Fanti, A.-K., Greco, A., Wang, X., Oguro, H., Zhang, Q., Morrison, S. J., Rodewald, H.-R., & Höfer, T. (2020) · SSRN Electronic Journal · doi:10.1101/2020.08.06.239186 · Cited by 24

Dynamics of Chromatin Accessibility During Hematopoietic Stem Cell Differentiation Into Progressively Lineage-Committed Progeny

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Tracking hematopoietic stem cells and their progeny using whole-genome sequencing

Lee-Six, H., & Kent, D. G. (2020) · Experimental Hematology · doi:10.1016/j.exphem.2020.01.004 · Cited by 26

CD4+ teff cell heterogeneity: the perspective from single-cell transcriptomics

Zemmour, D., Kiner, E., & Benoist, C. O. (2020) · Current Opinion in Immunology · doi:10.1016/j.coi.2020.02.004 · Cited by 24

Transcriptional characterization of human megakaryocyte polyploidization and lineage commitment

Choudry, F., Bagger, F. O., Macaulay, I. C., Farrow, S., Burden, F., Kempster, C., McKinney, H., Olsen, L. R., Huang, N., Downes, K., et al. (2021) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.15271 · Cited by 31

Megakaryocyte Cytoskeletal Proteins in Platelet Biogenesis and Diseases

Mbiandjeu, S. C. T., Balduini, A., & Malara, A. (2021) · Thrombosis and Haemostasis · doi:10.1055/s-0041-1731717 · Cited by 25

Hematopoietic stem and progenitor cells improve survival from sepsis by boosting immunomodulatory cells

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Myeloid Fatty Acid Metabolism Activates Neighboring Hematopoietic Stem Cells to Promote Heart Failure With Preserved Ejection Fraction

Filipp, M. E., Ge, Z., DeBerge, M., Lantz, C. W., Glinton, K. E., Gao, P., Smolgovsky, S. A., Dai, J., Zhao, Y., Yvan‐Charvet, L., et al. (2025) · Circulation · doi:10.1161/circulationaha.124.070248 · Cited by 28

Megakaryocyte Diversity in Ontogeny, Functions and Cell-Cell Interactions

Khatib-Massalha, E., & Méndez‐Ferrer, S. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.840044 · Cited by 26

Stem Cells, Hematopoiesis and Lineage Tracing: Transplantation-Centric Views and Beyond

Konturek-Cieśla, A., & Bryder, D. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.903528 · Cited by 24

EBF1 primes B-lymphoid enhancers and limits the myeloid bias in murine multipotent progenitors

Lenaerts, A., Kuciński, I., Deboutte, W., Derecka, M., Cauchy, P., Manke, T., Göttgens, B., & Grosschedl, R. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20212437 · Cited by 24

Linking Benzene, in Utero Carcinogenicity and Fetal Hematopoietic Stem Cell Niches: A Mechanistic Review

Yusoff, N. A., Hamid, Z. A., Budin, S. B., & Taib, I. S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076335 · Cited by 23

A track of the clones: new developments in cellular barcoding

Lyne, A.-M., Kent, D. G., Laurenti, E., Cornils, K., Glauche, I., & Perié, L. (2018) · Experimental Hematology · doi:10.1016/j.exphem.2018.11.005 · Cited by 21

Dual recombinases-based genetic lineage tracing for stem cell research with enhanced precision

Jin, H., Liu, K., & Zhou, B. (2021) · Science China Life Sciences · doi:10.1007/s11427-020-1889-9 · Cited by 22

Megakaryocytes as the Regulator of the Hematopoietic Vascular Niche

Zhan, H., & Kaushansky, K. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.912060 · Cited by 23

Nanoparticles targeting hematopoietic stem and progenitor cells: Multimodal carriers for the treatment of hematological diseases

Cruz, L. J., Rezaei, S., Grosveld, F. G., Philipsen, S., & Eich, C. (2022) · Frontiers in Genome Editing · doi:10.3389/fgeed.2022.1030285 · Cited by 23

