In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9

Swiech, Lukasz, Heidenreich, Matthias, Banerjee, Abhishek, Habib, Naomi, Li, Yinqing, Trombetta, John, Sur, Mriganka, Zhang, Feng·2015·Nature Biotechnology

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  4. [Use of a new peroral anticoryza drug. Experience in the industrial medical practice].
    G Schäfer · 1971 · PubMed
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  57. Additional file 2 of Doxycycline-dependent Cas9-expressing pig resources for conditional in vivo gene nullification and activation
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  58. Additional file 1 of Removal of a partial genomic duplication restores synaptic transmission and behavior in the MyosinVA mutant mouse Flailer
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  59. Additional file 3 of Doxycycline-dependent Cas9-expressing pig resources for conditional in vivo gene nullification and activation
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  60. Additional file 1 of Doxycycline-dependent Cas9-expressing pig resources for conditional in vivo gene nullification and activation
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  61. Additional file 1 of Detection of CRISPR-mediated genome modifications through altered methylation patterns of CpG islands
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  62. Additional file 4 of Doxycycline-dependent Cas9-expressing pig resources for conditional in vivo gene nullification and activation
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