Human antibodies from transgenic animals.

Continuous cultures of fused cells secreting antibody of predefined specificity

Köhler, G., & Milstein, C. (1975) · Nature · doi:10.1038/256495a0 · Cited by 17,200 · see citing works

Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal Cancer

Cunningham, D., Humblet, Y., Siena, S., Khayat, D., Bleiberg, H., Santoro, A., Bets, D., Mueser, M., Harstrick, A., Verslype, C., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa033025 · Cited by 5,035 · see citing works

Enhancement of Antitumor Immunity by CTLA-4 Blockade

Leach, D. R., Krummel, M. F., & Allison, J. P. (1996) · Science · doi:10.1126/science.271.5256.1734 · Cited by 3,955 · see citing works

Phage antibodies: filamentous phage displaying antibody variable domains

McCafferty, J., Griffiths, A. D., Winter, G. P., & Chiswell, D. J. (1990) · Nature · doi:10.1038/348552a0 · Cited by 2,427 · see citing works

Influence of Immunogenicity on the Long-Term Efficacy of Infliximab in Crohn's Disease

Baert, F., Noman, M., Vermeire, S., Assche, G. V., Haens, G. D., Carbonez, A., & Rutgeerts, P. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa020888 · Cited by 2,012 · see citing works

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes

Mansour, S. L., Thomas, K. R., & Capecchi, M. R. (1988) · Nature · doi:10.1038/336348a0 · Cited by 1,683 · see citing works

Cancer regression and autoimmunity induced by cytotoxic t lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

Phan, G. Q., Yang, J. C., Sherry, R. M., Hwu, P., Topalian, S. L., Schwartzentruber, D. J., Restifo, N. P., Haworth, L. R., Seipp, C. A., Freezer, L. J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1533209100 · Cited by 1,575 · see citing works

Replacing the complementarity-determining regions in a human antibody with those from a mouse

Jones, P. T., Dear, P. H., Foote, J., Neuberger, M. S., & Winter, G. (1986) · Nature · doi:10.1038/321522a0 · Cited by 1,406 · see citing works

Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains.

Morrison, S. L., Johnson, M. J., Herzenberg, L. A., & Oi, V. T. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.21.6851 · Cited by 1,040 · see citing works

Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients

Hodi, F. S., Mihm, M. C., Soiffer, R. J., Haluska, F. G., Butler, M., Seiden, M. V., Davis, T., Henry-Spires, R., MacRae, S., Willman, A., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0830997100 · Cited by 1,006 · see citing works

Anti–Interleukin-12 Antibody for Active Crohn's Disease

Mannon, P., Fuss, I. J., Mayer, L., Elson, C. O., Sandborn, W. J., Present, D. H., Dolin, B. J., Goodman, N., Groden, C. A., Hornung, R. L., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa033402 · Cited by 844 · see citing works

Diversity in the CDR3 Region of VH Is Sufficient for Most Antibody Specificities

Xu, J. L., & Davis, M. M. (2000) · Immunity · doi:10.1016/s1074-7613(00)00006-6 · Cited by 779 · see citing works

A Single-Dose Placebo-Controlled Study of AMG 162, a Fully Human Monoclonal Antibody to RANKL, in Postmenopausal Women

Bekker, P. J., Holloway, D. L., Rasmussen, A. S., Murphy, R., Martin, S. W., Leese, P. T., Holmes, G. B., Dunstan, C. R., & DePaoli, A. M. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040305 · Cited by 770 · see citing works

A Randomized Clinical Trial of OKT3 Monoclonal Antibody for Acute Rejection of Cadaveric Renal Transplants

Ortho Multicenter Transplant Study Group* (1985) · New England Journal of Medicine · doi:10.1056/nejm198508083130601 · Cited by 720 · see citing works

An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus

Traggiai, E., Becker, S., Subbarao, K., Kolesnikova, L., Uematsu, Y., Gismondo, M. R., Murphy, B. R., Rappuoli, R., & Lanzavecchia, A. (2004) · Nature Medicine · doi:10.1038/nm1080 · Cited by 697 · see citing works

Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas

Teeling, J. L. (2004) · Blood · doi:10.1182/blood-2004-01-0039 · Cited by 630 · see citing works

Structure-Immunogenicity Relationships of Therapeutic Proteins

Hermeling, S., Crommelin, D. J. A., Schellekens, H., & Jiskoot, W. (2004) · Pharmaceutical Research · doi:10.1023/b:pham.0000029275.41323.a6 · Cited by 617 · see citing works

Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy

Yang, X. (2001) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(00)00134-7 · Cited by 463 · see citing works

Autoimmunity in a Phase I Trial of a Fully Human Anti-Cytotoxic T-Lymphocyte Antigen-4 Monoclonal Antibody With Multiple Melanoma Peptides and Montanide ISA 51 for Patients With Resected Stages III and IV Melanoma

Sanderson, K. M., Scotland, R., Lee, P. P., Liu, D., Groshen, S. G., Snively, J., Sian, S., Nichol, G. M., Davis, T. A., Keler, T., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2005.01.128 · Cited by 432 · see citing works

Antigen-specific human antibodies from mice comprising four distinct genetic modifications

Lönberg, N., Taylor, L. D., Harding, F., Trounstine, M. L., Higgins, K. M., Schramm, S. R., Kuo, C.-C., Mashayekh, R., Wymore, K., McCabe, J. G., et al. (1994) · Nature · doi:10.1038/368856a0 · Cited by 399 · see citing works

Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice

Mendez, M. J., Green, L. L., Corvalán, J. R. F., Jia, X., Maynard-Currie, C. E., Yang, X.-D., Gallo, M., Louie, D. M., Lee, D. V., Erickson, K. L., et al. (1997) · Nature Genetics · doi:10.1038/ng0297-146 · Cited by 376 · see citing works

Kinetic and affinity limits on antibodies produced during immune responses.

Foote, J., & Eisen, H. N. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1254 · Cited by 375 · see citing works

Combination Therapy Enhances the Inhibition of Tumor Growth with the Fully Human Anti–Type 1 Insulin-Like Growth Factor Receptor Monoclonal Antibody CP-751,871

Cohen, B. D., Baker, D. A., Soderstrom, C. I., Tkalcevic, G. T., Rossi, A. M., Miller, P. E., Tengowski, M. W., Wang, F., Gualberto, A., BEEBE, J. S., et al. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1070 · Cited by 367 · see citing works

Fully Humanized Neutralizing Antibodies to Interleukin-8 (ABX-IL8) Inhibit Angiogenesis, Tumor Growth, and Metastasis of Human Melanoma

Huang, S., Mills, L., Mian, B. M., Tellez, C. S., McCarty, M. F., Yang, X., Gudas, J. M., & Bar‐Eli, M. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64164-8 · Cited by 361 · see citing works

Antigen–specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs

Green, L. L., Hardy, M. C., Maynard-Currie, C. E., Tsuda, H., Louie, D. M., Mendez, M. J., Abderrahim, H., Noguchi, M., Smith, D. H., Zeng, Y. C., et al. (1994) · Nature Genetics · doi:10.1038/ng0594-13 · Cited by 355 · see citing works

Germ-line transmission of a disrupted β2microglobulin gene produced by homologous recombination in embryonic stem cells

Zijlstra, M., Li, E., Sajjadi, F., Subramani, S., & Jaenisch, R. (1989) · Nature · doi:10.1038/342435a0 · Cited by 347 · see citing works

Safety, Pharmacokinetics, and Activity of ABX-EGF, a Fully Human Anti–Epidermal Growth Factor Receptor Monoclonal Antibody in Patients With Metastatic Renal Cell Cancer

Rowinsky, E. K., Schwartz, G. H., Gollob, J., Thompson, J. A., Vogelzang, N. J., Figlin, R. A., Bukowski, R. M., Haas, N. B., Lockbaum, P., Li, Y.-P., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.11.061 · Cited by 329 · see citing works

Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy.

Yang, X., Jia, X., Corvalan, J. R. F., Wang, P., Davis, C., & Jakobovits, A. (1999) · PubMed · Cited by 328 · see citing works

Current Status and Future Prospects

Wood, C. E., Baker, G., & Trounson, A. (1984) · Springer eBooks · doi:10.1007/978-1-4471-3317-9_2 · Cited by 306 · see citing works

Germ-Line Transmission of a c- abl Mutation Produced by Targeted Gene Disruption in ES Cells

Schwartzberg, P. L., Goff, S. P., & Robertson, E. J. (1989) · Science · doi:10.1126/science.2554496 · Cited by 272 · see citing works

Cloned transchromosomic calves producing human immunoglobulin

Kuroiwa, Y., Kasinathan, P., Choi, Y. J., et al. (2002) · Nature Biotechnology · doi:10.1038/nbt727 · Cited by 268 · see citing works