A new view of the mammary epithelial hierarchy and its implications for breast cancer initiation and metastasis

Anstine, L. J., & Keri, R. A. (2019) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2019.24 · Cited by 22

microRNA-22 promotes megakaryocyte differentiation through repression of its target, GFI1

Weiss, C. N., & Ito, K. (2019) · Blood Advances · doi:10.1182/bloodadvances.2018023804 · Cited by 22

Single-cell methods in myeloproliferative neoplasms: old questions, new technologies

O’Sullivan, J., Mead, A. J., & Psaila, B. (2022) · Blood · doi:10.1182/blood.2021014668 · Cited by 24

SON is an essential m6A target for hematopoietic stem cell fate

Luo, H., Cortés-López, M., Tam, C. L., Xiao, M. J., Wakiro, I., Chu, K. L., Pierson, A., Chan, M., Chang, K., Yang, X., et al. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.11.006 · Cited by 21

Stochastically Timed Competition Between Division and Differentiation Fates Regulates the Transition From B Lymphoblast to Plasma Cell

Zhou, J. H. S., Markham, J. F., Duffy, K. R., & Hodgkin, P. D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02053 · Cited by 21

Hoxb5 defines the heterogeneity of self-renewal capacity in the hematopoietic stem cell compartment

Sakamaki, T., Kao, K. S., Nishi, K., Chen, J. Y., Sadaoka, K., Fujii, M., Takaori‐Kondo, A., Weissman, I. L., & Miyanishi, M. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.12.077 · Cited by 21

The 28 + 28 day design is an effective sampling time for analyzing mutant frequencies in rapidly proliferating tissues of MutaMouse animals

Marchetti, F., Zhou, G., LeBlanc, D. P. M., White, P. A., Williams, A., Yauk, C. L., & Douglas, G. R. (2021) · Archives of Toxicology · doi:10.1007/s00204-021-02977-6 · Cited by 21

New frameworks for hematopoiesis derived from single-cell genomics

Safina, K. R., & van Galen, P. (2024) · Blood · doi:10.1182/blood.2024024006 · Cited by 23

Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations

Singh, I., Fernández-Pérez, D., Sanchez, P. S., & Rodriguez-Fraticelli, A. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.01.012 · Cited by 30

Hematopoietic Progenitors and the Bone Marrow Niche Shape the Inflammatory Response and Contribute to Chronic Disease

Xu, Y., Murphy, A. J., & Fleetwood, A. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042234 · Cited by 23

Loss of Dnmt3a increases self-renewal and resistance to pegIFN-α in JAK2 -V617F–positive myeloproliferative neoplasms

Usart, M., Stetka, J., Paz, D. L., Hansen, N., Kimmerlin, Q., Fonseca, T. A., Lock, M., Kubovčáková, L., Karjalainen, R., Hao-Shen, H., et al. (2024) · Blood · doi:10.1182/blood.2023020270 · Cited by 22

The role of platelets and megakaryocytes in sepsis and ARDS

Leung, G. M., & Middleton, E. A. (2024) · The Journal of Physiology · doi:10.1113/jp284879 · Cited by 21

Population dynamics modeling reveals that myeloid bias involves both HSC differentiation and progenitor proliferation biases

Singh, A., Chia, J. J., Rao, D. S., & Hoffmann, A. (2025) · Blood · doi:10.1182/blood.2024025598 · Cited by 21

Nfe2 is dispensable for early but required for adult thrombocyte formation and function in zebrafish

Rost, M. S., Shestopalov, I. A., Liu, Y., Vo, A. H., Richter, C. E., Emly, S. M., Barrett, F. G., Stachura, D. L., Holinstat, M. A., Zon, L. I., et al. (2018) · Blood Advances · doi:10.1182/bloodadvances.2018021865 · Cited by 21

