The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Combinatorial discovery of polymers resistant to bacterial attachment
Open accessAbstract
Bacterial attachment and subsequent biofilm formation pose key challenges to the optimal performance of medical devices. In this study, we determined the attachment of selected bacterial species to hundreds of polymeric materials in a high-throughput microarray format. Using this method, we identified a group of structurally related materials comprising ester and cyclic hydrocarbon moieties that substantially reduced the attachment of pathogenic bacteria (Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli). Coating silicone with these 'hit' materials achieved up to a 30-fold (96.7%) reduction in the surface area covered by bacteria compared with a commercial silver hydrogel coating in vitro, and the same material coatings were effective at reducing bacterial attachment in vivo in a mouse implant infection model. These polymers represent a class of materials that reduce the attachment of bacteria that could not have been predicted to have this property from the current understanding of bacteria-surface interactions.
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Cites
Bacterial Biofilms: A Common Cause of Persistent Infections
Costerton, J. W., Stewart, P. S., & Greenberg, E. P. (1999) · Science · doi:10.1126/science.284.5418.1318 · Cited by 12,167
Hidron, A. I., Edwards, J. R., Patel, J., Horan, T. C., Sievert, D. M., Pollock, D. A., Fridkin, S. K., & National Healthcare Safety Network Team and Participating National Healthcare Safety Network Facilities (2008) · Infection Control & Hospital Epidemiology · doi:10.1086/591861 · Cited by 3,724
Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells
Anderson, D. G., Levenberg, S., & Langer, R. (2004) · Nature Biotechnology · doi:10.1038/nbt981 · Cited by 747
Self-citation
Cited by
Rummel, C. D., Jahnke, A., Gorokhova, E., Kühnel, D., & Schmitt-Jansen, M. (2017) · Environmental Science & Technology Letters · doi:10.1021/acs.estlett.7b00164 · Cited by 1,444
Antibacterial surfaces: the quest for a new generation of biomaterials
Hasan, J., Crawford, R. J., & Ivanova, E. P. (2013) · Trends in Biotechnology · doi:10.1016/j.tibtech.2013.01.017 · Cited by 955
Muratov, E. N., Bajorath, J., Sheridan, R. P., Tetko, I. V., Filimonov, D., Poroikov, V., Oprea, T. I., Baskin, I. I., Varnek, A., Roitberg, A., et al. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00098a · Cited by 913
Tuson, H. H., & Weibel, D. B. (2013) · Soft Matter · doi:10.1039/c3sm27705d · Cited by 720
Biomaterial-Associated Infection: Locating the Finish Line in the Race for the Surface
Busscher, H. J., van der Mei, H. C., Subbiahdoss, G., Jutte, P. C., van den Dungen, J. J. A. M., Zaat, S. A. J., Schultz, M. J., & Grainger, D. W. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004528 · Cited by 707
Metadata
- Authors
- Hook, A. L., Chang, C.-Y., Yang, J., Luckett, J., Cockayne, A., Atkinson, S., Mei, Y., Bayston, R., Irvine, D. J., Langer, R., Anderson, D. G., Williams, P., Davies, M. C., & Alexander, M. R.
- Venue
- Nature Biotechnology
- Published
- 2012-08-12
- Volume
- 30
- Issue
- 9
- Pages
- 868-875
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W2162234852
- Cited by
- 376
- References
- 3
- FWCI
- 10.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hook, A. L., Chang, C.-Y., Yang, J., Luckett, J., Cockayne, A., Atkinson, S., Mei, Y., Bayston, R., Irvine, D. J., Langer, R., Anderson, D. G., Williams, P., Davies, M. C., & Alexander, M. R. (2012). Combinatorial discovery of polymers resistant to bacterial attachment. Nature Biotechnology. https://doi.org/10.1038/nbt.2316
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