Functional expression and germline atransmission of a human chromosome fragment in chimaeric mice

Tomizuka, K., Yoshida, H., Uejima, H., Kugoh, H., Sato, K., Ohguma, A., Hayasaka, M., Hanaoka, K., Oshimura, M., & Ishida, I. (1997) · Nature Genetics · doi:10.1038/ng0697-133 · Cited by 267 · see citing works

High-avidity human IgGκ monoclonal antibodies from a novel strain of minilocus transgenic mice

Fishwild, D. M., O'Donnell, S. L., Bengoechea, T. G., Hudson, D., Harding, F., Bernhard, S. L., Jones, D., Kay, R. M., Higgins, K. M., Schramm, S. R., et al. (1996) · Nature Biotechnology · doi:10.1038/nbt0796-845 · Cited by 266 · see citing works

Human monoclonal antibody production

James, K. E., & Bell, G. (1987) · Journal of Immunological Methods · doi:10.1016/0022-1759(87)90170-0 · Cited by 223 · see citing works

Preclinical and clinical evaluations of ABX-EGF, a fully human anti-epidermal growth factor receptor antibody

Foon, K. A., Yang, X.-D., Weiner, L. M., et al. (2004) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2003.09.098 · Cited by 218 · see citing works

Double trans-chromosomic mice: Maintenance of two individual human chromosome fragments containing Ig heavy and κ loci and expression of fully human antibodies

Tomizuka, K., Shinohara, T., Yoshida, H., Uejima, H., Ohguma, A., Tanaka, S., Sato, K., Oshimura, M., & Ishida, I. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.722 · Cited by 202 · see citing works

Early high-affinity neutralizing anti-viral IgG responses without further overall improvements of affinity.

Roost, H.-P., Bachmann, M. F., Haag, A. F., et al. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1257 · Cited by 199 · see citing works

The Imprint of Somatic Hypermutation on the Repertoire of Human Germline V Genes

Tomlinson, I. M., Walter, G., Jones, P., Dear, P. H., Sonnhammer, E. L. L., & Winter, G. P. (1996) · Journal of Molecular Biology · doi:10.1006/jmbi.1996.0127 · Cited by 197 · see citing works

Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model

Villadsen, L. S., Schuurman, J., Beurskens, F. J. M., Dam, T. N., Dagnæs‐Hansen, F., Skov, L., Rygaard, J., Voorhorst‐Ogink, M. M., Gerritsen, A. F., van Dijk, M. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318986 · Cited by 193 · see citing works

Will immunogenicity limit the use, efficacy, and future development of therapeutic monoclonal antibodies?

Kuus-Reichel, K., Grauer, L. S., Karavodin, L. M., Knott, C., Krusemeier, M., & Kay, N. E. (1994) · Clinical and Diagnostic Laboratory Immunology · doi:10.1128/cdli.1.4.365-372.1994 · Cited by 185 · see citing works

Sequential targeting of the genes encoding immunoglobulin-μ and prion protein in cattle

Kuroiwa, Y., Kasinathan, P., Matsushita, H., et al. (2004) · Nature Genetics · doi:10.1038/ng1373 · Cited by 179 · see citing works

Fully human anti-interleukin-8 monoclonal antibodies: potential therapeutics for the treatment of inflammatory disease states

Yang, X., Corvalán, J. R. F., Wang, P., Roy, C. M.-N., & Davis, C. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.66.3.401 · Cited by 174 · see citing works

Cytotoxic T Lymphocyte-Associated Antigen 4 Blockade in Patients with Metastatic Melanoma

Robinson, M. R., Chan, C. C., Yang, J. C.-H., Rubin, B. I., Gracia, G. J., Sen, H. N., Csaky, K. G., & Rosenberg, S. A. (2004) · Journal of Immunotherapy · doi:10.1097/00002371-200411000-00008 · Cited by 159 · see citing works

Manipulation of human minichromosomes to carry greater than megabase-sized chromosome inserts

Kuroiwa, Y., Tomizuka, K., Shinohara, T., et al. (2000) · Nature Biotechnology · doi:10.1038/80287 · Cited by 155 · see citing works

A repertoire of monoclonal antibodies with human heavy chains from transgenic mice.

