Cited by 1,494Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

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Changing potency by spontaneous fusion

Ying, Qi-Long, Nichols, Jennifer, Evans, Edward P., Smith, Austin G.·2002·Nature

DOI 10.1038/nature729

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Abstract

Recent reports have suggested that mammalian stem cells residing in one tissue may have the capacity to produce differentiated cell types for other tissues and organs 1-9. Here we define a mechanism by which progenitor cells of the central nervous system can give rise to non-neural derivatives. Cells taken from mouse brain were co-cultured with pluripotent embryonic stem cells. Following selection for a transgenic marker carried only by the brain cells, undifferentiated stem cells are recovered in which the brain cell genome has undergone epigenetic reprogramming. However, these cells also carry a transgenic marker and chromosomes derived from the embryonic stem cells. Therefore the altered phenotype does not arise by direct conversion of brain to embryonic stem cell but rather through spontaneous generation of hybrid cells. The tetraploid hybrids exhibit full pluripotent character, including multilineage contribution to chimaeras. We propose that transdetermination consequent to cell fusion 10 could underlie many observations otherwise attributed to an intrinsic plasticity of tissue stem cells 9.

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Nichols, J., Zevnik, B., Anastassiadis, K., Niwa, H., Klewe-Nebenius, D., Chambers, I., Schöler, H. R., & Smith, A. G. (1998) · Cell · doi:10.1016/s0092-8674(00)81769-9 · Cited by 3,394
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Ferrari, G., Cusella, G., Angelis, D., Coletta, M., Paolucci, E., Stornaiuolo, A., Cossu, G., & Mavilio, F. (1998) · Science · doi:10.1126/science.279.5356.1528 · Cited by 2,721
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Lagasse, E., Connors, H., Al-Dhalimy, M., Reitsma, M., Dohse, M., Osborne, L., Wang, X., Finegold, M., Weissman, I. L., & Grompe, M. (2000) · Nature Medicine · doi:10.1038/81326 · Cited by 2,314
The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium
Doetschman, T., Eistetter, H. R., Katz, M., Schmidt, W., & Kemler, R. (1985) · Development · doi:10.1242/dev.87.1.27 · Cited by 1,962
Turning Blood into Brain: Cells Bearing Neuronal Antigens Generated in Vivo from Bone Marrow
Mezey, É., Chandross, K. J., Harta, G., Maki, R. A., & McKercher, S. R. (2000) · Science · doi:10.1126/science.290.5497.1779 · Cited by 1,814
From Marrow to Brain: Expression of Neuronal Phenotypes in Adult Mice
Brazelton, T. R., Rossi, F. M. V., Keshet, G. I., & Blau, H. M. (2000) · Science · doi:10.1126/science.290.5497.1775 · Cited by 1,666
Genetic variants and strains of the laboratory mouse
(1990) · Choice Reviews Online · doi:10.5860/choice.28-1324 · Cited by 1,492

Show all 30 references

Research works printed but not linked: 1

Robertson, E. J. Teratocarcinoma and Embryo-derived Stem Cells: A Practical Approach (IRL, Oxford, 1987)

