Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans
Open accessAbstract
Age-related disease risk has been linked to short sleep duration and sleep disturbances; however, the specific molecular pathways linking sleep loss with diseases of aging are poorly defined. Key cellular events seen with aging, which are thought to contribute to disease, may be particularly sensitive to sleep loss. We tested whether one night of partial sleep deprivation (PSD) would increase leukocyte gene expression indicative of DNA damage responses (DDR), the senescence-associated secretory phenotype (SASP), and senescence indicator p16(INK4a) in older adult humans, who are at increased risk for cellular senescence. Community-dwelling older adults aged 61-86years (n=29; 48% male) underwent an experimental partial sleep deprivation (PSD) protocol over 4 nights, including adaptation, an uninterrupted night of sleep, partial sleep deprivation (sleep restricted 3-7AM), and a subsequent full night of sleep. Blood samples were obtained each morning to assess peripheral blood mononuclear cell (PBMC) gene expression using Illumina HT-12 arrays. Analyses of microarray results revealed that SASP (p<.05) and DDR (p=.08) gene expression were elevated from baseline to PSD nights. Gene expression changes were also observed from baseline to PSD in NFKB2, NBS1 and CHK2 (all p's<.05). The senescence marker p16(INK4a) (CDKN2A) was increased 1day after PSD compared to baseline (p<.01), however confirmatory RT-PCR did not replicate this finding. One night of partial sleep deprivation activates PBMC gene expression patterns consistent with biological aging in this older adult sample. PSD enhanced the SASP and increased the accumulation of damage that initiates cell cycle arrest and promotes cellular senescence. These findings causally link sleep deprivation to the molecular processes associated with biological aging.
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Dietary and lifestyle habits and exposure to pollutants can increase oxidative stress, upregulate mitogenic signaling pathways, and cause genomic and epigenomic perturbations that induce the senescence-associated secretory phenotype.
“dietary and lifestyle habits, as well as exposure to a variety of different pollutants, can increase oxidative stress, upregulate mitogenic signaling pathways and cause genomic and epigenomic perturbations8,60,62,63 that can induce the SASP.”
From Chronic inflammation in the etiology of disease across the life span (2019) · cites this paper as [62]
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López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
The DNA-damage response in human biology and disease
Jackson, S. P., & Bartek, J. (2009) · Nature · doi:10.1038/nature08467 · Cited by 6,092 · see citing works
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206 · see citing works
Cellular senescence: when bad things happen to good cells
Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441 · see citing works
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891 · see citing works
Epidemiology of insomnia: what we know and what we still need to learn
Ohayon, M. M. (2002) · Sleep Medicine Reviews · doi:10.1053/smrv.2002.0186 · Cited by 3,743 · cited 2× · see citing works
“Disease morbidity and mortality risk are elevated among those with short sleep duration and poor sleep quality (Ohayon, 2002; Center for Disease Control, 2011; Colten and Altevogt, 2006; Motivala, 2011).”
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · cited 1× · see citing works
“…by replicative (e.g., critically short telomeres) or cell stress (e.g., DNA damage) pathways, and preceded by signaling of DNA damage response (DDR) elements derived from telomeric or non-telomeric damage (Campisi, 2005; Effros, 2005; Blackburn, 2005, 2000; Campisi and d’Adda di Fagagna, 2007).”
Springer Science+Business Media
Технология (2013) · Betascript Publishing eBooks · Cited by 3,071 · see citing works
Geroscience: Linking Aging to Chronic Disease
Kennedy, B. K., Berger, S. L., Brunet, A., Campisi, J., Cuervo, A. M., Epel, E. S., Franceschi, C., Lithgow, G. J., Morimoto, R. I., Pessin, J. E., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.039 · Cited by 2,764 · see citing works
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
Campisi, J. (2005) · Cell · doi:10.1016/j.cell.2005.02.003 · Cited by 2,359 · cited 4× · see citing works
“…specific signaling molecules responsive to the DDR: ATM which phosphorylates CHK2 (checkpoint kinase-2) to promote growth arrest, and NBS1, which can participate in DNA repair, especially in the telomeric region, when part of the MRE11-RAD50-NBS1 (MRN) complex Campisi and d’Adda di Fagagna, 2007.”
InfluentialPersistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1909 · Cited by 2,232 · see citing works
Irwin, M. R., Olmstead, R., & Carroll, J. E. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.014 · Cited by 2,085 · see citing works
Self-citationSleep Complaints Among Elderly Persons: An Epidemiologic Study of Three Communities
Foley, D. J., Monjan, A. A., Brown, S. L., Simonsick, E. M., Wallace, R. B., & Blazer, D. G. (1995) · Sleep · doi:10.1093/sleep/18.6.425 · Cited by 1,610 · see citing works
Ink4a/Arf expression is a biomarker of aging
Krishnamurthy, J., Torrice, C., Ramsey, M. R., Kovalev, G. I., Al-Regaiey, K., Su, L., & Sharpless, N. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22475 · Cited by 1,486 · see citing works
Telomere states and cell fates
Blackburn, E. H. (2000) · Nature · doi:10.1038/35040500 · Cited by 1,372 · see citing works
The metabolic consequences of sleep deprivation
Knutson, K. L., Spiegel, K., Penev, P., & Van Cauter, E. (2007) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.01.002 · Cited by 1,365 · see citing works
Inflammatory networks during cellular senescence: causes and consequences.
