The DOI matches its Crossref record; 131 of the 131 references it cites were found in a registry or an index.
Modulating the stem cell niche for tissue regeneration
Open accessAbstract
The field of regenerative medicine holds considerable promise for treating diseases that are currently intractable. Although many researchers are adopting the strategy of cell transplantation for tissue repair, an alternative approach to therapy is to manipulate the stem cell microenvironment, or niche, to facilitate repair by endogenous stem cells. The niche is highly dynamic, with multiple opportunities for intervention. These include administration of small molecules, biologics or biomaterials that target specific aspects of the niche, such as cell-cell and cell–extracellular matrix interactions, to stimulate expansion or differentiation of stem cells, or to cause reversion of differentiated cells to stem cells. Nevertheless, there are several challenges in targeting the niche therapeutically, not least that of achieving specificity of delivery and responses. We envisage that successful treatments in regenerative medicine will involve different combinations of factors to target stem cells and niche cells, applied at different times to effect recovery according to the dynamics of stem cell–niche interactions.
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Self-citationNiche Cadherins Control the Quiescence-to-Activation Transition in Muscle Stem Cells
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Metadata
- Authors
- Lane, S. W., Williams, D. A., & Watt, F. M.
- Venue
- Nature Biotechnology
- Published
- 2014-08
- Volume
- 32
- Issue
- 8
- Pages
- 795-803
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W1977109906
- Cited by
- 615
- References
- 131
- FWCI
- 24.76
- Type
- journal article
- Language
- en
- Open access
- green
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