Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells
Abstract
Identification of biomaterials that support appropriate cellular attachment, proliferation and gene expression patterns is critical for tissue engineering and cell therapy. Here we describe an approach for rapid, nanoliter-scale synthesis of biomaterials and characterization of their interactions with cells. We simultaneously characterize over 1,700 human embryonic stem cell-material interactions and identify a host of unexpected materials effects that offer new levels of control over human embryonic stem cell behavior.
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Synthetic polymer-based culture allows organoid formation conditions to be evaluated using high-throughput methods.
“Synthetic polymer-based culture allows organoid formation conditions to be evaluated using high-throughput methods143–145.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [145]
Cites
Embryonic Stem Cell Lines Derived from Human Blastocysts
Thomson, J. A., Itskovitz‐Eldor, J., Shapiro, S. S., Waknitz, M. A., Swiergiel, J. J., Marshall, V. S., & Jones, J. M. (1998) · Science · doi:10.1126/science.282.5391.1145 · Cited by 15,947 · see citing works
Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray
Schena, M., Shalon, D., Davis, R. W., & Brown, P. O. (1995) · Science · doi:10.1126/science.270.5235.467 · Cited by 9,609 · see citing works
Moll, R., Franke, W. W., Schiller, D. L., Geiger, B., & Krepler, R. (1982) · Cell · doi:10.1016/0092-8674(82)90400-7 · Cited by 5,239 · see citing works
Printing Proteins as Microarrays for High-Throughput Function Determination
MacBeath, G., & Schreiber, S. L. (2000) · Science · doi:10.1126/science.289.5485.1760 · Cited by 2,767 · see citing works
Role of cell shape in growth control
Folkman, J., & Moscona, A. (1978) · Nature · doi:10.1038/273345a0 · Cited by 2,422 · see citing works
Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle
Yaffe, D., & Saxel, O. (1977) · Nature · doi:10.1038/270725a0 · Cited by 2,153 · see citing works
Principles of Tissue Engineering
(2014) · Elsevier eBooks · doi:10.1016/c2011-0-07193-4 · Cited by 1,909 · see citing works
Spradling, A. C., Drummond‐Barbosa, D., & Kai, T. (2001) · Nature · doi:10.1038/35102160 · Cited by 1,429 · see citing works
Endothelial cells derived from human embryonic stem cells
Levenberg, S., Golub, J. S., Amit, M., Itskovitz‐Eldor, J., & Langer, R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032074999 · Cited by 818 · see citing works
Self-citationDifferentiation of human embryonic stem cells on three-dimensional polymer scaffolds
Levenberg, S., Huang, N. F., Lavik, E., Rogers, A. B., Itskovitz‐Eldor, J., & Langer, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1735463100 · Cited by 691 · see citing works
Self-citationPrinciples of Tissue Engineering
Pegg, D. E. (1999) · Cryobiology · doi:10.1006/cryo.1999.2214 · Cited by 566 · see citing works
Extracellular matrix remodelling and cellular differentiation
Streuli, C. H. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)00026-5 · Cited by 512 · see citing works
Polymeric Growth Factor Delivery Strategies for Tissue Engineering
Chen, R. R., & Mooney, D. J. (2003) · Pharmaceutical Research · doi:10.1023/a:1025034925152 · Cited by 435 · see citing works
Printing Small Molecules as Microarrays and Detecting Protein−Ligand Interactions en Masse
MacBeath, G., Koehler, A. N., & Schreiber, S. L. (1999) · Journal of the American Chemical Society · doi:10.1021/ja991083q · Cited by 423 · see citing works
High content screening applied to large-scale cell biology
Abraham, V. (2003) · Trends in biotechnology · doi:10.1016/j.tibtech.2003.10.012 · Cited by 288 · see citing works
Functional Biomaterials: Design of Novel Biomaterials
Sakiyama‐Elbert, S. E., & Hubbell, J. A. (2001) · Annual Review of Materials Research · doi:10.1146/annurev.matsci.31.1.183 · Cited by 238 · see citing works
Photoinitiated Polymerization of Biomaterials
Fisher, J. P., Dean, D., Engel, P. S., & Mikos, A. G. (2001) · Annual Review of Materials Research · doi:10.1146/annurev.matsci.31.1.171 · Cited by 165 · see citing works
Plasma-treated PET surfaces improve the biocompatibility of human endothelial cells
Ramires, P. A., Mirenghi, L., Romano, A. R., Palumbo, F., & Nicolardi, G. (2000) · Journal of Biomedical Materials Research · doi:10.1002/1097-4636(20000905)51:3 · Cited by 127 · see citing works
CELL INTERACTIONS WITH POLYMERS
Saltzman, W. M. (2000) · Elsevier eBooks · doi:10.1016/b978-012436630-5/50023-4 · Cited by 32 · see citing works
Why do phospholipid polymers reduce protein adsorption?
