How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression

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Mdm2 promotes the rapid degradation of p53

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PUMA, a Novel Proapoptotic Gene, Is Induced by p53

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

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Restoration of p53 function leads to tumour regression in vivo

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Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function

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Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human Cancers

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Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

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