Cited by 1,494Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Changing potency by spontaneous fusion

Ying, Qi-Long, Nichols, Jennifer, Evans, Edward P., Smith, Austin G.·2002·Nature

DOI 10.1038/nature729

Open this paper in CoChat — free account

Abstract

Recent reports have suggested that mammalian stem cells residing in one tissue may have the capacity to produce differentiated cell types for other tissues and organs 1-9. Here we define a mechanism by which progenitor cells of the central nervous system can give rise to non-neural derivatives. Cells taken from mouse brain were co-cultured with pluripotent embryonic stem cells. Following selection for a transgenic marker carried only by the brain cells, undifferentiated stem cells are recovered in which the brain cell genome has undergone epigenetic reprogramming. However, these cells also carry a transgenic marker and chromosomes derived from the embryonic stem cells. Therefore the altered phenotype does not arise by direct conversion of brain to embryonic stem cell but rather through spontaneous generation of hybrid cells. The tetraploid hybrids exhibit full pluripotent character, including multilineage contribution to chimaeras. We propose that transdetermination consequent to cell fusion 10 could underlie many observations otherwise attributed to an intrinsic plasticity of tissue stem cells 9.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nature729

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Bone marrow cells regenerate infarcted myocardium
Orlic, D., Kajstura, J., Chimenti, S., Jakoniuk, I., Anderson, S. M., Li, B., Pickel, J. M., McKay, R. D. G., Nadal‐Ginard, B., Bodine, D. M., et al. (2001) · Nature · doi:10.1038/35070587 · Cited by 5,149
Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells
Niwa, H., Miyazaki, J., & Smith, A. G. (2000) · Nature Genetics · doi:10.1038/74199 · Cited by 3,904
Self-citation
Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4
Nichols, J., Zevnik, B., Anastassiadis, K., Niwa, H., Klewe-Nebenius, D., Chambers, I., Schöler, H. R., & Smith, A. G. (1998) · Cell · doi:10.1016/s0092-8674(00)81769-9 · Cited by 3,394
Self-citation
Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors
Ferrari, G., Cusella, G., Angelis, D., Coletta, M., Paolucci, E., Stornaiuolo, A., Cossu, G., & Mavilio, F. (1998) · Science · doi:10.1126/science.279.5356.1528 · Cited by 2,721
Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell
Krause, D. S., Theise, N. D., Collector, M. I., Henegariu, O., Hwang, S., Gardner, R. L., Neutzel, S., & Sharkis, S. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00328-2 · Cited by 2,647
Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
Lagasse, E., Connors, H., Al-Dhalimy, M., Reitsma, M., Dohse, M., Osborne, L., Wang, X., Finegold, M., Weissman, I. L., & Grompe, M. (2000) · Nature Medicine · doi:10.1038/81326 · Cited by 2,314
The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium
Doetschman, T., Eistetter, H. R., Katz, M., Schmidt, W., & Kemler, R. (1985) · Development · doi:10.1242/dev.87.1.27 · Cited by 1,962
Turning Blood into Brain: Cells Bearing Neuronal Antigens Generated in Vivo from Bone Marrow
Mezey, É., Chandross, K. J., Harta, G., Maki, R. A., & McKercher, S. R. (2000) · Science · doi:10.1126/science.290.5497.1779 · Cited by 1,814
From Marrow to Brain: Expression of Neuronal Phenotypes in Adult Mice
Brazelton, T. R., Rossi, F. M. V., Keshet, G. I., & Blau, H. M. (2000) · Science · doi:10.1126/science.290.5497.1775 · Cited by 1,666
Genetic variants and strains of the laboratory mouse
(1990) · Choice Reviews Online · doi:10.5860/choice.28-1324 · Cited by 1,492

Flagged first, then by citations

Show all 30 references

Research works printed but not linked: 1

Robertson, E. J. Teratocarcinoma and Embryo-derived Stem Cells: A Practical Approach (IRL, Oxford, 1987)