Ishihara, K., Nomura, H., Mihara, T., Kurita, K., Iwasaki, Y., & Nakabayashi, N. (1998) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(199802)39:2
Flagged first, then by citations
1 of the 21 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Liu, Y., Ai, K., & Lu, L. (2014) · Chemical Reviews · doi:10.1021/cr400407a · Cited by 4,794 · see citing works
Lutolf, M. P., & Hubbell, J. A. (2005) · Nature Biotechnology · doi:10.1038/nbt1055 · Cited by 4,551 · see citing works
Hydrogels in regenerative medicine
Slaughter, B. V., Khurshid, S. S., Fisher, O. Z., Khademhosseini, A., & Peppas, N. A. (2009) · Advanced Materials · doi:10.1002/adma.200802106 · Cited by 2,703 · see citing works
Growth Factors, Matrices, and Forces Combine and Control Stem Cells
Discher, D. E., Mooney, D. J., & Zandstra, P. W. (2009) · Science · doi:10.1126/science.1171643 · Cited by 2,666 · see citing works
Nanomedicine: current status and future prospects
Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2005) · The FASEB Journal · doi:10.1096/fj.04-2747rev · Cited by 2,029 · see citing works
Complexity in biomaterials for tissue engineering
Place, E., Evans, N. D., & Stevens, M. M. (2009) · Nature Materials · doi:10.1038/nmat2441 · Cited by 1,735 · see citing works
Nanotechnology in Drug Delivery and Tissue Engineering: From Discovery to Applications
Shi, J., Votruba, A. R., Farokhzad, O. C., & Langer, R. (2010) · Nano Letters · doi:10.1021/nl102184c · Cited by 1,620 · see citing works
Self-citationMicroscale technologies for tissue engineering and biology
Khademhosseini, A., Langer, R., Borenstein, J. T., & Vacanti, J. P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507681102 · Cited by 1,553 · see citing works
Self-citationDesigning materials to direct stem-cell fate
Lütolf, M. P., Gilbert, P. M., & Blau, H. M. (2009) · Nature · doi:10.1038/nature08602 · Cited by 1,389 · see citing works
Biomaterials for bone tissue engineering
Stevens, M. M. (2008) · Materials Today · doi:10.1016/s1369-7021(08)70086-5 · Cited by 1,200 · see citing works
Weissleder, R. (2006) · Science · doi:10.1126/science.1125949 · Cited by 1,107 · see citing works
Harnessing nanotopography and integrin–matrix interactions to influence stem cell fate
Dalby, M. J., Gadegaard, N., & Oreffo, R. O. C. (2014) · Nature Materials · doi:10.1038/nmat3980 · Cited by 1,082 · see citing works
Engineering Hydrogels as Extracellular Matrix Mimics
Geçkil, H., Xu, F., Zhang, X., Moon, S., & Demirci, U. (2010) · Nanomedicine · doi:10.2217/nnm.10.12 · Cited by 943 · see citing works
Cell-specific targeting of nanoparticles by multivalent attachment of small molecules
Weissleder, R., Kelly, K., Sun, E. Y., Shtatland, T., & Josephson, L. (2005) · Nature Biotechnology · doi:10.1038/nbt1159 · Cited by 898 · see citing works
Extracellular matrix-based materials for regenerative medicine
Hussey, G. S., Dziki, J. L., & Badylak, S. F. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0023-x · Cited by 844 · see citing works
Benoit, D. S. W., Schwartz, M. P., Durney, A. R., & Anseth, K. S. (2008) · Nature Materials · doi:10.1038/nmat2269 · Cited by 825 · see citing works
Synthetic polymer scaffolds for tissue engineering
Place, E., George, J. H., Williams, C. K., & Stevens, M. M. (2009) · Chemical Society Reviews · doi:10.1039/b811392k · Cited by 820 · see citing works
An extracellular matrix microarray for probing cellular differentiation
Flaim, C. J., Chien, S., & Bhatia, S. N. (2005) · Nature Methods · doi:10.1038/nmeth736 · Cited by 800 · see citing works
Versatile, Fully Automated, Microfluidic Cell Culture System
Gómez-Sjöberg, R., Leyrat, A. A., Pirone, D. M., Chen, C. S., & Quake, S. R. (2007) · Analytical Chemistry · doi:10.1021/ac071311w · Cited by 619 · see citing works
