Senolytics for Cancer Therapy: Is All that Glitters Really Gold?

The senescence-associated secretory phenotype: the dark side of tumor suppression

Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206 · see citing works

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,178 · see citing works

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

Baker, D. J., Childs, B. G., Durik, M., Wijers, M. E., Sieben, C. J., Zhong, J., A. Saltness, R., Jeganathan, K. B., Verzosa, G. C., Pezeshki, A., et al. (2016) · Nature · doi:10.1038/nature16932 · Cited by 2,891 · see citing works

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs

Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., et al. (2015) · Aging Cell · doi:10.1111/acel.12344 · Cited by 2,562 · cited 5× · see citing works

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

Xue, W., Zender, L., Miething, C., Dickins, R. A., Hernando, E., Krizhanovsky, V., Cordon-Cardo, C., & Lowe, S. W. (2007) · Nature · doi:10.1038/nature05529 · Cited by 2,473 · see citing works

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0092-9 · Cited by 2,287 · see citing works

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1909 · Cited by 2,232 · see citing works

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R.-M., Vijg, J., Van Steeg, H., Dollé, M. E. T., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.11.012 · Cited by 2,045 · see citing works

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

Tse, C., Shoemaker, A. R., Adickes, J., Anderson, M. G., Chen, J., Jin, S., Johnson, E. F., Marsh, K. C., Mitten, M. J., Nimmer, P., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5836 · Cited by 1,992 · see citing works

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

Chang, J., Wang, Y., Shao, L., Laberge, R.-M., Demaria, M., Campisi, J., Janakiraman, K., Sharpless, N. E., Ding, S., Feng, W., et al. (2016) · Nature Medicine · doi:10.1038/nm.4010 · Cited by 1,819 · see citing works

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

Kang, T.-W., Yevsa, T., Woller, N., Hoenicke, L., Wuestefeld, T., Dauch, D., Hohmeyer, A., Gereke, M., Rudalska, R., Potapova, A., et al. (2011) · Nature · doi:10.1038/nature10599 · Cited by 1,621 · see citing works

Cellular senescence mediates fibrotic pulmonary disease

Schafer, M. J., White, T. A., Iijima, K., Haak, A. J., Ligresti, G., Atkinson, E. J., Oberg, A. L., Birch, J., Salmonowicz, H., Zhu, Y., et al. (2017) · Nature Communications · doi:10.1038/ncomms14532 · Cited by 1,613 · cited 1× · see citing works

Senescence-associated β-galactosidase is lysosomal β-galactosidase.

Lee, B. Y., Han, J. A., Im, J. S., Morrone, A., Johung, K., Goodwin, E. C., Kleijer, W. J., DiMaio, D., & Hwang, E. S. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00199.x · Cited by 1,444 · see citing works

Programmed cell senescence during mammalian embryonic development

Muñoz-Espín, D., Cañamero, M., Maraver, A., Gómez-López, G., Contreras, J., Murillo-Cuesta, S., Rodríguez-Baeza, A., Varela-Nieto, I., Ruberte, J., Collado, M., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.019 · Cited by 1,428 · see citing works

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

Hickson, L. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M., Jensen, M. D., Jia, Q., Jordan, K. L., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.08.069 · Cited by 1,383 · cited 1× · see citing works

A proteomic atlas of senescence-associated secretomes for aging biomarker development

Basisty, N., Kale, A., Jeon, O. H., Kuehnemann, C., Payne, T., Rao, C., Holtz, A., Shah, S., Sharma, V., Ferrucci, L., et al. (2020) · PLOS Biology · doi:10.1371/journal.pbio.3000599 · Cited by 1,348 · see citing works

Cellular senescence promotes adverse effects of chemotherapy and cancer relapse

Demaria, M., O'Leary, M. N., Chang, J., Shao, L., Liu, S., Alimirah, F., Koenig, K., Le, C., Mitin, N., Deal, A. M., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0241 · Cited by 1,338 · see citing works

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

Bussian, T. J., Aziz, A., Meyer, C. F., Swenson, B. L., van Deursen, J. M., & Baker, D. J. (2018) · Nature · doi:10.1038/s41586-018-0543-y · Cited by 1,289 · see citing works

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

Justice, J. N., Nambiar, A. M., Tchkonia, T., LeBrasseur, N. K., Pascual, R., Hashmi, S. K., Prata, L., Masternak, M. M., Kritchevsky, S. B., Musi, N., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2018.12.052 · Cited by 1,261 · cited 1× · see citing works

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

The Tabula Muris Consortium, Almanzar, N., Antony, J., Baghel, A. S., Bakerman, I., Bansal, I., Barres, B. A., Beachy, P. A., Berdnik, D., Bilen, B., et al. (2020) · Nature · doi:10.1038/s41586-020-2496-1 · Cited by 1,247 · see citing works

Oncogene-induced senescence as an initial barrier in lymphoma development

Braig, M., Lee, S., Loddenkemper, C., Rudolph, C., Peters, A. H. F. M., Schlegelberger, B., Stein, H., Dörken, B., Jenuwein, T., & Schmitt, C. A. (2005) · Nature · doi:10.1038/nature03841 · Cited by 1,220 · see citing works