Sorted by citations

Items 101–200 of 1,000

Lymphoma-Specific Genetic Aberrations in Microvascular Endothelial Cells in B-Cell Lymphomas
Streubel, B., Chott, A., Huber, D., Exner, M., Jaeger, U., Wagner, O. F., & Schwarzinger, I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa033153 · Cited by 318
Human Mesenchymal Stem Cells Reprogram Adult Cardiomyocytes Toward a Progenitor-Like State Through Partial Cell Fusion and Mitochondria Transfer
Acquistapace, A., Bru, T., Lesault, P., Figeac, F., Coudert, A. E., Coz, O. L., Christov, C., Baudin, X., Auber, F., Yiou, R., et al. (2011) · Stem Cells · doi:10.1002/stem.632 · Cited by 312
In vivo contribution of murine mesenchymal stem cells into multiple cell-types under minimal damage conditions
Anjos‐Afonso, F., Siapati, E. K., & Bonnet, D. A. (2004) · Journal of Cell Science · doi:10.1242/jcs.01488 · Cited by 313
A role for chemistry in stem cell biology
Ding, S., & Schultz, P. G. (2004) · Nature Biotechnology · doi:10.1038/nbt987 · Cited by 314
Global stem cell research trend: Bibliometric analysis as a tool for mapping of trends from 1991 to 2006
Li, L., Ding, G., Nan, F., Wang, M.-H., & Ho, Y. (2009) · Scientometrics · doi:10.1007/s11192-008-1939-5 · Cited by 304
Human embryonic stem cells: research, ethics and policy
de Wert, G. M. W. R. (2003) · Human Reproduction · doi:10.1093/humrep/deg143 · Cited by 301
Neural stem cell therapy for neurological diseases: dreams and reality
Rossi, F., & Cattaneo, E. F. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn809 · Cited by 299
From Stem Cells to Viable Autologous Semilunar Heart Valve
Sutherland, F. W. H., Perry, T. E., Yu, Y., Sherwood, M. C., Aikawa, E. R., Masuda, Y., Garcia, G. A., McLellan, D. L., Engelmayr, G. C., Sacks, M. S., et al. (2005) · Circulation · doi:10.1161/circulationaha.104.498378 · Cited by 297
Adult Stem Cell Plasticity: Fact or Artifact?
RAFF, M. C. (2003) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.111301.143037 · Cited by 296
Cell fusion: A hidden enemy?
Duelli, D. M., & Lazebnik, Y. A. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00114-4 · Cited by 291
Neural cells derived from adult bone marrow and umbilical cord blood
Sanchez‐Ramos, J. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10337 · Cited by 291
Multipotent stem cells from adult olfactory mucosa
Murrell, W. G., Feron, F. P., Wetzig, A. R., Cameron, N., Splatt, K. J., Bellette, B., Bianco, J. I., Perry, C., Lee, G., & Mackay‐Sim, A. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20360 · Cited by 289
Induction of Dedifferentiation, Genomewide Transcriptional Programming, and Epigenetic Reprogramming by Extracts of Carcinoma and Embryonic Stem Cells
Taranger, C. K., Noer, A., Sørensen, A. L., Håkelien, A.-M., Boquest, A. C., & Collas, P. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-06-0572 · Cited by 287
Adult bone marrow-derived cells trans-differentiating into insulin-producing cells for the treatment of type I diabetes
Oh, S., Muzzonigro, T. M., Bae, S., Laplante, J., Hatch, H. M., & Petersen, B. E. (2004) · Laboratory Investigation · doi:10.1038/labinvest.3700074 · Cited by 284
Retinal transplantation of photoreceptors results in donor–host cytoplasmic exchange
Santos‐Ferreira, T., Llonch, S., Borsch, O., Postel, K., Haas, J., & Ader, M. (2016) · Nature Communications · doi:10.1038/ncomms13028 · Cited by 277
Adult stem cell plasticity
Poulsom, R., Alison, M. R., Forbes, S. J., & Wright, N. A. (2002) · The Journal of Pathology · doi:10.1002/path.1176 · Cited by 277
An introduction to stem cells
Alison, M. R., Poulsom, R., Forbes, S. J., & Wright, N. A. (2002) · The Journal of Pathology · doi:10.1002/path.1187 · Cited by 275
Nuclei of Embryonic Stem Cells Reprogram Somatic Cells
