In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9
Swiech, Lukasz, Heidenreich, Matthias, Banerjee, Abhishek, Habib, Naomi, Li, Yinqing, Trombetta, John, Sur, Mriganka, Zhang, Feng·2015·Nature Biotechnology
DOI 10.1038/nbt.3055
Cited by (771)
Items 501–600 of 771
- The role of the CRISPR‐Cas system in cancer drug development: Mechanisms of action and therapyArun Pandian Chandrasekaran, Janardhan Keshav Karapurkar, Hee Yong Chung, Suresh Ramakrishna · 2022 · Biotechnology Journal
- Synthetic biology approaches in cancer immunotherapy, genetic network engineering, and genome editingDeboki Chakravarti, Jang Hwan Cho, Benjamin H. Weinberg, Nicole M. L. Wong, Wilson W. Wong · 2016 · Integrative Biology
- CRISPR/Cas9 Gene Editing: A Novel Approach Towards Alzheimer's Disease TreatmentSiddhant Tripathi, Yashika Sharma, Rajesh A. Rane, Dileep Kumar · 2024 · CNS & Neurological Disorders - Drug Targets
- Long-Term Assessment of AAV-Mediated Zinc Finger Nuclease Expression in the Mouse BrainMuzna Zahur, Johan Tolö, Mathias Bähr, Sebastian Kügler · 2017 · Frontiers in Molecular Neuroscience
- CRISPR/Cas9: A Potential Life-Saving Tool. What’s next?Diana Gulei, Ioana Berindan‐Neagoe · 2017 · Molecular Therapy — Nucleic Acids
- Fronto-temporal dementia risk gene TMEM106B has opposing effects in different lysosomal storage disordersAzucena Pérez‐Cañamás, Hideyuki Takahashi, Jane A. Lindborg, Stephen M. Strittmatter · 2020 · Brain Communications
- Axl Is Essential for in-vitro Angiogenesis Induced by Vitreous From Patients With Proliferative Diabetic RetinopathyWenyi Wu, Huizuo Xu, Zhishang Meng, Jianxi Zhu, Siqi Xiong, Xiaobo Xia, Hetian Lei · 2021 · Frontiers in Medicine
- Methods for In Vivo CRISPR/Cas Editing of the Adult Murine RetinaSandy S. C. Hung, Fan Li, Jiang-Hui Wang, Anna Elizabeth King, Bang Viet Bui, Guei‐Sheung Liu, Alex William Hewitt · 2017 · Methods in molecular biology
- Postnatal therapeutic approaches in genetic neurodevelopmental disordersGilad Levy, Boaz Barak · 2020 · Neural Regeneration Research
- Neuronal activity regulates the nuclear proteome to promote activity-dependent transcriptionWendy A. Herbst, Weixian Deng, James Akira Wohlschlegel, Jennifer M. Achiro, Kelsey C. Martin · 2021 · The Journal of Cell Biology
- Innovation in nanomedicine and engineered nanomaterials for therapeutic purposesMaricla Galetti, Stefano Rossi, Cristina Caffarra, Amparo Guerrero Gerbolés, Michele Miragoli · 2019 · Elsevier eBooks
- Genome editing in animals: an overviewJaya Bharati, Meeti Punetha, B.A.A. Sai Kumar, G.M. Vidyalakshmi, Mihir Sarkar, Michael J. D’Occhio, Raj Kumar Singh · 2019 · Elsevier eBooks
- Div-Seq: A single nucleus RNA-Seq method reveals dynamics of rare adult newborn neurons in the CNSNaomi Habib, Yinqing Li, Matthias Heidenreich, Lukasz J. Swiech, John J. Trombetta, Feng Zhang, Aviv Regev · 2016 · bioRxiv (Cold Spring Harbor Laboratory)
- Removal of a partial genomic duplication restores synaptic transmission and behavior in the MyosinVA mutant mouse FlailerFernando J. Bustos, Swarna Pandian, Henny Haensgen, Jian-Ping Zhao, Haley Strouf, Matthias Heidenreich, Lukasz J. Swiech, Benjamin E. Deverman, Viviana Gradinaru, Feng Zhang et al. · 2023 · BMC Biology
- Promise of adeno-associated virus as a gene therapy vector for cardiovascular diseasesAbesh Bera, Dwaipayan Sen · 2017 · Heart Failure Reviews