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

Childs, B. G., Baker, D. J., Wijshake, T., Conover, C. A., Campisi, J., & van Deursen, J. M. (2016) · Science · doi:10.1126/science.aaf6659 · Cited by 1,195 · see citing works

Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors

Zhu, Y., Tchkonia, T., Fuhrmann‐Stroissnigg, H., Dai, H. M., Ling, Y. Y., Stout, M. B., Pirtskhalava, T., Giorgadze, N., Johnson, K. O., Giles, C. B., et al. (2016) · Aging Cell · doi:10.1111/acel.12445 · Cited by 1,148 · see citing works

Senescence-associated reprogramming promotes cancer stemness

Milanovic, M., Fan, D. N. Y., Belenki, D., Däbritz, J. H. M., Zhao, Z., Yu, Y., Dörr, J. R., Dimitrova, L., Lenze, D., Monteiro Barbosa, I. A., et al. (2018) · Nature · doi:10.1038/nature25167 · Cited by 1,131 · see citing works

Forging a signature of in vivo senescence

Sharpless, N. E., & Sherr, C. J. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3960 · Cited by 1,104 · see citing works

Senolytic CAR T cells reverse senescence-associated pathologies

Amor, C., Feucht, J., Leibold, J., Ho, Y.-J., Zhu, C., Alonso-Curbelo, D., Mansilla-Soto, J., Boyer, J. A., Li, X., Giavridis, T., et al. (2020) · Nature · doi:10.1038/s41586-020-2403-9 · Cited by 1,098 · see citing works

A Senescence Program Controlled by p53 and p16INK4a Contributes to the Outcome of Cancer Therapy

Schmitt, C. A., Fridman, J. S., Yang, M., Lee, S., Baranov, E., Hoffman, R. M., & Lowe, S. W. (2002) · Cell · doi:10.1016/s0092-8674(02)00734-1 · Cited by 1,050 · see citing works

Lamin B1 loss is a senescence-associated biomarker

Freund, A., Laberge, R.-M., Demaria, M., & Campisi, J. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-10-0884 · Cited by 1,046 · see citing works

Cellular senescence drives age-dependent hepatic steatosis

Ogrodnik, M., Miwa, S., Tchkonia, T., Tiniakos, D., Wilson, C. L., Lahat, A., Day, C. P., Burt, A., Palmer, A., Anstee, Q. M., et al. (2017) · Nature Communications · doi:10.1038/ncomms15691 · Cited by 1,044 · see citing works

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

Yosef, R., Pilpel, N., Tokarsky-Amiel, R., Biran, A., Ovadya, Y., Cohen, S., Vadai, E., Dassa, L., Shahar, E., Condiotti, R., et al. (2016) · Nature Communications · doi:10.1038/ncomms11190 · Cited by 1,032 · see citing works

Fisetin is a senotherapeutic that extends health and lifespan

Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.09.015 · Cited by 1,032 · see citing works

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

Zhang, P., Kishimoto, Y., Grammatikakis, I., Gottimukkala, K., Cutler, R. G., Zhang, S., Abdelmohsen, K., Bohr, V. A., Misra Sen, J., Gorospe, M., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0372-9 · Cited by 977 · see citing works

Unmasking Transcriptional Heterogeneity in Senescent Cells

Hernandez-Segura, A., de Jong, T. V., Melov, S., Guryev, V., Campisi, J., & Demaria, M. (2017) · Current Biology · doi:10.1016/j.cub.2017.07.033 · Cited by 972 · cited 4× · see citing works

Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?

Neckers, L., & Workman, P. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-1000 · Cited by 960 · see citing works

Cellular senescence as a tumor-suppressor mechanism

Campisi, J. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)02151-1 · Cited by 936 · see citing works

Senescence-associated β-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells

Kurz, D. J., Decary, S., Hong, Y., & Erusalimsky, J. D. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.20.3613 · Cited by 899 · see citing works

Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease

Roberts, A. W., Seymour, J. F., Brown, J. R., Wierda, W. G., Kipps, T. J., Khaw, S. L., Carney, D. A., He, S., Huang, D. C. S., Xiong, H., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.34.7898 · Cited by 833 · see citing works

Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence

Passos, J. F., Saretzki, G., Ahmed, S., Nelson, G., Richter, T., Peters, H., Wappler, I., Birket, M. J., Harold, G., Schaeuble, K., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050110 · Cited by 796 · cited 1× · see citing works

Senescence Induced by Altered Telomere State, Not Telomere Loss

Karlseder, J., Smogorzewska, A., & de Lange, T. (2002) · Science · doi:10.1126/science.1069523 · Cited by 796 · see citing works

Non-Cell-Autonomous Tumor Suppression by p53

Lujambio, A., Akkari, L., Simon, J., Grace, D., Tschaharganeh, D. F., Bolden, J. E., Zhao, Z., Thapar, V., Joyce, J. A., Krizhanovsky, V., et al. (2013) · Cell · doi:10.1016/j.cell.2013.03.020 · Cited by 766 · see citing works

New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

Zhu, Y., Doornebal, E. J., Pirtskhalava, T., Giorgadze, N., Wentworth, M., Fuhrmann-Stroissnigg, H., Niedernhofer, L. J., Robbins, P. D., Tchkonia, T., & Kirkland, J. L. (2017) · Aging · doi:10.18632/aging.101202 · Cited by 757 · see citing works