Vertical silicon nanowires as a universal platform for delivering biomolecules into living cells
Shalek, A. K., Robinson, J. T., Karp, E. S., Lee, J. S., Ahn, D., Yoon, M., Sutton, A., Jorgolli, M., Gertner, R. S., Gujral, T. S., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909350107 · Cited by 563 · see citing works
Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells
Mei, Y., Saha, K., Bogatyrev, S. R., Yang, J., Hook, A. L., Kalcioglu, Z. I., Cho, S., Mitalipova, M. M., Pyzocha, N., Rojas, F., et al. (2010) · Nature Materials · doi:10.1038/nmat2812 · Cited by 543 · see citing works
Self-citationBone regeneration: molecular and cellular interactions with calcium phosphate ceramics.
Barrère, F., van Blitterswijk, C., & de Groot, K. (2006) · PubMed Central · Cited by 539 · see citing works
Lim, J. Y., & Donahue, H. J. (2007) · Tissue Engineering · doi:10.1089/ten.2006.0154 · Cited by 537 · see citing works
Lee, P. J., Hung, P. J., & Lee, L. P. (2007) · Biotechnology and Bioengineering · doi:10.1002/bit.21360 · Cited by 507 · see citing works
Engineered Microenvironments for Controlled Stem Cell Differentiation
Burdick, J. A., & Vunjak-Novakovic, G. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0131 · Cited by 485 · see citing works
Biomaterials for stem cell differentiation
Dawson, E. R., Mapili, G., Erickson, K., Taqvi, S., & Roy, K. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.08.037 · Cited by 447 · see citing works
25th Anniversary Article: Designer Hydrogels for Cell Cultures: A Materials Selection Guide
Thiele, J., Ma, Y., Bruekers, S. M. C., Ma, S., & Huck, W. T. S. (2013) · Advanced Materials · doi:10.1002/adma.201302958 · Cited by 432 · see citing works
Up in the air: oxygen tolerance in controlled/living radical polymerisation
Yeow, J., Chapman, R., Gormley, A. J., & Boyer, C. A. (2018) · Chemical Society Reviews · doi:10.1039/c7cs00587c · Cited by 415 · see citing works
Towards organoid culture without Matrigel
Kozlowski, M. T., Crook, C. J., & Ku, H. T. (2021) · Communications Biology · doi:10.1038/s42003-021-02910-8 · Cited by 409 · see citing works
Smart biomaterials design for tissue engineering and regenerative medicine
Furth, M. E., Atala, A., & Dyke, M. E. V. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.07.042 · Cited by 397 · see citing works
Microfabricated Biomaterials for Engineering 3D Tissues
Zorlutuna, P., Annabi, N., Camci‐Unal, G., Nikkhah, M., Cha, J. M., Nichol, J. W., Manbachi, A., Bae, H., Chen, S., & Khademhosseini, A. (2012) · Advanced Materials · doi:10.1002/adma.201104631 · Cited by 394 · see citing works
An algorithm-based topographical biomaterials library to instruct cell fate
Unadkat, H. V., Hulsman, M., Cornelissen, K., Papenburg, B. J., Truckenmüller, R. K., Carpenter, A. E., Weßling, M., Post, G. F., Uetz, M., Reinders, M. J. T., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109861108 · Cited by 380 · see citing works
Combinatorial discovery of polymers resistant to bacterial attachment
Hook, A. L., Chang, C., Yang, J., Luckett, J., Cockayne, A., Atkinson, S., Mei, Y., Bayston, R., Irvine, D. J., Langer, R., et al. (2012) · Nature Biotechnology · doi:10.1038/nbt.2316 · Cited by 374 · see citing works
Self-citationControlling size, shape and homogeneity of embryoid bodies using poly(ethylene glycol) microwells
Karp, J. M., Yeh, J., Eng, G. M., Fukuda, J., Blumling, J., Suh, K. Y., Cheng, J., Mahdavi, A., Borenstein, J. T., Langer, R., et al. (2007) · Lab on a Chip · doi:10.1039/b705085m · Cited by 368 · see citing works
Self-citationStructure/property studies of polymeric gene delivery using a library of poly(β-amino esters)
Anderson, D. G., Akinc, A., Hossain, N., & Langer, R. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.11.015 · Cited by 361 · see citing works