- Unraveling of Central Nervous System Disease Mechanisms Using CRISPR Genome ManipulationAino Vesikansa · 2018 · Journal of Central Nervous System Disease
- In vivo nuclear capture and molecular profiling identifies Gmeb1 as a transcriptional regulator essential for dopamine neuron functionLuis M. Tuesta, Mohamed Nadhir Djekidel, Renchao Chen, Falong Lu, Wengang Wang, Bernardo Luis Sabatini, Yi Zhang · 2019 · Nature Communications
- Methodological approaches to understand the molecular mechanism of structural plasticity of dendritic spinesTakayasu Mikuni, Motokazu Uchigashima · 2020 · European Journal of Neuroscience
- CRISPR/Cas: a potential gene-editing tool in the nervous systemYanxia Gao, Kexin Gao, Hui Yang · 2020 · Cell Regeneration
- Delivery Methods, Resources and Design Tools in CRISPR/CasMuhammad Aamir Aslam, Masooma Hammad, Aftab Ahmad, Josef Altenbuchner, Hazrat Ali · 2021 · Springer eBooks
- Applying CRISPR-Cas9 screens to dissect hematological malignanciesDeepak Narayanan Iyer, Aaron David Schimmer, Hong Chang · 2022 · Blood Advances
- Nutritional and Nanotechnological Modulators of MicrogliaDušica Maysinger, Issan Zhang · 2016 · Frontiers in Immunology
- Long-stem shaped multifunctional molecular beacon for highly sensitive nucleic acids determination via intramolecular and intermolecular interactions based strand displacement amplificationJianguo Xu, Tingting Zheng, Jingqing Le, Lee Jia · 2017 · The Analyst
- Applying switchable Cas9 variants to in vivo gene editing for therapeutic applicationsEmily M. Mills, Victoria L. Barlow, Louis Y. P. Luk, Yu‐Hsuan Tsai · 2019 · Cell Biology and Toxicology
- New Additions to the CRISPR Toolbox: CRISPR- CLONInG and CRISPR- CLIP for Donor Construction in Genome EditingDorjee T.N. Shola, Chingwen Yang, Vhy-Shelta Kewaldar, Pradip Kar, Victor Bustos · 2020 · The CRISPR Journal
- Normal vitreous promotes angiogenesis via activation of AxlWenyi Wu, Xiaobo Xia, Luosheng Tang, Fei Yao, Huizuo Xu, Hetian Lei · 2020 · The FASEB Journal
- Viral and Nonviral Transfer of Genetic Materials to Adipose Tissues: Toward a Gold Standard ApproachSteven M. Romanelli, Ormond A. MacDougald · 2020 · Diabetes
- Application of CRISPR-Cas systems in neuroscienceDeepro Bonnerjee, Sangram Bagh · 2021 · Progress in molecular biology and translational science
- Rapid in vivo multiplexed editing (RIME) of the adult mouse liverTakeshi Katsuda, Hector Cure, Jonathan Sussman, Kamen P. Simeonov, Christopher J. Krapp, Zoltan Pierre Arany, Markus Grompe, Ben Z. Stanger · 2022 · Hepatology
- Dnmt3a in the dorsal dentate gyrus is a key regulator of fear renewalZhiting Gong, Qiang Zhou · 2018 · Scientific Reports
- Targeted Gene Activation Using RNA-Guided NucleasesAlexander Brown, Wendy S. Woods, Pablo Pérez‐Piñera · 2016 · Methods in molecular biology
- Basic and Clinical Application of Adeno-Associated Virus–Mediated Genome EditingXiubin He, Haihua Xie, Xiexie Liu, Feng Gu · 2018 · Human Gene Therapy
- Revisiting a Telencephalic Extent of the Ascending Reticular Activating SystemEdison K. Miyawaki, Shamik Bhattacharyya, Matthew Torre · 2023 · Cellular and Molecular Neurobiology
- Vector enabled CRISPR gene editing – A revolutionary strategy for targeting the diversity of brain pathologiesHelen Forgham, Liwei Liu, Jiayuan Zhu, Ibrahim Javed, Weibo Cai, Ruirui Qiao, Thomas Paul Davis · 2023 · Coordination Chemistry Reviews
