Cited by 145Microbial Metabolic Engineering and BioproductionBiofuel production and bioconversionFungal and yeast genetics research

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Mixed Lactic Acid–Alcoholic Fermentation by Saccharomyes cerevisiae Expressing the Lactobacillus casei L(+)–LDH

Dequin, Sylvie, Barre, Pierre·1994·Nature Biotechnology

DOI 10.1038/nbt0294-173

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Abstract

We describe the construction of a Saccharomyces cerevisiae strain expressing the gene encoding the L(+)-lactate dehydrogenase [L(+)-LDH)] from Lactobacillus casei. The recombinant strain is able to perform a mixed lactic acid-alcoholic fermentation. Yeast cells expressing the L(+)-LDH gene from the yeast alcohol dehydrogenase (ADH1) promoter on a multicopy plasmid simultaneously convert glucose to both ethanol and lactate, with up to 20% of the glucose transformed into L(+)-lactate. Such strains may be used in every field where both biological acidification and alcoholic fermentation are required.

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Authors: Dequin, S., & Barre, P.
Affiliations: Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
ORCID: Dequin, Sylvie
Venue: Nature Biotechnology
Publisher: Springer Science and Business Media LLC
Published: 1994-02
Volume: 12
Issue: 2
Pages: 173-177
ISSN: 0733-222X (ISSN-L)
1087-0156
1546-1696
DOI: 10.1038/nbt0294-173
OpenAlex: W1972332967
Cited by: 145
References: 32
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 5 · 2016: 4 · 2015: 6 · 2014: 10 · 2013: 6 · 2012: 6
FWCI: 0.89
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (unspecified)
Locations: Nature Biotechnology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: Saccharomyces cerevisiae, L-lactate dehydrogenase, Lactobacillus casei, recombinant yeast, ethanol production, lactic acid production, ADH1 promoter, multicopy plasmid, biological acidification, heterologous expression
MeSH terms: Alcohol Dehydrogenase, Ethanol, Base Sequence, Cloning, Molecular, Fermentation, Genetic Vectors, Glucose, L-Lactate Dehydrogenase, Lactates, Lacticaseibacillus casei, Molecular Sequence Data, Oligodeoxyribonucleotides, Promoter Regions, Genetic, Recombinant Proteins, Saccharomyces cerevisiae, Restriction Mapping, Polymerase Chain Reaction, Mutagenesis, Site-Directed, Lactic Acid

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Mixed Lactic Acid–Alcoholic Fermentation by Saccharomyes cerevisiae Expressing the Lactobacillus casei L(+)–LDH

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