Why do viruses cause cancer? Highlights of the first century of human tumour virology

Moore, P. S., & Chang, Y. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2961 · Cited by 752 · see citing works

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

Roos, C. M., Zhang, B., Palmer, A. K., Ogrodnik, M. B., Pirtskhalava, T., Thalji, N. M., Hagler, M., Jurk, D., Smith, L. A., Casaclang‐Verzosa, G., et al. (2016) · Aging Cell · doi:10.1111/acel.12458 · Cited by 738 · see citing works

Identification of HSP90 inhibitors as a novel class of senolytics

Fuhrmann-Stroissnigg, H., Ling, Y. Y., Zhao, J., McGowan, S. J., Zhu, Y., Brooks, R. W., Grassi, D., Gregg, S. Q., Stripay, J. L., Dorronsoro, A., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00314-z · Cited by 701 · see citing works

A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity

Khan, S., Zhang, X., Lv, D., Zhang, Q., He, Y., Zhang, P., Liu, X., Thummuri, D., Yuan, Y., Wiegand, J. S., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0668-z · Cited by 688 · see citing works

Targeting senescent cells alleviates obesity-induced metabolic dysfunction

Palmer, A. K., Xu, M., Zhu, Y., Pirtskhalava, T., Weivoda, M. M., Hachfeld, C. M., Prata, L. G., van Dijk, T. H., Verkade, E., Casaclang‐Verzosa, G., et al. (2019) · Aging Cell · doi:10.1111/acel.12950 · Cited by 658 · see citing works

Untitled work

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Tau protein aggregation is associated with cellular senescence in the brain

Musi, N., Valentine, J. M., Sickora, K. R., Baeuerle, E., Thompson, C. S., Shen, Q., & Orr, M. E. (2018) · Aging Cell · doi:10.1111/acel.12840 · Cited by 595 · see citing works

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo

Mosteiro, L., Pantoja, C., Alcazar, N., Marión, R. M., Chondronasiou, D., Rovira, M., Fernandez-Marcos, P. J., Muñoz-Martin, M., Blanco-Aparicio, C., Pastor, J., et al. (2016) · Science · doi:10.1126/science.aaf4445 · Cited by 589 · see citing works

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition

Pereira, B. I., Devine, O. P., Vukmanovic-Stejic, M., Chambers, E. S., Subramanian, P., Patel, N., Virasami, A., Sebire, N. J., Kinsler, V., Valdovinos, A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10335-5 · Cited by 556 · see citing works

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy

Dörr, J. R., Yu, Y., Milanovic, M., Beuster, G., Zasada, C., Däbritz, J. H. M., Lisec, J., Lenze, D., Gerhardt, A., Schleicher, K., et al. (2013) · Nature · doi:10.1038/nature12437 · Cited by 541 · see citing works

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

Ogrodnik, M., Zhu, Y., Langhi, L. G. P., Tchkonia, T., Krüger, P., Fielder, E., Victorelli, S., Ruswhandi, R. A., Giorgadze, N., Pirtskhalava, T., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.12.008 · Cited by 536 · see citing works

Tumor Suppressor and Aging Biomarker p16INK4a Induces Cellular Senescence without the Associated Inflammatory Secretory Phenotype

Coppé, J.-P., Rodier, F., Patil, C. K., Freund, A., Desprez, P.-Y., & Campisi, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.257071 · Cited by 506 · see citing works

Senescent cell clearance by the immune system: Emerging therapeutic opportunities

Prata, L. G. P. L., Ovsyannikova, I. G., Tchkonia, T., & Kirkland, J. L. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2019.04.003 · Cited by 497 · see citing works

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

Ruhland, M. K., Loza, A. J., Capietto, A.-H., Luo, X., Knolhoff, B. L., Flanagan, K. C., Belt, B. A., Alspach, E., Leahy, K., Luo, J., et al. (2016) · Nature Communications · doi:10.1038/ncomms11762 · Cited by 496 · see citing works

Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway

Kurppa, K. J., Liu, Y., To, C., Zhang, T., Fan, M., Vajdi, A., Knelson, E. H., Xie, Y., Lim, K., Cejas, P., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2019.12.006 · Cited by 475 · see citing works

Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes

Aguayo-Mazzucato, C., Andle, J., Lee, T. B., Midha, A., Talemal, L., Chipashvili, V., Hollister-Lock, J., van Deursen, J., Weir, G., & Bonner-Weir, S. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.05.006 · Cited by 469 · see citing works

Pro-senescence therapy for cancer treatment

Nardella, C., Clohessy, J. G., Alimonti, A., & Pandolfi, P. P. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3057 · Cited by 437 · see citing works

Escape from Therapy-Induced Accelerated Cellular Senescence in p53-Null Lung Cancer Cells and in Human Lung Cancers

Roberson, R. S., Kussick, S. J., Vallieres, E., Chen, S.-Y. J., & Wu, D. Y. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-1270 · Cited by 428 · see citing works