- Transduction of antigen-presenting cells in the brain by AAV9 warrants caution in preclinical studiesJohn Forsayeth, Krystof S. Bankiewicz · 2015 · Molecular Therapy
- Gene Editing for Treatment of Neurological InfectionsMartyn K. White, Rafal Kaminski, Hassen S. Wollebo, Wenhui Hu, Thomas Malcolm, Kamel Khalili · 2016 · Neurotherapeutics
- Increasing the precision of gene editing in vitro, ex vivo, and in vivoKatherine P. Mueller, Jared Carlson-Stevermer, Krishanu Saha · 2018 · Current Opinion in Biomedical Engineering
- In vivo cell type-specific CRISPR gene editing for sleep researchHiroshi Yamaguchi, Luı́s de Lecea · 2018 · Journal of Neuroscience Methods
- Widespread labeling and genomic editing of the fetal central nervous system by in utero CRISRP AAV9-PHP.eB administrationShuntong Hu, Tao Yang, Yu Wang · 2020 · Development
- In vivo genome editing in single mammalian brain neurons through CRISPR-Cas9 and cytosine base editorsBeomjong Song, Chan Young Kang, Jun Hee Han, Masanobu Kano, Arthur Konnerth, Sangsu Bae · 2021 · Computational and Structural Biotechnology Journal
- Imaging endogenous synaptic proteins in primary neurons at single-cell resolution using CRISPR/Cas9Takahiko Matsuda, Izumi Oinuma · 2019 · Molecular Biology of the Cell
- Engineered AAV vectors for improved central nervous system gene deliveryMelissa A. Kotterman, David V. Schaffer · 2015 · Neurogenesis
- CdSe Quantum Dot-Based Delivery System for CRISPR-Cas9 Mediated Microglial Gene ModulationHyeon-Gu Yeo, Jinyoung Won, Lee Wha Gwon, Seokbeom Roh, Wi-jae Lee, Kyung Seob Lim, Chang‐Yeop Jeon, Junghyung Park, A Reum Je, Jincheol Seo et al. · 2024 · ACS Applied Nano Materials
- TAxI-peptide targeted Cas12a ribonuclease protein nanoformulations increase genome editing in hippocampal neuronsDrew L. Sellers, Kunwoo Lee, Niren Murthy, Suzie Hwang Pun · 2023 · Journal of Controlled Release
- How chromosomal translocations arise to cause cancer: Gene proximity, trans-splicing, and DNA end joiningPatrick Streb, Eric Kowarz, T Benz, Jennifer Reis, Rolf Marschalek · 2023 · iScience
- Targeting Hepatitis B Virus DNA Using Designer Gene EditorsHenrik Zhang, Thomas Tu · 2023 · Clinics in Liver Disease
- Targeted Delivery of Chimeric Antigen Receptor into T Cells via CRISPR-Mediated Homology-Directed Repair with a Dual-AAV6 Transduction SystemPablo Diego Moço, Omar Farnós, David M. Sharon, Amine Kamen · 2023 · Current Issues in Molecular Biology
- Intranasal delivery of shRNA to knockdown the 5HT-2A receptor enhances memory and alleviates anxietyTroy T. Rohn, Dean I. Radin, Tracy Brandmeyer, Peter G. Seidler, Barry J. Linder, Tom Lytle, John L. Mee, Fabio M. Macciardi · 2024 · Translational Psychiatry
- Gene editing for corneal disease managementSudhanshu P. Raikwar, Apoorva S Raikwar, Shyam Sunder Chaurasia, Rajiv R. Mohan · 2016 · World Journal of Translational Medicine
- Role of Chromatin Remodeling Genes and TETs in the Development of Human Midbrain Dopaminergic NeuronsXiang Li, Guobin Huang, Wenjing Shu, Chunli Gong, Nan Cao, Rui Chen, Jixi Li, Hao Lu, Gaofeng Jiang · 2020 · Stem Cell Reviews and Reports
- Visualizing Arc protein dynamics and localization in the mammalian brain using AAV-mediated in situ gene labelingMartino Avallone, Joaquín Pardo, Tadiwos Feyissa Mergiya, Jana Rájová, Atte Räsänen, Marcus Davidsson, Malin Åkerblom, Luís Quintino, Darshan Kumar, Clive R. Bramham et al. · 2023 · Frontiers in Molecular Neuroscience