Application of single-cell RNA sequencing methodologies in understanding haematopoiesis and immunology

Ranzoni, A. M., Strzelecka, P. M., & Cvejic, A. (2019) · Essays in Biochemistry · doi:10.1042/ebc20180072 · Cited by 21

Chromatin Complexes Maintain Self-Renewal of Myeloid Progenitors in AML: Opportunities for Therapeutic Intervention

Uckelmann, H. J., & Armstrong, S. A. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.05.013 · Cited by 20

Hematopoietic stem cell heterogeneity is linked to the initiation and therapeutic response of myeloproliferative neoplasms

Tong, J., Sun, T., Ma, S., Zhao, Y., Ju, M., Gao, Y., Zhu, P., Tan, P., Fu, R., Zhang, A., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.02.026 · Cited by 18

Single-cell fate decisions of bipotential hematopoietic progenitors

Brand, M., & Morrissey, E. R. (2020) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000592 · Cited by 19

Hematopoietic Stem Cell Dynamics Are Regulated by Progenitor Demand: Lessons from a Quantitative Modeling Approach

Klose, M., Florian, M. C., Gerbaulet, A., Geiger, H., & Glauche, I. (2019) · Stem Cells · doi:10.1002/stem.3005 · Cited by 19

The bone marrow hematopoietic niche and its adaptation to infection

Gomes, A. C., Saraiva, M., & Gomes, M. S. (2021) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2020.05.014 · Cited by 18

LoxCode in vivo barcoding reveals epiblast clonal fate bias to fetal organs

Weber, T., Biben, C., Miles, D. C., Glaser, S. P., Tomei, S., Lin, C., Kueh, A. J., Pál, M., Zhang, S., Tam, P., et al. (2025) · Cell · doi:10.1016/j.cell.2025.04.026 · Cited by 26

Revisiting the lineage contribution of hematopoietic stem and progenitor cells

Gao, S., Zhang, Y., & Liu, F. (2023) · Development · doi:10.1242/dev.201609 · Cited by 17

Increased iron uptake by splenic hematopoietic stem cells promotes TET2-dependent erythroid regeneration

Tseng, Y.-J., Kageyama, Y., Murdaugh, R. L., Kitano, A., Kim, J. H., Hoegenauer, K. A., Tiessen, J., Smith, M. H., Uryu, H., Takahashi, K., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-44718-0 · Cited by 21

Vascular Regulation of Hematopoietic Stem Cell Homeostasis, Regeneration, and Aging

Ramalingam, P., Butler, J. M., & Poulos, M. G. (2021) · Current Stem Cell Reports · doi:10.1007/s40778-021-00198-2 · Cited by 18

Platelet Heterogeneity in Myeloproliferative Neoplasms

Thomas, S. J., & Krishnan, A. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.121.316373 · Cited by 18

Concurrent stem- and lineage-affiliated chromatin programs precede hematopoietic lineage restriction

Safi, F., Dhapola, P., Warsi, S., Sommarin, M. N. E., Erlandsson, E., Ungerbäck, J., Warfvinge, R., Sitnicka, E., Bryder, D., Böiers, C., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110798 · Cited by 17

Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells

Cova, G., Taroni, C., Deau, M.-C., Cai, Q., Mittelheisser, V., Philipps, M., Jung, M., Cerciat, M., Le Gras, S., Thibault-Carpentier, C., et al. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20202317 · Cited by 17

Longitudinal assessment of clonal mosaicism in human hematopoiesis via mitochondrial mutation tracking

Lareau, C. A., Ludwig, L. S., & Sankaran, V. G. (2019) · Blood Advances · doi:10.1182/bloodadvances.2019001196 · Cited by 17

Developmental cues license megakaryocyte priming in murine hematopoietic stem cells

Kristiansen, T. A., Zhang, Q., Vergani, S., Boldrin, E., Krausse, N., André, O., Nordenfelt, P., Sigvardsson, M., Bryder, D., Ungerbäck, J., et al. (2022) · Blood Advances · doi:10.1182/bloodadvances.2021006861 · Cited by 17