Tae, J., & Schöler, H. R. (2004) · Stem Cells · doi:10.1634/stemcells.22-6-941 · Cited by 275
Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion
Newsome, P. N., Johannessen, I., Boyle, S., Dalakas, E., McAulay, K. A., Samuel, K., Rae, F., Forrester, L. M., Turner, M., Hayes, P. C., et al. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00401-3 · Cited by 275
Stem and progenitor cell-mediated tumor selective gene therapy
Aboody, K. S., Najbauer, J., & Danks, M. K. (2008) · Gene Therapy · doi:10.1038/gt.2008.41 · Cited by 272
Transplanted adult hematopoietic stems cells differentiate into functional endothelial cells
Bailey, A. S., Jiang, S., Afentoulis, M. E., Baumann, C. I., Schroeder, D. A., Olson, S. B., Wong, M. H., & Fleming, W. (2003) · Blood · doi:10.1182/blood-2003-05-1684 · Cited by 270
Determination of bone marrow–derived endothelial progenitor cell significance in angiogenic growth factor–induced neovascularization in vivo
Murayama, T., Tepper, O. M., Silver, M., Ma, H., Losordo, D. W., Isner, J. M., Asahara, T., & Kalka, C. (2002) · Experimental Hematology · doi:10.1016/s0301-472x(02)00867-6 · Cited by 268
Heterogeneity of mesenchymal stromal cell preparations
Ho, A. D., Wagner, W., & Franke, W. W. (2008) · Cytotherapy · doi:10.1080/14653240802217011 · Cited by 265
Neurosphere and neurosphere-forming cells: morphological and ultrastructural characterization
Bez, A., Corsini, E., Curti, D., Biggiogera, M., Colombo, A., Nicosia, R. F., Pagano, S., & Parati, E. A. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.061 · Cited by 261
Nephrogenic Factors Promote Differentiation of Mouse Embryonic Stem Cells into Renal Epithelia
Kim, D., & Dressler, G. R. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005050544 · Cited by 266
Bone Marrow–Derived Cells for Enhancing Collateral Development
Kinnaird, T. D., Stabile, E., Burnett, M. S., & Epstein, S. E. (2004) · Circulation Research · doi:10.1161/01.res.0000137878.26174.66 · Cited by 268
Stem cell plasticity
Lakshmipathy, U., & Verfaillie, C. M. (2004) · Blood Reviews · doi:10.1016/j.blre.2004.03.001 · Cited by 264
Contribution of hematopoietic stem cells to skeletal muscle
Corbel, S. Y., Lee, A., Yi, L., Duenas, J., Brazelton, T. R., Blau, H. M., & Rossi, F. M. V. (2003) · Nature Medicine · doi:10.1038/nm959 · Cited by 264
Cell–cell fusion
Chen, E. H., Grote, E., Mohler, W., & Vignery, A. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.03.033 · Cited by 263
Muscle stem cells differentiate into haematopoietic lineages but retain myogenic potential
Cao, B., Zheng, B. J., Jankowski, R. J., Kimura, S., Ikezawa, M., Deasy, B. M., Cummins, J. H., Epperly, M., Qu‐Petersen, Z., & Huard, J. (2003) · Nature Cell Biology · doi:10.1038/ncb1008 · Cited by 263
Mesenchymal Stem Cell Preparations—Comparing Apples and Oranges
Wagner, W., & Ho, A. D. (2007) · Stem Cell Reviews and Reports · doi:10.1007/s12015-007-9001-1 · Cited by 260
Notch Promotes Neural Lineage Entry by Pluripotent Embryonic Stem Cells
Lowell, S., Benchoua, A., Heavey, B., & Smith, A. G. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040121 · Cited by 260
Self-citation
A Genome-Scale RNAi Screen for Oct4 Modulators Defines a Role of the Paf1 Complex for Embryonic Stem Cell Identity
Ding, L., Paszkowski‐Rogacz, M., Nitzsche, A., Slabicki, M. M., Heninger, A., de Vries, I., Kittler, R., Junqueira, M., Shevchenko, A., Schulz, H., et al. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.03.009 · Cited by 263
Directing Stem Cell Differentiation into the Chondrogenic Lineage In Vitro
Heng, B. C., Cao, T., & Lee, E. H. (2004) · Stem Cells · doi:10.1634/stemcells.2004-0062 · Cited by 254
Stem cells in retinal regeneration: past, present and future
Ramsden, C. M., Powner, M. B., Carr, A. F., Smart, M. J. K., da Cruz, L., & Coffey, P. J. (2013) · Development · doi:10.1242/dev.092270 · Cited by 259
Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells
Taléns‐Visconti, R. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i36.5834 · Cited by 253
Human Embryonic Germ Cell Derivatives Facilitate Motor Recovery of Rats with Diffuse Motor Neuron Injury
Kerr, D. A., Lladó, J., Shamblott, M. J., Maragakis, N. J., Irani, D. N., Crawford, T. O., Krishnan, C., Dike, S., Gearhart, J. D., & Rothstein, J. D. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-12-05131.2003 · Cited by 251
Bone marrow-derived cells that populate the adult mouse brain preserve their hematopoietic identity
Vallières, L., & Sawchenko, P. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-12-05197.2003 · Cited by 245
Albumin-expressing hepatocyte-like cells develop in the livers of immune-deficient mice that received transplants of highly purified human hematopoietic stem cells
Wang, X., Ge, S., McNamara, G. T., Hao, Q., Crooks, G. M., & Nolta, J. A. (2003) · Blood · doi:10.1182/blood-2002-05-1338 · Cited by 243
Regulation of Progenitor Cell Fusion by ABCB5 P-glycoprotein, a Novel Human ATP-binding Cassette Transporter
Frank, N. Y., Pendse, S. S., Lapchak, P. H., Margaryan, A., Shlain, D., Doeing, C., Sayegh, M. H., & Frank, M. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308700200 · Cited by 242
Tissue-specific muscle, neural and liver stem/progenitor cells reside in the bone marrow, respond to an SDF-1 gradient and are mobilized into peripheral blood during stress and tissue injury
Kucia, M., Ratajczak, J., Reca, R., Janowska-Wieczorek, A., & Ratajczak, M. Z. (2003) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2003.09.025 · Cited by 240
Kinetics of Liver Repopulation after Bone Marrow Transplantation
Wang, X., Montini, E., Al-Dhalimy, M., Lagasse, E., Finegold, M. J., & Grompe, M. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64212-5 · Cited by 236
Stem cells and repair of the heart
Mathur, A., & Martin, J. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16632-4 · Cited by 235
Ectoderm to Mesoderm Lineage Switching During Axolotl Tail Regeneration
Echeverri, K., & Tanaka, E. M. (2002) · Science · doi:10.1126/science.1077804 · Cited by 232
Enhancers are activated by p300/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release
Narita, T., Ito, S., Higashijima, Y., Chu, W. K., Neumann, K., Walter, J., Satpathy, S., Liebner, T., Hamilton, W. B., Maskey, E., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.03.008 · Cited by 228
Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis.
Gu, G.-Q., Brown, J. R., & Melton, D. (2003) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00330-1 · Cited by 236
Treatment of severe autoimmune disease by stem-cell transplantation
Sykes, M., & Nikolic, B. (2005) · Nature · doi:10.1038/nature03728 · Cited by 225
Small Molecules that Induce Cardiomyogenesis in Embryonic Stem Cells
Wu, X., Ding, S., Ding, Q., Gray, N. S., & Schultz, P. G. (2004) · Journal of the American Chemical Society · doi:10.1021/ja038950i · Cited by 226
Adult Bone Marrow Stromal Cells in the Embryonic Brain: Engraftment, Migration, Differentiation, and Long-Term Survival
Muñoz‐Elías, G., Marcus, A. J., Coyne, T. M., Woodbury, D., & Black, I. B. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5060-03.2004 · Cited by 224
Stem Cells: Hype and Reality
Verfaillie, C. M., Pera, M. F., & Lansdorp, P. M. (2002) · Hematology · doi:10.1182/asheducation-2002.1.369 · Cited by 223
Age‐related impairment of mesenchymal progenitor cell function
Stolzing, A., & Scutt, A. M. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00213.x · Cited by 219
Physiological Coupling of Donor and Host Cardiomyocytes After Cellular Transplantation