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Behfar, A., Zingman, L. V., Hodgson, D. M., Rauzier, J., Kane, G. C., Terzic, A., & Pucéat, M. (2002) · The FASEB Journal · doi:10.1096/fj.02-0072com · Cited by 477
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Zhao, Y. L., Glesne, D. A., & Huberman, E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0536882100 · Cited by 458
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Li, H., Liu, H., & Heller, S. (2003) · Nature Medicine · doi:10.1038/nm925 · Cited by 463
The post‐natal heart contains a myocardial stem cell population
Hierlihy, A. M., Seale, P., Lobe, C. G., Rudnicki, M. A., & Megeney, L. A. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03477-4 · Cited by 452
Cardiac Stem Cells and Mechanisms of Myocardial Regeneration
Leri, A., Kajstura, J., & Anversa, P. (2005) · Physiological Reviews · doi:10.1152/physrev.00013.2005 · Cited by 451
Mesenchymal stem cells: isolation, in vitro expansion and characterization.
Nardi, N., & Meirelles, L. D. S. (2006) · Handbook of experimental pharmacology · doi:10.1007/3-540-31265-x_11 · Cited by 274
Adult vasculogenesis occurs through in situ recruitment, proliferation, and tubulization of circulating bone marrow–derived cells
Tepper, O. M., Capla, J. M., Galiano, R. D., Ceradini, D. J., Callaghan, M. J., Kleinman, M. E., & Gurtner, G. C. (2004) · Blood · doi:10.1182/blood-2004-03-1051 · Cited by 446
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Baum, C., Düllmann, J., Li, Z., Fehse, B., Meyer, J., Williams, D. A., & Kalle, C. V. (2003) · Blood · doi:10.1182/blood-2002-07-2314 · Cited by 431
Contribution of transplanted bone marrow cells to Purkinje neurons in human adult brains
Weimann, J. M., Charlton, C. A., Brazelton, T. R., Hackman, R. C., & Blau, H. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337659100 · Cited by 429
Isolation and characterization of multipotent human periodontal ligament stem cells
Gay, I., Chen, S., & MacDougall, M. J. (2007) · Orthodontics and Craniofacial Research · doi:10.1111/j.1601-6343.2007.00399.x · Cited by 420
One strategy for cell and gene therapy: Harnessing the power of adult stem cells to repair tissues
Prockop, D. J., Gregory, C. A., & Spees, J. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834138100 · Cited by 417
Citrullination regulates pluripotency and histone H1 binding to chromatin
Christophorou, M. A., Castelo‐Branco, G., Halley‐Stott, R. P., Oliveira, C. S., Loos, R., Radzisheuskaya, A., Mowen, K. A., Bertone, P., Silva, J., Zernicka‐Goetz, M., et al. (2014) · Nature · doi:10.1038/nature12942 · Cited by 409
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Ridder, K., Keller, S., Dams, M., Rupp, A.-K., Schlaudraff, J., Del Turco, D., Starmann, J., Macas, J., Karpova, D., Devraj, K., et al. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001874 · Cited by 412
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Lin, F., Cordes, K. R., Li, L., Hood, L., Couser, W. G., Shankland, S. J., & Igarashi, P. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000061595.28546.a0 · Cited by 409
Lack of a Fusion Requirement for Development of Bone Marrow-Derived Epithelia
Harris, R. G., Herzog, E. L., Bruscia, E. M., Grove, J. E., Arnam, J. S. V., & Krause, D. S. (2004) · Science · doi:10.1126/science.1098925 · Cited by 407
Transdifferentiation potential of human mesenchymal stem cells derived from bone marrow
Song, L., & Tuan, R. S. (2004) · The FASEB Journal · doi:10.1096/fj.03-1100fje · Cited by 395
A genome-wide RNAi screen identifies a new transcriptional module required for self-renewalPreprint
Hu, G., Kim, J., Xu, Q., Leng, Y., Orkin, S. H., & Elledge, S. J. (2009) · Genes & Development · doi:10.1101/gad.1769609 · Cited by 400
Damaged epithelia regenerated by bone marrow–derived cells in the human gastrointestinal tract
Okamoto, R., Yajima, T., Yamazaki, M., Kanai∥, T., Mukai, M., Okamoto, S., Ikeda, Y., Hibi∥, T., Inazawa, J., & Watanabe, M. (2002) · Nature Medicine · doi:10.1038/nm755 · Cited by 382
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Cell fusion-independent differentiation of neural stem cells to the endothelial lineage
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Authors: Ying, Q.-L., Nichols, J., Evans, E. P., & Smith, A. G.
Affiliations: University of Edinburgh (GB)
University of Oxford (GB)
Corresponding author: Smith, Austin G.
ORCID: Ying, Qi-Long
Nichols, Jennifer
Smith, Austin G.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2002-03-13
Volume: 416
Issue: 6880
Pages: 545-548
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature729
OpenAlex: W2109794889
Cited by: 1,494
References: 30
Citations by year: 2026: 4 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 10 · 2021: 9 · 2020: 12 · 2019: 8 · 2018: 7 · 2017: 26 · 2016: 11 · 2015: 23 · 2014: 34 · 2013: 36 · 2012: 62
FWCI: 79.91
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
ERA (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: transdetermination, cell fusion, stem cell potency, epigenetic reprogramming, tetraploid hybrids, embryonic stem cells, pluripotency, chimerism
MeSH terms: Animals, Anti-Bacterial Agents, Antigens, Differentiation, Blastocyst, Brain, Cell Differentiation, Cell Fusion, Cell Line, Cells, Cultured, Chimera, Cinnamates, Drug Resistance, Embryo, Mammalian, Female, Embryonic and Fetal Development, Hybrid Cells, Hygromycin B, Male, Mice, Inbred C57BL, Mice, Transgenic, Neurons, Stem Cells, Coculture Techniques, Mice

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