Freund, A., Orjalo, A. V., Desprez, P.-Y., & Campisi, J. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.03.003 · Cited by 1,354 · see citing works
Telomere dysfunction induces metabolic and mitochondrial compromise
Sahin, E., Colla, S., Liesa, M., Moslehi, J., Müller, F. L., Guo, M., Cooper, M., Kotton, D., Fabian, A. J., Walkey, C., et al. (2011) · Nature · doi:10.1038/nature09787 · Cited by 1,319 · see citing works
Chien, Y., Scuoppo, C., Wang, X., Fang, X., Balgley, B., Bolden, J. E., Premsrirut, P., Luo, W., Chicas, A., Lee, C. S., et al. (2011) · Genes & Development · doi:10.1101/gad.17276711 · Cited by 1,046 · see citing works
Reciprocal regulation of the neural and innate immune systems
Irwin, M. R., & Cole, S. W. (2011) · Nature Reviews Immunology · doi:10.1038/nri3042 · Cited by 910 · cited 10× · see citing works
“The release of norepinephrine stimulates b-adrenergic receptors on immune cells to activate transcriptional elements, including NF-jB (Irwin and Cole, 2011; Cole et al., 2010).”
InfluentialSelf-citationSleep Deprivation and Activation of Morning Levels of Cellular and Genomic Markers of Inflammation
Irwin, M. R. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.16.1756 · Cited by 850 · see citing works
Self-citationTelomeres and telomerase: Their mechanisms of action and the effects of altering their functions
Blackburn, E. H. (2005) · FEBS Letters · doi:10.1016/j.febslet.2004.11.036 · Cited by 838 · see citing works
Chronic inflammation induces telomere dysfunction and accelerates ageing in mice
Jurk, D., Wilson, C., Passos, J. F., Oakley, F., Correia-Melo, C., Greaves, L., Saretzki, G., Fox, C., Lawless, C., Anderson, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms5172 · Cited by 814 · see citing works
Cardiovascular, inflammatory, and metabolic consequences of sleep deprivation
Mullington, J. M., Haack, M., Toth, M., Serrador, J. M., & Meier-Ewert, H. K. (2009) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2008.10.003 · Cited by 783 · see citing works
Salminen, A., Kauppinen, A., & Kaarniranta, K. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2011.12.006 · Cited by 763 · see citing works
Sleep deprivation as a neurobiologic and physiologic stressor: allostasis and allostatic load
McEwen, B. S. (2006) · Metabolism · doi:10.1016/j.metabol.2006.07.008 · Cited by 624 · see citing works
Salminen, A., Huuskonen, J., Ojala, J., Kauppinen, A., Kaarniranta, K., & Suuronen, T. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2007.09.002 · Cited by 581 · see citing works
Möller-Levet, C. S., Archer, S. N., Bucca, G., Laing, E. E., Slak, A., Kabiljo, R., Lo, J. C. Y., Santhi, N., von Schantz, M., Smith, C. P., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217154110 · Cited by 576 · see citing works
A functional genomic perspective on human well-being
Fredrickson, B. L., Grewen, K. M., Coffey, K. A., Algoe, S. B., Firestine, A. M., Arevalo, J. M. G., Ma, J., & Cole, S. W. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305419110 · Cited by 512 · cited 1× · see citing works
“…MCP-4, chemokine C-X-C motif ligand (CXCL)-1, CXCL-2, CXCL-3, granulocyte macrophage colony-stimulating factor (GMCSF), intracellular adhesion molecule (ICAM)-1) that promote disease (Effros, 2005; Campisi and d’Adda di Fagagna, 2007; Erusalimsky, 2009; Coppé et al., 2010; Freund et al., 2010).”
