Cited by 1,494Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

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Changing potency by spontaneous fusion

Ying, Qi-Long, Nichols, Jennifer, Evans, Edward P., Smith, Austin G.·2002·Nature

DOI 10.1038/nature729

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Abstract

Recent reports have suggested that mammalian stem cells residing in one tissue may have the capacity to produce differentiated cell types for other tissues and organs 1-9. Here we define a mechanism by which progenitor cells of the central nervous system can give rise to non-neural derivatives. Cells taken from mouse brain were co-cultured with pluripotent embryonic stem cells. Following selection for a transgenic marker carried only by the brain cells, undifferentiated stem cells are recovered in which the brain cell genome has undergone epigenetic reprogramming. However, these cells also carry a transgenic marker and chromosomes derived from the embryonic stem cells. Therefore the altered phenotype does not arise by direct conversion of brain to embryonic stem cell but rather through spontaneous generation of hybrid cells. The tetraploid hybrids exhibit full pluripotent character, including multilineage contribution to chimaeras. We propose that transdetermination consequent to cell fusion 10 could underlie many observations otherwise attributed to an intrinsic plasticity of tissue stem cells 9.

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Authors: Ying, Q.-L., Nichols, J., Evans, E. P., & Smith, A. G.
Affiliations: University of Edinburgh (GB)
University of Oxford (GB)
Corresponding author: Smith, Austin G.
ORCID: Ying, Qi-Long
Nichols, Jennifer
Smith, Austin G.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2002-03-13
Volume: 416
Issue: 6880
Pages: 545-548
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature729
OpenAlex: W2109794889
Cited by: 1,494
References: 30
Citations by year: 2026: 4 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 10 · 2021: 9 · 2020: 12 · 2019: 8 · 2018: 7 · 2017: 26 · 2016: 11 · 2015: 23 · 2014: 34 · 2013: 36 · 2012: 62
FWCI: 79.91
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
ERA (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: transdetermination, cell fusion, stem cell potency, epigenetic reprogramming, tetraploid hybrids, embryonic stem cells, pluripotency, chimerism
MeSH terms: Animals, Anti-Bacterial Agents, Antigens, Differentiation, Blastocyst, Brain, Cell Differentiation, Cell Fusion, Cell Line, Cells, Cultured, Chimera, Cinnamates, Drug Resistance, Embryo, Mammalian, Female, Embryonic and Fetal Development, Hybrid Cells, Hygromycin B, Male, Mice, Inbred C57BL, Mice, Transgenic, Neurons, Stem Cells, Coculture Techniques, Mice

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