Optimization of CRISPR–Cas system for clinical cancer therapy

Meng, X. L., Wu, T., Lou, Q., Niu, K., Jiang, L., Xiao, Q., Xu, T., & Zhang, L. (2022) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10474 · Cited by 18

Apoptosis in megakaryocytes: Safeguard and threat for thrombopoiesis

Yang, S., Wang, L., Wu, Y., Wu, A., Huang, F., Tang, X., Kantawong, F., Anuchapreeda, S., Qin, D., Mei, Q., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1025945 · Cited by 20

Platelets for advanced drug delivery in cancer

Cacic, D. L., Hervig, T. A., & Reikvam, H. (2023) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2023.2217378 · Cited by 17

Inflammasomes and the Maintenance of Hematopoietic Homeostasis: New Perspectives and Opportunities

Yang, L., Hu, M., Lu, Y., Han, S., & Wang, J. (2021) · Molecules · doi:10.3390/molecules26020309 · Cited by 18

Discrete regulatory modules instruct hematopoietic lineage commitment and differentiation

Georgolopoulos, G., Psatha, N., Iwata, M., Nishida, A., Som, T., Yiangou, M., Stamatoyannopoulos, J. A., & Vierstra, J. D. (2021) · Nature Communications · doi:10.1038/s41467-021-27159-x · Cited by 16

Expansion of human megakaryocyte-biased hematopoietic stem cells by biomimetic Microniche

Li, Y., He, M. T., Zhang, W., Liu, W., Xu, H., Yang, M., Zhang, H., Liang, H., Li, W., Wu, Z., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37954-3 · Cited by 20

The heart is a resident tissue for hematopoietic stem and progenitor cells in zebrafish

Bornhorst, D., Hejjaji, A. V., Steuter, L., Woodhead, N. M., Maier, P., Gentile, A., Alhajkadour, A., Santis, O., Weber, M., Kikhi, K., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51920-7 · Cited by 16

Clones assemble! The clonal complexity of blood during ontogeny and disease

Ganuza, M., Hall, T., Obeng, E. A., & McKinney‐Freeman, S. (2020) · Experimental Hematology · doi:10.1016/j.exphem.2020.01.009 · Cited by 17

Clonal tracking of haematopoietic cells: insights and clinical implications

Cordes, S., Wu, C., & Dunbar, C. E. (2020) · British Journal of Haematology · doi:10.1111/bjh.17175 · Cited by 17

Germline ETV6 mutation promotes inflammation and disrupts lymphoid development of early hematopoietic progenitors

Zhou, C., Uluisik, R. C., Rowley, J. W., David, C., Jones, C. L., Scharer, C. D., Noetzli, L. J., Fisher, M. H., Kirkpatrick, G. D., Bark, K., et al. (2022) · Experimental Hematology · doi:10.1016/j.exphem.2022.06.002 · Cited by 16

Assembling the layers of the hematopoietic system: A window of opportunity for thymopoiesis in the embryo

Soares‐da‐Silva, F., Elsaid, R., Peixoto, M. M., Nogueira, G., Pereira, P., Bandeira, A., & Cumano, A. (2023) · Immunological Reviews · doi:10.1111/imr.13187 · Cited by 17

Clonal tracking of erythropoiesis in rhesus macaques

Fan, X., Wu, C., Truitt, L. L., Espinoza, D. A., Sellers, S. E., Bonifacino, A. C., Zhou, Y., Cordes, S., Krouse, A. E., Metzger, M. E., et al. (2019) · Haematologica · doi:10.3324/haematol.2019.231811 · Cited by 15

Single-cell lineage tracing approaches to track kidney cell development and maintenance

Yoon, B., Kim, H., Jung, S. W., & Park, J. (2024) · Kidney International · doi:10.1016/j.kint.2024.01.045 · Cited by 14

