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p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation
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“p53 regulates glucose transporters (GLUTs) that promote glucose transport across the cellular plasma membrane to inhibit glucose uptake.84,85”
From p53: from understanding its structure to advances in therapeutic targeting (2026) · cites this paper as [85]
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“6 ), which functions as a transcriptional activator and exerts its biological activity by inducing expression of its target gene”
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p53 Regulates Mitochondrial Respiration
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Glycolytic Enzymes Can Modulate Cellular Life Span
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Transcriptional Cross Talk between NF-κB and p53
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“Primary cultured cells from p53-deficient ( p53 −/− ) mice are easily transformed by a diverse range of oncogene”
BackgroundSelf-citation
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Cited by
Blinded by the Light: The Growing Complexity of p53
Vousden, K. H., & Prives, C. (2009) · Cell · doi:10.1016/j.cell.2009.04.037 · Cited by 3,163
NF-κB, inflammation, immunity and cancer: coming of age
Taniguchi, K., & Karin, M. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.142 · Cited by 2,679
Cancer cell metabolism: warburg and beyond
Hsu, P. P., & Sabatini, D. M. (2008) · Cell · doi:10.1016/j.cell.2008.08.021 · Cited by 2,452
“Other work also suggests that p53-mediated regulation of glucose metabolism may be dependent on the transcription factor NF-κB (Kawauchi et al., 2008).”
BackgroundNF-κB, an Active Player in Human Cancers
Xia, Y., Shen, S., & Verma, I. M. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0112 · Cited by 1,213
P53 in survival, death and metabolic health: a lifeguard with a licence to kill.
Kruiswijk, F., Labuschagne, C. F., & Vousden, K. H. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4007 · Cited by 1,080
Metadata
- Authors
- Kawauchi, K., Araki, K., Tobiume, K., & Tanaka, N.
- Venue
- Nature Cell Biology
- Published
- 2008-04-06
- Volume
- 10
- Issue
- 5
- Pages
- 611-618
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2029000257
- Cited by
- 637
- References
- 8
- FWCI
- 8.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
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- Kawauchi, K., Araki, K., Tobiume, K., & Tanaka, N. (2008). p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation. Nature Cell Biology. https://doi.org/10.1038/ncb1724
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