Self-citationSynthetic polymer coatings for long-term growth of human embryonic stem cells
Villa-Diaz, L. G., Nandivada, H., Ding, J., Nogueira-de-Souza, N. C., Krebsbach, P. H., O’Shea, K., Lahann, J., & Smith, G. D. (2010) · Nature Biotechnology · doi:10.1038/nbt.1631 · Cited by 361 · see citing works
Wang, W., Itaka, K., Ohba, S., Nishiyama, N., Chung, U., Yamasaki, Y., & Kataoka, K. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.01.030 · Cited by 349 · see citing works
Polymeric Biomaterials in Tissue Engineering
Kohane, D. S., & Langer, R. (2008) · Pediatric Research · doi:10.1203/01.pdr.0000305937.26105.e7 · Cited by 347 · see citing works
Self-citationCell Culture Models in Microfluidic Systems
Meyvantsson, I., & Beebe, D. J. (2008) · Annual Review of Analytical Chemistry · doi:10.1146/annurev.anchem.1.031207.113042 · Cited by 342 · see citing works
From teratocarcinomas to embryonic stem cells and beyond: a history of embryonic stem cell research
Solter, D. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1827 · Cited by 329 · see citing works
Controlled differentiation of stem cells
Hwang, N. S.-Y., Varghese, S., & Elisseeff, J. H. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.08.036 · Cited by 324 · see citing works
Self-Assembled Proteins and Peptides for Regenerative Medicine
Hosseinkhani, H., Hong, P., & Yü, D. (2013) · Chemical Reviews · doi:10.1021/cr300131h · Cited by 324 · see citing works
Exploring and exploiting chemistry at the cell surface
Mager, M. D., LaPointe, V. L. S., & Stevens, M. M. (2011) · Nature Chemistry · doi:10.1038/nchem.1090 · Cited by 321 · see citing works
Advances in tissue engineering
Langer, R., & Vacanti, J. P. (2015) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2015.10.022 · Cited by 317 · see citing works
Self-citationBioinspired Materials for Controlling Stem Cell Fate
Fisher, O. Z., Khademhosseini, A., Langer, R., & Peppas, N. A. (2009) · Accounts of Chemical Research · doi:10.1021/ar900226q · Cited by 315 · see citing works
Self-citationDesign and Printing Strategies in 3D Bioprinting of Cell‐Hydrogels: A Review
Lee, J. M., & Yeong, W. Y. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600435 · Cited by 312 · see citing works
Biocompatibility and drug delivery systems
Kohane, D. S., & Langer, R. (2010) · Chem. Sci. · doi:10.1039/c0sc00203h · Cited by 307 · see citing works
Self-citationDielectrophoresis for manipulation of micro/nano particles in microfluidic systems
Zhang, C., Khoshmanesh, K., Mitchell, A., & Kalantar‐Zadeh, K. (2009) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-009-2922-6 · Cited by 307 · see citing works
Advanced biomaterials for skeletal tissue regeneration: Instructive and smart functions
Barrère, F., Mahmood, T. A., de Groot, K., & van Blitterswijk, C. (2008) · Materials Science and Engineering R Reports · doi:10.1016/j.mser.2007.12.001 · Cited by 307 · see citing works
Chatterjee, K., Lin‐Gibson, S., Wallace, W. E., Parekh, S. H., Lee, Y. J., Cicerone, M. T., Young, M. F., & Simon, C. G. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.03.024 · Cited by 307 · see citing works
Anderson, D. G., Burdick, J. A., & Langer, R. (2004) · Science · doi:10.1126/science.1099987 · Cited by 303 · see citing works
Self-citationCartilage tissue engineering: its potential and uses
Kuo, C. K., Li, W., Mauck, R. L., & Tuan, R. S. (2005) · Current Opinion in Rheumatology · doi:10.1097/01.bor.0000198005.88568.df · Cited by 299 · see citing works
Fernandes, T. G., Diogo, M. M., Clark, D. S., Dordick, J. S., & Cabral, J. M. S. (2009) · Trends in biotechnology · doi:10.1016/j.tibtech.2009.02.009 · Cited by 284 · see citing works