Brüggemann, M., Caskey, H. M., Teale, C., et al. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.17.6709 · Cited by 153 · see citing works

CNTO 95, a fully human monoclonal antibody that inhibits αv integrins, has antitumor and antiangiogenic activity in vivo

Trikha, M., Zhao, Z., Nemeth, J. A., Chen, Q., Sharp, C. M., Emmell, E., Giles-Komar, J. M., & Nakada, M. T. (2004) · International Journal of Cancer · doi:10.1002/ijc.20116 · Cited by 153 · see citing works

Dual Mode of Action of a Human Anti-Epidermal Growth Factor Receptor Monoclonal Antibody for Cancer Therapy

Bleeker, W. K., van Bueren, J. J. L., van Ojik, H. H., Gerritsen, A. F., Pluyter, M., Houtkamp, M., Halk, E., Goldstein, J., Schuurman, J., van Dijk, M. A., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.7.4699 · Cited by 151 · see citing works

Fully human anti-interleukin 8 antibody inhibits tumor growth in orthotopic bladder cancer xenografts via down-regulation of matrix metalloproteases and nuclear factor-kappaB.

Mian, B. M., Dinney, C. P., Bermejo, C. E., Sweeney, P., Tellez, C. S., Yang, X., Gudas, J. M., McConkey, D. J., & Bar‐Eli, M. (2003) · PubMed · Cited by 148 · see citing works

Immunogenicity of therapeutic monoclonal antibodies.

Pendley, C. E., Schantz, A., & Wagner, C. (2003) · PubMed · Cited by 144 · see citing works

Activity and Safety of CTLA-4 Blockade Combined with Vaccines in Cynomolgus Macaques

Keler, T., Halk, E., Vitale, L. A., O’Neill, T., Blanset, D. L., Lee, S., Srinivasan, M., Graziano, R. F., Davis, T. A., Lönberg, N., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.11.6251 · Cited by 134 · see citing works

Production of Human Monoclonal and Polyclonal Antibodies in TransChromo Animals

Ishida, I., Tomizuka, K., Yoshida, H., et al. (2002) · Cloning and Stem Cells · doi:10.1089/153623002753632084 · Cited by 132 · see citing works

The creation of diversity in the human immunoglobulin Vλ repertoire

Ignatovich, O., Tomlinson, I. M., Jones, P. T., & Winter, G. P. (1997) · Journal of Molecular Biology · doi:10.1006/jmbi.1997.0956 · Cited by 130 · see citing works

Antibody Therapy in the Management of Shiga Toxin-Induced Hemolytic Uremic Syndrome

Tzipori, S., Sheoran, A. S., Akiyoshi, D. E., et al. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.4.926-941.2004 · Cited by 126 · see citing works

Role of Dendritic Cell Phenotype, Determinant Spreading, and Negative Costimulatory Blockade in Dendritic Cell-Based Melanoma Immunotherapy

Ribas, A., Glaspy, J. A., Lee, Y., Dissette, V. B., Seja, E., Vu, H. T., Tchekmedyian, N. S., Oseguera, D. K., Comin-Anduix, B., Wargo, J. A., et al. (2004) · Journal of Immunotherapy · doi:10.1097/00002371-200409000-00004 · Cited by 119 · see citing works

Mannose Receptor Targeting of Tumor Antigen pmel17 to Human Dendritic Cells Directs Anti-Melanoma T Cell Responses via Multiple HLA Molecules

Ramakrishna, V., Treml, J., Vitale, L. A., Connolly, J. E., O’Neill, T. J., Smith, P. A., Jones, C. L., He, L.-Z., Goldstein, J., Wallace, P. K., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.2845 · Cited by 114 · see citing works

The human anti-CD30 antibody 5F11 shows in vitro and in vivo activity against malignant lymphoma

Borchmann, P., Treml, J., Hansen, H. P., et al. (2003) · Blood · doi:10.1182/blood-2003-02-0515 · Cited by 114 · see citing works

Human Stx2-Specific Monoclonal Antibodies Prevent Systemic Complications of Escherichia coli O157:H7 Infection

Mukherjee, J., Chios, K., Fishwild, D. M., et al. (2002) · Infection and Immunity · doi:10.1128/iai.70.2.612-619.2002 · Cited by 111 · see citing works

Detection of cell surface and intracellular antigens by human monoclonal antibodies. Hybrid cell lines derived from lymphocytes of patients with malignant melanoma.

