In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9

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Items 101–200 of 771

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2. A deep insight into CRISPR/Cas9 application in CAR-T cell-based tumor immunotherapies
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3. Mitigating off-target effects in CRISPR/Cas9-mediated in vivo gene editing
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5. Genome editing at the crossroads of delivery, specificity, and fidelity
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6. Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration
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7. Selective disruption of an oncogenic mutant allele by CRISPR/Cas9 induces efficient tumor regression
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8. Nuclear PGK1 Alleviates ADP‐Dependent Inhibition of CDC7 to Promote DNA Replication
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9. Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells
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10. Efficient delivery of nuclease proteins for genome editing in human stem cells and primary cells
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11. Cas9/sgRNA selective targeting of the P23H Rhodopsin mutant allele for treating retinitis pigmentosa by intravitreal AAV9.PHP.B-based delivery
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12. CRISPR-Cas: Converting A Bacterial Defence Mechanism into A State-of-the-Art Genetic Manipulation Tool
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13. Clinical applications of the CRISPR/Cas9 genome-editing system: Delivery options and challenges in precision medicine
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14. CRISPR/Cas9‐mediated genome editing: From basic research to translational medicine
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15. CRISPR/Cas9: a powerful genetic engineering tool for establishing large animal models of neurodegenerative diseases
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16. AAV-mediated CRISPR/cas gene editing of retinal cells in vivo
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17. Recent advances in nanotherapeutic strategies for spinal cord injury repair
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18. Genome Engineering Using Adeno-associated Virus: Basic and Clinical Research Applications
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19. Engineering Delivery Vehicles for Genome Editing
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20. Cancer CRISPR Screens In Vivo
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21. A new age in functional genomics using CRISPR/Cas9 in arrayed library screening
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22. Genetically modified pig models for neurodegenerative disorders
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23. CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage
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24. The Self-Inactivating KamiCas9 System for the Editing of CNS Disease Genes
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25. In vivo genome editing via the HITI method as a tool for gene therapy
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26. Genomic tools for behavioural ecologists to understand repeatable individual differences in behaviour
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27. Culturing primary neurons from rat hippocampus and cortex
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28. Precision cancer mouse models through genome editing with CRISPR-Cas9
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29. All-in-one adeno-associated virus delivery and genome editing by Neisseria meningitidis Cas9 in vivo
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30. Conditional Single Vector CRISPR/SaCas9 Viruses for Efficient Mutagenesis in the Adult Mouse Nervous System
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31. Creating and evaluating accurate CRISPR-Cas9 scalpels for genomic surgery
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32. Site-directed RNA repair of endogenous Mecp2 RNA in neurons
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33. Protein Delivery into the Cell Cytosol using Non-Viral Nanocarriers
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34. Modeling Disease In Vivo With CRISPR/Cas9
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35. CRISPR/Cas9 for Human Genome Engineering and Disease Research
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36. CRISPR–Cas9-mediated gene knockout in primary human airway epithelial cells reveals a proinflammatory role for MUC18
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37. Efficient in vivo gene editing using ribonucleoproteins in skin stem cells of recessive dystrophic epidermolysis bullosa mouse model
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38. Advancing chimeric antigen receptor T cell therapy with CRISPR/Cas9
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39. Genetic dissection of the different roles of hypothalamic kisspeptin neurons in regulating female reproduction
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40. Genome Editing Reveals Glioblastoma Addiction to MicroRNA-10b
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41. CRISPR/Cas System and Factors Affecting Its Precision and Efficiency
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42. In Vivo Delivery Systems for Therapeutic Genome Editing
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43. Myotonic Dystrophies: State of the Art of New Therapeutic Developments for the CNS
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44. CRISPR/Cas9 delivery with one single adenoviral vector devoid of all viral genes
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45. MeCP2: A Critical Regulator of Chromatin in Neurodevelopment and Adult Brain Function
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46. AAV ablates neurogenesis in the adult murine hippocampus
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47. Recent Advances in CRISPR‐Cas9 Genome Editing Technology for Biological and Biomedical Investigations
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48. Drug addiction: a curable mental disorder?