Naderi‐Meshkin, H., Matin, M. M., & Bahrami, A. R. (2011) · Journal of Biomaterials Applications · doi:10.1177/0885328211408946 · Cited by 281 · see citing works
Biomaterial microarrays: rapid, microscale screening of polymer–cell interaction
Anderson, D. G., Putnam, D. A., Lavik, E., Mahmood, T. A., & Langer, R. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.11.052 · Cited by 278 · see citing works
Self-citationKobolák, J., Dinnyés, A., Memić, A., Khademhosseini, A., & Mobasheri, A. (2015) · Methods · doi:10.1016/j.ymeth.2015.09.016 · Cited by 272 · see citing works
Heterogeneity of mesenchymal stromal cell preparations
Ho, A. D., Wagner, W., & Franke, W. W. (2008) · Cytotherapy · doi:10.1080/14653240802217011 · Cited by 265 · see citing works
Langner, S., Häse, F., Perea, J. D., Stubhan, T., Hauch, J., Roch, L. M., Heumueller, T., Aspuru‐Guzik, A., & Brabec, C. J. (2020) · Advanced Materials · doi:10.1002/adma.201907801 · Cited by 263 · see citing works
Single-Cell Microarray for Analyzing Cellular Response
Yamamura, S., Kishi, H., Tokimitsu, Y., Kondo, S., Honda, R., Rao, S. R., Omori, M., Tamiya, E., & Muraguchi, A. (2005) · Analytical Chemistry · doi:10.1021/ac0515632 · Cited by 260 · see citing works
Mesenchymal Stem Cell Preparations—Comparing Apples and Oranges
Wagner, W., & Ho, A. D. (2007) · Stem Cell Reviews and Reports · doi:10.1007/s12015-007-9001-1 · Cited by 260 · see citing works
The Effect of Surface Nanometre-Scale Morphology on Protein Adsorption
Scopelliti, P. E., Borgonovo, A., Indrieri, M., Giorgetti, L., Bongiorno, G. A., Carbone, R., Podestà, A., & Milani, P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011862 · Cited by 256 · see citing works
Kennedy, S. B., Washburn, N. R., Simon, C. G., & Amis, E. J. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.02.044 · Cited by 253 · see citing works
Ku, S. H., Lee, J. S., & Park, C. B. (2010) · Langmuir · doi:10.1021/la102825p · Cited by 247 · see citing works
Biomaterial delivery of morphogens to mimic the natural healing cascade in bone
Mehta, M., Schmidt‐Bleek, K., Duda, G. N., & Mooney, D. J. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.05.006 · Cited by 244 · see citing works
Controlling Stem Cell Fate with Material Design
Marklein, R. A., & Burdick, J. A. (2009) · Advanced Materials · doi:10.1002/adma.200901055 · Cited by 242 · see citing works
Khademhosseini, A., Yeh, J., Eng, G. M., Karp, J. M., Kaji, H., Borenstein, J. T., Farokhzad, O. C., & Langer, R. (2005) · Lab on a Chip · doi:10.1039/b508096g · Cited by 238 · see citing works
Self-citationMicromolding of photocrosslinkable hyaluronic acid for cell encapsulation and entrapment
Khademhosseini, A., Eng, G. M., Yeh, J., Fukuda, J., Blumling, J., Langer, R., & Burdick, J. A. (2006) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30821 · Cited by 236 · see citing works
Self-citation3-D microwell culture of human embryonic stem cells
Mohr, J. C., de Pablo, J. J., & Palecek, S. P. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.07.012 · Cited by 234 · see citing works
Tavana, H., Jović, A., Mosadegh, B., Lee, Q. Y., Liu, X., Luker, K. E., Luker, G. D., Weiss, S. J., & Takayama, S. (2009) · Nature Materials · doi:10.1038/nmat2515 · Cited by 232 · see citing works
Microvalve-based bioprinting – process, bio-inks and applications
Ng, W. L., Lee, J. M., Yeong, W. Y., & Naing, M. W. (2017) · Biomaterials Science · doi:10.1039/c6bm00861e · Cited by 231 · see citing works
Material Cues as Potent Regulators of Epigenetics and Stem Cell Function
Crowder, S. W., Leonardo, V., Whittaker, T. E., Papathanasiou, P., & Stevens, M. M. (2016) · Cell stem cell · doi:10.1016/j.stem.2015.12.012 · Cited by 230 · see citing works
Barthès, J., Özçelik, H., Hindié, M., Halili, A. N., Hasan, A., & Vrana, N. E. (2014) · BioMed Research International · doi:10.1155/2014/921905 · Cited by 229 · see citing works