Self-citationLiu, Y., Sanoff, H. K., Cho, H., Burd, C. E., Torrice, C., Ibrahim, J. G., Thomas, N. E., & Sharpless, N. E. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00489.x · Cited by 509 · see citing works
Partial night sleep deprivation reduces natural killer and celhdar immune responses in humans
Irwin, M., McClintick, J., Costlow, C., Fortner, M., White, J., & Gillin, J. C. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.5.8621064 · Cited by 480 · see citing works
Self-citationSleep Loss Activates Cellular Inflammatory Signaling
Irwin, M. R., Wang, M., Ribeiro, D., Cho, H. J., Olmstead, R., Breen, E. C., Martinez-Maza, O., & Cole, S. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.004 · Cited by 467 · see citing works
Self-citationVascular endothelial senescence: from mechanisms to pathophysiology
Erusalimsky, J. D. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91353.2008 · Cited by 399 · see citing works
Irwin, M. R., Thompson, J., Miller, C., Gillin, J. C., & Ziegler, M. G. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.6.5788 · Cited by 389 · see citing works
Self-citationRedwine, L. S., Hauger, R. L., Gillin, J. C., & Irwin, M. R. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.10.6871 · Cited by 373 · see citing works
Self-citationImpact of Sleep and Sleep Loss on Neuroendocrine and Metabolic Function
van Cauter, E., Holmbäck, U., Knutson, K., Leproult, R., Miller, A., Nedeltcheva, A., Pannain, S., Penev, P., Tasali, E., & Spiegel, K. (2007) · Hormone Research in Paediatrics · doi:10.1159/000097543 · Cited by 353 · see citing works
The role of CD8<sup>+</sup> T‐cell replicative senescence in human aging
Effros, R. B., Dagarag, M., Spaulding, C., & Man, J. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00259.x · Cited by 336 · see citing works
Coppé, J.-P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P.-Y., & Campisi, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060301 · Cited by 302 · cited 8× · see citing works
“Further selection was made of additional individual genes important in signaling senescence and initiating the inflammatory cytokine response after DDR: ATM, NBS1 (NBN), and CHK2 Coppé et al., 2008; Rodier et al., 2009.”
InfluentialRedwine, L. S. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.10.3597 · Cited by 285 · see citing works
Aging Impairs the Unfolded Protein Response to Sleep Deprivation and Leads to Proapoptotic Signaling
Naidoo, N. N., Ferber, M., Master, M., Zhu, Y., & Pack, A. I. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5685-07.2008 · Cited by 282 · see citing works
Nocturnal catecholamines and immune function in insomniacs, depressed patients, and control subjects
Irwin, M., Clark, C., Kennedy, B., Christian Gillin, J., & Ziegler, M. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(03)00031-x · Cited by 268 · see citing works
Self-citationComputational identification of gene–social environment interaction at the human <i>IL6</i> locus
Cole, S. W., Arevalo, J. M. G., Takahashi, R., Sloan, E. K., Lutgendorf, S. K., Sood, A. K., Sheridan, J. F., & Seeman, T. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911515107 · Cited by 256 · see citing works
Self-citationPalesh, O. G., Aldridge-Gerry, A. A., Zeitzer, J. M., Koopman, C., Neri, E., Giese‐Davis, J., Jo, B., KRAEMER, H. C., Nouriani, B., & Spiegel, D. (2014) · SLEEP · doi:10.5665/sleep.3642 · Cited by 235 · see citing works
Vgontzas, A. N., Zoumakis, M., Bixler, E. O., Lin, H.-M., Prolo, P., Vela‐Bueno, A., Kales, A., & Chrousos, G. P. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021176 · Cited by 235 · see citing works
Glucocorticoids suppress selected components of the senescence‐associated secretory phenotype
Laberge, R., Zhou, L., Sarantos, M. R., Rodier, F., Freund, A., de Keizer, P. L. J., Liu, S., Demaria, M., Cong, Y., Kapahi, P., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00818.x · Cited by 229 · see citing works
Activation of nuclear factor-kappa B signalling promotes cellular senescence
Rovillain, E. M. I., Mansfield, L., Caetano, C., Álvarez‐Fernández, M., Caballero, O. L., Medema, R. H., Hummerich, H., & Jat, P. (2011) · Oncogene · doi:10.1038/onc.2010.611 · Cited by 197 · see citing works
Sleep and Inflammation: Psychoneuroimmunology in the Context of Cardiovascular Disease
Motivala, S. J. (2011) · Annals of Behavioral Medicine · doi:10.1007/s12160-011-9280-2 · Cited by 151 · see citing works
Cell Injury and Repair Resulting from Sleep Loss and Sleep Recovery in Laboratory Rats
Everson, C. A., Henchen, C. J., Szabo, A., & Hogg, N. (2014) · Sleep · doi:10.5665/sleep.4244 · Cited by 136 · see citing works
Sleep duration and metabolic syndrome in adult populations: a meta-analysis of observational studies
