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Changing potency by spontaneous fusion
Abstract
Recent reports have suggested that mammalian stem cells residing in one tissue may have the capacity to produce differentiated cell types for other tissues and organs 1-9. Here we define a mechanism by which progenitor cells of the central nervous system can give rise to non-neural derivatives. Cells taken from mouse brain were co-cultured with pluripotent embryonic stem cells. Following selection for a transgenic marker carried only by the brain cells, undifferentiated stem cells are recovered in which the brain cell genome has undergone epigenetic reprogramming. However, these cells also carry a transgenic marker and chromosomes derived from the embryonic stem cells. Therefore the altered phenotype does not arise by direct conversion of brain to embryonic stem cell but rather through spontaneous generation of hybrid cells. The tetraploid hybrids exhibit full pluripotent character, including multilineage contribution to chimaeras. We propose that transdetermination consequent to cell fusion 10 could underlie many observations otherwise attributed to an intrinsic plasticity of tissue stem cells 9.
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“indicating the absence of transplant-to-host cell fusion events”
From Xenotransplanted human cortical neurons reveal species-specific development and functional integration into mouse visual circuits (2019) · cites this paper as Ying et al., 2002
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Metadata
- Authors
- Ying, Q.-L., Nichols, J., Evans, E. P., & Smith, A. G.
- Affiliations
- University of Edinburgh (GB)
- University of Oxford (GB)
- Corresponding author
- Smith, Austin G.
- Venue
- Nature
- Published
- 2002-03-13
- Volume
- 416
- Issue
- 6880
- Pages
- 545-548
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2109794889
- Cited by
- 1,494
- References
- 30
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 10 · 2021: 9 · 2020: 12 · 2019: 8 · 2018: 7 · 2017: 26 · 2016: 11 · 2015: 23 · 2014: 34 · 2013: 36 · 2012: 62
- FWCI
- 79.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- ERA (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- transdetermination, cell fusion, stem cell potency, epigenetic reprogramming, tetraploid hybrids, embryonic stem cells, pluripotency, chimerism
- MeSH terms
- Animals, Anti-Bacterial Agents, Antigens, Differentiation, Blastocyst, Brain, Cell Differentiation, Cell Fusion, Cell Line, Cells, Cultured, Chimera, Cinnamates, Drug Resistance, Embryo, Mammalian, Female, Embryonic and Fetal Development, Hybrid Cells, Hygromycin B, Male, Mice, Inbred C57BL, Mice, Transgenic, Neurons, Stem Cells, Coculture Techniques, Mice
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