High throughput methods applied in biomaterial development and discovery
Hook, A. L., Anderson, D. G., Langer, R., Williams, P. M., Davies, M. C., & Alexander, M. R. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.09.037 · Cited by 228 · see citing works
Self-citationBiofabrication: an overview of the approaches used for printing of living cells
Ferris, C. J., Gilmore, K. G., Wallace, G. G., & Panhuis, M. I. H. (2013) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-013-4853-6 · Cited by 227 · see citing works
Three-dimensional biomaterials for the study of human pluripotent stem cells
Kraehenbuehl, T. P., Langer, R., & Ferreira, L. (2011) · Nature Methods · doi:10.1038/nmeth.1671 · Cited by 226 · see citing works
Self-citationGruene, M., Pflaum, M., Hess, C. W., Diamantouros, S. E., Schlie, S., Deiwick, A., Koch, L., Wilhelmi, M. H., Jockenhoevel, S., Haverich, A., et al. (2011) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2011.0185 · Cited by 225 · see citing works
Soen, Y., Mori, A., Palmer, T. D., & Brown, P. O. (2006) · Molecular Systems Biology · doi:10.1038/msb4100076 · Cited by 223 · see citing works
Micro-bioreactor array for controlling cellular microenvironments
Figallo, E., Cannizzaro, C., Gerecht, S., Burdick, J. A., Langer, R., Elvassore, N., & Vunjak-Novakovic, G. (2007) · Lab on a Chip · doi:10.1039/b700063d · Cited by 220 · see citing works
Self-citationDesigning synthetic materials to control stem cell phenotype
Saha, K., Pollock, J. F., Schaffer, D. V., & Healy, K. E. (2007) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2007.05.030 · Cited by 219 · see citing works
Molecular Imaging of Cardiovascular Disease
Jaffer, F. A., Libby, P., & Weissleder, R. (2007) · Circulation · doi:10.1161/circulationaha.106.647164 · Cited by 217 · see citing works
Integrating novel technologies to fabricate smart scaffolds
Moroni, L., de Wijn, J. R., & van Blitterswijk, C. (2008) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856208784089571 · Cited by 215 · see citing works
Tuning compliance of nanoscale polyelectrolyte multilayers to modulate cell adhesion
Thompson, M. T., Berg, M. C., Tobias, I. S., Rubner, M. F., & Vliet, K. J. V. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.05.003 · Cited by 215 · see citing works
Nanoliter scale microbioreactor array for quantitative cell biology
Lee, P. J., Hung, P. J., Rao, V. M., & Lee, L. P. (2005) · Biotechnology and Bioengineering · doi:10.1002/bit.20745 · Cited by 212 · see citing works
Tunable Supramolecular Hydrogels for Selection of Lineage-Guiding Metabolites in Stem Cell Cultures
Alakpa, E. V., Jayawarna, V., Lampel, A., Burgess, K., West, C. C., Bakker, S. C. J., Roy, S., Javid, N., Fleming, S., Lamprou, D. A., et al. (2016) · Chem · doi:10.1016/j.chempr.2016.07.001 · Cited by 211 · see citing works
A versatile approach to high-throughput microarrays using thiol-ene chemistry
Gupta, N., Lin, B. F., Campos, L. M., Dimitriou, M. D., Hikita, S. T., Treat, N. D., Tirrell, M., Clegg, D., Krämer, E. J., & Hawker, C. J. (2009) · Nature Chemistry · doi:10.1038/nchem.478 · Cited by 209 · see citing works
Leakage-Free Bonding of Porous Membranes into Layered Microfluidic Array Systems
Chueh, B.-H., Huh, D., Kyrtsos, C. R., Houssin, T., Futai, N., & Takayama, S. (2007) · Analytical Chemistry · doi:10.1021/ac062118p · Cited by 208 · see citing works
Design of three‐dimensional biomimetic scaffolds
Owen, S. C., & Shoichet, M. S. (2010) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32834 · Cited by 205 · see citing works
Janson, I. A., & Putnam, A. J. (2014) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35254 · Cited by 203 · see citing works