Ju, S.-Y., & Choi, W.-S. (2013) · Nutrition & Diabetes · doi:10.1038/nutd.2013.8 · Cited by 130 · see citing works
Jackowska, M., Hamer, M., Carvalho, L. A., Erusalimsky, J. D., Butcher, L., & Steptoe, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047292 · Cited by 127 · see citing works
Cellular stress/the unfolded protein response: Relevance to sleep and sleep disorders
Naidoo, N. N. (2009) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.01.001 · Cited by 116 · see citing works
Geriatric Medicine: An Evidence-Based Approach
Sowers, J. R. (2003) · JAMA · doi:10.1001/jama.290.15.2068 · Cited by 114 · see citing works
Chen, X., Redline, S. S., Shields, A. E., Williams, D. R., & Williams, M. A. (2014) · Annals of Epidemiology · doi:10.1016/j.annepidem.2014.05.014 · Cited by 109 · see citing works
Shorter Leukocyte Telomere Length in Midlife Women with Poor Sleep Quality
Prather, A. A., Puterman, E., Lin, J., O'Donovan, A., Krauss, J., Tomiyama, A. J., Epel, E. S., & Blackburn, E. H. (2011) · Journal of Aging Research · doi:10.4061/2011/721390 · Cited by 100 · see citing works
Petit, L. (2003) · Age and Ageing · doi:10.1093/ageing/32.1.19 · Cited by 100 · see citing works
Associations between Rotating Night Shifts, Sleep Duration, and Telomere Length in Women
Liang, G., Schernhammer, E. S., Qi, L., Gao, X., Vivo, I. D., & Han, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023462 · Cited by 99 · see citing works
Cribbet, M. R., Carlisle, M., Cawthon, R. M., Uchino, B. N., Williams, P. G., Smith, T. W., Gunn, H. E., & Light, K. C. (2014) · Sleep · doi:10.5665/sleep.3308 · Cited by 93 · see citing works
Prather, A. A., Gurfein, B., Moran, P., Daubenmier, J., Acree, M., Bacchetti, P., Sinclair, E., Lin, J., Blackburn, E., Hecht, F. M., et al. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.12.011 · Cited by 79 · see citing works
Sleep deprivation as a probe of homeostatic sleep regulation in primary alcoholics
Irwin, M. R., Gillin, J. C., Dang, J., Weissman, J., Phillips, E., & Ehlers, C. L. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01304-x · Cited by 72 · see citing works
Self-citationSleep Deprivation and Divergent Toll-like Receptor-4 Activation of Cellular Inflammation in Aging
Carroll, J. E., Carrillo, C., Olmstead, R., Witarama, T., Breen, E. C., Yokomizo, M., Seeman, T. E., & Irwin, M. R. (2015) · Sleep · doi:10.5665/sleep.4398 · Cited by 67 · see citing works
Self-citationChen, S., Lin, J., Matsuguchi, T., Blackburn, E. H., Yeh, F., Best, L. G., Devereux, R. B., Lee, E. T., Howard, B. V., Roman, M. J., et al. (2014) · Aging · doi:10.18632/aging.100671 · Cited by 66 · see citing works
The UPR and the Anti-oxidant Response: Relevance to Sleep and Sleep Loss
Brown, M., & Naidoo, N. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8114-8 · Cited by 61 · see citing works
Taffett, G. E. (2003) · Springer eBooks · doi:10.1007/0-387-22621-4_3 · Cited by 60 · see citing works
Irwin, M. R., & Ziegler, M. G. (2005) · Hypertension · doi:10.1161/01.hyp.0000153517.44295.07 · Cited by 55 · see citing works
Self-citationRestorative Biological Processes and Health
Robles, T. F., & Carroll, J. (2011) · Social and Personality Psychology Compass · doi:10.1111/j.1751-9004.2011.00368.x · Cited by 51 · see citing works
Self-citationThe role of CD8 T cell replicative senescence in human aging.
Effros, R. B. (2005) · PubMed · Cited by 41 · see citing works
Roles of Endoplasmic Reticulum and Energetic Stress in Disturbed Sleep
Naidoo, N. N. (2012) · NeuroMolecular Medicine · doi:10.1007/s12017-012-8179-9 · Cited by 20 · see citing works
Flagged first, then by citations
3 of the 70 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [12]Colten HR Altevogt BM Research I of MUS. C on SM and. Sleep disorders and sleep deprivation: an unmet public health problem 2006 National Academies Press 20669438
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Inflammation and aging: signaling pathways and intervention therapies
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Couvineau, A., Voisin, T., Nicole, P., Gratio, V., Abad, C., & Tan, Y. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00709 · Cited by 86 · see citing works
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Carroll, J. E., Esquivel, S., Goldberg, A., Seeman, T. E., Effros, R. B., Dock, J., Olmstead, R., Breen, E. C., & Irwin, M. R. (2016) · Sleep · doi:10.5665/sleep.5526 · Cited by 85 · see citing works
Self-citationCasagrande, S., Stier, A., Monaghan, P., Loveland, J. L., Boner, W., Lupi, S., Trevisi, R., & Hau, M. (2020) · Journal of Experimental Biology · doi:10.1242/jeb.222513 · Cited by 85 · see citing works
The effect of sleep deprivation and disruption on DNA damage and health of doctors