Inducing and exploiting vulnerabilities for the treatment of liver cancer

Wang, C., Vegna, S., Jin, H., Benedict, B., Lieftink, C., Ramirez, C., de Oliveira, R. L., Morris, B., Gadiot, J., Wang, W., et al. (2019) · Nature · doi:10.1038/s41586-019-1607-3 · Cited by 427 · see citing works

Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer

Ruscetti, M., Morris, J. P., Mezzadra, R., Russell, J., Leibold, J., Romesser, P. B., Simon, J., Kulick, A., Ho, Y.-J., Fennell, M., et al. (2020) · Cell · doi:10.1016/j.cell.2020.03.008 · Cited by 424 · see citing works

Enhancing Chemotherapy Efficacy in Pten-Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity

Toso, A., Revandkar, A., Di Mitri, D., Guccini, I., Proietti, M., Sarti, M., Pinton, S., Zhang, J., Kalathur, M., Civenni, G., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.044 · Cited by 418 · see citing works

p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells

Iannello, A., Thompson, T. W., Ardolino, M., Lowe, S. W., & Raulet, D. H. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20130783 · Cited by 414 · see citing works

Cellular senescence as a tumor-suppressor mechanism

Campisi, J. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)82148-6 · Cited by 390 · see citing works

Identification and characterization of Cardiac Glycosides as senolytic compounds

Triana-Martínez, F., Picallos-Rabina, P., Da Silva-Álvarez, S., Pietrocola, F., Llanos, S., Rodilla, V., Soprano, E., Pedrosa, P., Ferreirós, A., Barradas, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12888-x · Cited by 384 · see citing works

Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer

Di Micco, R., Sulli, G., Dobreva, M., Liontos, M., Botrugno, O. A., Gargiulo, G., dal Zuffo, R., Matti, V., d'Ario, G., Montani, E., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2170 · Cited by 382 · see citing works

Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs

Chang, B.-D., Xuan, Y., Broude, E. V., Zhu, H., Schott, B., Fang, J., & Roninson, I. B. (1999) · Oncogene · doi:10.1038/sj.onc.1203078 · Cited by 382 · see citing works

The p38 MAPK signaling pathway: A major regulator of skeletal muscle development

Keren, A., Tamir, Y., & Bengal, E. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.03.017 · Cited by 372 · see citing works

Oncogene-Induced Cell Senescence — Halting on the Road to Cancer

Mooi, W. J., & Peeper, D. S. (2006) · New England Journal of Medicine · doi:10.1056/nejmra062285 · Cited by 371 · see citing works

Cardiac glycosides are broad-spectrum senolytics

Guerrero, A., Herranz, N., Sun, B., Wagner, V., Gallage, S., Guiho, R., Wolter, K., Pombo, J., Irvine, E. E., Innes, A. J., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0122-z · Cited by 359 · see citing works

Global reorganization of the nuclear landscape in senescent cells

Chandra, T., Ewels, P. A., Schoenfelder, S., Furlan-Magaril, M., Wingett, S. W., Kirschner, K., Thuret, J.-Y., Andrews, S., Fraser, P., & Reik, W. (2015) · Cell Reports · doi:10.1016/j.celrep.2014.12.055 · Cited by 348 · see citing works

A versatile drug delivery system targeting senescent cells

Muñoz‐Espín, D., Rovira, M., Galiana, I., Giménez, C., Lozano‐Torres, B., Paez‐Ribes, M., Llanos, S., Chaib, S., Muñoz‐Martín, M., Ucero, A. C., et al. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201809355 · Cited by 339 · see citing works

Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence

Tai, H., Wang, Z., Gong, H., Han, X., Zhou, J., Wang, X., Wei, X., Ding, Y., Huang, N., Qin, J., et al. (2017) · Autophagy · doi:10.1080/15548627.2016.1247143 · Cited by 334 · see citing works

Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium

Brighton, P. J., Maruyama, Y., Fishwick, K., Vrljicak, P., Tewary, S., Fujihara, R., Muter, J., Lucas, E. S., Yamada, T., Woods, L., et al. (2017) · eLife · doi:10.7554/elife.31274 · Cited by 323 · see citing works

Galacto‐conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity

González‐Gualda, E., Pàez‐Ribes, M., Lozano‐Torres, B., Macias, D., Wilson, J. R., González‐López, C., Ou, H., Mirón‐Barroso, S., Zhang, Z., Lérida‐Viso, A., et al. (2020) · Aging Cell · doi:10.1111/acel.13142 · Cited by 303 · see citing works

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

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CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers

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Senolytics (DQ) Mitigates Radiation Ulcers by Removing Senescent Cells

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Depletion of senescent-like neuronal cells alleviates cisplatin-induced peripheral neuropathy in mice

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Cancer cell senescence: a new frontier in drug development

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Controlled induction and targeted elimination of p16 INK4a ‐expressing chondrocytes in cartilage explant culture

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Tumor-induced senescent T cells promote the secretion of pro-inflammatory cytokines and angiogenic factors by human monocytes/macrophages through a mechanism that involves Tim-3 and CD40L

Ramello, M. C., Tosello, J., Canale, F. P., Mena, H. A., Negrotto, S., Gastman, B., Gruppi, A., Rodríguez, E. V. A., & Montes, C. L. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.451 · Cited by 49 · see citing works