Houghton, A. N., Brooks, H., Côté, R. J., et al. (1983) · The Journal of Experimental Medicine · doi:10.1084/jem.158.1.53 · Cited by 110 · see citing works

A defective Vkappa A2 allele in Navajos which may play a role in increased susceptibility to haemophilus influenzae type b disease.

Feeney, A. J., Atkinson, M. J., Cowan, M. J., et al. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118669 · Cited by 106 · see citing works

Cre-loxP-mediated gene replacement: a mouse strain producing humanized antibodies

Zou, Y.-R., Müller, W., Gu, H., & Rajewsky, K. (1994) · Current Biology · doi:10.1016/s0960-9822(00)00248-7 · Cited by 104 · see citing works

The human heavy chain Ig V region gene repertoire is biased at all stages of B cell ontogeny, including early pre-B cells

Kraj, P. J., Rao, S. P., Glas, A. M., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.12.5824 · Cited by 102 · see citing works

A Fully Human Monoclonal Antibody (CR002) Identifies PDGF-D as a Novel Mediator of Mesangioproliferative Glomerulonephritis

Ostendorf, T., van Roeyen, C. R. C., Peterson, J. D., et al. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000083393.00959.02 · Cited by 95 · see citing works

Efficacy and safety of ABI793, a novel human anti-human CD154 monoclonal antibody, in cynomolgus monkey renal allotransplantation1

Schüler, W., Bigaud, M., Brinkmann, V., et al. (2004) · Transplantation · doi:10.1097/01.tp.0000116563.72763.83 · Cited by 90 · see citing works

Pre-B cell receptor-mediated selection of pre-B cells synthesizing functional mu heavy chains.

Kline, G. H., Hartwell, L., Beck‐Engeser, G., et al. (1998) · PubMed · Cited by 86 · see citing works

Human normal hepatocytes are susceptible to apoptosis signal mediated by both TRAIL-R1 and TRAIL-R2

Mori, E., Thomas, M., Motoki, K., Nakazawa, K., Tahara, T., Tomizuka, K., Ishida, I., & Kataoka, S. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401331 · Cited by 84 · see citing works

Pre-B Cell Receptor-Mediated Selection of Pre-B Cells Synthesizing Functional μ Heavy Chains

Kline, G. H., Hartwell, L., Beck-Engeser, G. B., et al. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.4.1608 · Cited by 83 · see citing works

Human immunoglobulin transgenes undergo rearrangement, somatic mutation and class switching in mice that lack endogenous IgM

Taylor, L. D., Carmack, C. E., Huszar, D., et al. (1994) · International Immunology · doi:10.1093/intimm/6.4.579 · Cited by 75 · see citing works

The evolutionary and structural ‘logic’ of antigen receptor diversity

Davis, M. M. (2004) · Seminars in Immunology · doi:10.1016/j.smim.2004.08.003 · Cited by 69 · see citing works

HuMax-CD4

Skov, L., Kragballe, K., Zachariae, C. O. C., et al. (2003) · Archives of Dermatology · doi:10.1001/archderm.139.11.1433 · Cited by 68 · see citing works

Estimation of the indirect effect of Haemophilus influenzae type b conjugate vaccine in an American Indian population

Moulton, L. H., Chung, S.-E., Croll, J., Reid, R., Weatherholtz, R., & Santosham, M. (2000) · International Journal of Epidemiology · doi:10.1093/ije/29.4.753 · Cited by 68 · see citing works

Immunoglobulin light chain variable region gene sequences for human antibodies to Haemophilus influenzae type b capsular polysaccharide are dominated by a limited number of V kappa and V lambda segments and VJ combinations.

Adderson, E. E., Shackelford, P. G., Insel, R. A., et al. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115649 · Cited by 67 · see citing works

Production and Characterization of Protective Human Antibodies against Shiga Toxin 1

Mukherjee, J., Chios, K., Fishwild, D. M., et al. (2002) · Infection and Immunity · doi:10.1128/iai.70.10.5896-5899.2002 · Cited by 62 · see citing works

PSMA specific antibodies and their diagnostic and therapeutic use

Holmes, E. H. (2001) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.10.3.511 · Cited by 60 · see citing works

A Human Immunoglobulin λ Locus Is Similarly Well Expressed in Mice and Humans

Popov, A. V., Zou, X., Xian, J., et al. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.10.1611 · Cited by 58 · see citing works