Cheung, V., Yuen, V. M.-Y., Wong, G. T. C., & Choi, S. W. (2019) · Anaesthesia · doi:10.1111/anae.14533 · Cited by 81 · see citing works
Carroll, J., Bower, J. E., & Ganz, P. A. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00580-3 · Cited by 79 · see citing works
Self-citationChronic stress exposure and daily stress appraisals relate to biological aging marker p16INK4a
Rentscher, K. E., Carroll, J., Repetti, R. L., Cole, S. W., Reynolds, B. M., & Robles, T. F. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.12.006 · Cited by 69 · see citing works
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Gordleeva, S., Игоревич, К. О., Ivanchenko, M., Zaikin, A. A., & Franceschi, C. (2020) · Seminars in Immunopathology · doi:10.1007/s00281-020-00816-x · Cited by 62 · see citing works
Zheng, Y., Zhang, L., Bonfili, L., de Vivo, L., Eleuteri, A. M., & Bellesi, M. (2023) · Nutrients · doi:10.3390/nu15061518 · Cited by 58 · see citing works
Lawrence, M., Goyal, A., Pathak, S., & Ganguly, P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137411 · Cited by 54 · see citing works
Naler, L. B., Hsieh, Y.-P., Geng, S., Zhou, Z., Li, L., & Lu, C. (2022) · Communications Biology · doi:10.1038/s42003-022-03035-2 · Cited by 54 · see citing works
Jhanji, M., Rao, C. N., Massey, J. C., Hope, M. C., Zhou, X., Keene, C. D., Ma, T., Wyatt, M. D., Stewart, J. A., & Sajish, M. (2022) · Nature Communications · doi:10.1038/s41467-022-30785-8 · Cited by 53 · see citing works
Tempaku, P. F., Hirotsu, C., Mazzotti, D. R., Xavier, G., Maurya, P. K., Brietzke, E. M., Belangero, S. I., Poyares, D. R., Bittencourt, L., & Tufik, S. (2018) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.7532 · Cited by 53 · see citing works
Hou, J., Yun, Y. J., Xue, J., Jeon, B.-M., & Kim, S. (2020) · Phytotherapy Research · doi:10.1002/ptr.6636 · Cited by 53 · see citing works
Carroll, J., Irwin, M. R., Seeman, T. E., Roux, A. V. D., Prather, A. A., Olmstead, R., Epel, E. S., Lin, J., & Redline, S. S. (2019) · SLEEP · doi:10.1093/sleep/zsz089 · Cited by 49 · see citing works
Self-citationChronic Intermittent Hypoxia Triggers a Senescence-like Phenotype in Human White Preadipocytes
Polonis, K., Becari, C., Chahal, C. A. A., Zhang, Y., Allen, A. M., Kellogg, T. A., Somers, V. K., & Singh, P. (2020) · Scientific Reports · doi:10.1038/s41598-020-63761-7 · Cited by 48 · see citing works
Postpartum sleep loss and accelerated epigenetic aging
Carroll, J., Ross, K. M., Horvath, S., Okun, M. L., Hobel, C. J., Rentscher, K. E., Coussons‐Read, M. E., & Schetter, C. D. (2021) · Sleep Health · doi:10.1016/j.sleh.2021.02.002 · Cited by 49 · see citing works
Self-citationThe impact of insomnia on frailty and the hallmarks of aging
Carvalhas-Almeida, C., Cavadas, C., & Álvaro, A. R. (2022) · Aging Clinical and Experimental Research · doi:10.1007/s40520-022-02310-w · Cited by 49 · see citing works
Stress and immunological aging
Reed, R. G. (2019) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2019.01.012 · Cited by 36 · see citing works
Effects of the dual orexin receptor antagonist DORA‐22 on sleep in 5XFAD mice
Duncan, M. J., Farlow, H., Tirumalaraju, C., Yun, D., Wang, C., Howard, J. A., Sanden, M. N., O’Hara, B. F., McQuerry, K., & Bachstetter, A. D. (2019) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2019.01.003 · Cited by 34 · see citing works
Cellular Senescence in Traumatic Brain Injury: Evidence and Perspectives
Schwab, N., Leung, E., & Hazrati, L. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.742632 · Cited by 33 · see citing works
Erfanizadeh, M., Noorafshan, A., Namavar, M. R., Karbalay‐Doust, S., & Talaei‐Khozani, T. (2020) · Biological Research · doi:10.1186/s40659-020-00300-8 · Cited by 28 · see citing works
Cell Senescence and Central Regulators of Immune Response
Lunin, S. M., Novoselova, E. G., Glushkova, O. V., Parfenyuk, S. B., Novoselova, T. V., & Khrenov, M. O. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084109 · Cited by 28 · see citing works
Moreno‐Villanueva, M., von Scheven, G., Feiveson, A. H., Bürkle, A., Wu, H., & Goel, N. (2018) · SLEEP · doi:10.1093/sleep/zsy067 · Cited by 28 · see citing works
Prather, A. A. (2019) · Sleep and Health · doi:10.1016/b978-0-12-815373-4.00024-1 · Cited by 27 · see citing works
Maternal Sleep in Pregnancy and Postpartum Part II: Biomechanisms and Intervention Strategies
Carroll, J., Teti, D., Hall, M., & Christian, L. (2019) · Current Psychiatry Reports · doi:10.1007/s11920-019-1000-9 · Cited by 23 · see citing works
Self-citationLifestyle interventions to delay senescence
Martel, J., Ojcius, D. M., & Young, J. D. (2023) · Biomedical Journal · doi:10.1016/j.bj.2023.100676 · Cited by 29 · see citing works
Hypertension and cellular senescence
Afşar, B., & Afşar, R. E. (2023) · Biogerontology · doi:10.1007/s10522-023-10031-4 · Cited by 21 · see citing works