Wnt signaling couples G2 phase control with differentiation during hematopoiesis in Drosophila

Goins, L. M., Girard, J. R., Mondal, B. C., Buran, S., Su, C. C., Tang, R., Biswas, T., Kissi, J. A., & Banerjee, U. K. (2024) · Developmental Cell · doi:10.1016/j.devcel.2024.05.023 · Cited by 18

New genetic tools for the in vivo study of hematopoietic stem cell function

Upadhaya, S., Reizis, B., & Sawai, C. M. (2018) · Experimental Hematology · doi:10.1016/j.exphem.2018.02.004 · Cited by 15

The changing face of hematopoiesis: a spectrum of options is available to stem cells

Brown, G., Tsapogas, P., & Ceredig, R. (2018) · Immunology and Cell Biology · doi:10.1111/imcb.12055 · Cited by 15

Modeling human RNA spliceosome mutations in the mouse: not all mice were created equal

Xu, J. J., Smeets, M. F. M. A., Tan, S. Y., Wall, M., Purton, L. E., & Walkley, C. R. (2018) · Experimental Hematology · doi:10.1016/j.exphem.2018.11.001 · Cited by 15

Systems analysis of hematopoiesis using single-cell lineage tracing

Rodriguez-Fraticelli, A., & Camargo, F. D. (2020) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000624 · Cited by 16

Usp22 is an intracellular regulator of systemic emergency hematopoiesis

Dietlein, N., Wang, X., Metz, J., Disson, O., Shang, F., Beyersdörffer, C., Rodriguez-Correa, E., Lipka, D. B., Begus‐Nahrmann, Y., Kosinsky, R. L., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.abq2061 · Cited by 15

Metabolism in stem cell driven leukaemia: parallels between haematopoiesis and immunity

Rattigan, K. M., Zarou, M. M., & Helgason, G. V. (2023) · Blood · doi:10.1182/blood.2022018258 · Cited by 16

GraphDDP: a graph-embedding approach to detect differentiation pathways in single-cell-data using prior class knowledge

Costa, F., Grün, D., & Backofen, R. (2018) · Nature Communications · doi:10.1038/s41467-018-05988-7 · Cited by 17

Memory of Divisional History Directs the Continuous Process of Primitive Hematopoietic Lineage Commitment

Bernitz, J. M., Rapp, K., Daniel, M. G., Shcherbinin, D., Yuan, Y., Gomes, A., Waghray, A., Brosh, R., Lachmann, A., Ma’ayan, A., et al. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.03.005 · Cited by 17

Trim47 prevents hematopoietic stem cell exhaustion during stress by regulating MAVS-mediated innate immune pathway

Chen, F., Lu, Y., Xu, Y., Chen, N., Yang, L., Zhong, X., Zeng, H., Liu, Y., Chen, Z., Zhang, Q., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51199-8 · Cited by 14

DARLIN mouse for in vivo lineage tracing at high efficiency and clonal diversity

Li, L., Bowling, S., Lin, H., Chen, D., Wang, S., & Camargo, F. D. (2025) · Nature Protocols · doi:10.1038/s41596-025-01141-z · Cited by 14

Layered immune system development in mice and humans

Dorshkind, K. A., & Crooks, G. M. (2023) · Immunological Reviews · doi:10.1111/imr.13198 · Cited by 14

Slow cycling and durable Flt3+ progenitors contribute to hematopoiesis under native conditions

Solomon, M. P., Song, B., Govindarajah, V., Good, S., Arasu, A., Hinton, E. B., Thakkar, K., Bartram, J., Filippi, M., Cancelas, J. A., et al. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20231035 · Cited by 16

Interleukins in Platelet Biology: Unraveling the Complex Regulatory Network

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Integrative single‐cell expression and functional studies unravels a sensitization to cytarabine‐based chemotherapy through HIF pathway inhibition in AML leukemia stem cells

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