Protective and Nonprotective Human Immunoglobulin M Monoclonal Antibodies toCryptococcus neoformansGlucuronoxylomannan Manifest Different Specificities and Gene Use Profiles

Maitta, R. W., Datta, K., Chang, Q., Luo, R. X., Witover, B., Subramaniam, K. S., & Pirofski, L. (2004) · Infection and Immunity · doi:10.1128/iai.72.8.4810-4818.2004 · Cited by 57 · see citing works

Efficient Isolation of Novel Human Monoclonal Antibodies with Neutralizing Activity Against HIV-1 from Transgenic Mice Expressing Human Ig Loci

He, Y., Honnen, W. J., Krachmarov, C. P., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.1.595 · Cited by 56 · see citing works

Antibody repertoires of four- and five-feature translocus mice carrying human immunoglobulin heavy chain and kappa and lambda light chain yeast artificial chromosomes.

Nicholson, I., Zou, X., Popov, A. V., et al. (1999) · PubMed · Cited by 55 · see citing works

Decreased frequency of rearrangement due to the synergistic effect of nucleotide changes in the heptamer and nonamer of the recombination signal sequence of the V kappa gene A2b, which is associated with increased susceptibility of Navajos to Haemophilus influenzae type b disease.

Nadel, B., Tang, A. Y. B., Lugo‐Villarino, G., Love, V. A., Escuro, G., & Feeney, A. J. (1998) · PubMed · Cited by 55 · see citing works

High efficiency creation of human monoclonal antibody-producing hybridomas

Dessain, S. K., Adekar, S. P., Stevens, J. B., et al. (2004) · Journal of Immunological Methods · doi:10.1016/j.jim.2004.05.005 · Cited by 50 · see citing works

Antibody Repertoires of Four- and Five-Feature Translocus Mice Carrying Human Immunoglobulin Heavy Chain and κ and λ Light Chain Yeast Artificial Chromosomes

Nicholson, I., Zou, X., Popov, A. V., et al. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.12.6898 · Cited by 50 · see citing works

Decreased Frequency of Rearrangement due to the Synergistic Effect of Nucleotide Changes in the Heptamer and Nonamer of the Recombination Signal Sequence of the Vκ Gene A2b, Which Is Associated with Increased Susceptibility of Navajos to Haemophilus influenzae Type b Disease

Nadel, B., Tang, A. Y. B., Lugo‐Villarino, G., Love, V. A., Escuro, G., & Feeney, A. J. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.11.6068 · Cited by 50 · see citing works

Regulation of B Cell Development by Variable Gene Complexity in Mice Reconstituted with Human Immunoglobulin Yeast Artificial Chromosomes

Green, L. L., & Jakobovits, A. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.3.483 · Cited by 48 · see citing works

Prospects for the therapeutic use of human monoclonal antibodies.

Larrick, J. W., & Bourla, J. M. (1986) · PubMed · Cited by 48 · see citing works

Structure-Function Relationships for Human Antibodies to Pneumococcal Capsular Polysaccharide from Transgenic Mice with Human Immunoglobulin Loci

Chang, Q., Zhong, Z., Lees, A., Pekna, M., & Pirofski, L. (2002) · Infection and Immunity · doi:10.1128/iai.70.9.4977-4986.2002 · Cited by 46 · see citing works

Increased frequency of both total and specific monoclonal antibody producing hybridomas using a fusion partner that constitutively expresses recombinant IL-6

Harris, J. F., Hawley, R. G., Hawley, T. S., et al. (1992) · Journal of Immunological Methods · doi:10.1016/0022-1759(92)90173-q · Cited by 45 · see citing works

Antibody producing human-human hybridomas. II. Derivation and characterization of an antibody specific for human leukemia cells.

Olsson, L., Andreasen, R. B., Öst, Å., et al. (1984) · The Journal of Experimental Medicine · doi:10.1084/jem.159.2.537 · Cited by 44 · see citing works

Immunoglobulin genes in transgenic mice

Alt, F. W., Blackwell, T. K., & Yancopoulos, G. D. (1985) · Trends in Genetics · doi:10.1016/0168-9525(85)90089-7 · Cited by 41 · see citing works

Idiopathic thrombocytopenic purpura in pregnancy

Sainio, S., Joutsi, L., Järvenpää, A., et al. (1998) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1034/j.1600-0412.1998.770303.x · Cited by 41 · see citing works

