In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9
Swiech, Lukasz, Heidenreich, Matthias, Banerjee, Abhishek, Habib, Naomi, Li, Yinqing, Trombetta, John, Sur, Mriganka, Zhang, Feng·2015·Nature Biotechnology
DOI 10.1038/nbt.3055
Cited by (771)
Items 701–771 of 771
- Translational Research on DMD in JapanShin’ichi Takeda, Tetsuya Nagata · 2016 · Springer eBooks
- Genome Editing in Stem CellsLeon Tejwani, Cleber A. Trujillo, Charles A. Thomas, Alysson Renato Muotri · 2016 · Springer eBooks
- Biology of AAV Vectors in the Central Nervous SystemGiridhar Murlidharan · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
- [Use of a new peroral anticoryza drug. Experience in the industrial medical practice].G Schäfer · 1971 · PubMed
- Development of a Viral Toolbox to Study the Role of m6A RNA Methylation in MemoryColleen J. Gillon · 2016 · TSpace (University of Toronto)
- Modeling Disease In Vivo WithEleanor Dow · 2015
- Multiscale Genome Engineering: Genome-Wide Screens and Targeted ApproachesNeville E. Sanjana · 2017 · Research and perspectives in neurosciences
- 基于CRISPR/Cas9基因编辑技术的人类遗传疾病基因治疗相关研究进展可 门, 醒妹 段, 阳 杨, 于全 魏 · 2017 · Scientia Sinica Vitae
- CRISPR/Cas9技术在生物医学领域的非病毒及病毒载体舟 秦, 可 门, 珽 徐, 治尧 何, 于全 魏, 阳 杨 · 2017 · Scientia Sinica Vitae
- Inherited Retinal DiseasesAla Moshiri, Amirfarbod Yazdanyar · 2018 · Current practices in ophthalmology
- Genetically Altered Mice as an Approach for the Investigation of Obesity and Metabolic DiseaseRebecca Dumbell, Roger Cox · 2018
- Clustered regularly interspaced short palindromic repeats-Cas9 gene therapy: The top 50 most-cited papersJude Howaidi, Ali Howaidi, Faisal Howaidi · 2019 · Journal of Nature and Science of Medicine
- Validation of a CRISPR/cas9-based technology platform for examining specific immune gene functions in an experimental murine model of IBDRui Wang, Sean Graham, Ning Sun, Donna McCarthy, Ruoqi Peng, Jamie Erickson, Xiaochun Zhu, Marc A. Wurbel, Robert W. Dunstan, Namjin Chung et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- A loss-of-function study of CRTC1 in hippocampal neurons at basal state and during long-term synaptic plasticityAgnes Fang Yi Lim · 2019
- Construction of Viral Vectors for Cell Type-specific CRISPR Gene Editing in the Adult Mouse BrainHiroshi Yamaguchi, Luı́s de Lecea · 2019 · BIO-PROTOCOL
- New Additions to the CRISPR Toolbox: CRISPR- CLONInG and CRISPR- CLIP for Donor Construction in Genome EditingDorjee T.N. Shola, Chingwen Yang, Vhy-Shelta Kewaldar, Pradip Kar, Victor Bustos · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- Gene editing and central nervous system regenerationSara Monteiro Lopes, Luís Pereira de Almeida · 2020 · Elsevier eBooks
- Adeno-associated virus-mediated gene therapy in central nervous system genetic disordersWidler Casy, Qinglan Ling, Frances C. Shaffo, Sarah E. Sinnett, Steven James Gray · 2020 · Elsevier eBooks
- Development of CRISPR/Cas-mediated gene editing in the retinaFengJiu Li · 2020 · UTAS Research Repository
- CRISPR knockdown of GABA A alpha3 subunits on thalamic reticular neurons enhances deep sleepDavid S. Uygun, Chun Zhi Yang, Elena R. Tilli, Fumi Katsuki, James Timothy McKenna, James M. McNally, Ritchie Edward Brown, Radhika Basheer · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- In vivo gene editing of outer hair cells prevents progressive hearing loss in a dominant-negative KCNQ4 murine modelByunghwa Noh, John Hoon Rim, Ramu Gopalappa, Haiyue Lin, Kyu Min Kim, Heon Yung Gee, Jae Young Choi, Seokjoong Kim, Jinsei Jung · 2021 · Research Square