Rubart, M., Pasumarthi, K. B. S., Nakajima, H., Soonpaa, M. H., Nakajima, H. O., & Field, L. J. (2003) · Circulation Research · doi:10.1161/01.res.0000075089.39335.8c · Cited by 221
Region-specific generation of cholinergic neurons from fetal human neural stem cells grafted in adult rat
Wu, P., Tarasenko, Y. I., Gu, Y., Huang, L.-Y. M., Coggeshall, R. E., & Yu, Y. (2002) · Nature Neuroscience · doi:10.1038/nn974 · Cited by 221
Stem cells for regenerative medicine: advances in the engineering of tissues and organs
Ringe, J., Kaps, C., Burmester, G.-R. X. F. D., & Sittinger, M. (2002) · Die Naturwissenschaften · doi:10.1007/s00114-002-0344-9 · Cited by 220
Cardiomyogenic Potential of C-Kit + –Expressing Cells Derived From Neonatal and Adult Mouse Hearts
Zaruba, M., Soonpaa, M. H., Reuter, S. P., & Field, L. J. (2010) · Circulation · doi:10.1161/circulationaha.109.909093 · Cited by 216
Mesenchymal Stem Cells and the Artery Wall
Abedin, M., Tintut, Y., & Demer, L. L. (2004) · Circulation Research · doi:10.1161/01.res.0000143421.27684.12 · Cited by 216
Neural transdifferentiation of mesenchymal stem cells – a critical review
Krabbe, C., Zimmer, J., & Meyer, M. (2005) · Apmis · doi:10.1111/j.1600-0463.2005.apm_3061.x · Cited by 214
Xenotransplanted human cortical neurons reveal species-specific development and functional integration into mouse visual circuits
Linaro, D., Vermaercke, B., Iwata, R., Ramaswamy, A., Davis, B. A., Boubakar, L., Libé-Philippot, B., Bilheu, A., Bruyne, L. D., Gall, D., et al. (2019) · doi:10.1101/626218 · Cited by 210
“Transplantation of GFP human neurons into transgenic mice in which tdTomato is expressed in pyramidal neurons revealed no GFP/tdTomato double-positive cells (0 of 40 cells examined by confocal microscopy, n = 2 animals) (Figure S1), indicating the absence of transplant-to-host cell fusion events (Ying et al., 2002).”
Background
FGF-2 controls the differentiation of resident cardiac precursors into functional cardiomyocytes
Rosenblatt‐Velin, N., Lepore, M. G., Cartoni, C., Beermann, F., & Pedrazzini, T. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23418 · Cited by 208
Stem cells for ischemic brain injury: A critical review
Burns, T. C., Verfaillie, C. M., & Low, W. C. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22038 · Cited by 208
Cell-to-cell fusion as a link between viruses and cancer
Duelli, D. M., & Lazebnik, Y. A. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2272 · Cited by 209
Cell fusion causes confusion
Wurmser, A. E., & Gage, F. H. (2002) · Nature · doi:10.1038/416485a · Cited by 204
Embryonic and adult stem cell therapy
Brignier, A., & Gewirtz, A. M. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.09.032 · Cited by 205
Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle‐derived stem cells expressing bone morphogenetic protein 4 and soluble flt‐1
Matsumoto, T., Cooper, G. M., Gharaibeh, B., Meszaros, L. B., Li, G., Ūsas, A., Fu, F. H., & Huard, J. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24443 · Cited by 203
Myocardial-tissue-specific phenotype of maternal microchimerism in neonatal lupus congenital heart block
Stevens, A. M., Hermes, H. M., Rutledge, J. C., Buyon, J. P., & Nelson, J. L. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14795-2 · Cited by 200
Epigenetic Reprogramming ofOCT4andNANOGRegulatory Regions by Embryonal Carcinoma Cell Extract
Freberg, C. T., Dahl, J. A., Barrand, S., & Collas, P. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-01-0029 · Cited by 198
Both Cell Fusion and Transdifferentiation Account for the Transformation of Human Peripheral Blood CD34-Positive Cells Into Cardiomyocytes In Vivo
Zhang, S., Wang, D., Estrov, Z. E., Raj, S. D., Willerson, J. T., & Yeh, E. T. H. (2004) · Circulation · doi:10.1161/01.cir.0000150796.18473.8e · Cited by 196
The role of stem cells in aging
