Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 1,912

The DOI matches its Crossref record.

In vitro differentiation of transplantable neural precursors from human embryonic stem cells

Zhang, Su-Chun, Wernig, Marius, Duncan, Ian D., Brüstle, Oliver, Thomson, James A.·2001·Nature Biotechnology
DOI 10.1038/nbt1201-1129
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/nbt1201-1129

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 26

  1. Thomson, J.A. et al. Embryonic stem cell lines derived from human blastocysts. Science 282, 1145–1147 (1998). · DOI · Paper page
  2. Reubinoff, B.E., Pera, M.F., Fong, C.-F., Trounson, A. & Bongso, A. Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat. Biotechnol. 18, 399–404 (2000). · DOI · Paper page
  3. Thomson, J.A. & Odorico, J.S. Human embryonic stem cell and embryonic germ cell lines. Trends Biotechnol. 18, 53–57 (2000). · doi:10.1016/s0167-7799(99)01410-9
  4. Amit, M. et al. Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture. Dev. Biol. 227, 271–278 (2000). · DOI · Paper page
  5. Wiles, M.V. & Keller, G. Multiple hematopoietic lineages develop from embryonic stem (ES) cells in culture. Development 111, 259–267 (1991). · DOI · Paper page
  6. Klug, M.G., Soonpaa, M.H., Koh, G.Y. & Field, L.J. Genetically selected cardiomyocytes from differentiating embryonic stem cells form stable intracardiac grafts. J. Clin. Invest. 98, 216–224 (1996). · DOI · Paper page
  7. Soria, B. et al. Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes 49, 157–162 (2000). · DOI · Paper page
  8. Bain, G., Kitchens, D., Yao, M., Huettner, J.E. & Gottlieb, D.I. Embryonic stem cells express neuronal properties in vitro. Dev. Biol. 168, 342–357 (1995). · DOI · Paper page
  9. Okabe, S., Forsberg-Nilsson, K., Spiro, A.C., Segal, M. & McKay, R.D.G. Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro. Mech. Dev. 59, 89–102 (1996). · DOI · Paper page
  10. Mujtaba, T. et al. Lineage-restricted neural precursors can be isolated from both the mouse neural tube and cultured ES cells. Dev. Biol. 214, 113–127 (1999). · DOI · Paper page
  11. Brustle, O. et al. Embryonic stem cell–derived glial precursors: a source of myelinating transplants. Science 285, 754–756 (1999). · DOI · Paper page
  12. Brustle, O. et al. In vitro–generated neural precursors participate in mammalian brain development. Proc. Natl. Acad. Sci. USA 94, 14809–14814 (1997). · DOI · Paper page
  13. McDonald, J.W. et al. Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord. Nat. Med. 5, 1410–1412 (1999). · DOI · Paper page
  14. Zhang, S.-C., Ge, B. & Duncan, I.D. Tracing human oligodendroglial development in vitro. J. Neurosci. Res. 59, 421–429 (2000). · DOI
  15. Zhang, S.-C., Ge, B. & Duncan, I.D. Adult brain retains the potential to generate oligodendroglial progenitors with extensive myelination capacity. Proc. Natl. Acad. Sci. USA 96, 4089–4094 (1999). · DOI · Paper page
  16. Lendahl, U., Zimmerman, L.B. & McKay, R.D. CNS stem cells express a new class of intermediate filament protein. Cell 60, 585–595 (1990). · DOI · Paper page
  17. Kaneko, Y. et al. Musashi1: an evolutionally conserved marker for CNS progenitor cells including neural stem cells. Dev. Neurosci. 22, 139–153 (2000). · DOI · Paper page
  18. Svendsen, C.N., Clarke, D.J., Rosser, A.E. & Dunnett, S.B. Survival and differentiation of rat and human epidermal growth factor–responsive precursor cells following grafting into the lesioned adult central nervous system. Exp. Neurol. 137, 376–388 (1996). · DOI · Paper page
  19. Carpenter, M.K. et al. In vitro expansion of a multipotent population of human neural progenitor cells. Exp. Neurol. 158, 265–278 (1999). · DOI · Paper page
  20. Vescovi, A.L. et al. Isolation and cloning of multipotential stem cells from the embryonic human CNS and establishment of transplantable human neural stem cell lines by epigenetic stimulation. Exp. Neurol. 156, 71–83 (1999). · DOI · Paper page
  21. Flax, J.D. et al. Engraftable human neural stem cells respond to developmental cues, replace neurons and express foreign genes. Nat. Biotechnol. 16, 1033–1039 (1998). · DOI · Paper page
  22. Svendsen, C.N., Caldwell, M.A. & Ostenfeld, O. Human neural stem cells: isolation, expansion and transplantation. Brain Pathol. 9, 499–513 (1999). · DOI
  23. Fricker, R.A. et al. Site-specific migration and neuronal differentiation of human neural progenitor cells after transplantation in the adult rat brain. J. Neurosci. 19, 5990–6005 (1999). · DOI · Paper page
  24. Brustle, O. et al. Chimeric brains generated by intraventricular transplantation with human brain cells into embryonic rats. Nat. Biotechnol. 16, 1040–1044 (1998). · DOI · Paper page
  25. Kalyani, A.D., Hobson, K. & Rao, M.S. Neuroepithelial stem cells from the embryonic spinal cord: isolation, characterization and clonal analysis. Dev. Biol. 186, 202–223 (1997). · DOI · Paper page
  26. Tropepe, V. et al. Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon. Dev. Biol. 208, 166–188 (1999). · DOI · Paper page

Cited by

See all 1,912

Metadata

Authors
Zhang, S.-C., Wernig, M., Duncan, I. D., Brüstle, O., & Thomson, J. A.
Venue
Nature Biotechnology
Publisher
Springer Science and Business Media LLC
Published
2001-12
Volume
19
Issue
12
Pages
1129-1133
ISSN
  • 0733-222X (ISSN-L)
  • 1087-0156
  • 1546-1696
DOI
10.1038/nbt1201-1129
OpenAlex
W2033284482
Cited by
1,912
References
0
FWCI
24.10
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (unspecified)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: In vitro differentiation of transplantable neural precursors from human embryonic stem cells. https://app.cochat.ai/papers/10.1038/nbt1201-1129
The paper
Zhang, S.-C., Wernig, M., Duncan, I. D., Brüstle, O., & Thomson, J. A. (2001). In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Nature Biotechnology. https://doi.org/10.1038/nbt1201-1129

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.