- Effects of Nutrition on Pubertal Timing at the Neuroendocrine and Cellular LevelsElvira Rodríguez-Vázquez, Juan Manuel Castellano, Manuel Tena‐Sempere · 2021 · Elsevier eBooks
- Получение трансгенных эмбриональных стволовых клеток крысы с использованием системы CRISPR/Cpf1 для индуцируемого нокаута геновВладимир Владимирович Шерстюк, Сурен Минасович Закиян · 2021 · Biochemistry (Moscow)
- Generation of Transgenic Rat Embryonic Stem Cells Using the CRISPR/Cpf1 System for Inducible Gene KnockoutВладимир Владимирович Шерстюк, Suren M. Zakian · 2021 · Biochemistry (Moscow)
- Influência da via de sinalização HIPPO na segregação entre a massa interna celular e o trofectoderma em embriões bovinosCaroline Pereira da Costa · 2020
- Genetic causes and stem-cell-based therapeutic strategies in neuromuscular diseasesLe Guo · 2021
- CRISPR/Cas9 Inducible Gene Knockout in Brown Adipose TissueSteven M. Romanelli · 2021 · Deep Blue (University of Michigan)
- Right tool for the right job : Exploring the diversity of type V CRISPR-Cas systemsWen Y. Wu · 2021
- Intellectual DisabilityPierre L. Roubertoux, Michèle Carlier · 2016 · Springer eBooks
- Extension and Improvement of CRISPR-Based TechnologyZiheng Zhang, Ping Wang, Ji‐Long Liu · 2022 · Springer eBooks
- Faculty Opinions recommendation of Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease.Dan Lindholm · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- A neural substrate for negative affect dictates parental behaviourSalvatore Lecca, Mauro Congiu, Lea Royon, Leonardo Restivo, Benôıt Girard, Noémie Mazaré, Camilla Bellone, Ludovic Telley, Manuel Mameli · 2022 · Research Square
- Faculty Opinions recommendation of Virus-Mediated Genome Editing via Homology-Directed Repair in Mitotic and Postmitotic Cells in Mammalian Brain.Søren Warming · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Methods for In Vivo Gene ManipulationLisa M. Monteggia, Wei Xu · 2017 · Oxford University Press eBooks
- Faculty Opinions recommendation of In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation.Thomas Biederer · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of Efficient In Vivo Liver-Directed Gene Editing Using CRISPR/Cas9.Irina M. Conboy · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- CRISPR base editing of cis -regulatory elements enables target gene perturbationsColin K.W. Lim, Tristan X. McCallister, Christian Saporito-Magriñá, Garrett D. McPheron, Ramya Krishnan, M. Alejandra Zeballos C., Jackson E. Powell, Lindsay V. Clark, Pablo Pérez‐Piñera, Thomas Gaj · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Genome Editing with CRISPR‐Cas SystemsPeter Lotfy, Patrick D. Hsu · 2022 · Wiley eBooks
- CRISPR for gene editing in neuroscience and neurological diseaseJanine Louise Ostick · 2017 · Advances in Clinical Neuroscience & Rehabilitation
- Chapter 1. Basic Principles of Molecular Biology and GenomicsClaes Wahlestedt, Mark M. Rasenick, Jiang-Zhou Yu, Zane R. Zeier · 2024 · American Psychiatric Association Publishing eBooks
- CRISPR screening meets spatial omics: Opportunities and challengesYinxing Ma · 2024 · Elsevier eBooks
- Adeno-associated virus-mediated gene therapy in central nervous system genetic disordersQinglan Ling, Andrea Boitnott, Irvin T. Garza, Widler Casy, Frances C. Shaffo, Sarah E. Sinnett, Steven James Gray · 2024 · Elsevier eBooks