Zant, G. E. V., & Liang, Y. (2003) · Experimental Hematology · doi:10.1016/s0301-472x(03)00088-2 · Cited by 197
Hepatic stem cells
Forbes, S. J., Vig, P., Poulsom, R., Thomas, H. C., & Alison, M. R. (2002) · The Journal of Pathology · doi:10.1002/path.1163 · Cited by 195
Bone marrow as a home of heterogenous populations of nonhematopoietic stem cells
Kucia, M., Reca, R., Jala, V. R., Dawn, B., Ratajczak, J., & Ratajczak, M. Z. (2005) · Leukemia · doi:10.1038/sj.leu.2403796 · Cited by 195
Advances in Reprogramming Somatic Cells to Induced Pluripotent Stem Cells
Patel, M. J., & Yang, S. (2010) · Stem Cell Reviews and Reports · doi:10.1007/s12015-010-9123-8 · Cited by 194
Intratracheal mesenchymal stem cell administration attenuates monocrotaline-induced pulmonary hypertension and endothelial dysfunction
Baber, S. R., Deng, W., Master, R. G., Bunnell, B. A., Taylor, B. K., Murthy, S. N., Hyman, A. L., & Kadowitz, P. J. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00173.2006 · Cited by 193
Pluripotency and nuclear reprogramming
Yamanaka, S. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.2261 · Cited by 199
Efficient generation of neural precursors from adult human skin: astrocytes promote neurogenesis from skin-derived stem cells
Joannides, A. J., Gaughwin, P., Schwiening, C. J., Majed, H., Sterling, J. C., Compston, A., & Chandran, S. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16630-0 · Cited by 192
Control of three-dimensional substrate stiffness to manipulate mesenchymal stem cell fate toward neuronal or glial lineages
Her, G. J., Wu, H., Chen, M., Chen, M., Chang, S.-C., & Wang, T. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.10.012 · Cited by 189
Myoendothelial Differentiation of Human Umbilical Cord Blood–Derived Stem Cells in Ischemic Limb Tissues
Pesce, M., Orlandi, A., Iachininoto, M. G., Straino, S., Torella, A. R., Rizzuti, V., Pompilio, G., Bonanno, G., Scambia, G., & Capogrossi, M. C. (2003) · Circulation Research · doi:10.1161/01.res.0000090624.04507.45 · Cited by 189
Stat3 and c-Myc genome-wide promoter occupancy in embryonic stem cells
Kidder, B. L., Yang, J., & Palmer, S. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003932 · Cited by 184
Differentiation of human bone marrow-derived cells into buccal epithelial cells in vivo: a molecular analytical study
Tran, S. D., Pillemer, S. R., Dutra, A., Barrett, A. J., Brownstein, M., Key, S., Pak, E. D., Leakan, R. A., Kingman, A., Yamada, K. M., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12894-2 · Cited by 184
Hematopoietic origin of glomerular mesangial cells
Masuya, M., Drake, C. J., Fleming, P. A., Reilly, C. M., Zeng, H., Hill, W., Martin-Studdard, A., Hess, D. C., & Ogawa, M. (2003) · Blood · doi:10.1182/blood-2002-04-1076 · Cited by 183
Reduced Oct4 Expression Directs a Robust Pluripotent State with Distinct Signaling Activity and Increased Enhancer Occupancy by Oct4 and Nanog
Karwacki-Neisius, V., Göke, J., Osorno, R., Halbritter, F., Ng, J. H., Weiße, A. Y., Wong, F. C. K., Gagliardi, A., Mullin, N. P., Festuccia, N., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.04.023 · Cited by 177
Hair follicle dermal cells repopulate the mouse haematopoietic system
Lako, M., Armstrong, L., Cairns, P. M., Harris, S. J., Hole, N., & Jahoda, C. A. B. (2002) · Journal of Cell Science · doi:10.1242/jcs.00060 · Cited by 182
Strategies for Directing the Differentiation of Stem Cells Into the Osteogenic Lineage In Vitro
Heng, B. C., Cao, T., Stanton, L. W., Robson, P., & Olsen, B. R. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040714 · Cited by 182
Fetal stem cells
O’Donoghue, K., & Fisk, N. M. (2004) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2004.06.010 · Cited by 179
Keratinocyte Stem Cells: a Commentary1