Kidney Disease as a Driver of Immunosenescence
Song, Z., Tsou, S., Martin, F., Kayumov, M., Xiao, Y., Zhou, H., Abdi, R., & Tullius, S. G. (2025) · Journal of the American Society of Nephrology · doi:10.1681/asn.0000000896 · Cited by 20 · see citing works
Mehrzadi, S., Sheibani, M., Koosha, F., Alinaghian, N., Pourhanifeh, M. H., Tabaeian, S. P., Reiter, R. J., & Hosseinzadeh, A. (2023) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2023.2267439 · Cited by 19 · see citing works
Hansen, J. L., Carroll, J., Seeman, T. E., Cole, S. W., & Rentscher, K. E. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.10.022 · Cited by 21 · see citing works
Self-citationLee, H., Kim, B., & Park, T. (2024) · Clinical Epigenetics · doi:10.1186/s13148-024-01706-x · Cited by 18 · see citing works
Christian, L. M. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.03.010 · Cited by 18 · see citing works
Impact of Sleep Deprivation on Major Neuroinflammatory Signal Transduction Pathways
Mahalakshmi, A. M., Lokesh, P., Hediyal, T. A., Kalyan, M., Vichitra, C., Essa, M. M., Qoronfleh, M. W., Pandi-Perumal, S. R., & Chidambaram, S. B. (2022) · Sleep and Vigilance · doi:10.1007/s41782-022-00203-6 · Cited by 17 · see citing works
Jean‐Louis, G., Shochat, T., Youngstedt, S. D., Briggs, A., Williams, E. T., Jin, P., Bubu, O. M., & Seixas, A. A. (2021) · Sleep Medicine · doi:10.1016/j.sleep.2021.09.004 · Cited by 16 · see citing works
Metabolism of sleep and aging: Bridging the gap using metabolomics
Sengupta, A., & Weljie, A. M. (2018) · Nutrition and Healthy Aging · doi:10.3233/nha-180043 · Cited by 16 · see citing works
Ding, Y., Lin, H., Zhou, S., Wang, K., Li, L., Zhang, Y., Yao, Y., Gao, M., Liu, X., & He, N. (2018) · Aging and Disease · doi:10.14336/ad.2018.0204 · Cited by 16 · see citing works
Transcriptomic markers of biological aging in breast cancer survivors: a longitudinal study
Carroll, J., Crespi, C. M., Cole, S., Ganz, P. A., Petersen, L., & Bower, J. E. (2024) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djae201 · Cited by 15 · see citing works
Self-citationLee, C., Lin, J., Prokop, A., Gopalakrishnan, V., Hanna, R. N., Papa, E., Freeman, A., Patel, S., Yu, W., Huhn, M., et al. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.868015 · Cited by 15 · see citing works
Iloabuchi, C., Innes, K. E., & Sambamoorthi, U. (2020) · Sleep Health · doi:10.1016/j.sleh.2019.12.003 · Cited by 13 · see citing works
Carroll, J., Olmstead, R. E., Cole, S. W., Breen, E. C., Arevalo, J. M. G., & Irwin, M. R. (2023) · GeroScience · doi:10.1007/s11357-023-00741-5 · Cited by 13 · see citing works
Self-citationA health equity framework to support the next generation of cancer population simulation models
Chapman, C. H., Jayasekera, J. C., Dash, C., Sheppard, V. B., & Mandelblatt, J. S. (2023) · JNCI Monographs · doi:10.1093/jncimonographs/lgad017 · Cited by 13 · see citing works
Sleep, inflammation, and perception of sad facial emotion: A laboratory-based study in older adults
Piber, D., Eisenberger, N. I., Olmstead, R., Cho, H. J., Breen, E. C., Boyle, C. C., Karmarkar, E. N., Guzman, M., Kim, H., & Irwin, M. R. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.06.011 · Cited by 13 · see citing works
Self-citationA Revisit to Etiopathogenesis and Therapeutic Strategies in Alzheimer’s Disease
Kumar, M., & Bansal, N. (2021) · Current Drug Targets · doi:10.2174/1389450122666211118125233 · Cited by 13 · see citing works
Cohn, W., Zhu, C., Campagna, J. J., Bilousova, T. V., Spilman, P. R., Teter, B., Li, F., Guo, R., Elashoff, D. A., Cole, G. M., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23095257 · Cited by 11 · see citing works
The application of protein microarray assays in psychoneuroimmunology
Ayling, K., Bowden, T., Tighe, P. J., Todd, I., Dilnot, E. M., Negm, O. H., Fairclough, L. C., & Vedhara, K. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.09.013 · Cited by 11 · see citing works
Hacking the functions of sleep: noninvasive approaches to stimulate sleep neurophysiology
Krugliakova, E., Breuer, F., Adelhöfer, N., Alonso, A., Besedovsky, L., Murphy, K. R., Peters, E., Raczek, K., Rasch, B., Salvesen, L., et al. (2025) · Physiological Reviews · doi:10.1152/physrev.00007.2025 · Cited by 15 · see citing works
Feltes, B. C., & Alvares, L. D. O. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16131 · Cited by 10 · see citing works
Ahmed, S., Gozal, D., & Khalyfa, A. (2025) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2025.102170 · Cited by 10 · see citing works
Wu, Q., Klopack, E. T., Kim, J. K., Arpawong, T. E., Thyagarajan, B., Cole, S., Faul, J. D., Zhou, F., & Crimmins, E. M. (2025) · Nature Communications · doi:10.1038/s41467-025-64835-8 · Cited by 9 · see citing works