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49. Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats
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50. CRISPR/Cas systems: Delivery and application in gene therapy
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51. Role for Wnt Signaling in Retinal Neuropil Development: Analysis via RNA-Seq and In Vivo Somatic CRISPR Mutagenesis
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52. In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation
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53. Application of the CRISPR/Cas9 System to Drug Resistance in Breast Cancer
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54. In vivo genome editing rescues photoreceptor degeneration via a Cas9/RecA-mediated homology-directed repair pathway
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55. In vivo blunt-end cloning through CRISPR/Cas9-facilitated non-homologous end-joining
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56. Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis
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57. Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration
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58. CRISPR genome engineering and viral gene delivery: A case of mutual attraction
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59. RNA Interference in the Age of CRISPR: Will CRISPR Interfere with RNAi?
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60. Efficient Gene Transfer to the Central Nervous System by Single-Stranded Anc80L65
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61. Molecular Therapies for Inherited Retinal Diseases—Current Standing, Opportunities and Challenges
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62. Therapeutic potential of CRISPR/Cas9 gene editing in engineered T‐cell therapy
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63. Programmable DNA repair with CRISPRa/i enhanced homology-directed repair efficiency with a single Cas9
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64. The Development of an AAV-Based CRISPR SaCas9 Genome Editing System That Can Be Delivered to Neurons in vivo and Regulated via Doxycycline and Cre-Recombinase
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65. MeCP2 mutations: progress towards understanding and treating Rett syndrome
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66. Use of CRISPR/Cas9 technology efficiently targetted goat myostatin through zygotes microinjection resulting in double-muscled phenotype in goats
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67. The deletion of mutant SOD1 via CRISPR/Cas9/sgRNA prolongs survival in an amyotrophic lateral sclerosis mouse model
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68. Developmental Dynamics of Rett Syndrome
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69. CRISPR/Cas9-mediated gene knockout in the mouse brain using in utero electroporation
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70. Supernova: A Versatile Vector System for Single-Cell Labeling and Gene Function Studies in vivo
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71. Current approaches in CRISPR-Cas9 mediated gene editing for biomedical and therapeutic applications
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72. Next stop for the CRISPR revolution: RNA‐guided epigenetic regulators
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73. CRISPR/Cas9 Genome Editing for Tissue‐Specific In Vivo Targeting: Nanomaterials and Translational Perspective
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74. The Role of Kiss1 Neurons As Integrators of Endocrine, Metabolic, and Environmental Factors in the Hypothalamic–Pituitary–Gonadal Axis
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75. Applications of CRISPR Genome Engineering in Cell Biology
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76. Nanomedicine-based cancer immunotherapy: recent trends and future perspectives
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77. New pathogenic insights from large animal models of neurodegenerative diseases
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78. CRISPR–Cas9 a boon or bane: the bumpy road ahead to cancer therapeutics
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79. Inhibition of PKCδ reduces amyloid-β levels and reverses Alzheimer disease phenotypes
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80. In Vivo Genome Editing as a Therapeutic Approach
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81. CRISPR-Cas9 genome engineering: Treating inherited retinal degeneration
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82. CRISPR-Cas9 technology: applications and human disease modelling
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83. Cre-dependent Cas9-expressing pigs enable efficient in vivo genome editing
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84. CRISPR/CAS9-Mediated Genome Editing of miRNA-155 Inhibits Proinflammatory Cytokine Production by RAW264.7 Cells
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85. Different Methods of Delivering CRISPR/Cas9 Into Cells
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86. Optic nerve regeneration screen identifies multiple genes restricting adult neural repair
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87. Postnatal Cardiac Gene Editing Using CRISPR/Cas9 With AAV9-Mediated Delivery of Short Guide RNAs Results in Mosaic Gene Disruption
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88. RETRACTED: Genomic Decoding of Neuronal Depolarization by Stimulus-Specific NPAS4 Heterodimers
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89. Gene editing and its applications in biomedicine
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90. CNS-restricted Transduction and CRISPR/Cas9-mediated Gene Deletion with an Engineered AAV Vector
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91. The CRISPR/Cas9 genome editing methodology as a weapon against human viruses.
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92. Gene-Specific Targeting of DNA Methylation in the Mammalian Genome
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93. Expression of CRISPR/Cas single guide RNAs using small tRNA promoters
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94. In vivo genome editing as a potential treatment strategy for inherited retinal dystrophies
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95. Evolving AAV-delivered therapeutics towards ultimate cures
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96. Targeted Gene Editing of Glia Maturation Factor in Microglia: a Novel Alzheimer’s Disease Therapeutic Target
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97. CRISPR/Cas9-based genome editing in the era of CAR T cell immunotherapy
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98. Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation
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99. Engineered Nanomaterials to Potentiate CRISPR/Cas9 Gene Editing for Cancer Therapy
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100. Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice
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