- Advances in CRISPR/Cas9 Technology for in Vivo TranslationYağız Anıl Çiçek, David C. Luther, Jessica A. Kretzmann, Vincent M. Rotello · 2019 · Biological and Pharmaceutical Bulletin
- Neuropeptide Signaling is Required to Implement a Line Attractor Encoding a Persistent Internal Behavioral StateGeorge Mountoufaris, Aditya Nair, Bin Yang, Dong‐Wook Kim, David J. Anderson · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- CRISPR-mediated gene editing for the surgeon scientistStephen J. O’Brien, Matthew B. Ekman, Stephen E. Manek, Susan Galandiuk · 2019 · Surgery
- Genome Editing of Pik3cd Impedes Abnormal Retinal AngiogenesisWenyi Wu, Gaoen Ma, Hui Qi, Lijun Dong, Fang Chen, Yun Wang, Xingxing Mao, Xiaoqing Guo, Jing Z Cui, Joanne Aiko Matsubara et al. · 2022 · Human Gene Therapy
- CRISPR/SaCas9-based gene editing rescues photoreceptor degeneration throughout a rhodopsin-associated autosomal dominant retinitis pigmentosa mouse modelWei Du, Jiarui Li, Xin Tang, Wenzhen Yu, Mingwei Zhao · 2023 · Experimental Biology and Medicine
- Ablation of OCT4 function in cattle embryos by double electroporation of CRISPR-Cas for DNA and RNA targeting (CRISPR-DART)Jada L Nix, Gustavo Pimenta Schettini, Savannah L. Speckhart, Alan D. Ealy, Fernando H. Biase · 2023 · PNAS Nexus
- Exploitation of enhanced prime editing for blocking aberrant angiogenesisXionggao Huang, Wenyi Wu, Hui Qi, Xiaohe Yan, Lijun Dong, Yanhui Yang, Qing Zhang, Gaoen Ma, Guoming Zhang, Hetian Lei · 2024 · Journal of Advanced Research
- Neuroepigenetic EditingPeter J. Hamilton, Carissa J. Lim, Eric J. Nestler, Elizabeth A. Heller · 2024 · Methods in molecular biology
- Muscle cell-derived Ccl8 is a negative regulator of skeletal muscle regenerationA. Boss-Kennedy, D. Kim, P. Barai, C. Maldonado, A. Reyes-Ordoñez, J. Chen · 2024 · The FASEB Journal
- Safety and efficacy evaluations of an adeno-associated virus variant for preparing IL10-secreting human neural stem cell-based therapeuticsMira Cho, Kwangsoo Jung, Seung‐Hyun Kim, Il‐Sun Kim, Miri Kim, Mikyung Shin, Haeshin Lee, Kook In Park, Jae‐Hyung Jang · 2019 · Gene Therapy
- TAT-MeCP2 protein variants rescue disease phenotypes in human and mouse models of Rett syndromeHannes Steinkellner, Prakasha M Kempaiah, Alexander V. Beribisky, Sandra Pferschy, Julia Etzler, Anna Huber, Victoria Sarne, Winfried Neuhaus, Mario Kuttke, Jan Bauer et al. · 2022 · International Journal of Biological Macromolecules
- Editing the Neuronal Genome: a CRISPR View of Chromatin Regulation in Neuronal Development, Function, and Plasticity.Marty G. Yang, Anne E. West · 2016 · Europe PMC (PubMed Central)
- CRISPR/Cas9 system-mediated impairment of synaptobrevin/VAMP function in postmitotic hippocampal neuronsPatricia M. Horvath, Ege T. Kavalali, Lisa M. Monteggia · 2016 · Journal of Neuroscience Methods
- Efficient One-Step Fusion PCR Based on Dual-Asymmetric Primers and Two-Step AnnealingYilan Liu, Jinjin Chen, Anders Thygesen · 2017 · Molecular Biotechnology
- Repairing the Brain: Gene TherapyTomas Björklund · 2018 · Journal of Parkinson s Disease
- Design and Assembly of CRISPR/Cas9 Lentiviral and rAAV Vectors for Targeted Genome EditingIvette M. Sandoval, Timothy J. Collier, Fredric P. Manfredsson · 2019 · Methods in molecular biology