Eliminating senescent chondrogenic progenitor cells enhances chondrogenesis under intermittent hydrostatic pressure for the treatment of OA

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Reactive oxygen species generation is essential for cisplatininduced accelerated senescence in hepatocellular carcinoma

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Senolytic compounds control a distinct fate of androgen receptor agonist- and antagonist-induced cellular senescent LNCaP prostate cancer cells

Pungsrinont, T., Sutter, M. F., Ertingshausen, M. C. C. M., Lakshmana, G., Kokal, M., Khan, A. S., & Baniahmad, A. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-00422-2 · Cited by 46 · see citing works

Elimination of p19ARF‐expressing cells protects against pulmonary emphysema in mice

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Oxidative stress-induced miRNAs modulate AKT signaling and promote cellular senescence in uterine leiomyoma

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High-Speed Live-Cell Interferometry: A New Method for Quantifying Tumor Drug Resistance and Heterogeneity

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The murine dialysis fistula model exhibits a senescence phenotype: pathobiological mechanisms and therapeutic potential

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Diversity of DNA damage response of astrocytes and glioblastoma cell lines with various p53 status to treatment with etoposide and temozolomide

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Hematologic Tumor Cell Resistance to the BCL-2 Inhibitor Venetoclax: A Product of Its Microenvironment?

Leverson, J. D., & Cojocari, D. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00458 · Cited by 36 · see citing works

Connecting cancer relapse with senescence

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Novel senescence associated gene, YPEL3, is repressed by estrogen in ER+ mammary tumor cells and required for tamoxifen‐induced cellular senescence

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Persistence of senescent prostate cancer cells following prolonged neoadjuvant androgen deprivation therapy

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Whole‐exome sequencing reveals novel genetic variants associated with diverse phenotypes of melanoma cells

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Single-Cell Transcriptome Analysis Reveals Six Subpopulations Reflecting Distinct Cellular Fates in Senescent Mouse Embryonic Fibroblasts

Chen, W., Wang, X., Wei, G., Huang, Y., Shi, Y., Li, D., Qiu, S., Zhou, B., Cao, J., Chen, M., et al. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00867 · Cited by 26 · see citing works

Dynamic Metabolic Response to Adriamycin-Induced Senescence in Breast Cancer Cells

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Detection of cellular senescence within human invasive breast carcinomas distinguishes different breast tumor subtypes

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Preliminary Results of a Phase II Open-Label, Randomized Study of the BH3 Mimetic Protein Navitoclax (ABT-263) with or without Rituximab for Treatment of Previously Untreated B-Cell Chronic Lymphocytic Leukemia

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Therapy‐Induced Senescence Is a Predictor of Treatment Outcome in Acute Myeloid Leukemia

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Exploiting senescence for the treatment of cancer

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Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy

Prasanna, P. G. S., Citrin, D. E., Hildesheim, J., Ahmed, M. M., Venkatachalam, S., Riscuta, G., Xi, D., Zheng, G., van Deursen, J., Goronzy, J. J., et al. (2021) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djab064 · Cited by 351 · see citing works

Cellular senescence and the tumour microenvironment

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Cellular Senescence: Molecular Targets, Biomarkers, and Senolytic Drugs

Kudlová, N., Sanctis, J. B. D., & Hajdúch, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084168 · Cited by 176 · see citing works

GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment

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The role of cellular senescence and SASP in tumour microenvironment

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Senescent tumor cells: an overlooked adversary in the battle against cancer

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SASP Modulation for Cellular Rejuvenation and Tissue Homeostasis: Therapeutic Strategies and Molecular Insights

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Biomarkers of Cellular Senescence and Aging: Current State‐of‐the‐Art, Challenges and Future Perspectives

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The controversial role of senescence-associated secretory phenotype (SASP) in cancer therapy

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cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis

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Androgen-deprivation induced senescence in prostate cancer cells is permissive for the development of castration-resistance but susceptible to senolytic therapy

Carpenter, V. J., Saleh, T., Lee, S. M., Murray, G. F., Reed, J. C., Souers, A. J., Faber, A. C., Harada, H., & Gewirtz, D. A. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114765 · Cited by 56 · see citing works

Toward precision interventions and metrics of inflammaging

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Long-term cardiovascular complications following sepsis: is senescence the missing link?

Merdji, H., Schini‐Kerth, V. B., Meziani, F., & Toti, F. (2021) · Annals of Intensive Care · doi:10.1186/s13613-021-00937-y · Cited by 53 · see citing works

Therapy-induced senescence as a component of tumor biology: Evidence from clinical cancer

Saleh, T., Bloukh, S., Hasan, M., & Shboul, S. A. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188994 · Cited by 54 · see citing works

Senescent cells in cancer therapy: why and how to remove them

Zhang, J., Zhang, D., & Yu, B. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.07.002 · Cited by 50 · see citing works

Cellular senescence and the blood–brain barrier: Implications for aging and age-related diseases

Knopp, R. C., Erickson, M. A., Rhea, E. M., Reed, M. J., & Banks, W. A. (2023) · Experimental Biology and Medicine · doi:10.1177/15353702231157917 · Cited by 44 · see citing works