Khademhosseini, A., Ferreira, L., Blumling, J., Yeh, J., Karp, J. M., Fukuda, J., & Langer, R. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.06.035 · Cited by 202 · see citing works
Self-citationCombinatorial Signaling Microenvironments for Studying Stem Cell Fate
Flaim, C. J., Teng, D., Chien, S., & Bhatia, S. N. (2008) · Stem Cells and Development · doi:10.1089/scd.2007.0085 · Cited by 195 · see citing works
Evolution of Dip-Pen Nanolithography (DPN): From Molecular Patterning to Materials Discovery
Liu, G., Petrosko, S. H., Zheng, Z., & Mirkin, C. A. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00725 · Cited by 193 · see citing works
Smart chemistry in polymeric nanomedicine
Tong, R., Tang, L., Ma, L., Tu, C., Baumgartner, R., & Cheng, J. (2014) · Chemical Society Reviews · doi:10.1039/c4cs00133h · Cited by 191 · see citing works
High-Throughput Methods in the Discovery and Study of Biomaterials and Materiobiology
Yang, L., Pijuan‐Galito, S., Rho, H. S., Vasilevich, A. S., Eren, A. D., Ge, L., Habibović, P., Alexander, M. R., de Boer, J., Carlier, A., et al. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00752 · Cited by 187 · see citing works
Long-term human pluripotent stem cell self-renewal on synthetic polymer surfaces
Brafman, D. A., Chang, C., Fernandez-Perez, A., Willert, K., Varghese, S., & Chien, S. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.08.007 · Cited by 178 · see citing works
Hydrogels for Musculoskeletal Tissue Engineering
Varghese, S., & Elisseeff, J. H. (2006) · Advances in Polymer Science · doi:10.1007/12_072 · Cited by 173 · see citing works
Enabling stem cell therapies through synthetic stem cell–niche engineering
Peerani, R., & Zandstra, P. W. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41158 · Cited by 173 · see citing works
Assessment of stem cell/biomaterial combinations for stem cell-based tissue engineering
Neuß, S., Apel, C., Buttler, P., Denecke, B., Dhanasingh, A. E., Ding, X., Grafahrend, D., Gröger, A., Hemmrich, K., Herr, A., et al. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.09.022 · Cited by 172 · see citing works
Nakajima, M., Ishimuro, T., Kato, K., Ko, I.-K., Hirata, I., Arima, Y., & Iwata, H. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.10.004 · Cited by 169 · see citing works
Stem cell integrins: Implications for ex-vivo culture and cellular therapies
Prowse, A. B. J., Chong, F., Gray, P. P., & Munro, T. P. (2010) · Stem Cell Research · doi:10.1016/j.scr.2010.09.005 · Cited by 167 · see citing works
Bioengineered Liver Models for Drug Testing and Cell Differentiation Studies
Underhill, G. H., & Khetani, S. R. (2017) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2017.11.012 · Cited by 167 · see citing works
- Authors
- Anderson, D. G., Levenberg, S., & Langer, R.
- Affiliations
- Massachusetts Institute of Technology (US)
- Venue
- Nature Biotechnology
- Published
- 2004-06-13
- Volume
- 22
- Issue
- 7
- Pages
- 863-866
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W2052098523
- Cited by
- 747
- References
- 21
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 7 · 2023: 8 · 2022: 12 · 2021: 19 · 2020: 26 · 2019: 17 · 2018: 28 · 2017: 26 · 2016: 38 · 2015: 37 · 2014: 48 · 2013: 53 · 2012: 59
- FWCI
- 33.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HL 60435, R01HL060435)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- human embryonic stem cells, cell-material interactions, biomaterials, tissue engineering, cell therapy, cell attachment, cell proliferation, gene expression
- MeSH terms
- Biocompatible Materials, Embryo, Mammalian, Humans, Polymers, Stem Cells, Combinatorial Chemistry Techniques, Microarray Analysis
About these checks
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