- CRISPR-Cas: Removing Boundaries of the NatureNicat Cebrailoglu, Ali Burask Yildiz, Özlem Akkaya, Yelda Özden Çiftçi · 2019 · European Journal of Biology
- CRISPR/Cas9-targeting of CD40 in hematopoietic stem cells limits immune activation mediated by anti-CD40Rui Wang, Sean Graham, Ning Sun, Donna McCarthy, Ruoqi Peng, Jamie Erickson, L. O'Connor, Xiaochun Zhu, Marc A. Wurbel, Robert W. Dunstan et al. · 2020 · PLoS ONE
- Modulating Cas9 activity for precision gene editingMerve Uslu, Pınar Si̇yah, Andrew John Harvey, Fatih Kocabaş · 2021 · Progress in molecular biology and translational science
- Gene Therapy for Rett Syndrome: Prospects and ChallengesKamal K.E. Gadalla, Paul D. Ross, Ralph D. Hector, Noha Gamal Bahey, Mark E.S. Bailey, Stuart Cobb · 2015 · Future Neurology
- Prime Editing of Vascular Endothelial Growth Factor Receptor 2 Attenuates Angiogenesis In VitroGaoen Ma, Hui Qi, Hongwei Deng, Lijun Dong, Qing Zhang, Junkai Ma, Yanhui Yang, Xiaohe Yan, Yajian Duan, Hetian Lei · 2024 · The CRISPR Journal
- Using synthetic biology to understand the gut-brain axisAngela Cesaro, Esther Broset, Gregory J. Salimando, Sebahat Öztekin, David Mai, Mariko L. Bennett, César de la Fuente‐Núñez · 2025 · Cell Reports Physical Science
- Glutamatergic signaling from melanin-concentrating hormone-producing neurons: A requirement for memory regulation, but not for metabolism controlPhạm Xuân Thắng, Yoshifumi Abe, Yasutaka Mukai, Daisuke Ono, Kenji F. Tanaka, Yu Ohmura, Hiroaki Wake, Akihiro Yamanaka · 2024 · PNAS Nexus
- Abcb4-defect cholangitis mouse model with hydrophobic bile acid composition by in vivo liver-specific gene deletionKota Tsuruya, Keiko Yokoyama, Yusuke Mishima, Kinuyo Ida, Takuma Araki, Satsuki Ieda, Masato Ohtsuka, Yutaka Inagaki, Akira Honda, Tatehiro Kagawa et al. · 2024 · Journal of Lipid Research
- CRISPR-dCas9-mediated CpG island editing: A potential game-changer for diabetes treatmentKhokon Kumar Dutta · 2024 · Journal of Bioscience and Environment Research
- Genome editing-based approaches for imaging protein localization and dynamics in the mammalian brainTakayasu Mikuni · 2019 · Neuroscience Research
- Normal vitreous promotes angiogenesi via the epidermal growth factor receptorMengling You, Xiaobo Xia, Haibo Li, Jiayu Wu, Rong Rong, Zhou Zeng, Kun Xiong, Jufang Huang, Luosheng Tang, Hetian Lei et al. · 2020 · The FASEB Journal
- In vitro gene editing using primary cells derived from Cas9-expressing pigsSeokho Kim, Jin-Gu No, Seunghoon Lee, Areum Choi, Namwoong Hyung, Ju Young Lee, Tae‐Uk Kwak, Won Seok Ju, Jae-Yeong Lee, Poongyeon Lee et al. · 2024 · Journal of Animal Science and Technology
- Pharmacodynamics of anti-HIV gene therapy using viral vectors and targeted endonucleasesPavitra Roychoudhury, Harshana S. De Silva Feelixge, Harlan Linver Pietz, Daniel Stone, Keith R. Jerome, Joshua Tisdell Schiffer · 2016 · Journal of Antimicrobial Chemotherapy
- Artificial virus particlesDébora Ferreira, Ivone M. Martins · 2016 · Elsevier eBooks
- Microglial Barriers to Viral Gene DeliveryJohn V. Pluvinage, Tony Wyss‐Coray · 2017 · Neuron
- The Application of Omics Data to the Development of AOPsMary T. McBride · 2018 · Springer eBooks
- Gene-edited CRISPy Critters for alcohol researchGregg E. Homanics · 2018 · Alcohol