- CRISPR/Cas9-based genetic engineering for translational research in neurological disordersPlaton Megagiannis, Guy Armand Rouleau, Yang Zhou · 2024 · Elsevier eBooks
- Genome Editing Technologies for Investigation of Activity-Dependent TranscriptionJennifer J. Tuscher, Robert A. Phillips, Jeremy J. Day · 2024 · Springer eBooks
- From Circuits to Drug Targets: The Promise of Opto- and Chemogenetics for Drug DiscoveryDennis Kätzel · 2024 · Royal Society of Chemistry eBooks
- Disruption of the Novel Nested Gene Aff3ir Mediates Disturbed Flow-Induced Atherosclerosis in MiceShuo He, Lei Huang, Zhuozheng Chen, Ze Yuan, Yue Zhao, Lingfang Zeng, Yi Zhu, Jinlong He · 2024 · eLife
- Gene Editing for ATXN3 Inactivation in Machado-Joseph disease: CRISPR-Cas9 as a Therapeutic Alternative to TALEN-Induced ToxicitySara Monteiro Lopes, Miguel Monteiro Lopes, Daniela Camargo de Oliveira, Magda M. Santana, Ana Rita Fernandes, Ana Vasconcelos‐Ferreira, Dina Pereira, Maria Casquinha, Clévio Nóbrega, Carlos A. Matos et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Co-release of opposing signaling molecules controls the escalation and release of aggressionRachel E. Gatlin, J. Gagon, Damhyeon Kwak, Sewon Park, Hailee Walker, Lo Kronheim, T. Everett, Ashley Covington, Michaela M. Fluck, Tobias Zickmund et al. · 2025 · bioRxiv
- Disruption of the Novel Nested Gene Aff3ir Mediates Disturbed Flow-Induced Atherosclerosis in MiceShuo He, Lei Huang, Zhuozheng Chen, Ze Yuan, Yue Zhao, Lingfang Zeng, Yi Zhu, Jinlong He · 2025 · eLife
- Evolution of behavior: Genotype to phenotypeMackenzie R. Prichard · 2025 · Elsevier eBooks
- Crispr/Cas9 Delivery for Glioma Treatment: A Systematic ReviewThiago Andrés Navarro Álvarez, Ricardo Andrés Novoa Álvarez, Jaime Antonio Navarro Parra · 2025 · Journal of Posthumanism
- Advancement of CRISPR/Cas9 in Translational BiomedicinesNeha Atale, Qinglin Kong, Vibha Rani · 2025 · Advances in Science, Technology & Innovation/Advances in science, technology & innovation
- Circuit-specific gene editing for precision modulation of neuronal activity with CRISPR-rabies virusZijian Zhang, Jing Xu, Elizabeth A. Matthews, Samantha Deasy, Lewei He, Diego Arroyo, Enhui Pan, Arvin Deshmukh, Kiran Shehnaz Kaur, James O McNamara et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Evolution of Mammalian Regulatory Networks in the BrainRajee Ganesan, Andreas R. Pfenning · 2025 · Annual Review of Animal Biosciences
- Legal and Ethical Repercussions of CRISPR-CAS9 in IndiaRajat Banerjee, Kuntal Pal · 2025 · IGI Global eBooks
- Additional file 3 of Removal of a partial genomic duplication restores synaptic transmission and behavior in the MyosinVA mutant mouse FlailerFernando J. Bustos, Swarna Pandian, Henny Haensgen, Jian-Ping Zhao, Haley Strouf, Matthias Heidenreich, Lukasz J. Swiech, Benjamin E. Deverman, Viviana Gradinaru, Feng Zhang et al. · 2024 · Figshare
- Additional file 2 of Doxycycline-dependent Cas9-expressing pig resources for conditional in vivo gene nullification and activationQin Jin, Liu, Xiaoyi, Zhenpeng Zhuang, Huang, Jiayuan, Shixue Gou, Shi, Hui, Yu Zhao, Ouyang, Zhen, Liu, Zhaoming, Li, Lei et al. · 2023 · Figshare
