Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 859

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression

Lin, Tongxiang, Chao, Connie, Saito, Shin'ichi, Mazur, Sharlyn J., Murphy, Maureen E., Appella, Ettore, Xu, Yang·2005·Nature Cell Biology
DOI 10.1038/ncb1211
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/ncb1211

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 1 references

Research works printed but not linked: 22

  1. Ko, L. J. & Prives, C. p53: puzzle and paradigm. Genes Dev. 10, 1054–1072 (1996). · DOI · Paper page
  2. Mitsui, K. et al. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 113, 631–642 (2003). · DOI · Paper page
  3. Chambers, I. et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 113, 643–655 (2003). · DOI · Paper page
  4. Okamoto, K. et al. A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell 60, 461–472 (1990). · DOI · Paper page
  5. Niwa, H., Miyazaki, J. & Smith, A. G. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nature Genet. 24, 372–376 (2000). · DOI · Paper page
  6. Hoffman, W. H., Biade, S., Zilfou, J. T., Chen, J. & Murphy, M. Transcriptional repression of the anti-apoptotic survivin gene by wild type p53. J. Biol. Chem. 277, 3247–3257 (2002). · DOI · Paper page
  7. Rohwedel, J., Guan, K. & Wobus, A. M. Induction of cellular differentiation by retinoic acid in vitro. Cells Tissues Organs 165, 190–202 (1999). · DOI · Paper page
  8. Sabapathy, K., Klemm, M., Jaenisch, R. & Wagner, E. F. Regulation of ES cell differentiation by functional and conformational modulation of p53. EMBO J. 16, 6217–6229 (1997). · DOI · Paper page
  9. Lutzker, S. G. & Levine, A. J. A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation, Nature Med. 2, 804–810 (1996). · DOI · Paper page
  10. Xu, Y. Regulation of p53 responses by post-translational modifications. Cell Death Differ. 10, 400–403 (2003). · DOI · Paper page
  11. Luo, J. L., et al. Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: a new biomedical research tool. Oncogene 20, 320–328 (2001). · DOI
  12. Savatier, P., Lapillonne, H., van Grunsven, L. A., Rudkin, B. B. & Samarut, J. Withdrawal of differentiation inhibitory activity/leukemia inhibitory factor up-regulates D-type cyclins and cyclin-dependent kinase inhibitors in mouse embryonic stem cells. Oncogene 12, 309–322 (1996).
  13. Bischoff, J. R., Friedman, P. N., Marshak, D. R., Prives, C. & Beach, D. Human p53 is phosphorylated by p60–cdc2 and cyclin B–cdc2. Proc. Natl Acad. Sci. USA 87, 4766–4770 (1990). · DOI · Paper page
  14. Wang, Y. & Prives, C. Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases. Nature 376, 88–91 (1995). · DOI · Paper page
  15. Wu, Z. et al. Mutation of mouse p53 Ser23 and the response to DNA damage. Mol. Cell. Biol. 22, 2441–2449 (2002). · DOI · Paper page
  16. Murphy, M. et al. Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a. Genes Dev. 13, 2490–2501 (1999). · DOI · Paper page
  17. Chao, C. et al. p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage. EMBO J. 19, 4967–4975 (2000). · DOI · Paper page
  18. Aladjem, M. I. et al. ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage. Curr. Biol. 8, 145–155 (1998). · DOI · Paper page
  19. Chao, C., Saito, S., Anderson, C. W., Appella, E. & Xu, Y. Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage. Proc. Natl Acad. Sci. USA 97, 11936–11941 (2000). · DOI · Paper page
  20. Yoshida-Koide, U. et al. Involvement of Ras in extraembryonic endoderm differentiation of embryonic stem cells. Biochem. Biophys. Res. Commun. 313, 475–481 (2004). · doi:10.1016/j.bbrc.2003.11.138
  21. Corbet, S. W., Clarke, A. R., Gledhill, S. & Wyllie, A. H. P53-dependent and -independent links between DNA-damage, apoptosis and mutation frequency in ES cells. Oncogene 18, 1537–1544 (1999). · DOI
  22. Boley, S. E., Wong, V. A., French, J. E. & Recio, L. p53 heterozygosity alters the mRNA expression of p53 target genes in the bone marrow in response to inhaled benzene. Toxicol. Sci. 66, 209–215 (2002). · DOI

Cited by

See all 859

Metadata

Authors
Lin, T., Chao, C., Saito, S., Mazur, S. J., Murphy, M. E., Appella, E., & Xu, Y.
Venue
Nature Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2004-12-26
Volume
7
Issue
2
Pages
165-171
ISSN
  • 1465-7392 (ISSN-L)
  • 1476-4679
DOI
10.1038/ncb1211
OpenAlex
W1976878409
Cited by
859
References
1
FWCI
8.09
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. https://app.cochat.ai/papers/10.1038/ncb1211
The paper
Lin, T., Chao, C., Saito, S., Mazur, S. J., Murphy, M. E., Appella, E., & Xu, Y. (2005). p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nature Cell Biology. https://doi.org/10.1038/ncb1211

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.