- Gene and epigenetic editing in the treatment of primary ciliopathiesElisa Molinari, John Andrew Sayer · 2021 · Progress in molecular biology and translational science
- Get ready for the CRISPR/Cas system: A beginner's guide to the engineering and design of guide RNAsShufeng Ma, Jie Lv, Zinan Feng, Zhili Rong, Ying Lin · 2021 · The Journal of Gene Medicine
- Expression, Purification, Characterization and Cellular Uptake of MeCP2 VariantsAlexander V. Beribisky, Hannes Steinkellner, Sofia Geislberger, Anna Huber, Victoria Sarne, John Christodoulou, Franco A. Laccone · 2022 · The Protein Journal
- In vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturationNathan J. VanDusen, Julianna Y. Lee, Weiliang Gu, Isha Sethi, Yanjiang Zheng, Justin S. King, Pingzhu Zhou, Shengbao Suo, Yuxuan Guo, Qing Ma et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- Cytosine methylase and hydroxymethylase activity in mammalian mitochondriaLisa S. Shock, Prashant V. Thakkar, Jason M. Robinson, Shirley M. Taylor · 2025 · Frontiers in Cell and Developmental Biology
- A new method for the robust expression and single-step purification of dCas9 for CRISPR interference/activation (CRISPRi/a) applicationsHarshita Pandey, Binduma Yadav, Koushik Shah, Raminder Kaur, Diksha Choudhary, Nishtha Sharma, Vikas Rishi · 2024 · Protein Expression and Purification
- Viral delivery of genome-modifying proteins for cellular reprogrammingJacob Giehm Mikkelsen · 2018 · Current Opinion in Genetics & Development
- CRISPR/Cas-mediated genome editing in mice for the development of drug delivery mechanismSowbhagya Ramachandregowda, Harsha Muktha, Thippenahalli Narasimhaiah Ramakrishnaiah, Adagur Sudarshan Surendra, Yesudas Tanvi, Karayi Nivitha, Somashekara Rajashekara · 2023 · Molecular Biology Reports
- Application of CRISPR-Cas9 Technology in FishNilav Aich, Janmejay Parhi, Sagar Chandra Mandal, Lopamudra Sahoo · 2023 · Springer eBooks
- Cell-Specific Single Viral Vector CRISPR/Cas9 Editing and Genetically Encoded Tool Delivery in the Central and Peripheral Nervous SystemsJamie C. Moffa, India N. Bland, Jessica R. Tooley, Vani Kalyanaraman, Monique R. Heitmeier, Meaghan C. Creed, Bryan A. Copits · 2024 · eNeuro
- CRISPR-ERA for Switching Off (Onco) GenesIgnacio García‐Tuñón, Elena Vuelta, Sandra Pérez‐Ramos, Jesús María Hernández‐Rivas, Lucía Méndez, María Herrero, Manuel Sánchez‐Martín · 2019 · IntechOpen eBooks
- Detection of CRISPR-mediated genome modifications through altered methylation patterns of CpG islandsMichele Farris, Pamela A. Texter, Agustin A. Mora, Michael V. Wiles, Ellen F. Mac Garrigle, Sybil Ann Klaus, Kristine M. Rosfjord · 2020 · BMC Genomics
- CRISPR–Cas Gene Editing for Neurological DiseaseBryan P. Simpson, Beverly L. Davidson · 2019 · Elsevier eBooks
- In Vivo Single-Cell Genotyping of Mouse Cortical Neurons Transfected with CRISPR/Cas9André Steinecke, Nobuhiro Kurabayashi, Yasufumi Hayano, Yugo Ishino, Hiroki Taniguchi · 2019 · Cell Reports
- Gene Therapy Methods and Their Applications in Neurological DisordersMingjie Li, B. Joy Snider · 2018 · Elsevier eBooks
- Single-cell mosaicism analysis reveals cell-type-specific somatic mutational burden in Alzheimer’s DementiaKousi, Maria, Boix, Carles, Park, Yongjin P., Mathys, Hansruedi, Sledzieski, Samuel, Peng, Zhuyu, Bennett, David A., Tsai, Li-Huei, Kellis, Manolis · 2022