Self-citationPiber, D., Olmstead, R. E., Cho, J. H., & Irwin, M. R. (2023) · SLEEP · doi:10.1093/sleep/zsad130 · Cited by 9 · see citing works
Self-citationRyu, S., Morey, B. N., Lee, G., Kawachi, I. I., Redline, S. S., & Lee, S. (2022) · American Journal of Epidemiology · doi:10.1093/aje/kwac211 · Cited by 7 · see citing works
Rest, Repair, Repeat: The Complex Relationship of Autophagy and Sleep
Ullern, H., Schnur, P., Boccara, C. N., & Knævelsrud, H. (2025) · Journal of Molecular Biology · doi:10.1016/j.jmb.2025.169227 · Cited by 6 · see citing works
Christian, L. M., Kiecolt‐Glaser, J. K., Cole, S. W., Burd, C. E., Madison, A. A., Wilson, S. J., & Rosko, A. E. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.04.019 · Cited by 6 · see citing works
Self-citationSkinspan: A Holistic Roadmap for Extending Skin Longevity With Evidence‐Based Interventions
Kream, E. J., Fabi, S. G., & Boen, M. (2025) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.70432 · Cited by 5 · see citing works
Hormonal changes during aging and their effects on quality of life
Coggins, C., Patel, S., Nigam, S., & Rai, V. (2025) · Exploration of Endocrine and Metabolic Diseases · doi:10.37349/eemd.2025.101447 · Cited by 5 · see citing works
Alhazzaa, O. A., Abahussin, H. M., Majrashi, M. A., Alotaibi, M. S., Alkhrayef, M. N., Alhamdan, Z. A., & Alawad, A. O. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1743142 · Cited by 5 · see citing works
Sun, L., Zhang, J., Li, W., Sheng, J., Xiao, S., & Initiative, A. D. N. (2023) · BMC Medicine · doi:10.1186/s12916-023-02910-x · Cited by 5 · see citing works
Zhang, Y.-W., Shen, Y., Zhang, H., Yao, H., & Hu, B. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106070 · Cited by 5 · see citing works
Elevated DNA damage without signs of aging in the short-sleeping Mexican cavefish
Lloyd, E., Xia, F., Moore, K., Zertuche Mery, C., Rastogi, A., Kozol, R. A., Kenzor, O., Warren, W., Appelbaum, L., Moran, R. L., et al. (2025) · eLife · doi:10.7554/elife.99191.3 · Cited by 5 · see citing works
Premature aging in serious mental illness
Diniz, B. S., Fries, G. R., Kuo, C.-L., Xu, M., & Lenze, E. J. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-026-02322-4 · Cited by 4 · see citing works
Chronic Kidney Disease and Cellular Senescence
Morevati, M., Tavenier, J., Scheibye‐Knudsen, M., Houlind, M. B., Hedayati, A., & Hornum, M. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27073205 · Cited by 4 · see citing works
Altered sleep and inflammation are related to outcomes in neonatal encephalopathy
Hurley, T., Stewart, P., McCarthy, R., O’Dea, M. I., Kelly, L. A., Daly, M. C., Butler, J. M., McCarthy, R., Miletín, J., Sweetman, D., et al. (2024) · Acta Paediatrica · doi:10.1111/apa.17457 · Cited by 4 · see citing works
Sharma, A., Muresanu, D. F., Lafuente, J. V., Ozkızılcık, A., Tian, Z. R., Buzoianu, A. D., & Sharma, H. S. (2017) · Springer eBooks · doi:10.1007/978-3-319-57696-1_5 · Cited by 4 · see citing works
Qiao, Y., Zhao, J., Liu, M., Liu, J., Qiao, Z., Xu, R., Ning, X., Sun, S., & Chen, X. (2026) · Biomolecules · doi:10.3390/biom16040611 · Cited by 3 · see citing works
Degenerative changes induced by paradoxical sleep deprivation in rat sublingual glands
de Aguiar, G. C., Souza, A. C. F., de Souza, D. V., Neto, M. M., Sueur, L. D. P. L., Malinverni, A. C. D. M., Antunes, H. K. M., & Ribeiro, D. A. (2023) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-023-08041-6 · Cited by 3 · see citing works
Neighborhood opportunity and cellular senescence in a national sample of U.S. adults
Rodrigues, M., Bather, J. R., Crump, A. A., Kranz, E. O., Cole, S. W., & Cuevas, A. G. (2026) · Social Science & Medicine · doi:10.1016/j.socscimed.2026.119196 · Cited by 2 · see citing works
Self-citationNoordam, R., Ao, L., Stroo, J. F., van Dijk, K. W., & van Heemst, D. (2024) · European Journal of Clinical Investigation · doi:10.1111/eci.14189 · Cited by 2 · see citing works
The role of sleep in the aging processes
Isaev, R. I., Mkhitaryan, E. A., Cherdak, M. A., Vasilevskaya, V. V., Marakhovskaya, E. A., & Arbatskiy, M. S. (2024) · Problems of Geroscience · doi:10.37586/2949-4745-3-2024-141-153 · Cited by 2 · see citing works
On the Role of Sleep in the Aging Processes
Isaev, R. I., Mkhitaryan, E. A., Cherdak, M. A., Vasilevskaya, V. V., Marakhovskaya, E. A., & Arbatskiy, M. S. (2024) · Advances in Gerontology · doi:10.1134/s2079057025600053 · Cited by 2 · see citing works
Xu, K., Xu, Y., Qin, Y., Zhang, Y., Zheng, H., Chen, C., & Su, Y. (2025) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.66.3.57 · Cited by 2 · see citing works
Washburn, P. J. (2016) · International Journal of User-Driven Healthcare · doi:10.4018/ijudh.2016010102 · Cited by 2 · see citing works
When wrinkles appear on the immune system can it be reversed?