- Additional file 1 of Removal of a partial genomic duplication restores synaptic transmission and behavior in the MyosinVA mutant mouse FlailerFernando J. Bustos, Swarna Pandian, Henny Haensgen, Jian-Ping Zhao, Haley Strouf, Matthias Heidenreich, Lukasz J. Swiech, Benjamin E. Deverman, Viviana Gradinaru, Feng Zhang et al. · 2023 · Figshare
- Additional file 3 of Doxycycline-dependent Cas9-expressing pig resources for conditional in vivo gene nullification and activationQin Jin, Liu, Xiaoyi, Zhenpeng Zhuang, Huang, Jiayuan, Shixue Gou, Shi, Hui, Yu Zhao, Ouyang, Zhen, Liu, Zhaoming, Li, Lei et al. · 2023 · Figshare
- Additional file 1 of Doxycycline-dependent Cas9-expressing pig resources for conditional in vivo gene nullification and activationQin Jin, Liu, Xiaoyi, Zhenpeng Zhuang, Huang, Jiayuan, Shixue Gou, Shi, Hui, Yu Zhao, Ouyang, Zhen, Liu, Zhaoming, Li, Lei et al. · 2023 · Figshare
- Additional file 1 of Detection of CRISPR-mediated genome modifications through altered methylation patterns of CpG islandsMichele Farris, Pamela A. Texter, Agustin A. Mora, Wiles, Michael V., Mac Garrigle, Ellen F., Klaus, Sybil A., Kristine M. Rosfjord · 2020 · Figshare
- Additional file 4 of Doxycycline-dependent Cas9-expressing pig resources for conditional in vivo gene nullification and activationQin Jin, Liu, Xiaoyi, Zhenpeng Zhuang, Huang, Jiayuan, Shixue Gou, Shi, Hui, Yu Zhao, Ouyang, Zhen, Liu, Zhaoming, Li, Lei et al. · 2023 · Figshare
- Etude du rôle de la protéine kinase DCLK3 dans les mécanismes de neurodégénérescence dans la maladie de HuntingtonLucie de Longprez · 2018 · theses.fr (ABES)
- Interaction entre la protéine Tau et la protéine p54nrb : effet sur la maturation des miARN au sein des paraspecklesMarine Denéchaud · 2022 · theses.fr (ABES)
- Development of a new therapeutic approach based on peptide nanoparticles delivering CRISPR-Cas9 for the specific targeting of KRAS mutationsVeronica Guzman Gonzalez · 2023
- Advances in the regulation of bone metabolism by central nuclei: a new perspective on the brain-bone axisGuanhao Yang, Xuan Huang, Duorun Qiu, Anzhao Wang, Denghui Liu, Zhongtang Liu · 2026 · Frontiers in Neuroscience
- Intersectional CRISPR-Cas9 genetic targeting reveals acute role of Na V 1.1 in proprioceptive behavior and functionCyrrus M. Espino, Isaac J. Villegas, Serena Ortiz, Nadya J Berber, Julian A. N. M. Halmai, Kyle D. Fink, Theanne N. Griffith · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Beta2* Nicotinic Receptors Regulate Exploratory and Social Behavior Through Functionally Distinct Neuronal PopulationsHelena Janíčková, Alice Abbondanza, Jan Eliáš, Chandani Verma, Amanda Barboza, Martin Čapek, Trisha Dhabalia, Andrea Grígelová, Sylvie Dumas, Veronique Bernard · 2026 · Research Square
- StitchR-based dual-AAV delivery strategies enable efficient transduction of defined neural cell populationsNengsong Luo, Gao Y, Zengpeng Han, Peng Su, Fuqiang Xu, K Z Lin · 2026 · Molecular Brain
- Nup153 regulates neuronal responsiveness through HDAC1-mediated epigenetic modulationAbhinav Soni, Stavroula Petridi, Maria Ludovica Sforza, Diana Kluetsch, Koki Sakurai, Xin Hu, Nicole Rund, Anne Karasinsky, Julia Hernandez Pineda, Judith Houtman et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- The Onset of Breathing at Birth Switches Off Regenerative CapacityXuan Song, Xinyi Cai, Shane Hegarty, Davide Speri, Masahiro Yasuda, Ryan Donahue, Joanna Stanicka, Ting Yan, Susu Mao, Sarah Yang et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)