Considering therapy-induced senescence as a mechanism of tumour dormancy contributing to disease recurrence

Saleh, T., & Gewirtz, D. A. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01787-6 · Cited by 42 · see citing works

Single-Cell Transcriptomics Reveals the Expression of Aging- and Senescence-Associated Genes in Distinct Cancer Cell Populations

Saul, D., & Kosinsky, R. L. (2021) · Cells · doi:10.3390/cells10113126 · Cited by 39 · see citing works

COVID-19 Immunobiology: Lessons Learned, New Questions Arise

Kaklamanos, A., Belogiannis, K., Skendros, P., Gorgoulis, V. G., Vlachoyiannopoulos, P. G., & Tzioufas, A. G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.719023 · Cited by 37 · see citing works

Anti-aging: senolytics or gerostatics (unconventional view)

Blagosklonny, M. V. (2021) · Oncotarget · doi:10.18632/oncotarget.28049 · Cited by 38 · see citing works

Emerging Roles of Vitamin B12 in Aging and Inflammation

Simonenko, S. Y., Bogdanova, D. A., & Kuldyushev, N. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25095044 · Cited by 39 · see citing works

Cellular senescence offers distinct immunological vulnerabilities in cancer

Zhou, L., Ma, B., & Ruscetti, M. A. (2024) · Trends in cancer · doi:10.1016/j.trecan.2024.11.010 · Cited by 36 · see citing works

Clinical and Biological Aspects of Disseminated Tumor Cells and Dormancy in Breast Cancer

Ring, A., Spataro, M., WICKI, A. N., & Aceto, N. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.929893 · Cited by 32 · see citing works

Impact of Cancer Stem Cells on Therapy Resistance in Gastric Cancer

Otaegi-Ugartemendia, M., Matheu, A., & Carrasco‐García, E. (2022) · Cancers · doi:10.3390/cancers14061457 · Cited by 32 · see citing works

Senotherapeutic-like effect of Silybum marianum flower extract revealed on human skin cells

Woo, J., Shin, S., Cho, E., Ryu, D., Garandeau, D., Chajra, H., Fréchet, M., Park, D., & Jung, E. (2021) · PLoS ONE · doi:10.1371/journal.pone.0260545 · Cited by 31 · see citing works

Olaparib-Induced Senescence Is Bypassed through G2–M Checkpoint Override in Olaparib-Resistant Prostate Cancer

Lombard, A. P., Armstrong, C. M., D'Abronzo, L. S., Ning, S., Leslie, A. R., Sharifi, M., Lou, W., Evans, C. P., Dall’Era, M., Chen, H.-W., et al. (2022) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-21-0604 · Cited by 29 · see citing works

Targeting chemoresistant senescent pancreatic cancer cells improves conventional treatment efficacy

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The hypoxia-inducible factor-1α in stemness and resistance to chemotherapy in gastric cancer: Future directions for therapeutic targeting

Özcan, G. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1082057 · Cited by 29 · see citing works

Single-Cell Transcriptomic Analysis Identifies Senescent Osteocytes That Trigger Bone Destruction in Breast Cancer Metastasis

Kaur, J., Adhikari, M., Sabol, H. M., Anloague, A., Khan, S., Kurihara, N., Diaz‐delCastillo, M., Andreasen, C. M., Barnes, C. L., Stambough, J. B., et al. (2024) · Cancer Research · doi:10.1158/0008-5472.can-24-0857 · Cited by 32 · see citing works

A three-marker signature identifies senescence in human breast cancer exposed to neoadjuvant chemotherapy

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The Expression of the Senescence-Associated Biomarker Lamin B1 in Human Breast Cancer

Saleh, T., Alhesa, A., El‐Sadoni, M., Shahin, N. A., Alsharaiah, E., Shboul, S. A., Awad, H., Bloukh, S., Al-Balas, M., Alsalem, M., et al. (2022) · Diagnostics · doi:10.3390/diagnostics12030609 · Cited by 27 · see citing works

A Critical Appraisal of the Utility of Targeting Therapy-Induced Senescence for Cancer Treatment

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Senotherapies: A novel strategy for synergistic anti-tumor therapy

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N7-methylguanosine methylation of tRNAs regulates survival to stress in cancer

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Protective roles of cytoplasmic p21Cip1 /Waf1 in senolysis and ferroptosis of lung cancer cells

Koyanagi, A., Kotani, H., Iida, Y., Tanino, R., Kartika, I. D., Kishimoto, K., & Harada, M. (2022) · Cell Proliferation · doi:10.1111/cpr.13326 · Cited by 23 · see citing works

Obesity triggers tumoral senescence and renders poorly immunogenic malignancies amenable to senolysis

Fournier, F., Diaz-Marin, R., Pilon, F., Neault, M., Juneau, R., Girouard, G., Wilson, A. M., Larrivée, B., Mallette, F. A., Crespo‐Garcia, S., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2209973120 · Cited by 23 · see citing works

New Horizons in cellular senescence for clinicians

Witham, M. D., Granic, A., Miwa, S., Passos, J. F., Richardson, G. D., & Sayer, A. A. (2023) · Age and Ageing · doi:10.1093/ageing/afad127 · Cited by 25 · see citing works

