Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

Rodier, Francis, Coppé, Jean-Philippe, Patil, Christopher K., Hoeijmakers, Wieteke A. M., Muñoz, Denise P., Raza, Saba R., Freund, Adam, Campeau, Eric +2 more·2009·Nature Cell Biology

DOI 10.1038/ncb1909

Cited by (1,014)

Items 301–400 of 1,014

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Anna Gritsenko, Jack Green, David Brough, Gloria López‐Castejón · 2020 · Cytokine & Growth Factor Reviews
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Chen, Qian, Liu, Kai, Robinson, Andria R, Clauson, Cheryl L, Blair, Harry C, Robbins, Paul D, Niedernhofer, Laura J, Ouyang, Hongjiao · 2013 · Journal of Bone and Mineral Research
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Holly Nicola Wilkinson, Christopher Clowes, Kayleigh L. Banyard, Paolo Matteuci, Kimberly A. Mace, Matthew J. Hardman · 2019 · Journal of Investigative Dermatology
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Siobhán Q. Gregg, Verónica Gutiérrez, Andria Rasile Robinson, Tyler B. Woodell, Atsunori Nakao, Mark A. Ross, George K. Michalopoulos, Lora Heather Rigatti, Carrie E. Rothermel, Irene Kamileri et al. · 2011 · Hepatology
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Qin Qiu, Yuqi Lin, Yucui Ma, Xiaoling Li, Juan Boo Liang, Zhiyan Chen, Kaifeng Liu, Yuge Huang, Hui Luo, Riming Huang et al. · 2021 · Frontiers in Immunology
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Jörg J. Goronzy, Guangjin Li, Zhen Yang, Cornelia M. Weyand · 2013 · Frontiers in Immunology
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Tomoaki Higo, Atsuhiko T. Naito, Tomokazu S. Sumida, Masato Shibamoto, Katsuki Okada, Seitaro Nomura, Akito Nakagawa, Toshihiro Yamaguchi, Taku Sakai, Akihito Hashimoto et al. · 2017 · Nature Communications
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Carroll, Judith E., Cole, Steven W., Seeman, Teresa E., Breen, Elizabeth C., Witarama, Tuff, Arevalo, Jesusa M.G., Ma, Jeffrey, Irwin, Michael R. · 2016 · Brain, Behavior, and Immunity
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Fiona Jane Stapleton, Pablo Argüeso, Penny A. Asbell, Dimitri T. Azar, Charles F. Bosworth, Wei Chen, Joseph B. Ciolino, Jennifer P. Craig, Juana Gallar, Anat Galor et al. · 2025 · American Journal of Ophthalmology
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Lafargue, Audrey, Degorre, Charlotte, Corre, Isabelle, Alves-Guerra, Marie-Clotilde, Gaugler, Marie-Hélène, Vallette, François, Pecqueur, Claire, Paris, François · 2017 · Free Radical Biology and Medicine
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Differential effects of nitro-PAHs and amino-PAHs on cytokine and chemokine responses in human bronchial epithelial BEAS-2B cells
Johan Øvrevik, Volker Manfred Arlt, Elisabeth Øya · 2009 · Toxicology and Applied Pharmacology
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Fielder, Edward, von Zglinicki, Thomas, Jurk, Diana · 2017 · Journal of Alzheimer's Disease
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Wang, Boshi, Varela‐Eirin, Marta, Brandenburg, Simone M, Hernandez‐Segura, Alejandra, van Vliet, Thijmen, Jongbloed, Elisabeth M, Wilting, Saskia M, Ohtani, Naoko, Jager, Agnes, Demaria, Marco · 2022 · The EMBO Journal
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Lei Miao, Yuhua Wang, C. Michael Lin, Yang Xiong, Naihan Chen, Lu Zhang, William Y. Kim, Leaf Huang · 2015 · Journal of Controlled Release
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Joana Neves, Marco Demaria, Judith Campisi, Heinrich Jasper · 2015 · Developmental Cell
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Ewa Sikora, Anna Bielak-Żmijewska, Grażyna Mosieniak · 2021 · Ageing Research Reviews
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Ribezzo, Flavia, Shiloh, Yosef, Schumacher, Björn · 2016 · Seminars in Cancer Biology