Potten, C. S., & Booth, C. E. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.00020.x · Cited by 180
Bone-Marrow-Derived Cells Contribute to Glomerular Endothelial Repair in Experimental Glomerulonephritis
Rookmaaker, M. B., Smits, A. M., Tolboom, H., Wout, K. V. '., Martens, A. C., Goldschmeding, R., Joles, J. A., van Zonneveld, A. J., Gröne, H.-J., Rabelink, T. J., et al. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63683-8 · Cited by 179
An In Vivo Analysis of Hematopoietic Stem Cell Potential
Visconti, R. P., Ebihara, Y., LaRue, A. C., Fleming, P. A., McQuinn, T. C., Masuya, M., Minamiguchi, H., Markwald, R. R., Ogawa, M., & Drake, C. J. (2006) · Circulation Research · doi:10.1161/01.res.0000207384.81818.d4 · Cited by 177
Prometheus's Vulture and the Stem-Cell Promise
Rosenthal, N. A. (2003) · New England Journal of Medicine · doi:10.1056/nejmra020849 · Cited by 177
An In Vivo Model for Monitoring Trans-Differentiation of Bone Marrow Cells into Functional Hepatocytes
Terai, S. (2003) · The Journal of Biochemistry · doi:10.1093/jb/mvg173 · Cited by 175
Bone marrow as a source of circulating CXCR4+ tissue‐committed stem cells
Kucia, M., Ratajczak, J., & Ratajczak, M. Z. (2005) · Biology of the Cell · doi:10.1042/bc20040069 · Cited by 173
Strategies for directing the differentiation of stem cells into the cardiomyogenic lineage in vitro
Heng, B. C. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.12.022 · Cited by 173
Mesenchymal Stem Cells Transfer Mitochondria to the Cells with Virtually No Mitochondrial Function but Not with Pathogenic mtDNA Mutations
Cho, Y. M., Kim, J. H., Kim, M., Park, S. J., Koh, S. H., Ahn, H. S., Kang, G. H., Lee, J.-B., Park, K. S., & Lee, H. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032778 · Cited by 173
The developmental dismantling of pluripotency is reversed by ectopic Oct4 expression
Osorno, R., Tsakiridis, A., Wong, F. C. K., Cambray, N., Economou, C., Wilkie, R., Blin, G., Scotting, P. J., Chambers, I., & Wilson, V. A. (2012) · Development · doi:10.1242/dev.078071 · Cited by 172
Fip1 regulates mRNA alternative polyadenylation to promote stem cell self‐renewal
Lackford, B. L., Yao, C., Charles, G. M., Weng, L., Zheng, X., Choi, E., Xie, X. S., Wan, J., Xing, Y., Freudenberg, J., et al. (2014) · The EMBO Journal · doi:10.1002/embj.201386537 · Cited by 165
Biology of bone marrow-derived endothelial cell precursors
Schatteman, G. C., Dunnwald, M., & Jiao, C. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00662.2006 · Cited by 160
C1qR p defines a new human stem cell population with hematopoietic and hepatic potential
Danet, G. H., Luongo, J. L., Butler, G., Lu, M. M., Tenner, A. J., Simon, M. C., & Bonnet, D. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162104799 · Cited by 164
Human CD34 + cells differentiate into microglia and express recombinant therapeutic protein
Asheuer, M., Pflumio, F., Benhamida, S., Dubart‐Kupperschmitt, A., Fouquet, F., Imai, Y., Aubourg, P. R., & Cartier, N. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306431101 · Cited by 163
Transformation of Human Umbilical Mesenchymal Cells into Neurons in vitro
Fu, Y.-S., Shih, Y., Cheng, Y.-C., & Min, M. (2004) · Journal of Biomedical Science · doi:10.1007/bf02256131 · Cited by 162
Stem cells, cell transplantation and liver repopulation
Oertel, M., & Shafritz, D. A. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2007.12.004 · Cited by 162
Small molecules, big roles – the chemical manipulation of stem cell fate and somatic cell reprogramming
Zhang, Y., Li, W., Laurent, T., & Ding, S. (2012) · Journal of Cell Science · doi:10.1242/jcs.096032 · Cited by 165
Muscle-derived stem cells for musculoskeletal tissue regeneration and repair
Peng, H., & Huard, J. (2004) · Transplant Immunology · doi:10.1016/j.trim.2003.12.009 · Cited by 163