Biochemical and Cellular Characterization of New Radio-Resistant Cell Lines Reveals a Role of Natural Flavonoids to Bypass Senescence

Russo, M., Spagnuolo, C., Moccia, S., Tedesco, I., Lauria, F., & Russo, G. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010301 · Cited by 21 · see citing works

Simple Detection of Unstained Live Senescent Cells with Imaging Flow Cytometry

Malavolta, M., Giacconi, R., Piacenza, F., Strizzi, S., Cardelli, M., Bigossi, G., Marcozzi, S., Tiano, L., Marcheggiani, F., Matacchione, G., et al. (2022) · Cells · doi:10.3390/cells11162506 · Cited by 22 · see citing works

Cellular Aging and Senescence in Cancer: A Holistic Review of Cellular Fate Determinants

Tufail, M., Huang, Y., Hu, J.-J., Liang, J., He, C., Wan, W., Jiang, C., Wu, H., & Li, N. (2024) · Aging and Disease · doi:10.14336/ad.2024.0421 · Cited by 22 · see citing works

Alleviation of cisplatin-induced neuropathic pain, neuronal apoptosis, and systemic inflammation in mice by rapamycin

Alotaibi, M. R., Alaqil, F. A., Alqahtani, F., Alanazi, M., Nadeem, A., Ahmad, S. F., Lapresa, R., Alharbi, M., Alshammari, A., Alotaibi, M., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.891593 · Cited by 23 · see citing works

Senolytic Therapy: A Potential Approach for the Elimination of Oncogene-Induced Senescent HPV-Positive Cells

Saleh, T., Khasawneh, A. I., Himsawi, N. M., Abu-Raideh, J. A., Ejeilat, V., Elshazly, A. M., & Gewirtz, D. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415512 · Cited by 21 · see citing works

Therapy-induced senescence is finally escapable, what is next?

Saleh, T. (2024) · Cell Cycle · doi:10.1080/15384101.2024.2364579 · Cited by 21 · see citing works

The Cross Talk between Cellular Senescence and Melanoma: From Molecular Pathogenesis to Target Therapies

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Protective role of cytoplasmic p21Cip1/Waf1 in apoptosis of CDK4/6 inhibitor‐induced senescence in breast cancer cells

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Antagonizing the irreversible thrombomodulin-initiated proteolytic signaling alleviates age-related liver fibrosis via senescent cell killing

Pan, C. C., Maeso‐Díaz, R., Lewis, T. R., Xiang, K., Tan, L., Liang, Y., Wang, L., Yang, F., Yin, T., Wang, C., et al. (2023) · Cell Research · doi:10.1038/s41422-023-00820-4 · Cited by 19 · see citing works

Sorafenib, rapamycin, and venetoclax attenuate doxorubicin-induced senescence and promote apoptosis in HCT116 cells

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Integrated multicomponent interventions to support healthy aging of the whole person

Langevin, H. M., Weber, W. J., & Chen, W. (2023) · Aging Cell · doi:10.1111/acel.14001 · Cited by 18 · see citing works

Potential Use of Senolytics for Pharmacological Targeting of Precancerous Lesions

Saleh, T., & Carpenter, V. J. (2021) · Molecular Pharmacology · doi:10.1124/molpharm.121.000361 · Cited by 17 · see citing works

Cellular Senescence as a Brake or Accelerator for Oncogenic Transformation and Role in Lymphatic Metastasis

Banerjee, P., Gaddam, N., Pandita, T. K., & Chakraborty, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032877 · Cited by 17 · see citing works

Targeting Inhibitor of Apoptosis Proteins to Overcome Chemotherapy Resistance—A Marriage between Targeted Therapy and Cytotoxic Chemotherapy

Barroso, T., Melo-Alvim, C., Ribeiro, L., Casimiro, S., & Costa, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713385 · Cited by 17 · see citing works

Epigenetic dynamics of aging and cancer development: current concepts from studies mapping aging and cancer epigenomes

Bisht, S., Mao, Y., & Easwaran, H. (2024) · Current Opinion in Oncology · doi:10.1097/cco.0000000000001020 · Cited by 17 · see citing works

Inhibition of glutaminase elicits senolysis in therapy-induced senescent melanoma cells

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Tumor cell malignancy: A complex trait built through reciprocal interactions between tumors and tissue-body system

Feunteun, J., Ostyn, P., & Delaloge, S. (2022) · iScience · doi:10.1016/j.isci.2022.104217 · Cited by 16 · see citing works

Cellular senescence in neuroblastoma

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Can 3D bioprinting solve the mystery of senescence in cancer therapy?