Destabilizing loop swaps in the CDRs of an immunoglobulin VL domain

Helms, L. R., & Wetzel, R. B. (1995) · Protein Science · doi:10.1002/pro.5560041012 · Cited by 39 · see citing works

Generation, immunologic characterization and antitumor effects of human monoclonal antibodies for carcinoembryonic antigen

Imakiire, T., Kuroki, M., Kuroki, M., et al. (2003) · International Journal of Cancer · doi:10.1002/ijc.11608 · Cited by 38 · see citing works

A PROSPECTIVE RANDOMIZED STUDY OF PROPHYLACTIC OKT3 VERSUS EQUINE ANTITHYMOCYTE GLOBULIN AFTER HEART TRANSPLANTATION-INCREASED MORBIDITY WITH OKT3

Macdonald, P. S., Mundy, J. A., KEOGH, A. M., et al. (1993) · Transplantation · doi:10.1097/00007890-199301000-00021 · Cited by 37 · see citing works

Antibody Producing Human-Human Hybridomas

Olsson, L. (1984) · Springer eBooks · doi:10.1007/978-1-4684-4649-4_18 · Cited by 35 · see citing works

Combination of the Human Anti-CD30 Antibody 5F11 with Cytostatic Drugs Enhances Its Antitumor Activity against Hodgkin and Anaplastic Large Cell Lymphoma Cell Lines

Heuck, F., Ellermann, J., Borchmann, P., et al. (2004) · Journal of Immunotherapy · doi:10.1097/00002371-200409000-00003 · Cited by 35 · see citing works

Variable region sequences of a protective human monoclonal antibody specific for the Haemophilus influenzae type b capsular polysaccharide

Lucas, A. H., Larrick, J. W., & Reason, D. C. (1994) · Infection and Immunity · doi:10.1128/iai.62.9.3873-3880.1994 · Cited by 35 · see citing works

Block in Development at the Pre-B-II to Immature B Cell Stage in Mice Without Igκ and Igλ Light Chain

Zou, X., Piper, T. A., Smith, J. A., Allen, N. D., Xian, J., & Brüggemann, M. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.3.1354 · Cited by 32 · see citing works

Constraints on the Hydropathicity and Sequence Composition of HCDR3 are Conserved Across Evolution

Link, J. M., Ivanov, I. I., Ippolito, G. C., et al. (2002) · CRC Press eBooks · doi:10.1201/9780203216514.ch3 · Cited by 28 · see citing works

Correlation of the Km(1) immunoglobulin allotype with anti-polysaccharide antibodies in Caucasian adults.

Ambrosino, D. M., Barrus, V. A., DeLange, G. G., et al. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112585 · Cited by 25 · see citing works

Differential Effects of Administration of a Human Anti-CD4 Monoclonal Antibody, HM6G, in Nonhuman Primates

Fishwild, D. M., Hudson, D., Deshpande, U., et al. (1999) · Clinical Immunology · doi:10.1006/clim.1999.4734 · Cited by 23 · see citing works

Clinical experience with monoclonal antibodies to epidermal growth factor receptor

Calvo, E., & Rowinsky, E. K. (2005) · Current Oncology Reports · doi:10.1007/s11912-005-0034-9 · Cited by 21 · see citing works

Isolation and Characterization of Human Monoclonal Antibodies to Digoxin

Ball, W. J., Kasturi, R., Dey, P., et al. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.4.2291 · Cited by 20 · see citing works

Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide. V. In vivo expression of individual antibody clones is dependent on Ig CH haplotypes and the categories of antigen.

Chung, G. H., Scott, M. G., Kim, K. H., et al. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.8.4352 · Cited by 18 · see citing works

HMOCC-1, a human monoclonal antibody that inhibits adhesion of ovarian cancer cells to human mesothelial cells

Suzuki, N., Aoki, D., Tamada, Y., et al. (2004) · Gynecologic Oncology · doi:10.1016/j.ygyno.2004.06.024 · Cited by 18 · see citing works

Class Switching in Human Immunoglobulin Transgenic Mice

Harding, F., & Lönberg, N. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb55879.x · Cited by 17 · see citing works

Fully human IgG and IgM antibodies directed against the carcinoembryonic antigen (CEA) Gold 4 epitope and designed for radioimmunotherapy (RIT) of colorectal cancers

Garambois, V., Fabienne, G., Foulquier, E., et al. (2004) · BMC Cancer · doi:10.1186/1471-2407-4-75 · Cited by 15 · see citing works