Sibaii, H., El-Zayat, S. R., & Khalil, M. (2020) · European Cytokine Network · doi:10.1684/ecn.2020.0441 · Cited by 3 · see citing works
Buntinx, Y., Hendrix, J., Wyns, A., Campenhout, J. V., Xiong, H.-Y., Laeremans, T., Cuesta‐Sancho, S., Aerts, J. L., Nijs, J., & Polli, A. (2025) · Biomolecules · doi:10.3390/biom15111601 · Cited by 1 · see citing works
Elkattawy, H. A., El-Sherbiny, M., Elsherbiny, N. M., Wahid, R. M., El-sayed, S. F., Henidi, H. A., El‐Gamal, R., Alshehri, S., & Asdaq, S. M. B. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1742343 · Cited by 1 · see citing works
Sleep, Psychoneuroimmunology, and Mind–Body Medicine
Yan, Q. (2016) · Springer eBooks · doi:10.1007/978-3-319-45111-4_5 · Cited by 1 · see citing works
Age-Related Changes in Immune Regulation by Noncoding RNAs
Wang, W., Qian, F., & Montgomery, R. R. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_109 · Cited by 1 · see citing works
Senescence: No country for old cells
Martel, J., Ojcius, D. M., & Young, J. D. (2023) · Biomedical Journal · doi:10.1016/j.bj.2023.100697 · Cited by 1 · see citing works
Wang, W., Chen, Y., Shen, Y., Chen, J., Yao, X., Cheng, Y., Xu, J., Ma, L., Chen, Y., & Zhang, C. (2024) · Rejuvenation Research · doi:10.1089/rej.2024.0008 · Cited by 1 · see citing works
Sleep Disorders/Sleep-Wake Disorders
Bertelli, M. O., Bianco, A., Buonaguro, E. F., Merli, M. P., Rossi, M., Forte, L., & Scuticchio, D. (2022) · Springer eBooks · doi:10.1007/978-3-319-95720-3_26 · Cited by 1 · see citing works
Tempaku, P. F., Hirotsu, C., Silva, V., & Tufik, S. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.07.014 · Cited by 1 · see citing works
Naler, L. B., Hsieh, Y.-P., Geng, S., Zhou, Z., Li, L., & Lu, C. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.28.437377 · Cited by 1 · see citing works
- Authors
- Carroll, J. E., Cole, S. W., Seeman, T. E., Breen, E. C., Witarama, T., Arevalo, J. M. G., Ma, J., & Irwin, M. R.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Carroll, Judith E.
- ORCID
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 51
- Pages
- 223-229
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC4679552
- OpenAlex
- W1279301897
- Cited by
- 129
- References
- 70
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 26 · 2023: 15 · 2022: 11 · 2021: 10 · 2020: 12 · 2019: 14 · 2018: 7 · 2017: 2 · 2016: 7
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Aging (R01 AG034588)
- UCLA Older Americans Independence Center (P30 AG028748)
- UCLA Clinical and Translational Science Institute (UL1TR000124)
- National Institute of Mental Health (T32 MH019925)
- NIA (K01 AG044462)
- American Sleep Medicine Foundation
- Cousins Center for Psychoneuroimmunology
- USC/UCLA Center on Biodemography & Population Health (P30 AG017265)
- UCLA Neuroscience Genomics Core Laboratory
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- sleep restriction, DNA damage response, senescence-associated secretory phenotype, cellular senescence, p16INK4a, leukocyte gene expression, peripheral blood mononuclear cells, aging, NFKB2, NBS1, Chk2, age-related disease risk, older adults
- MeSH terms
- Aged, Aged, 80 and over, Aging, DNA Damage, Female, Humans, Leukocytes, Mononuclear, Male, Middle Aged, Phenotype, Sleep Deprivation, Cellular Senescence, Genes, p16
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