Shboul, S. A., DeLuca, V. J., Dweiri, Y. M., & Saleh, T. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101732 · Cited by 15 · see citing works

Cytoprotective, Cytotoxic and Cytostatic Roles of Autophagy in Response to BET Inhibitors

Elshazly, A. M., & Gewirtz, D. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612669 · Cited by 14 · see citing works

Immunosenescence and the Geriatric Giants: Molecular Insights into Aging and Healthspan

Fetarayani, D., Kahdina, M., Waitupu, A., Pratiwi, L., Ningtyas, M. C., Adytia, G. J., & Sutanto, H. (2025) · Medical Sciences · doi:10.3390/medsci13030100 · Cited by 14 · see citing works

Pro-tumorigenic role of type 2 diabetes-induced cellular senescence in colorectal cancer

Melia, F., Udomjarumanee, P., Zinovkin, D. A., Arghiani, N., & Pranjol, M. Z. I. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.975644 · Cited by 14 · see citing works

Therapy‐induced senescent cancer cells exhibit complement activation and increased complement regulatory protein expression

Abu-Humaidan, A. H. A., Ismail, M. A., Ahmad, F. M., Shboul, S. A., Barham, R., Tadros, J. S., Alhesa, A., El‐Sadoni, M., Alotaibi, M. R., Ababneh, N. A., et al. (2024) · Immunology and Cell Biology · doi:10.1111/imcb.12727 · Cited by 13 · see citing works

An antibiotic that mediates immune destruction of senescent cancer cells

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The Role of Senescence, its Therapeutic Relevance and Clinical Implications in the Tumor Microenvironment

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The senescent mesothelial matrix accentuates colonization by ovarian cancer cells

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Autophagy and senescence facilitate the development of antiestrogen resistance in ER positive breast cancer

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STAT3/TGFBI signaling promotes the temozolomide resistance of glioblastoma through upregulating glycolysis by inducing cellular senescence

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Mesenchymal stem cells in the bone marrow microenvironment: a double-edged sword for AML

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BRD4 Inhibition as a Strategy to Prolong the Response to Standard of Care in Estrogen Receptor-Positive Breast Cancer

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Cisplatin Provokes Peripheral Nociception and Neuronal Features of Therapy-Induced Senescence and Calcium Dysregulation in Rats

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Immune senescence in non-small cell lung cancer management: therapeutic relevance, biomarkers, and mitigating approaches

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An updated look into reactive oxygen species and cyclophosphamide-induced ovarian damage

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Cellular senescence in cancer: Friend or fraud?

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Targeting treatment resistance in cervical cancer: A new avenue for senolytic therapies

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AKT1 Is Required for a Complete Palbociclib-Induced Senescence Phenotype in BRAF-V600E-Driven Human Melanoma

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Targeting therapy-induced senescence as a novel strategy to combat chemotherapy-induced peripheral neuropathy

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Characterization of radiation-induced micronuclei associated with premature senescence, and their selective removal by senolytic drug, ABT-263

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Senolytic vaccination: a new mandate for cardiovascular health?

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Current clinical trials for craniopharyngiomas: what’s on the horizon?

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Implications of cellular senescence in paediatric pituitary tumours

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Senolysis of gemcitabine‐induced senescent human pancreatic cancer cells

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Hypoxia, Stem Cells and Cancer Stem Cells

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Oral Senescence: From Molecular Biology to Clinical Research

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Therapeutic Senolysis of Axitinib-Induced Senescent Human Lung Cancer Cells

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Advances in Cutaneous Melanoma Therapy: The Emerging Role of CDK4/6 Inhibitors

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A narrative review of therapy-induced senescence in cancer: mechanisms, immune interplay, and therapeutic opportunities

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Emerging strategies in senotherapeutics: from broad-spectrum senolysis to precision reprogramming

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Pro-Apoptotic Activity of MCL-1 Inhibitor in Trametinib-Resistant Melanoma Cells Depends on Their Phenotypes and Is Modulated by Reversible Alterations Induced by Trametinib Withdrawal

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Exosomal dynamics: Bridging the gap between cellular senescence and cancer therapy

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Harnessing Senolytics and PARP Inhibition to Expand the Antitumor Activity of CDK4/6 Inhibitors in Prostate Cancer

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Effectiveness of PROTAC BET Degraders in Combating Cisplatin Resistance in Head and Neck Cancer Cells

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A Conversation with ChatGPT on Contentious Issues in Senescence and Cancer Research

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Future Perspectives in Senescence-Based Therapies for Head and Neck Cancer

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Proteolysis targeting chimeras as senolytics: An emerging senotherapy for combating aging

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Therapeutic Targeting of the Pentose Phosphate Pathway in Colorectal Cancer Using 6‐Aminonicotinamide and 5‐Fluorouracil

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Cellular senescence: A novel mechanism of therapeutic resistance in prostate cancer

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Disproportionality Analysis of Hematologic Adverse Event Signals Associated with Venetoclax in Combination with Senescence-Inducing Chemotherapy

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Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer MetastasisPreprint

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T-Cell Immunosenescence in Systemic Lupus Erythematosus: Molecular Mechanisms and Therapeutic Perspectives

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Decoding the tumor-aging axis: from bench to clinical

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Combination treatment with hyaluronic acid synthesis and Bcl-2 inhibitors induces senolytic elimination of oral squamous cell carcinoma cells in vitro

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A Critical Appraisal of the Utility of Targeting Therapy-Induced Senescence for Cancer Treatment

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Senolytics for cancer treatment: complexities and opportunities

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Senolytics: charting a new course or enhancing existing anti-tumor therapies?

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Senogenic-senolytic treatment strategies enhance tumor control and can improve survival in murine cancer models: a systematic review

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Senolytics: from pharmacological inhibitors to immunotherapies, a promising future for patients’ treatment

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