HMMC-1

Nozawa, S., Aoki, D., Tsukazaki, K., et al. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0802 · Cited by 14 · see citing works

Silencing of the immunoglobulin heavy chain locus by removal of all eight constant-region genes in a 200-kb region

Ren, L., Zou, X., Smith, J. A., & Brüggemann, M. (2004) · Genomics · doi:10.1016/j.ygeno.2004.06.008 · Cited by 12 · see citing works

Idiopathic thrombocytopenic purpura in pregnancy. Successful management with immunoglobulin infusion

Rose, V. L. (1985) · JAMA · doi:10.1001/jama.254.18.2626 · Cited by 12 · see citing works

Three-Dimensional Quantitative Structure−Activity Relationship Analysis of Ligand Binding to Human Sequence Antidigoxin Monoclonal Antibodies Using Comparative Molecular Field Analysis

Farr, C. D., Tabet, M. R., Ball, W. J., et al. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm0102811 · Cited by 10 · see citing works

Monoclonal antibody-based immunotherapy of Hodgkin's lymphoma.

Borchmann, P., Schnell, R., Schulz, H., et al. (2004) · PubMed · Cited by 8 · see citing works

Human monoclonal antibodies produced in transgenic BABκ,λ mice recognising idiotypic immunoglobulins of human lymphoma cells

Suárez, E., Yáñez, R., Barrios, Y., et al. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2004.03.035 · Cited by 5 · see citing works

Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease

Kearns, A. E., Khosla, S., & Kostenuik, P. J. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0014 · Cited by 824 · see citing works

Potential aggregation prone regions in biotherapeutics: A survey of commercial monoclonal antibodies

Wang, X., Das, T. K., Singh, S. K., & Kumar, S. (2009) · mAbs · doi:10.4161/mabs.1.3.8035 · Cited by 198 · see citing works

Developments and Challenges for mAb-Based Therapeutics

Goswami, S., Wang, W., Arakawa, T., & Ohtake, S. (2013) · Antibodies · doi:10.3390/antib2030452 · Cited by 144 · see citing works

Human Monoclonal Antibodies: The Benefits of Humanization

Waldmann, H. (2019) · Methods in Molecular Biology · doi:10.1007/978-1-4939-8958-4_1 · Cited by 80 · see citing works

Generation and characterization of human monoclonal neutralizing antibodies with distinct binding and sequence features against SARS coronavirus using XenoMouse®

Coughlin, M., Lou, G., Martinez, O., Masterman, S. K., Olsen, O. A., Moksa, A. A., Farzan, M., Babcook, J. S., & Prabhakar, B. S. (2007) · Virology · doi:10.1016/j.virol.2006.09.029 · Cited by 70 · see citing works

Prediction of delayed retention of antibodies in hydrophobic interaction chromatography from sequence using machine learning

Jain, T., Boland, T., Lilov, A., Burnina, I., Brown, M., Xu, Y., & Vásquez, M. (2017) · Bioinformatics · doi:10.1093/bioinformatics/btx519 · Cited by 61 · see citing works

Development of scoring functions for antibody sequence assessment and optimization

Seeliger, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076909 · Cited by 24 · see citing works

Early Changes in Behavior Deficits, Amyloid β-42 Deposits and MAPK Activation in Doubly Transgenic Mice Co-expressing NSE-Controlled Human Mutant PS2 and APPsw

Hwang, D. Y., Cho, J. S., Oh, J. H., Shim, S. B., Jee, S. W., Lee, S. H., Seo, S. J., Song, C. W., Lee, S. H., & Kim, Y. K. (2005) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-005-4950-x · Cited by 6 · see citing works

Transgenic mice: beyond the knockout

Miller, R. L. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00082.2010 · Cited by 25 · see citing works

[Transgenic mice in basic research].

Gassmann, M., Hennet, T., & Bauer, C. (1998) · PubMed · Cited by 1 · see citing works

In vivo expression of a conditional TGF-β1 transgene: no evidence for TGF-β1 transgene expression in SM22α-tTA transgenic mice

Lee, S., Agah, R., Xiao, M., et al. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2005.09.015 · Cited by 8 · see citing works

Endothelium‐specific Cre recombinase activity in flk‐1‐Cre transgenic mice

Licht, A. H., Raab, S., Höfmann, U., & Breier, G. (2004) · Developmental Dynamics · doi:10.1002/dvdy.10416 · Cited by 60 · see citing works