Authors: Ying, Q.-L., Nichols, J., Evans, E. P., & Smith, A. G.
Affiliations: University of Edinburgh (GB)
University of Oxford (GB)
Corresponding author: Smith, Austin G.
ORCID: Ying, Qi-Long
Nichols, Jennifer
Smith, Austin G.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2002-03-13
Volume: 416
Issue: 6880
Pages: 545-548
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature729
OpenAlex: W2109794889
Cited by: 1,494
References: 30
Citations by year: 2026: 4 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 10 · 2021: 9 · 2020: 12 · 2019: 8 · 2018: 7 · 2017: 26 · 2016: 11 · 2015: 23 · 2014: 34 · 2013: 36 · 2012: 62
FWCI: 79.91
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
ERA (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: transdetermination, cell fusion, stem cell potency, epigenetic reprogramming, tetraploid hybrids, embryonic stem cells, pluripotency, chimerism
MeSH terms: Animals, Anti-Bacterial Agents, Antigens, Differentiation, Blastocyst, Brain, Cell Differentiation, Cell Fusion, Cell Line, Cells, Cultured, Chimera, Cinnamates, Drug Resistance, Embryo, Mammalian, Female, Embryonic and Fetal Development, Hybrid Cells, Hygromycin B, Male, Mice, Inbred C57BL, Mice, Transgenic, Neurons, Stem Cells, Coculture Techniques, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Changing potency by spontaneous fusion

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks